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Conserved domains on  [gi|19111893|ref|NP_595101|]
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nucleoporin Gle1 [Schizosaccharomyces pombe]

Protein Classification

Smc and GLE1 domain-containing protein( domain architecture ID 10544838)

Smc and GLE1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLE1 pfam07817
GLE1-like protein; The members of this family are sequences that are similar to the human ...
 218-439 3.92e-71

GLE1-like protein; The members of this family are sequences that are similar to the human protein GLE1. This protein is localized at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm.


:

Pssm-ID: 462280  Cd Length: 234  Bit Score: 225.54  E-value: 3.92e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   218 SEKKELKNYCFTQKRKITPRLGQITKSNSQIMKIT----QLLQQTFQEARNTDPLVYKWVLNFFCKSVVKQAEAEVAVNP 293
Cdd:pfam07817   1 KQDPELKKYRFQLKRAINPKVGQLSNSSEQLTDITnelnELLDSGKPVPVGHPQLAYIWILNFLAKAIVSQAETEVSVKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   294 ISAYPLAKVCLLLQTQNADLKDLLFARLQKNCPWVIPFWYDH----GTENGKKKMGFKKLSDGHWEQNTTYNERQCGIFA 369
Cdd:pfam07817  81 EAAFPLARVAVGLWSRHPELGDLLLARFVKKCPYLVPFYPPKtcgqDTEEYRKRLGYKRSDDGKWETEDKYLERMSGIIR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   370 VYAAILSLDDSLA----------PESWRTFSRLLNLPSPSqlmksdlelgQTLCSIVSTYLDIAGQSLLRIYGRQAKKLI 439
Cdd:pfam07817 161 LYAAITQTPLPKSskqnphphglPIGWRWLARILNTEPLS----------NTTATLLGAFLEVAGNRLLQAYGKQFIKLL 230
DUF4670 super family cl37896
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 81-189 7.32e-07

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


The actual alignment was detected with superfamily member pfam15709:

Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 51.49  E-value: 7.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    81 KKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNREL-LEKKRIEAERQRlKDEEERRkkeLMEKEKKEKERIRLIEEQK 159
Cdd:pfam15709 353 KRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIrLRKQRLEEERQR-QEEEERK---QRLQLQAAQERARQQQEEF 428

                          90       100       110
                  ....*....|....*....|....*....|
gi 19111893   160 HKENEQRRLKQEQIDAKRKEEEarEKRMKE 189
Cdd:pfam15709 429 RRKLQELQRKKQQEEAERAEAE--KQRQKE 456
 
Name Accession Description Interval E-value
GLE1 pfam07817
GLE1-like protein; The members of this family are sequences that are similar to the human ...
 218-439 3.92e-71

GLE1-like protein; The members of this family are sequences that are similar to the human protein GLE1. This protein is localized at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm.


Pssm-ID: 462280  Cd Length: 234  Bit Score: 225.54  E-value: 3.92e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   218 SEKKELKNYCFTQKRKITPRLGQITKSNSQIMKIT----QLLQQTFQEARNTDPLVYKWVLNFFCKSVVKQAEAEVAVNP 293
Cdd:pfam07817   1 KQDPELKKYRFQLKRAINPKVGQLSNSSEQLTDITnelnELLDSGKPVPVGHPQLAYIWILNFLAKAIVSQAETEVSVKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   294 ISAYPLAKVCLLLQTQNADLKDLLFARLQKNCPWVIPFWYDH----GTENGKKKMGFKKLSDGHWEQNTTYNERQCGIFA 369
Cdd:pfam07817  81 EAAFPLARVAVGLWSRHPELGDLLLARFVKKCPYLVPFYPPKtcgqDTEEYRKRLGYKRSDDGKWETEDKYLERMSGIIR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   370 VYAAILSLDDSLA----------PESWRTFSRLLNLPSPSqlmksdlelgQTLCSIVSTYLDIAGQSLLRIYGRQAKKLI 439
Cdd:pfam07817 161 LYAAITQTPLPKSskqnphphglPIGWRWLARILNTEPLS----------NTTATLLGAFLEVAGNRLLQAYGKQFIKLL 230
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 81-189 7.32e-07

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 51.49  E-value: 7.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    81 KKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNREL-LEKKRIEAERQRlKDEEERRkkeLMEKEKKEKERIRLIEEQK 159
Cdd:pfam15709 353 KRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIrLRKQRLEEERQR-QEEEERK---QRLQLQAAQERARQQQEEF 428

                          90       100       110
                  ....*....|....*....|....*....|
gi 19111893   160 HKENEQRRLKQEQIDAKRKEEEarEKRMKE 189
Cdd:pfam15709 429 RRKLQELQRKKQQEEAERAEAE--KQRQKE 456
PTZ00121 PTZ00121
MAEBL; Provisional
 62-249 1.08e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    62 IADENVRIFPPLHKTIDWAKKRNVEEQNLIEQSITESQ----RIFSEKQRLEQERFNRELLEKKRIE---AERQRLKDEE 134
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEenkiKAAEEAKKAEEDKKKAEEAKKAEEDekkAAEALKKEAE 1699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   135 ERRKKELMEKEKKEKERIrliEEQKHKENEQRRLKQEQidAKRKEEEarEKRMKETFKDDPEEDSNMA------WSIIHK 208
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKKK---AEELKKAEEENKIKAEE--AKKEAEE--DKKKAEEAKKDEEEKKKIAhlkkeeEKKAEE 1772

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 19111893   209 IKTEVVAPISEKKELKNycfTQKRKITPRLGQITKSNSQIM 249
Cdd:PTZ00121 1773 IRKEKEAVIEEELDEED---EKRRMEVDKKIKDIFDNFANI 1810
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 71-190 9.29e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.45  E-value: 9.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    71 PPLHKTIDWAKKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNRELlEKKRIEAERQRLKDEEERRKKELMEKEKKEKE 150
Cdd:TIGR02794  61 PAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQA-EQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAE 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 19111893   151 RIRLIEEQKHKENEQRRLKQEQIDAKRKEEEAREKRMKET 190
Cdd:TIGR02794 140 AERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEA 179
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 86-189 1.35e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 1.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  86 EEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQ 165
Cdd:COG1196 351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL 430

                        90       100
                ....*....|....*....|....
gi 19111893 166 RRLKQEQIDAKRKEEEAREKRMKE 189
Cdd:COG1196 431 AELEEEEEEEEEALEEAAEEEAEL 454
 
Name Accession Description Interval E-value
GLE1 pfam07817
GLE1-like protein; The members of this family are sequences that are similar to the human ...
 218-439 3.92e-71

GLE1-like protein; The members of this family are sequences that are similar to the human protein GLE1. This protein is localized at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm.


Pssm-ID: 462280  Cd Length: 234  Bit Score: 225.54  E-value: 3.92e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   218 SEKKELKNYCFTQKRKITPRLGQITKSNSQIMKIT----QLLQQTFQEARNTDPLVYKWVLNFFCKSVVKQAEAEVAVNP 293
Cdd:pfam07817   1 KQDPELKKYRFQLKRAINPKVGQLSNSSEQLTDITnelnELLDSGKPVPVGHPQLAYIWILNFLAKAIVSQAETEVSVKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   294 ISAYPLAKVCLLLQTQNADLKDLLFARLQKNCPWVIPFWYDH----GTENGKKKMGFKKLSDGHWEQNTTYNERQCGIFA 369
Cdd:pfam07817  81 EAAFPLARVAVGLWSRHPELGDLLLARFVKKCPYLVPFYPPKtcgqDTEEYRKRLGYKRSDDGKWETEDKYLERMSGIIR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   370 VYAAILSLDDSLA----------PESWRTFSRLLNLPSPSqlmksdlelgQTLCSIVSTYLDIAGQSLLRIYGRQAKKLI 439
Cdd:pfam07817 161 LYAAITQTPLPKSskqnphphglPIGWRWLARILNTEPLS----------NTTATLLGAFLEVAGNRLLQAYGKQFIKLL 230
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 81-189 7.32e-07

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 51.49  E-value: 7.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    81 KKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNREL-LEKKRIEAERQRlKDEEERRkkeLMEKEKKEKERIRLIEEQK 159
Cdd:pfam15709 353 KRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIrLRKQRLEEERQR-QEEEERK---QRLQLQAAQERARQQQEEF 428

                          90       100       110
                  ....*....|....*....|....*....|
gi 19111893   160 HKENEQRRLKQEQIDAKRKEEEarEKRMKE 189
Cdd:pfam15709 429 RRKLQELQRKKQQEEAERAEAE--KQRQKE 456
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 97-189 2.26e-06

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 47.34  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    97 ESQRIFSEKQRLEQERFNREllekkrieaERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQRRlkQEQIDAK 176
Cdd:pfam05672  11 EAARILAEKRRQAREQRERE---------EQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRR--EEEERQR 79

                          90
                  ....*....|...
gi 19111893   177 RKEEEAREKRMKE 189
Cdd:pfam05672  80 KAEEEAEEREQRE 92
PTZ00121 PTZ00121
MAEBL; Provisional
 62-249 1.08e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    62 IADENVRIFPPLHKTIDWAKKRNVEEQNLIEQSITESQ----RIFSEKQRLEQERFNRELLEKKRIE---AERQRLKDEE 134
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEenkiKAAEEAKKAEEDKKKAEEAKKAEEDekkAAEALKKEAE 1699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   135 ERRKKELMEKEKKEKERIrliEEQKHKENEQRRLKQEQidAKRKEEEarEKRMKETFKDDPEEDSNMA------WSIIHK 208
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKKK---AEELKKAEEENKIKAEE--AKKEAEE--DKKKAEEAKKDEEEKKKIAhlkkeeEKKAEE 1772

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 19111893   209 IKTEVVAPISEKKELKNycfTQKRKITPRLGQITKSNSQIM 249
Cdd:PTZ00121 1773 IRKEKEAVIEEELDEED---EKRRMEVDKKIKDIFDNFANI 1810
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 86-189 4.49e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.71  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    86 EEQNLIEQSITESQRIfsEKQRLEQERFNRELLEKKR-----IEAERQRLKDEEERRKKELMEKEKKEKERIRL-IEEQK 159
Cdd:pfam15709 376 EELELEQQRRFEEIRL--RKQRLEEERQRQEEEERKQrlqlqAAQERARQQQEEFRRKLQELQRKKQQEEAERAeAEKQR 453

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 19111893   160 HKE------NEQRRL----KQEQIDAKRKEEEAREKRMKE 189
Cdd:pfam15709 454 QKElemqlaEEQKRLmemaEEERLEYQRQKQEAEEKARLE 493
PTZ00121 PTZ00121
MAEBL; Provisional
 83-202 6.54e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 6.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    83 RNVEEQNLIEQS-ITESQRIFSEKQRLEQERFNREllEKKRIEAERQRlKDEEERRKKELMEKEKKEKERIrliEEQKHK 161
Cdd:PTZ00121 1581 RKAEEAKKAEEArIEEVMKLYEEEKKMKAEEAKKA--EEAKIKAEELK-KAEEEKKKVEQLKKKEAEEKKK---AEELKK 1654

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 19111893   162 ENEQRRLKQEQIdaKRKEEEarEKRMKETFKDDPEEDSNMA 202
Cdd:PTZ00121 1655 AEEENKIKAAEE--AKKAEE--DKKKAEEAKKAEEDEKKAA 1691
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 82-188 9.07e-05

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 42.72  E-value: 9.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    82 KRNVEEQNLIEQSITESQRIFSEKQRLEQERFNREllEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHK 161
Cdd:pfam05672  26 QREREEQERLEKEEEERLRKEELRRRAEEERARRE--EEARRLEEERRREEEERQRKAEEEAEEREQREQEEQERLQKQK 103

                          90       100
                  ....*....|....*....|....*..
gi 19111893   162 ENEQRRLKQEqidAKRKEEEaREKRMK 188
Cdd:pfam05672 104 EEAEAKAREE---AERQRQE-REKIMQ 126
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 71-190 9.29e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.45  E-value: 9.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    71 PPLHKTIDWAKKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNRELlEKKRIEAERQRLKDEEERRKKELMEKEKKEKE 150
Cdd:TIGR02794  61 PAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQA-EQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAE 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 19111893   151 RIRLIEEQKHKENEQRRLKQEQIDAKRKEEEAREKRMKET 190
Cdd:TIGR02794 140 AERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEA 179
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 100-197 1.08e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 42.35  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   100 RIFSEKQRLEQERfNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEkeRIRLIEEQKHKENEQRRLKQEQidaKRKE 179
Cdd:pfam15346  42 RVEEARKIMEKQV-LEELEREREAELEEERRKEEEERKKREELERILEE--NNRKIEEAQRKEAEERLAMLEE---QRRM 115

                          90
                  ....*....|....*...
gi 19111893   180 EEAREKRMKETFKDDPEE 197
Cdd:pfam15346 116 KEERQRREKEEEEREKRE 133
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 86-189 1.35e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 1.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  86 EEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQ 165
Cdd:COG1196 351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL 430

                        90       100
                ....*....|....*....|....
gi 19111893 166 RRLKQEQIDAKRKEEEAREKRMKE 189
Cdd:COG1196 431 AELEEEEEEEEEALEEAAEEEAEL 454
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 73-186 1.49e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 1.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  73 LHKTIDWAKKRNVEEQNLIEQSITESQRIFSEKQRLEQERF----------NRELLEKKRIEAERQRLKDEEERRKKELM 142
Cdd:COG1196 237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEeleleleeaqAEEYELLAELARLEQDIARLEERRRELEE 316

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 19111893 143 EKEKKEKERIRLIEEQKHKENEQRRLKQEQIDAKRKEEEAREKR 186
Cdd:COG1196 317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 80-186 2.05e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  80 AKKRNVEEQNLIEQSITESQRIFSEKQRLEQERfNRELLEKKRIEAERQRLKDEEERrkkELMEKEKKEKERIRLIEEQK 159
Cdd:COG1196 272 LRLELEELELELEEAQAEEYELLAELARLEQDI-ARLEERRRELEERLEELEEELAE---LEEELEELEEELEELEEELE 347

                        90       100
                ....*....|....*....|....*..
gi 19111893 160 HKENEQRRLKQEQIDAKRKEEEAREKR 186
Cdd:COG1196 348 EAEEELEEAEAELAEAEEALLEAEAEL 374
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 86-189 4.36e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 4.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  86 EEQNLIEQSITESQRIFSEKQRLEQERfNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQ 165
Cdd:COG1196 289 EEYELLAELARLEQDIARLEERRRELE-ERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                        90       100
                ....*....|....*....|....
gi 19111893 166 RRLKQEQIDAKRKEEEAREKRMKE 189
Cdd:COG1196 368 LEAEAELAEAEEELEELAEELLEA 391
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 104-189 7.47e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 41.86  E-value: 7.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   104 EKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQRRLKQEQIDAKRKEEEAR 183
Cdd:pfam15709 329 EQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQRQEEEER 408


                  ....*.
gi 19111893   184 EKRMKE 189
Cdd:pfam15709 409 KQRLQL 414
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 81-197 8.01e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 41.86  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    81 KKRNVEEQNLIEQSITESQRIFS---EKQRLEQERFNRELL---------EKKRIEAERQRLKDEEERRKKELMekekke 148
Cdd:pfam15709 393 KQRLEEERQRQEEEERKQRLQLQaaqERARQQQEEFRRKLQelqrkkqqeEAERAEAEKQRQKELEMQLAEEQK------ 466

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 19111893   149 keriRLIEEQKHKENEQRRLKQEQIDAKRKEEEAREKRMKETFKDDPEE 197
Cdd:pfam15709 467 ----RLMEMAEEERLEYQRQKQEAEEKARLEAEERRQKEEEAARLALEE 511
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 86-186 1.28e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  86 EEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKK---ELMEKEKKEKERIRLIEEQKHKE 162
Cdd:COG1196 324 ELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAeeeLEELAEELLEALRAAAELAAQLE 403

                        90       100
                ....*....|....*....|....
gi 19111893 163 NEQRRLKQEQIDAKRKEEEAREKR 186
Cdd:COG1196 404 ELEEAEEALLERLERLEEELEELE 427
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 86-198 1.76e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  86 EEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLkDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQ 165
Cdd:COG1196 331 ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA-EAEEELEELAEELLEALRAAAELAAQLEELEEAE 409

                        90       100       110
                ....*....|....*....|....*....|...
gi 19111893 166 RRLKQEQIDAKRKEEEAREKRMKETFKDDPEED 198
Cdd:COG1196 410 EALLERLERLEEELEELEEALAELEEEEEEEEE 442
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 80-186 1.79e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  80 AKKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRkkelMEKEKKEKERIRLIEEQK 159
Cdd:COG1196 391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAA----EEEAELEEEEEALLELLA 466

                        90       100
                ....*....|....*....|....*..
gi 19111893 160 HKENEQRRLKQEQIDAKRKEEEAREKR 186
Cdd:COG1196 467 ELLEEAALLEAALAELLEELAEAAARL 493
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 80-197 1.98e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.56  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893   80 AKKRNVEEQNLIEQSITESQrifsEKQRLEQERFNRelLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQK 159
Cdd:PRK09510  74 AKRAEEQRKKKEQQQAEELQ----QKQAAEQERLKQ--LEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKA 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 19111893  160 HKENEQRRL----KQEQIDAKRKEE-EAREKRMKETFKDDPEE 197
Cdd:PRK09510 148 KAEAEAKRAaaaaKKAAAEAKKKAEaEAAKKAAAEAKKKAEAE 190
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 86-179 2.24e-03

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 37.98  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    86 EEQNLIEQSITESQRIFSE-KQRLEQERFNRELLEKKRIEAE--RQRLK----DEEERRKKELMEKEKKEKERIRLIEEQ 158
Cdd:pfam20492  20 EETKKAQEELEESEETAEElEEERRQAEEEAERLEQKRQEAEeeKERLEesaeMEAEEKEQLEAELAEAQEEIARLEEEV 99

                          90       100
                  ....*....|....*....|.
gi 19111893   159 KHKENEQRRLKQEQIDAKRKE 179
Cdd:pfam20492 100 ERKEEEARRLQEELEEAREEE 120
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 86-186 3.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 3.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893  86 EEQNLIEQSITESQRIFSEKQRLEQER---FNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKE 162
Cdd:COG1196 299 RLEQDIARLEERRRELEERLEELEEELaelEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                        90       100
                ....*....|....*....|....
gi 19111893 163 NEQRRLKQEQIDAKRKEEEAREKR 186
Cdd:COG1196 379 EELEELAEELLEALRAAAELAAQL 402
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 81-181 3.86e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.72  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    81 KKRNVEEQN--LIEQSITEsqrifsEKQRLEQERFNRELLEKKrIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQ 158
Cdd:pfam17380 485 DRKRAEEQRrkILEKELEE------RKQAMIEEERKRKLLEKE-MEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQ 557

                          90       100
                  ....*....|....*....|...
gi 19111893   159 KHKENEQRrlkqEQIDAKRKEEE 181
Cdd:pfam17380 558 MRKATEER----SRLEAMERERE 576
Caldesmon pfam02029
Caldesmon;
74-189 4.28e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 39.47  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    74 HKTIDWAKKRNVEEQNLIEQSITESQRIFSEkQRLEQERfnRELLEKKRIEAERQRLKDEEerRKKELMEKEKKEKERIR 153
Cdd:pfam02029 217 TKLKVTTKRRQGGLSQSQEREEEAEVFLEAE-QKLEELR--RRRQEKESEEFEKLRQKQQE--AELELEELKKKREERRK 291

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19111893   154 LIEEqkhkenEQRRLKQEQIDAKRKEEEAReKRMKE 189
Cdd:pfam02029 292 LLEE------EEQRRKQEEAERKLREEEEK-RRMKE 320
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 81-197 5.04e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    81 KKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIrliEEQKH 160
Cdd:pfam17380 356 EERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRA---EQEEA 432

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 19111893   161 KENEQRRLKQE---QIDAKRKEEEAREKRMkETFKDDPEE 197
Cdd:pfam17380 433 RQREVRRLEEErarEMERVRLEEQERQQQV-ERLRQQEEE 471
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 77-189 6.04e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    77 IDWAKKRNVEEQNLIEQSITESQRIFSE---KQRLEQERFNRELLEKKRiEAERQRLKDEEERRKKELMEKEKKEKERIR 153
Cdd:pfam17380 372 MEISRMRELERLQMERQQKNERVRQELEaarKVKILEEERQRKIQQQKV-EMEQIRAEQEEARQREVRRLEEERAREMER 450

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 19111893   154 LIEEQKHKENEQRRLKQEQIDAKRK----EEEAREKRMKE 189
Cdd:pfam17380 451 VRLEEQERQQQVERLRQQEEERKRKklelEKEKRDRKRAE 490
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 83-201 7.88e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.95  E-value: 7.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111893    83 RNVEEQNLIEQSITESQRIFSEKQRLEQ--ERFNRELLEKKRIEAE-----RQRLKDEEERRKKELMEKEKKEKERIRli 155
Cdd:pfam17380 433 RQREVRRLEEERAREMERVRLEEQERQQqvERLRQQEEERKRKKLElekekRDRKRAEEQRRKILEKELEERKQAMIE-- 510

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19111893   156 EEQKHK--------------ENEQRRLKQEQidaKRKEEEARE-KRMKETFKDDPEEDSNM 201
Cdd:pfam17380 511 EERKRKllekemeerqkaiyEEERRREAEEE---RRKQQEMEErRRIQEQMRKATEERSRL 568
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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