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Conserved domains on  [gi|63054666|ref|NP_594894|]
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guanyl-nucleotide exchange factor Sec74 [Schizosaccharomyces pombe]

Protein Classification

Sec7 and PH domain-containing protein( domain architecture ID 10475611)

protein containing domains Sec7, PH, and TPH

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
306-422 6.75e-31

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


:

Pssm-ID: 460178  Cd Length: 183  Bit Score: 119.87  E-value: 6.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666   306 KLCLRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNI 385
Cdd:pfam01369  63 IEVLKAFVDLFDFKGLRIDEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNP 142
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 63054666   386 HNRQKMTRAEFISNT----NLPTILPEILECFYDNITYTPF 422
Cdd:pfam01369 143 NVKKKMTLEDFIRNLrginDGKDFPDEYLEEIYDSIKKNEI 183
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
549-676 1.39e-04

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


:

Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 41.77  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666    549 VFKLGILIQNEKVRKDRLlsnREVGVILTSSQLMFFKNvywisglldqledfkrshsfspcyfSPHLTSLSADYIIPLSD 628
Cdd:smart00233   1 VIKEGWLYKKSGGGKKSW---KKRYFVLFNSTLLYYKS-------------------------KKDKKSYKPKGSIDLSG 52
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 63054666    629 L-VAYGDGSRIENELYSFSVKQKNQRTHVFSVTNVDELNDWLVKINFVS 676
Cdd:smart00233  53 CtVREAPDPDSSKKPHCFEIKTSDRKTLLLQAESEEEREKWVEALRKAI 101
 
Name Accession Description Interval E-value
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
306-422 6.75e-31

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 119.87  E-value: 6.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666   306 KLCLRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNI 385
Cdd:pfam01369  63 IEVLKAFVDLFDFKGLRIDEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNP 142
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 63054666   386 HNRQKMTRAEFISNT----NLPTILPEILECFYDNITYTPF 422
Cdd:pfam01369 143 NVKKKMTLEDFIRNLrginDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
309-422 2.25e-29

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 115.40  E-value: 2.25e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666 309 LRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSS-DECYILTFSLMILHTDFFNIHN 387
Cdd:cd00171  67 LHEFVDLFDFSGLRLDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSSSaDAAYTLAYSIIMLNTDLHNPNV 146
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 63054666 388 RQKMTRAEFISNT-------NLPtilPEILECFYDNITYTPF 422
Cdd:cd00171 147 KKKMTLEDFIKNLrgindgeDFP---REFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
309-422 4.87e-24

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 100.44  E-value: 4.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666    309 LRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYD--SSDECYILTFSLMILHTDFFNIH 386
Cdd:smart00222  70 LHAFVDLFDFSAKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPN 149
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 63054666    387 NRQKMTRAEFISNT----NLPTILPEILECFYDNITYTPF 422
Cdd:smart00222 150 VKKKMTLEDFIKNVrgsnDGEDLPREFLEELYDSIKNNEI 189
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
312-418 1.75e-15

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 81.79  E-value: 1.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666   312 YLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNIHNRQKM 391
Cdd:PLN03076  684 YVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKM 763
                          90       100       110
                  ....*....|....*....|....*....|....
gi 63054666   392 TRAEFISNT-------NLPTilpEILECFYDNIT 418
Cdd:PLN03076  764 SADDFIRNNrgiddgkDLPE---EFMRSLYERIS 794
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
549-676 1.39e-04

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 41.77  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666    549 VFKLGILIQNEKVRKDRLlsnREVGVILTSSQLMFFKNvywisglldqledfkrshsfspcyfSPHLTSLSADYIIPLSD 628
Cdd:smart00233   1 VIKEGWLYKKSGGGKKSW---KKRYFVLFNSTLLYYKS-------------------------KKDKKSYKPKGSIDLSG 52
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 63054666    629 L-VAYGDGSRIENELYSFSVKQKNQRTHVFSVTNVDELNDWLVKINFVS 676
Cdd:smart00233  53 CtVREAPDPDSSKKPHCFEIKTSDRKTLLLQAESEEEREKWVEALRKAI 101
PH pfam00169
PH domain; PH stands for pleckstrin homology.
549-676 4.29e-04

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 40.62  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666   549 VFKLGILIQNEKVRKDRLlsnREVGVILTSSQLMFFKNVywisglldqledfKRSHSFSPCYfsphltslsadyIIPLSD 628
Cdd:pfam00169   1 VVKEGWLLKKGGGKKKSW---KKRYFVLFDGSLLYYKDD-------------KSGKSKEPKG------------SISLSG 52
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 63054666   629 L-VAYGDGSRIENELYSFSVK---QKNQRTHVFSVTNVDELNDWLVKINFVS 676
Cdd:pfam00169  53 CeVVEVVASDSPKRKFCFELRtgeRTGKRTYLLQAESEEERKDWIKAIQSAI 104
 
Name Accession Description Interval E-value
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
306-422 6.75e-31

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 119.87  E-value: 6.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666   306 KLCLRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNI 385
Cdd:pfam01369  63 IEVLKAFVDLFDFKGLRIDEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNP 142
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 63054666   386 HNRQKMTRAEFISNT----NLPTILPEILECFYDNITYTPF 422
Cdd:pfam01369 143 NVKKKMTLEDFIRNLrginDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
309-422 2.25e-29

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 115.40  E-value: 2.25e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666 309 LRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSS-DECYILTFSLMILHTDFFNIHN 387
Cdd:cd00171  67 LHEFVDLFDFSGLRLDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSSSaDAAYTLAYSIIMLNTDLHNPNV 146
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 63054666 388 RQKMTRAEFISNT-------NLPtilPEILECFYDNITYTPF 422
Cdd:cd00171 147 KKKMTLEDFIKNLrgindgeDFP---REFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
309-422 4.87e-24

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 100.44  E-value: 4.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666    309 LRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYD--SSDECYILTFSLMILHTDFFNIH 386
Cdd:smart00222  70 LHAFVDLFDFSAKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPN 149
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 63054666    387 NRQKMTRAEFISNT----NLPTILPEILECFYDNITYTPF 422
Cdd:smart00222 150 VKKKMTLEDFIKNVrgsnDGEDLPREFLEELYDSIKNNEI 189
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
312-418 1.75e-15

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 81.79  E-value: 1.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666   312 YLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNIHNRQKM 391
Cdd:PLN03076  684 YVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKM 763
                          90       100       110
                  ....*....|....*....|....*....|....
gi 63054666   392 TRAEFISNT-------NLPTilpEILECFYDNIT 418
Cdd:PLN03076  764 SADDFIRNNrgiddgkDLPE---EFMRSLYERIS 794
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
549-676 1.39e-04

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 41.77  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666    549 VFKLGILIQNEKVRKDRLlsnREVGVILTSSQLMFFKNvywisglldqledfkrshsfspcyfSPHLTSLSADYIIPLSD 628
Cdd:smart00233   1 VIKEGWLYKKSGGGKKSW---KKRYFVLFNSTLLYYKS-------------------------KKDKKSYKPKGSIDLSG 52
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 63054666    629 L-VAYGDGSRIENELYSFSVKQKNQRTHVFSVTNVDELNDWLVKINFVS 676
Cdd:smart00233  53 CtVREAPDPDSSKKPHCFEIKTSDRKTLLLQAESEEEREKWVEALRKAI 101
PH pfam00169
PH domain; PH stands for pleckstrin homology.
549-676 4.29e-04

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 40.62  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054666   549 VFKLGILIQNEKVRKDRLlsnREVGVILTSSQLMFFKNVywisglldqledfKRSHSFSPCYfsphltslsadyIIPLSD 628
Cdd:pfam00169   1 VVKEGWLLKKGGGKKKSW---KKRYFVLFDGSLLYYKDD-------------KSGKSKEPKG------------SISLSG 52
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 63054666   629 L-VAYGDGSRIENELYSFSVK---QKNQRTHVFSVTNVDELNDWLVKINFVS 676
Cdd:pfam00169  53 CeVVEVVASDSPKRKFCFELRtgeRTGKRTYLLQAESEEERKDWIKAIQSAI 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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