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Conserved domains on  [gi|19111851|ref|NP_595059|]
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transporter Amf1 [Schizosaccharomyces pombe]

Protein Classification

MFS transporter( domain architecture ID 13024647)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 49-491 1.17e-158

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 455.57  E-value: 1.17e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  49 FIACTAQLMTQAGLGQSIAPNNIIGKSLGTtNPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLI 128
Cdd:cd17476   1 ATISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 129 SGFSyyaKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTY 208
Cdd:cd17476  80 AGFS---PNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 209 WTTAIVCIVFAIIGYFaiphieadeveekqkfdylgaffgvsglvlinfswnqgpvvgwqvpyvyilliigflslvvfvl 288
Cdd:cd17476 157 WFLAILAAIVAVAAIF---------------------------------------------------------------- 172

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 289 vekrvvqpilapsMMNSEMGCVLICVAAGWACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRL 368
Cdd:cd17476 173 -------------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL 239

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 369 KPTKIMVVSMIAFTVGTILIATAPIHQTYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSIS 448
Cdd:cd17476 240 PPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGIS 319

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 19111851 449 IGLGIAGTVETHLNHKGVDLIRGYRSAWYMGTGFGGLGVCVAI 491
Cdd:cd17476 320 IGLGIAGTVETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
 
Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 49-491 1.17e-158

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 455.57  E-value: 1.17e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  49 FIACTAQLMTQAGLGQSIAPNNIIGKSLGTtNPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLI 128
Cdd:cd17476   1 ATISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 129 SGFSyyaKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTY 208
Cdd:cd17476  80 AGFS---PNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 209 WTTAIVCIVFAIIGYFaiphieadeveekqkfdylgaffgvsglvlinfswnqgpvvgwqvpyvyilliigflslvvfvl 288
Cdd:cd17476 157 WFLAILAAIVAVAAIF---------------------------------------------------------------- 172

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 289 vekrvvqpilapsMMNSEMGCVLICVAAGWACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRL 368
Cdd:cd17476 173 -------------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL 239

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 369 KPTKIMVVSMIAFTVGTILIATAPIHQTYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSIS 448
Cdd:cd17476 240 PPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGIS 319

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 19111851 449 IGLGIAGTVETHLNHKGVDLIRGYRSAWYMGTGFGGLGVCVAI 491
Cdd:cd17476 320 IGLGIAGTVETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
48-444 3.48e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.29  E-value: 3.48e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  48 VFIACTAQLMTQAGLGQSIAPNNIIGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSL 127
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 128 ISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWT 207
Cdd:COG2814  91 LCAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 208 YWTTAIVCIVFAIIGYFAIPhieadEVEEKQKFDYLGAFFGVsglvlinfswnqgpvvgWQVPYVYILLIIGFLSlvvfv 287
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLP-----ESRPAARARLRGSLREL-----------------LRRPRLLLLLLLAFLL----- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 288 lvekrvvqpilapsmmnsemgcvlicvaagWACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKR 367
Cdd:COG2814 220 ------------------------------GFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19111851 368 LKPTKIMVVSMIAFTVGTILIATAPihqtYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVN 444
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
MFS_1 pfam07690
Major Facilitator Superfamily;
71-450 4.51e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.19  E-value: 4.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851    71 IIGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYyakSVIMFDVCRALTGI 150
Cdd:pfam07690  22 LLAEDLGIS-PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS---SLWLLLVLRVLQGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   151 APAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIE 230
Cdd:pfam07690  98 GAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   231 ADEVEEKQkfdylgaffgvsglvlinfswnqgpvvgwqvpyvyilliigflslvvfvlvEKRVVQPILAPSMMNSEMGCV 310
Cdd:pfam07690 177 SKRPKPAE---------------------------------------------------EARLSLIVAWKALLRDPVLWL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   311 LICVAAGWACFGIWMYYLWQFLENLRFaTPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIAT 390
Cdd:pfam07690 206 LLALLLFGFAFFGLLTYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL 284

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   391 APIHQTYWAQTFVSIIVTpWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIG 450
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLG-FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
PRK14995 PRK14995
SmvA family efflux MFS transporter;
83-298 3.94e-07

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 52.42  E-value: 3.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   83 QLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYYAKSVImfdVCRALTGIAPAFLLPNALAL 162
Cdd:PRK14995  42 ELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI---ATRALLAIGAAMIVPATLAG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  163 LGRVYPPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIEADeveEKQKFDY 242
Cdd:PRK14995 119 IRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGR---RDQPLNL 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 19111851  243 LGAFFGVSGLVLINFSWNQGpVVGWQVPYVYIL-LIIGFLSLVVFVLVEKRVVQPIL 298
Cdd:PRK14995 196 GHALMLIVAILLLVYSAKTA-LKGFLSLWVTSLtLLTGALLLGLFIRTQLAASRPMI 251
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 100-227 6.45e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 6.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   100 LIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRvYPPGKKKNLIFAL 179
Cdd:TIGR00895  70 LFFGPLADRIGRRRVLLWSILLFSVFTLLCAL---ATNVTQLLILRFLAGLGLGGLMPNLNALVSE-YAPKRFRGTAVGL 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 19111851   180 FGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIP 227
Cdd:TIGR00895 146 MFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
 
Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 49-491 1.17e-158

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 455.57  E-value: 1.17e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  49 FIACTAQLMTQAGLGQSIAPNNIIGKSLGTtNPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLI 128
Cdd:cd17476   1 ATISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 129 SGFSyyaKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTY 208
Cdd:cd17476  80 AGFS---PNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 209 WTTAIVCIVFAIIGYFaiphieadeveekqkfdylgaffgvsglvlinfswnqgpvvgwqvpyvyilliigflslvvfvl 288
Cdd:cd17476 157 WFLAILAAIVAVAAIF---------------------------------------------------------------- 172

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 289 vekrvvqpilapsMMNSEMGCVLICVAAGWACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRL 368
Cdd:cd17476 173 -------------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL 239

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 369 KPTKIMVVSMIAFTVGTILIATAPIHQTYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSIS 448
Cdd:cd17476 240 PPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGIS 319

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 19111851 449 IGLGIAGTVETHLNHKGVDLIRGYRSAWYMGTGFGGLGVCVAI 491
Cdd:cd17476 320 IGLGIAGTVETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 52-492 4.24e-47

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 167.74  E-value: 4.24e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  52 CTAQLMTQAGLGQSIAPNNIIGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGF 131
Cdd:cd17321   2 LLAVFLAALDVTIVNVALPTIARDLGAS-PSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 132 syyAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWtt 211
Cdd:cd17321  81 ---APSLAFLIAARALQGIGAAAIMPASLALIAATFPG-ERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL-- 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 212 aiVCIVFAIIGYFAIPhieadeveekqkfdylgAFFGVSGLVLINFswnqgpvvgwqvpyvyilliigflslvvfvlvek 291
Cdd:cd17321 155 --INVPIGLVALLLAR-----------------TFSGAVLAAFLLG---------------------------------- 181

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 292 rvvqpilapsmmnsemgcvlicvaagwACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPT 371
Cdd:cd17321 182 ---------------------------AALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 372 KIMVVSMIAFTVGTILIATAPIHQTYWaQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGL 451
Cdd:cd17321 235 LVLVAGLLLTAVGLLLLALLGADSSVW-LLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGV 313

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19111851 452 GIAGTVETHLNHKGVD--------------LIRGYRSAWYMGTGFGGLGVCVAIL 492
Cdd:cd17321 314 ALLGALLTAGLSANLGdsgvaallsaaaaaFAAGFHLAFLVAAALALLAALLALL 368
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 50-457 1.77e-27

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 115.80  E-value: 1.77e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  50 IACTAQLMTQAGLGQSIAPN-NIIGKSLGTTnpGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLI 128
Cdd:cd06179   1 AALCLAYFAQLFGVTLPAAVlPFIVADLGPS--SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 129 SGFsyyAKSVIMFDVCRALTGIAPAfLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQ--LSWWPW 206
Cdd:cd06179  79 AGT---AKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPN-KYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRW 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 207 TYWTTAIVCIVFAI---IGYFAIPHIEADEVEEKQK---FDYLGAFFGVSGLV--LINFSWNQGPvVGWQVPYVYILLII 278
Cdd:cd06179 154 IFYINAIFNALALIllfFFYHPPPRPQLHGSSTRQKlkrLDWVGLFLLIAGLVlfLLGLSWGGNP-YPWSSAHVIAPLVI 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 279 GFLSLVVFVLVEKRVV-QPILAPSMMNSEMGCVLICVAAGwacFGIWMYY----LWQFLENLRFAT-PLLVTAQLTPVGI 352
Cdd:cd06179 233 GGVLLIAFGLYEWKGTkDGLLPPRLLFRGRNFALILIVAF---VEGMIFYslniFWPQQISLLFTTdPLKAGLYQLPFGL 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 353 SGCAAALTTGYLLKRLKPTKI-MVVSMIAFTVGTILIATAPIHQTYWAQTFVSIIvtpwGMDMSFP--AATLMLSDFVPK 429
Cdd:cd06179 310 GTLFGAILAGLLLTKIKHIKWqLVAGFVLFTAFLALLALITPDNKALAIAFSVLA----GIGIGGPlvLAIVIVQLSVPP 385

                       410       420
                ....*....|....*....|....*...
gi 19111851 430 QHQGIAASLVSTVVNYSISIGLGIAGTV 457
Cdd:cd06179 386 EDIGTASGLLGSARALGGAVGTAIFTSI 413
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
48-444 3.48e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.29  E-value: 3.48e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  48 VFIACTAQLMTQAGLGQSIAPNNIIGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSL 127
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 128 ISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWT 207
Cdd:COG2814  91 LCAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 208 YWTTAIVCIVFAIIGYFAIPhieadEVEEKQKFDYLGAFFGVsglvlinfswnqgpvvgWQVPYVYILLIIGFLSlvvfv 287
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLP-----ESRPAARARLRGSLREL-----------------LRRPRLLLLLLLAFLL----- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 288 lvekrvvqpilapsmmnsemgcvlicvaagWACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKR 367
Cdd:COG2814 220 ------------------------------GFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19111851 368 LKPTKIMVVSMIAFTVGTILIATAPihqtYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVN 444
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
MFS_1 pfam07690
Major Facilitator Superfamily;
71-450 4.51e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.19  E-value: 4.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851    71 IIGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYyakSVIMFDVCRALTGI 150
Cdd:pfam07690  22 LLAEDLGIS-PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS---SLWLLLVLRVLQGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   151 APAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIE 230
Cdd:pfam07690  98 GAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   231 ADEVEEKQkfdylgaffgvsglvlinfswnqgpvvgwqvpyvyilliigflslvvfvlvEKRVVQPILAPSMMNSEMGCV 310
Cdd:pfam07690 177 SKRPKPAE---------------------------------------------------EARLSLIVAWKALLRDPVLWL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   311 LICVAAGWACFGIWMYYLWQFLENLRFaTPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIAT 390
Cdd:pfam07690 206 LLALLLFGFAFFGLLTYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL 284

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   391 APIHQTYWAQTFVSIIVTpWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIG 450
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLG-FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 72-325 3.87e-20

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 90.64  E-value: 3.87e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  72 IGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIA 151
Cdd:COG0477  40 IAADLGAS-SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL---APSPELLIAARALQGIG 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 152 PAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYF-----AI 226
Cdd:COG0477 116 AGGLMPGALALIAELFPA-RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRlpesrGL 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 227 PHIEADEVEEKQKFDYLGAFFGVSGLVLINFSWNQGPVVGWQVPYVYILLIIGFLSLVVFVLVEKRVVQPILAPSMMNSE 306
Cdd:COG0477 195 LLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLAL 274

                       250
                ....*....|....*....
gi 19111851 307 MGCVLICVAAGWACFGIWM 325
Cdd:COG0477 275 LLALLLLLLLLLLLLLLAL 293
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 83-440 6.64e-19

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 88.00  E-value: 6.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  83 QLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALAL 162
Cdd:cd17502  31 LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL---APNMTMLIVGRAIQGIGGGGLMSLAFII 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 163 LGRVYPP---GKKKNLIFALFGATApngfLLGSVFSGIFAQLSWWPWTYWttaivcivfaiigyfaiphieadeveekqk 239
Cdd:cd17502 108 IADLVPPrerGKYQGYIGAVFGIAS----VAGPLIGGAFTDHLSWRWCFY------------------------------ 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 240 fdylgaffgvsglvlINfswnqgpvvgwqvpyvyilLIIGFLSLVVFvlvekrvvqpilapsmmnSEMGCVLICVAAGWA 319
Cdd:cd17502 154 ---------------IN-------------------LPIGGLALALL------------------RTILLSSIFGFLFGG 181

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 320 CFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTK-IMVVSMIAFTVGTILIATAPIHQTYW 398
Cdd:cd17502 182 ALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpLIVIGTILMSVGAGLLTTLTLDTSKW 261

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 19111851 399 AQTFVSIIVTpWGMDMSFPAATLMLSDFVPKQHQGIAASLVS 440
Cdd:cd17502 262 LLIGYLILLG-LGLGIGFQQPLVAVQNAVPPADVGVATATNT 302
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 79-493 1.22e-18

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 87.63  E-value: 1.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  79 TNPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAfLLPN 158
Cdd:cd17504  28 TSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF---APNLPVLIAGRALQGIGGA-VFPL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 159 ALALLgRVYPPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIigyfAIPHIEADeveekq 238
Cdd:cd17504 104 AFALV-REEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA----LVPLIDLR------ 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 239 kfdylgaFFGVSGLVLINFswnqgpvvgwqvpyvyILLIIGFLSLVVFVLVEKRVVQPilapsmmnsemgcvlicvaaGW 318
Cdd:cd17504 173 -------LLRRRNVLLANI----------------TALLAGFGMFMVFQLLPQLLQLP--------------------TP 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 319 ACFGiwmyylwqflenlrfATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATapIHQTYW 398
Cdd:cd17504 210 TGFG---------------LGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAL--LHSSLW 272

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 399 AQTFVSIIVTpWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVET----HLNHKGVDLIRGYRS 474
Cdd:cd17504 273 ALVVALLLIG-IGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTtytvSITSGGVPTEGAYVL 351

                       410
                ....*....|....*....
gi 19111851 475 AWYMGTGFGGLGVCVAILT 493
Cdd:cd17504 352 AFLIGAALALAALLLSLLI 370
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 71-455 5.62e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.62  E-value: 5.62e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  71 IIGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGyiwFCIWSLISGFSYYAKSVIMFDVCRALTGI 150
Cdd:cd17325  21 LYAESLGAS-VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG---LLLLAVSTLLFAFATSYWQLLLARFLQGL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 151 APAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPhie 230
Cdd:cd17325  97 ASAAVWPAAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP--- 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 231 aDEVEEKQKFDYLGAFFGVSGLVLINFswnqgpvvgwqvPYVYILLIIGFLSLVVFVLVEkrvvqPILaPSMMNSEMGcv 310
Cdd:cd17325 173 -EPRPPPNKRAVSAARLRSGLRLLLRD------------RRLLALFLAIFVLAFAFGALE-----PFL-PLYAAELGG-- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 311 licvaagwacfgiwmyylwqflenlrfATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIAT 390
Cdd:cd17325 232 ---------------------------LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19111851 391 APihqtYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAG 455
Cdd:cd17325 285 AT----SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG 345
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 72-460 7.48e-15

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 76.08  E-value: 7.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  72 IGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYYAKSVIMFdvcRALTGIA 151
Cdd:cd17503  22 IMGDLGAS-LDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIF---RILQGFG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 152 PAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWttaiVCIVFAIIGYFAIPhiea 231
Cdd:cd17503  98 GGVLIPLAQTILLRIYPP-EKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFY----INLPIGILALLLAP---- 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 232 deveekqkfdylgaffgvsglvLINFSWNQGPVvgwqvpYVYILLIIGFLSLVVFVLvekrvvqpilapsmmnsemgcvl 311
Cdd:cd17503 169 ----------------------LLDLRLFKDRN------FTLGLLLSFLLGLGLFGA----------------------- 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 312 icvaagwacfgiwMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATA 391
Cdd:cd17503 198 -------------MFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFL 264

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19111851 392 PIHQTYWAQTFVSIIVTpWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVETH 460
Cdd:cd17503 265 TPDTSLWLIILPLFIRG-LGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-226 1.22e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.21  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  45 IVFVFIACTAQLMTQAGLGQSIAPnniIGKSLGTTNpGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCI 124
Cdd:COG2271  12 LALLFLAYFLNYLDRSNLSVAAPP---LQADLGLSA-AQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 125 WSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWW 204
Cdd:COG2271  88 ATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPP-KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163

                       170       180
                ....*....|....*....|..
gi 19111851 205 PWTYWTTAIVCIVFAIIGYFAI 226
Cdd:COG2271 164 RAAFLILGLPGLLLALLRFWLL 185
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 72-491 2.40e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 71.43  E-value: 2.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  72 IGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIA 151
Cdd:cd17324  25 IARDFGVS-VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL---APSFALLLLARALAGLA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 152 PAFLLPNALALLGRVYPPGKKKNLIFALFGATAPnGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIEA 231
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTL-GLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 232 devEEKQKFDYLGAFFGVsglvlinfswnqgpvvgWQVPYVYILLIIGFLSLvvfvlvekrvvqpilapsmmnsemgcvl 311
Cdd:cd17324 180 ---KKPGSLGLLSSLLLL-----------------LRNPRLRLAYLITFLLF---------------------------- 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 312 icvaagwACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATA 391
Cdd:cd17324 212 -------GGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 392 PihqtYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPkQHQGIAASLVSTVVNYSISIGLGIAGTVETHLnhkgvdlirG 471
Cdd:cd17324 285 P----SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHG---------G 350

                       410       420
                ....*....|....*....|
gi 19111851 472 YRSAWYMGTGFGGLGVCVAI 491
Cdd:cd17324 351 WAGVGWVGAALLLLALLLAL 370
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
80-493 1.20e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.52  E-value: 1.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  80 NPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIwfcIWSLISGFSYYAKSVIMFDVCRALTGIAPAFLLPNA 159
Cdd:COG2223  38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL---LLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVG 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 160 LALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIEADEVEEKQK 239
Cdd:COG2223 115 IALVSKWFPP-DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 240 --FDYLGAFFgvsglvlinfswnqgpvvGWQVPYVYILLIIGFLSLVVFVLVekrvvqpilAPSMMNSEMGcvLICVAAG 317
Cdd:COG2223 194 slRDQLEALR------------------DPRFWLLSLLYFGTFGSFIGFSSW---------LPPYLVDQFG--LSAATAG 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 318 wacfgiwmyylwqflenLRFATPLLVTAQLTPVGisgcaaalttGYLLKRLKPTKIMVVSMIAFTVGTILIATAPiHQTY 397
Cdd:COG2223 245 -----------------LLAALFALLGALGRPLG----------GWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLW 296

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 398 WAQTFVSIIVTPWGMDM-SFPAatlMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVethlnhkgVDLIRGYRSAW 476
Cdd:COG2223 297 LFLVLFLLLGLALGGGNgAVFA---LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL--------LDATGSYTAAF 365

                       410
                ....*....|....*..
gi 19111851 477 YMGTGFGGLGVCVAILT 493
Cdd:COG2223 366 LVFAVLALVALVLTLLL 382
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 72-466 1.28e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 69.14  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  72 IGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSyyaKSVIMFDVCRALTGIA 151
Cdd:cd17474  25 IAEALGAS-PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS---DSFALLLAGRALQGIG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 152 PAFLLPNALALLGRVYpPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWpWTYWTTAIVCIVfAIIGYFAIPHIEA 231
Cdd:cd17474 101 AAGLGPLALTLIGDLF-EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWR-YPFFLLAALIPV-AFLAILFLLPEPK 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 232 DEVEEKQKFDYLGAFFGVSGLVlinfswnqgpvvgwqvpyvyiLLIIGFLSLVVFVlvekrvvqpilapsmmnsemgcvl 311
Cdd:cd17474 178 EKAKSSSATKLRDLKKALRGRG---------------------LLTFLVSAFLYFF------------------------ 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 312 icvaagwaCFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLL-KRLKPTKIMVVSMIAFTVGtiLIAT 390
Cdd:cd17474 213 --------LYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLkKRFGARRILVIGLLLYALS--LLLL 282

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111851 391 APIHQTYWAqtFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVETHLNHKGV 466
Cdd:cd17474 283 GFVPSLALL--LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP 356
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 80-491 7.47e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 67.07  E-value: 7.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  80 NPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNA 159
Cdd:cd06174  29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF---APSFWLLLLGRFLLGLGSGLIDPAV 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 160 LALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSW--WPWTYWTTAIVCIVFAIIGYFAIPHIEADEVEEK 237
Cdd:cd06174 106 LALIADLFPE-RERGRALGLLQAFGSVGGILGPLLGGILASSLGfgWRAVFLIAAALALLAAILLLLVVPDPPESARAKN 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 238 QKFDYLgaffgvsglvlinfSWNQGPVVGWQVPYVYILLIIGFLSLVVFVlvekrvvqpilapsmmnsemgcvlicvaag 317
Cdd:cd06174 185 EEASSK--------------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYY------------------------------ 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 318 wacfgIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTK-IMVVSMIAFTVGTILIATAPIHQT 396
Cdd:cd06174 221 -----SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMALGLALLLLAPSLLL 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 397 YWAQTFVSIIvtpwGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVETHLNhkgvdlirGYRSAW 476
Cdd:cd06174 296 LLLLLLLLGF----GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--------GLTGAF 363

                       410
                ....*....|....*
gi 19111851 477 YMGTGFGGLGVCVAI 491
Cdd:cd06174 364 LVLAVLLLLAAILLL 378
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 91-441 5.52e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 64.13  E-value: 5.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  91 YSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFciwsLISGFS-YYAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPp 169
Cdd:cd17473  44 PALFIALFAPLAGWLADRFGRKRLLIAGLLLY----GIGGVAgLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFE- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 170 GKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSW-WPWTYWTTAIVCIVFAIigyFAIPHIEADEVEEKQKFDYLGAFFg 248
Cdd:cd17473 119 GEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWrAPFLVYLLALPVLILVL---LFLPEPARKSKSAASPGAATAAAL- 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 249 vsglvlinfswnqgpvvgwQVPYVYILLIIGFLSLVVFVLVekrvvqPILAPSmmnsemgcvlicvaagwacfgiwmyyl 328
Cdd:cd17473 195 -------------------PWKRVLPIYFLAFLAMLLFYVI------PIQLPF--------------------------- 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 329 wqFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAPIhqtyWAQTFVSIIVT 408
Cdd:cd17473 223 --LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG----LWVVLLGAILA 296

                       330       340       350
                ....*....|....*....|....*....|...
gi 19111851 409 PWGMDMSFPAATLMLSDFVPKQHQGIAASLVST 441
Cdd:cd17473 297 GLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 45-229 2.04e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 62.20  E-value: 2.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  45 IVFVFIACTAQLMTQAGLGQSIAPnniIGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGyiwFCI 124
Cdd:cd17319   5 IPLLFLAYVINYLDRVNISVAAPT---IMKDLGLS-PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVS---MLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 125 WSLISGFSYYAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWW 204
Cdd:cd17319  78 WSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPA-RERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGW 156

                       170       180
                ....*....|....*....|....*
gi 19111851 205 PWTYWTTAIVCIVFAIIGYFAIPHI 229
Cdd:cd17319 157 RWAFIIEGLLGLLLAVLWWFYLRQV 181
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 85-312 2.28e-09

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 59.68  E-value: 2.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851    85 SWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLI----SGFSYYAKSVIMFDVCRALTGIAPAF---LLP 157
Cdd:pfam06609  81 GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVgctaNKFNTLLAAMTLLGVAAGPAGASPLFigeLMS 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   158 NALALLGRVyppgkkknLIFALFGATAPNGFLLGSVFSgIFAQLSWWPWTYWTTAIVCIVFAIIGY----FAIPH-IEAD 232
Cdd:pfam06609 161 NKTKFLGLL--------IVSAPTIAMNGAGPYFGQRLA-IQGNWRWIFYIYIIMSAIAVLLIIIWYhppsFAQLHgKKAR 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   233 EVEEKQKFDYLGAFFGVSG--LVLINFSWNQGPVVGWQVPYVYILLIIGFLSLVVFVLVE--KRVVQPILAPSMMNSEMG 308
Cdd:pfam06609 232 KRDELAKLDWIGIFLVIAGtsLFLLGVSWGGKPNNPWNSAKIIGLISSGAGSLVIFALYEvfGKPEQPIIPPALFKDTRG 311


                  ....*.
gi 19111851   309 --CVLI 312
Cdd:pfam06609 312 fvCILI 317
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 91-227 1.21e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 53.73  E-value: 1.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  91 YSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPg 170
Cdd:cd17323  43 FVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL---APNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTP- 118

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19111851 171 KKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIP 227
Cdd:cd17323 119 EERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
80-441 1.47e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 53.70  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  80 NPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNA 159
Cdd:COG0738  41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLGLGLLDVAA 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 160 LALLGRVYPpgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSW---WPWTYWTTAIVCIVFAIIGYFA-IPHIEADEVE 235
Cdd:COG0738 118 NPYVAALGP--ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslsWHLPYLILAVLLLLLALLFLRSkLPEIEEEEEE 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 236 EKQKFDYLGAFfgvsglvlinfswnqgpvvgWQVPYVYILLIIGFLslvvFVLVEkrvvqpilapsmmnsemgcvlicva 315
Cdd:COG0738 196 AAGSAASLKSL--------------------LKNPRLLLGGLAIFL----YVGAE------------------------- 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 316 agwACFGIWMYylwQFLENLRFATPllVTAQLTPVGISGCAAA--LTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAPi 393
Cdd:COG0738 227 ---GAIGDWLP---LYLKDVLGLSE--ATAALGLSLFWGGMTIgrFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP- 297

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 19111851 394 hqtYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVST 441
Cdd:COG0738 298 ---GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 101-221 2.43e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.01  E-value: 2.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 101 IAGRLGDIYGHKKMFVLGyiwFCIWSLISGFSYYAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPgKKKNLIFALF 180
Cdd:cd17328  53 IFGYLGDRYNRKWILAVG---ILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPK-EKRTRALGVF 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 19111851 181 GATAPNGFLLGSVFSGIFAQLSW-WPWTYWTTAIVCIVFAII 221
Cdd:cd17328 129 YFAIPLGSGLGYVVGGLVAQATGgWRWAFRVTGVLGVLLAIL 170
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 72-455 3.74e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 52.19  E-value: 3.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  72 IGKSLGTTnPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIA 151
Cdd:cd17320  25 IARDLGAS-ASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL---ASSIEQLLIARFLQGLG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 152 PAFLLPNALALLgRVYPPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPhiEA 231
Cdd:cd17320 101 AAAGSVVARAIV-RDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP--ET 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 232 DEVEEKQKFdyLGAFFGVSGLVLINFswnqgpvvgwqvPYVYILLIIGFLSLVVFVLVekrvvqpILAPSMMNSEMGcvl 311
Cdd:cd17320 178 LPEEKRKPL--LSSLLRAYKRVLKNR------------RFLGYALALGLSFAGLFAYL-------AAAPFIYIEQLG--- 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 312 icvaagwacFGIWMYYLWQFlenlrfatpllvtaqltPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGT--ILIA 389
Cdd:cd17320 234 ---------LSPAQFGLLFA-----------------LNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAAlvLLLA 287

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111851 390 TAPIHQTYWAqTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHqGIAASLVSTVVNYSISIGLGIAG 455
Cdd:cd17320 288 ALLGGLSLWP-LVAPLFLIFFGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVG 351
PRK14995 PRK14995
SmvA family efflux MFS transporter;
83-298 3.94e-07

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 52.42  E-value: 3.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   83 QLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYYAKSVImfdVCRALTGIAPAFLLPNALAL 162
Cdd:PRK14995  42 ELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI---ATRALLAIGAAMIVPATLAG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  163 LGRVYPPGKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIEADeveEKQKFDY 242
Cdd:PRK14995 119 IRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGR---RDQPLNL 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 19111851  243 LGAFFGVSGLVLINFSWNQGpVVGWQVPYVYIL-LIIGFLSLVVFVLVEKRVVQPIL 298
Cdd:PRK14995 196 GHALMLIVAILLLVYSAKTA-LKGFLSLWVTSLtLLTGALLLGLFIRTQLAASRPMI 251
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
188-457 4.57e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.21  E-value: 4.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 188 FLLGSVFSGIFAQLSWW--PWTYWTTAIVCIVFAIIGYFA-----IPHI-----EADEVEEKQK-------FDYLGAFFG 248
Cdd:COG2211  84 ILIGAIPLALSFVLLFTapDLSPTGKLIYALVTYLLLGLAytlvnIPYSalgaeLTPDYEERTRlsswrfaFAGLGGLLA 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 249 VSGLVLINFSWNQGPVVGWQVPYVYILLIIGFLSLVVFVLVEKRVVQPILAPSMM--------NSEMGCVLICVAAGWAC 320
Cdd:COG2211 164 SVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKeslkallkNRPFLLLLLAYLLFFLA 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 321 FGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAPIHQTYWAQ 400
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19111851 401 TFVSIIVTPWGMDMSFPAAtlMLSDFVPKQHQ-------GIAASLVSTVVNYSISIGLGIAGTV 457
Cdd:COG2211 324 VLAALAGIGLGAILVLPWA--MLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLL 385
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
310-494 1.03e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.66  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 310 VLICVAAGWACFGIWMYYLWQFLENLRfATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIA 389
Cdd:COG2814  15 LALGAFLSGLGIGIVLPALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 390 TAPihqTYWaQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVETHLnhkgvdli 469
Cdd:COG2814  94 LAP---SLW-LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-------- 161

                       170       180
                ....*....|....*....|....*
gi 19111851 470 rGYRSAWYMGTGFGGLGVCVAILTV 494
Cdd:COG2814 162 -GWRWVFLVNAVLALLALLLLLRLL 185
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 100-433 2.06e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 2.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 100 LIAGRLGDIYGHKKMFVLGYIwfcIWSLISGFSYYAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPGKKKnLIFAL 179
Cdd:cd17329  53 LIGGRLADRFGRKPVMLAGLL---LRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRT-RAFSL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 180 FGATAPNGFLLGSVFSGIFAQLSwWPWTYWTTAIVCIVFAIIGYFAIPHIEADEVEEKQKfdylgAFFGVSGLVLINfsw 259
Cdd:cd17329 129 LYWAINLGVAIGPLLGGLLLLYS-FRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKT-----EILRGYKIVLRD--- 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 260 nqgpvvgwqvpYVYILLIIGFLSLvvfvlvekrvvqpilapsmmnsemgcvlicvaagWACFGIWMYYLWQFLENLRFAT 339
Cdd:cd17329 200 -----------RAFLLFLLASFLI----------------------------------SLIYFQLESTLPVYVVEILGLG 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 340 PLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAPIhqtyWAQTFVSIIVTPWGMDMSFPAA 419
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT----LAVLILAMIVLTLGEMLVFPAV 310

                       330
                ....*....|....
gi 19111851 420 TLMLSDFVPKQHQG 433
Cdd:cd17329 311 QTLVAALAPPDKRG 324
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 100-221 4.31e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 45.65  E-value: 4.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 100 LIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLgRVYPPGKKKNLIFAL 179
Cdd:cd17365  52 LLAGPLADRFGRKRVLLVSVALFGLFTLLTAF---AQSVLQLALLRFLTGLGLGAAMPNAITLV-SEYAPARRRSLAVTL 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 19111851 180 FGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAII 221
Cdd:cd17365 128 MFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 84-227 5.93e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 45.24  E-value: 5.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  84 LSWFPASYSLTVgtfiLIAGRLGDIYGHKKMFVLGyiwFCIWSLISGFSYYAKSVIMFD--VCRALTGIAPAFLLPNALA 161
Cdd:cd17380  40 LSSFFWGYALTQ----VLGGYLADRFGGKKVLLLA---VALWSLATLLTPLLAYSSLPLliLSRILLGLGEGVHFPSMTS 112

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111851 162 LLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIP 227
Cdd:cd17380 113 LFSRWVPV-SERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 95-224 1.47e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 44.17  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  95 VGTFI--LIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYYAKSVIMFDVCRALTGIAPAfLLPNALALLGRVYPPGKK 172
Cdd:cd17357  60 IGGAIgsFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACG-LSTGFVPMYLQEISPSEL 138

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 19111851 173 KNLIFALFGATAPNGFLLGSVFS--GIFAQLSWWPWTYWTTAIVCIVFAIIGYF 224
Cdd:cd17357 139 RGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAALPF 192
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 100-221 1.91e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.74  E-value: 1.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 100 LIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSyyaKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPGKKK---NLI 176
Cdd:cd17316  54 LLFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGfalGLL 130

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19111851 177 FALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAII 221
Cdd:cd17316 131 QSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL 175
Sugar_tr pfam00083
Sugar (and other) transporter;
83-224 2.90e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 43.41  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851    83 QLSWFPASYSltVGTFI--LIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYYAKSVIMFDVCRALTGIAPAFLLPNAL 160
Cdd:pfam00083  47 LSGLIVSIFS--VGCFIgsLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAP 124

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19111851   161 ALLGRVYPPGKKKNLI--FALFGATapnGFLLGSVFSGIFA---QLSWWPWTYWTTAIVCIVFAIIGYF 224
Cdd:pfam00083 125 MYISEIAPKKLRGALGslYQLAITF---GILLAYIFGLGLNktsNSDGWRIPLGLQLVPALLLIIGLLF 190
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 78-496 3.82e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.99  E-value: 3.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  78 TTNPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYYAK--SVIMFDVCRALTGIAPAFL 155
Cdd:cd06173  30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslSLWLLLVLAFLLGIASAFF 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 156 LPNALALLGRVYPPGKKKNLIfALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAiVCIVFAIIGYFAIPhIEADEVE 235
Cdd:cd06173 110 GPARQALLPELVPKEQLVRAN-ALNSLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSALLLLFIR-RPPPAAP 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 236 EKQKFDYLGAFFGVSGLVlinfswnqgpvvgWQVPYVYILLIIGFLSLVVFVLVEkrVVQPILAPSMMNsemgcvlicva 315
Cdd:cd06173 187 GESSSLLLRDLREGLRYL-------------RRSPLLRLLLLALALFALLGGALT--VLLPLLAKEVLG----------- 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 316 agwacfgiwmyylwqflenlrfATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAPIHq 395
Cdd:cd06173 241 ----------------------GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL- 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 396 tyWAQTFVSIIVTPWGMDMSFPAATLMLSDfVPKQHQGIAASLVSTVVNYSISIGLGIAGTVETHLNHKGVdlirgyrsa 475
Cdd:cd06173 298 --WLLLAALFLLGLAGGLFNVPLNTLLQLR-VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV--------- 365

                       410       420
                ....*....|....*....|.
gi 19111851 476 wymgtgFGGLGVCVAILTVFA 496
Cdd:cd06173 366 ------FLLAGALLLLAALLL 380
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-202 4.41e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 4.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  80 NPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIwSLISGFSYYAKSVIMFDVCRALTGIAPAFLLPNA 159
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL-GLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP 340

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 19111851 160 LALLGRVYPPGKKKN------LIFALFGATAPNGFLLGSVFSGIFAQLS 202
Cdd:COG2211 341 WAMLADVVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_1 pfam07690
Major Facilitator Superfamily;
310-455 5.39e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   310 VLICVAAGWACFGIWMYYLWQFLENLRFATPLLVTAQLTPVGISGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIA 389
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111851   390 TAPihqtYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAG 455
Cdd:pfam07690  81 FAS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG 142
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
356-499 5.92e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.16  E-value: 5.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 356 AAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAPihqtYWAQTFVSIIVTPWGMDMSFPAATLMLSDFVPKQHQGIA 435
Cdd:COG2271  60 LGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT----SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19111851 436 ASLVSTVVNYSISIGLGIAGTVETHLnhkgvdlirGYRSAWYMGTGFGGLGVCVAILTVFASYL 499
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAAF---------GWRAAFLILGLPGLLLALLRFWLLALAYF 190
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 100-227 9.74e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.45  E-value: 9.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 100 LIAGRLGDIYGHKKMFVLGyiwFCIWSLISGFSYYA--KSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPGKKKNLif 177
Cdd:cd17318  74 IPGGYLAEKYGAKRVLGYS---ILITALLTLLTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRL-- 148

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 19111851 178 alfGATAPNGFLLGSVF----SGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIP 227
Cdd:cd17318 149 ---TSIAYSGSQFGTVIamplSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 81-224 1.11e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.49  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  81 PGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYyakSVIMFDVCRALTGIAPAFLLPNAL 160
Cdd:cd17312  37 KDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST---SLWFFAVLWGLNGLFQSMGWPPCV 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19111851 161 ALLGRVYPPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYF 224
Cdd:cd17312 114 KLLGNWFSK-KERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFF 176
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 232-463 1.21e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.02  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 232 DEVEEKQKFDYLGAFFGVSGLVlinfswnqGPVVGW----QVPYVYILLIIGFLSLV--VFVLVEKRVVQPILAPSMmns 305
Cdd:cd17330 116 DEEERAKAFGIISAAFGLGFIL--------GPALGGflstPYGYALPFLVAAALALLnlVLVLFFLPPLRRLLLVYF--- 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 306 emgCVLICVAAGWACFGIWMYYLWQFlenlrfaTPLLVTAQLTPVGISGCAA-ALTTGYLLKRLKPTKIMVVSMIAFTVG 384
Cdd:cd17330 185 ---LIALAFAGLESVFSLFLKDRFGF-------SPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIG 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 385 TILIATAP-IHQTYWAQTFVSIivtpwGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVETHLNH 463
Cdd:cd17330 255 LLLLPFASsVPLLVLAAAILAF-----GTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 91-225 1.74e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 1.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  91 YSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPPG 170
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF---AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19111851 171 KKkNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFA 225
Cdd:cd17489 313 RR-GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 188-492 1.91e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.61  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 188 FLLGSVFSGIFAQLSW-WPWTYWTTAIVCIVFAIIGYFAIPHI------EADEVEEKQkfdylGAFFGVSGLVLINFSWN 260
Cdd:cd17471  65 LILLALLAGALGYLLFaFLRNYWVLLLVGVVLLSLGAAAFPQLfalareYADRSSGRD-----ATLFNSVLRAAFSLAWV 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 261 QGPVVGWQVPYVY----ILLIIGFLSLVVFVLV-----------EKRVVQPILAPSMMNSEMGCVLICVAAGWACfgIWM 325
Cdd:cd17471 140 IGPPLAFLLLDVLgftgLFLLAALLYLVVALLVlfllpsvkppaQKATPASSLVKAPVNRRLLLLFAAFTLLFAA--NSM 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 326 YYLwqflenlrfATPLLVTAQL----TPVGI-SGCAAA------LTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAP-I 393
Cdd:cd17471 218 YII---------AMPLYVTNELggseSWVGLlFGLAAAleipimLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATsL 288

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 394 HQTYWAQ----TFVSIIVTpwgmdmsfpAATLMLSDFVPKQhQGIAASLVSTVVNYSISIGLGIAGTVETHLnhkgvdli 469
Cdd:cd17471 289 WQLIALQllnaIFIGITAG---------LGISYFQDLMPGQ-PGLATTLYSNASRIGSLLGGLLAGVIAQYF-------- 350

                       330       340
                ....*....|....*....|...
gi 19111851 470 rGYRSAWYMGTGFGGLGvCVAIL 492
Cdd:cd17471 351 -GYRAVFLVCAVLALLA-LVLLL 371
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 86-433 2.29e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 40.31  E-value: 2.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  86 WFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAfLLPNALALLGR 165
Cdd:cd17388  42 VLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAF---APTLWWLYLGRIIAGITGA-TGAVAAAYIAD 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 166 VYPPGKK-KNliFALFGATAPNGFLLGSVFSGIFAQLS-WWPwtYWTTAIVCIVFAIIGYFAIPhieadeveEKQKFDYL 243
Cdd:cd17388 118 VTPPEQRaRN--FGLLGAAFGLGFIAGPALGGLLGEISpRAP--FLVAAGLNGLNFLLGLFVLP--------ESLPPERR 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 244 GAFFGVSGLVLINFSWNQGpvvgwqVPYVYILLIIGFLslvvfvlvekrvvqpilapsmmnseMGCVLICVAAGWACFGI 323
Cdd:cd17388 186 RAFRWRRANPFGSLRWLTG------FPGLLGLLAVFFL-------------------------IQLIGQVPATTWVLFTE 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 324 WmyylwqflenlRFA-TPLLVTAQLTPVGI-SGCAAALTTGYLLKRLKPTKIMVVSMIAFTVGTILIATAPihQTYWAqt 401
Cdd:cd17388 235 D-----------RFDwSPTMVGLSLAVFGLlHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFAT--QGWMV-- 299

                       330       340       350
                ....*....|....*....|....*....|..
gi 19111851 402 FVSIIVTPWGmDMSFPAATLMLSDFVPKQHQG 433
Cdd:cd17388 300 FPILILLALG-GIAGPALQGLLSRQVPENEQG 330
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 89-494 2.37e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.27  E-value: 2.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  89 ASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRVYP 168
Cdd:cd17489  38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL---ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIP 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 169 PGKKKNLIfALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIEADEVEEKQKFDYLGAFFG 248
Cdd:cd17489 115 PSRRGEGI-GYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVE 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 249 VSGLVlinfswnqgpvvgwqvPYVYILLI-IGFLSLVVFVlvekrvvqPILAPSMMNSEMGCVLICVAAgwacfgiwMYY 327
Cdd:cd17489 194 KKVLP----------------PALILFLAsIAYGAISTFL--------PLYAAERGISNAGLFFTVYAI--------ALL 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 328 LWQFLenlrfatpllvtaqltpvgisgcaaaltTGYLLKRLKPTKIMVVSMIAFTVGTILIATApihqTYWAQTFVSIIV 407
Cdd:cd17489 242 LSRPF----------------------------SGKLSDRKGPKTVIIPGLLLLALGLLLLSFA----GSPWMLLLAAVL 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 408 TPWGMDMSFPAATLMLSDFVPKQHQGIAASLVSTVVNYSISIGLGIAGTVETHLnhkgvdlirGYRSAWYMGTGFGGLGV 487
Cdd:cd17489 290 YGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF---------GYRAMFLLAAVVVLLAL 360


                ....*..
gi 19111851 488 CVAILTV 494
Cdd:cd17489 361 VLYIFLL 367
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 43-225 2.66e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.29  E-value: 2.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  43 HEIVFVFIACTAQLMTQAGLGQSIApnnIIGKSLGTTNPGQLSWFPASYSltVGTFI--LIAGRLGDIYGHKKMFVLGYI 120
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLP---LLAKEVLGGGAAGYGLLLAAFG--VGALLgaLLLGRLSKRRRRGRLLLIGAL 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 121 WFCIWSLISGFSyyaKSVIMFDVCRALTGIAPAFLLPNALALLGRVYPP---GKkknlIFALFGATAPNGFLLGSVFSGI 197
Cdd:cd06173 283 LLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDelrGR----VFSVYNALNSGAMPLGALLAGL 355

                       170       180
                ....*....|....*....|....*...
gi 19111851 198 FAQLSWWPWTYWTTAIVCIVFAIIGYFA 225
Cdd:cd06173 356 LADALGLSAVFLLAGALLLLAALLLLLL 383
PRK10504 PRK10504
putative transporter; Provisional
 72-288 4.59e-03

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 39.71  E-value: 4.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   72 IGKSLGTtNPGQLSWFPASYSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFSYYAKSVIMfdvCRALTGIA 151
Cdd:PRK10504  36 MAQSLGE-SPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLL---ARVLQGVG 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  152 PAFLLPNALALLGRVYPpgkKKNLIFALFGATAPN--GFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHI 229
Cdd:PRK10504 112 GAMMVPVGRLTVMKIVP---REQYMAAMTFVTLPGqvGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMPNY 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19111851  230 EAdeveEKQKFDYLGAFFGVSGLVLINFSWNQGPVVGWQVPYVYILLIIGFLSLVVFVL 288
Cdd:PRK10504 189 TM----QTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLL 243
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 91-258 5.79e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.12  E-value: 5.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851  91 YSLTVGTFILIAGRLGDIYGHKKMFVLGYIWFCIWSLIsgfSYYAKSVIMFDVCRALTG---IAPAfllpnALALLGRVY 167
Cdd:cd17472  41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLL---AAYATSIYGLILGRALQGsgaISSV-----VMALLADLT 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851 168 PPgKKKNLIFALFGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIPHIEADEVEEKQKFDYLGAFF 247
Cdd:cd17472 113 RE-ENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLL 191

                       170
                ....*....|.
gi 19111851 248 GVSGLVLINFS 258
Cdd:cd17472 192 KNKRLLRLDFS 202
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 100-227 6.45e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 6.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111851   100 LIAGRLGDIYGHKKMFVLGYIWFCIWSLISGFsyyAKSVIMFDVCRALTGIAPAFLLPNALALLGRvYPPGKKKNLIFAL 179
Cdd:TIGR00895  70 LFFGPLADRIGRRRVLLWSILLFSVFTLLCAL---ATNVTQLLILRFLAGLGLGGLMPNLNALVSE-YAPKRFRGTAVGL 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 19111851   180 FGATAPNGFLLGSVFSGIFAQLSWWPWTYWTTAIVCIVFAIIGYFAIP 227
Cdd:TIGR00895 146 MFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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