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Conserved domains on  [gi|19115876|ref|NP_594964|]
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DSC E3 ubiquitin ligase complex subunit Dsc4 [Schizosaccharomyces pombe]

Protein Classification

DSC4 family protein( domain architecture ID 10553508)

DSC4 family protein is a DUF1746 domain-containing protein similar to Schizosaccharomyces pombe Defective for SREBP cleavage protein 4, which is a component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1746 pfam08508
Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This ...
 18-129 2.64e-38

Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.


:

Pssm-ID: 430039  Cd Length: 116  Bit Score: 130.75  E-value: 2.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115876    18 SLDMLCYAIIAQQYFQDPTVLLLLLKVFVQLSYLTPKPFSQLNALP----LFYPLLLNFLISLMVRMFFNLPTAGESLDG 93
Cdd:pfam08508   1 SLDLLCYVLLSILYYMDCSFFRLLLRAFVQLSFLTPKPPHFPEPLPanrpLLVAILGSNLLCLLLHLLFGLPSAGEATRG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19115876    94 YLYGGSIINFIGEKNESSRIDFITSDLVLFCLQIFM 129
Cdd:pfam08508  81 YLHGGLIIDFIGQKGPSSRLHLLLLDLLILALQLLM 116
 
Name Accession Description Interval E-value
DUF1746 pfam08508
Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This ...
 18-129 2.64e-38

Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.


Pssm-ID: 430039  Cd Length: 116  Bit Score: 130.75  E-value: 2.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115876    18 SLDMLCYAIIAQQYFQDPTVLLLLLKVFVQLSYLTPKPFSQLNALP----LFYPLLLNFLISLMVRMFFNLPTAGESLDG 93
Cdd:pfam08508   1 SLDLLCYVLLSILYYMDCSFFRLLLRAFVQLSFLTPKPPHFPEPLPanrpLLVAILGSNLLCLLLHLLFGLPSAGEATRG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19115876    94 YLYGGSIINFIGEKNESSRIDFITSDLVLFCLQIFM 129
Cdd:pfam08508  81 YLHGGLIIDFIGQKGPSSRLHLLLLDLLILALQLLM 116
 
Name Accession Description Interval E-value
DUF1746 pfam08508
Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This ...
 18-129 2.64e-38

Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.


Pssm-ID: 430039  Cd Length: 116  Bit Score: 130.75  E-value: 2.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115876    18 SLDMLCYAIIAQQYFQDPTVLLLLLKVFVQLSYLTPKPFSQLNALP----LFYPLLLNFLISLMVRMFFNLPTAGESLDG 93
Cdd:pfam08508   1 SLDLLCYVLLSILYYMDCSFFRLLLRAFVQLSFLTPKPPHFPEPLPanrpLLVAILGSNLLCLLLHLLFGLPSAGEATRG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19115876    94 YLYGGSIINFIGEKNESSRIDFITSDLVLFCLQIFM 129
Cdd:pfam08508  81 YLHGGLIIDFIGQKGPSSRLHLLLLDLLILALQLLM 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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