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Conserved domains on  [gi|19112107|ref|NP_595315|]
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transporter [Schizosaccharomyces pombe]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 102-532 2.22e-124

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 369.60  E-value: 2.22e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 102 VVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIG 181
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 182 GGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSyLGWCWVFWIN 261
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 262 MIMGAVVIVIIFFFMPethgdtildykarylrnktrnmkwhtiherqrnprsaiyqactdsvsllitepIVVCFTLYLTV 341
Cdd:cd17323 160 AIISGFCLILIFLFLP-----------------------------------------------------IVLLLGLYVGL 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 342 VYIIGYIDFEGYPIVFAK-YSFDQGEIGLSFIGIGIGIVLAGACTPIIYVHYNRVY-TRRNGVMSPEDRLYPLFFGSIML 419
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEvYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLkKKNGGKPEPEARLPPAFIGAFLF 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 420 PISMFWFAWTCYPYhpyVHWIVPLISSIFFGWSLLFVFFVSYNYIIDSYQKLAASALAAATLVRYAASGGMSLVGRPMYV 499
Cdd:cd17323 267 PIGLFIFGWTIYPH---IHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFN 343

                       410       420       430
                ....*....|....*....|....*....|...
gi 19112107 500 NLGDHWATSLLGFISVGMIPIPFLFFIYGKKIR 532
Cdd:cd17323 344 NLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 102-532 2.22e-124

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 369.60  E-value: 2.22e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 102 VVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIG 181
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 182 GGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSyLGWCWVFWIN 261
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 262 MIMGAVVIVIIFFFMPethgdtildykarylrnktrnmkwhtiherqrnprsaiyqactdsvsllitepIVVCFTLYLTV 341
Cdd:cd17323 160 AIISGFCLILIFLFLP-----------------------------------------------------IVLLLGLYVGL 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 342 VYIIGYIDFEGYPIVFAK-YSFDQGEIGLSFIGIGIGIVLAGACTPIIYVHYNRVY-TRRNGVMSPEDRLYPLFFGSIML 419
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEvYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLkKKNGGKPEPEARLPPAFIGAFLF 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 420 PISMFWFAWTCYPYhpyVHWIVPLISSIFFGWSLLFVFFVSYNYIIDSYQKLAASALAAATLVRYAASGGMSLVGRPMYV 499
Cdd:cd17323 267 PIGLFIFGWTIYPH---IHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFN 343

                       410       420       430
                ....*....|....*....|....*....|...
gi 19112107 500 NLGDHWATSLLGFISVGMIPIPFLFFIYGKKIR 532
Cdd:cd17323 344 NLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
94-461 1.13e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.14  E-value: 1.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  94 PMWKKWIVVVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLL 173
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 174 MFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLG 253
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 254 WCWVFWINMIMGAVVIVIIFFFMPETHgdtildykarylrnktrnmkwhtiHERQRNPRSAIYQACTDSVSLLItepIVV 333
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESR------------------------PAARARLRGSLRELLRRPRLLLL---LLL 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 334 CFTLYLTVVYIIGYIDFegypIVFAKYSFDQGEIGLSFIGIGIGIVLAGACTPIIYVHYNRVYTrrngvmspedrlypLF 413
Cdd:COG2814 216 AFLLGFGFFALFTYLPL----YLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL--------------LL 277

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 19112107 414 FGSIMLPISMFWFAWTcypyhPYVHWIVPLISSIFFGWSLLFVFFVSY 461
Cdd:COG2814 278 IGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFPLLQAL 320
2_A_01_02 TIGR00880
Multidrug resistance protein;
143-279 2.82e-24

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 98.49  E-value: 2.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   143 VFLVGFGFGSLPFAPLSG----IYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFT 218
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGlltdRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19112107   219 PIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLGWCWVFWINMIMGAVVIVIIFFFMPET 279
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
105-450 3.01e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.01  E-value: 3.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   105 ISLIAFVVTFGSSVYSSGIGNVSM-DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGG 183
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   184 CAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICqSYLGWCWVFWINMI 263
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   264 MGAVVIVIIFFFMPETHGDTILDYKARYLRnktrnmkwhtiherqrnPRSAIYQACTDSVSLLITEPIVVCFTLYLTVVY 343
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS-----------------LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTY 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   344 IIGYIDFEGYPIVFAkysfdqgeIGLSFIGIGIGIVLAGACTPIIyvhynrvytrrnGVMSPEDRLYPLFFGSIMLPISM 423
Cdd:pfam07690 223 LPLYQEVLGLSALLA--------GLLLGLGGLLGAIGRLLLGRLS------------DRLGRRRRLLLALLLLILAALGL 282

                         330       340
                  ....*....|....*....|....*..
gi 19112107   424 FWFAWTcypYHPYVHWIVPLISSIFFG 450
Cdd:pfam07690 283 LLLSLT---LSSLWLLLALLLLGFGFG 306
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
125-280 2.26e-14

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 74.95  E-value: 2.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  125 NVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGST 204
Cdd:PRK11102  16 VIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19112107  205 PLSNCGGTLSDLFTPIQRTYVLpGFCTFPF-LGPIFGPIIGDFICQsYLGWCWVFWINMIMGAVVIVIIFFFMPETH 280
Cdd:PRK11102  96 ASVVINALMRDMFPKEEFSRMM-SFVTLVMtIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETL 170
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 102-532 2.22e-124

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 369.60  E-value: 2.22e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 102 VVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIG 181
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 182 GGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSyLGWCWVFWIN 261
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 262 MIMGAVVIVIIFFFMPethgdtildykarylrnktrnmkwhtiherqrnprsaiyqactdsvsllitepIVVCFTLYLTV 341
Cdd:cd17323 160 AIISGFCLILIFLFLP-----------------------------------------------------IVLLLGLYVGL 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 342 VYIIGYIDFEGYPIVFAK-YSFDQGEIGLSFIGIGIGIVLAGACTPIIYVHYNRVY-TRRNGVMSPEDRLYPLFFGSIML 419
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEvYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLkKKNGGKPEPEARLPPAFIGAFLF 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 420 PISMFWFAWTCYPYhpyVHWIVPLISSIFFGWSLLFVFFVSYNYIIDSYQKLAASALAAATLVRYAASGGMSLVGRPMYV 499
Cdd:cd17323 267 PIGLFIFGWTIYPH---IHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFN 343

                       410       420       430
                ....*....|....*....|....*....|...
gi 19112107 500 NLGDHWATSLLGFISVGMIPIPFLFFIYGKKIR 532
Cdd:cd17323 344 NLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
94-461 1.13e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.14  E-value: 1.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  94 PMWKKWIVVVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLL 173
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 174 MFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLG 253
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 254 WCWVFWINMIMGAVVIVIIFFFMPETHgdtildykarylrnktrnmkwhtiHERQRNPRSAIYQACTDSVSLLItepIVV 333
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESR------------------------PAARARLRGSLRELLRRPRLLLL---LLL 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 334 CFTLYLTVVYIIGYIDFegypIVFAKYSFDQGEIGLSFIGIGIGIVLAGACTPIIYVHYNRVYTrrngvmspedrlypLF 413
Cdd:COG2814 216 AFLLGFGFFALFTYLPL----YLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL--------------LL 277

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 19112107 414 FGSIMLPISMFWFAWTcypyhPYVHWIVPLISSIFFGWSLLFVFFVSY 461
Cdd:COG2814 278 IGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFPLLQAL 320
2_A_01_02 TIGR00880
Multidrug resistance protein;
143-279 2.82e-24

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 98.49  E-value: 2.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   143 VFLVGFGFGSLPFAPLSG----IYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFT 218
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGlltdRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19112107   219 PIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLGWCWVFWINMIMGAVVIVIIFFFMPET 279
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 105-455 5.78e-24

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 103.81  E-value: 5.78e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:cd17320   4 LALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRT----YVLPGFCtfpfLGPIFGPIIGDFIcQSYLGWCWVFWI 260
Cdd:cd17320  84 ASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAkifsLLMMILA----IAPALAPLLGGLL-LLFFGWRAIFVF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 261 NMIMGAVVIVIIFFFMPEThgdtildykarylrnktrnmkwhtiheRQRNPRSAIYQACTDSVSLLITEPIVVCFTLYLT 340
Cdd:cd17320 159 LALLGLLLLLLVLLFLPET---------------------------LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALG 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 341 VVYIIGYIDFEGYPIVFAK-YSFDQGEIGLSFIGIGIGIVLAGACtpiiyvhyNRVYTRRNGvmspEDRLypLFFGSIML 419
Cdd:cd17320 212 LSFAGLFAYLAAAPFIYIEqLGLSPAQFGLLFALNAIALILGSLL--------NGRLVRRFG----PRRL--LRLGLLLL 277

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 19112107 420 PISMFWFAWTCYPYHPYVHWIVPLISSIFFGWSLLF 455
Cdd:cd17320 278 LAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIF 313
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 94-281 1.13e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 98.34  E-value: 1.13e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  94 PMWKKWIVVVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLL 173
Cdd:COG0477   8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 174 MFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGdFICQSYLG 253
Cdd:COG0477  88 LFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG-GLLVAALG 166

                       170       180
                ....*....|....*....|....*...
gi 19112107 254 WCWVFWINMIMGAVVIVIIfFFMPETHG 281
Cdd:COG0477 167 WRWIFLINAPLGLLALVLR-LRLPESRG 193
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 100-280 6.09e-21

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 94.76  E-value: 6.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   100 IVVVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQ 179
Cdd:TIGR00710   5 AFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   180 IGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLGWCWVFW 259
Cdd:TIGR00710  85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILV-WLSWHAIFA 163

                         170       180
                  ....*....|....*....|.
gi 19112107   260 INMIMGAVVIVIIFFFMPETH 280
Cdd:TIGR00710 164 FLSLAGILLSALIFFILPETL 184
MFS_1 pfam07690
Major Facilitator Superfamily;
105-450 3.01e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.01  E-value: 3.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   105 ISLIAFVVTFGSSVYSSGIGNVSM-DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGG 183
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   184 CAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICqSYLGWCWVFWINMI 263
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   264 MGAVVIVIIFFFMPETHGDTILDYKARYLRnktrnmkwhtiherqrnPRSAIYQACTDSVSLLITEPIVVCFTLYLTVVY 343
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS-----------------LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTY 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   344 IIGYIDFEGYPIVFAkysfdqgeIGLSFIGIGIGIVLAGACTPIIyvhynrvytrrnGVMSPEDRLYPLFFGSIMLPISM 423
Cdd:pfam07690 223 LPLYQEVLGLSALLA--------GLLLGLGGLLGAIGRLLLGRLS------------DRLGRRRRLLLALLLLILAALGL 282

                         330       340
                  ....*....|....*....|....*..
gi 19112107   424 FWFAWTcypYHPYVHWIVPLISSIFFG 450
Cdd:pfam07690 283 LLLSLT---LSSLWLLLALLLLGFGFG 306
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 105-280 1.44e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 75.30  E-value: 1.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:cd17474   4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFIcqSYLGWCWVFWINMIM 264
Cdd:cd17474  84 SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRYPFFLLAAL 161

                       170
                ....*....|....*.
gi 19112107 265 GAVVIVIIFFFMPETH 280
Cdd:cd17474 162 IPVAFLAILFLLPEPK 177
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
125-280 2.26e-14

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 74.95  E-value: 2.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  125 NVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGST 204
Cdd:PRK11102  16 VIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19112107  205 PLSNCGGTLSDLFTPIQRTYVLpGFCTFPF-LGPIFGPIIGDFICQsYLGWCWVFWINMIMGAVVIVIIFFFMPETH 280
Cdd:PRK11102  96 ASVVINALMRDMFPKEEFSRMM-SFVTLVMtIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETL 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 105-524 3.42e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 74.39  E-value: 3.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQS-YLGWCWVFWINMI 263
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 264 MGAVVIVIIFFFMPETHgdtildykarylrnktrnmkwhtiHERQRNPRSAIYQACTDSVSLLITEPIVVCFTLYLTVVY 343
Cdd:cd06174 161 LALLAAILLLLVVPDPP------------------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVN 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 344 IIGYIDFEGYPIVFAKYsfdqgeIGLSFIGIGIGIVLAGACTPIIYVHYNRVYTRRNGvmspedRLYPLFFGSIMLPISM 423
Cdd:cd06174 217 LAYYSFSTLLPLFLLDL------GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG------RKPLLLIGLLLMALGL 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 424 FWFawtCYPYHPYVHWIVPLISSIFFGwsllFVFFVSYNYIIDSYQKLAASALAAATLVRYAASGGMSLVGRPMYVNLGD 503
Cdd:cd06174 285 ALL---LLAPSLLLLLLLLLLLGFGLG----GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357

                       410       420
                ....*....|....*....|.
gi 19112107 504 HWATSLLGFISVGMIPIPFLF 524
Cdd:cd06174 358 GLTGAFLVLAVLLLLAAILLL 378
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 105-272 3.79e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 74.13  E-value: 3.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:cd17321   1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLGWCWVFWINMIM 264
Cdd:cd17321  81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-LFGWRWIFLINVPI 159


                ....*...
gi 19112107 265 GAVVIVII 272
Cdd:cd17321 160 GLVALLLA 167
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 129-277 8.93e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 72.97  E-value: 8.93e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 129 DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSN 208
Cdd:cd17324  28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAI 107

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19112107 209 CGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLGWCWVFWINMIMGAVVIVIIFFFMP 277
Cdd:cd17324 108 AAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAAFLAIAVLALLAALLLWRLLP 175
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
98-276 9.21e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.60  E-value: 9.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  98 KWIVVVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTL 177
Cdd:COG2271   8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 178 FQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYlGWCWV 257
Cdd:COG2271  88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-GWRAA 166

                       170
                ....*....|....*....
gi 19112107 258 FWINMIMGAVVIVIIFFFM 276
Cdd:COG2271 167 FLILGLPGLLLALLRFWLL 185
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 107-272 3.49e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 70.67  E-value: 3.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 107 LIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGScVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQ 186
Cdd:cd17502   3 LALFLAALDQTIVATALPTIVAEFGGLSLVSWVGT-AYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 187 NIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLGWCWVFWINMIMGA 266
Cdd:cd17502  82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD-HLSWRWCFYINLPIGG 160


                ....*.
gi 19112107 267 VVIVII 272
Cdd:cd17502 161 LALALL 166
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 105-278 4.04e-13

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 71.64  E-value: 4.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   105 ISLIAFVVTFGSSVYSSGIGNVSM-----DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQ 179
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIptiagDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   180 IGGGCAQNIWTLVILRFFQGFFGS--TPLSNcgGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYlGWCWV 257
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGplIPLSF--STLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY-HWRWI 158

                         170       180
                  ....*....|....*....|.
gi 19112107   258 FWINMIMGAVVIVIIFFFMPE 278
Cdd:TIGR00711 159 FLINVPIGIIVVVVAFFILPR 179
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 105-272 3.12e-12

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 68.37  E-value: 3.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFgSLPFAP-LSGIYGRFVVYFCTLLMFTLFQIGGG 183
Cdd:cd17503   1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAI-MIPLSGwLADRFGTRRLFLTALALFTLGSLLCG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 184 CAQNIWTLVILRFFQGFFGS--TPLSNcgGTLSDLFTPIQRTYVLpGFCTFPF-LGPIFGPIIGDFICqSYLGWCWVFWI 260
Cdd:cd17503  80 LAPNLASLIIFRILQGFGGGvlIPLAQ--TILLRIYPPEKRGAAM-GLVGLVIlLAPAIGPTLGGWLT-DNLSWRWIFYI 155

                       170
                ....*....|..
gi 19112107 261 NMIMGAVVIVII 272
Cdd:cd17503 156 NLPIGILALLLA 167
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 129-278 5.55e-11

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 64.56  E-value: 5.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 129 DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGF--FGSTPL 206
Cdd:cd17328  28 DFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIgeASYSPI 107

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19112107 207 SncGGTLSDLFTPIQRTYVLpGFCTFPF-LGPIFGPIIGDFICQSYLGWCWVFWINMIMGAVVIVIIFFFMPE 278
Cdd:cd17328 108 A--PTIIADLFPKEKRTRAL-GVFYFAIpLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVRE 177
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 105-275 3.73e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 62.26  E-value: 3.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISvSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:cd06179   3 LCLAYFAQLFGVTLPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGF-FGSTPLSNCGgtLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQ-SYLGWCWVFWINM 262
Cdd:cd06179  82 AKSVNMLIGGQALIGIgAGTQGLGAAV--ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEaNAAGWRWIFYINA 159

                       170
                ....*....|...
gi 19112107 263 IMGAVVIVIIFFF 275
Cdd:cd06179 160 IFNALALILLFFF 172
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 105-280 8.78e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 60.67  E-value: 8.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYlGWCWVFWINMIM 264
Cdd:cd17325  81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAAL 159

                       170
                ....*....|....*.
gi 19112107 265 GAVVIVIIFFFMPETH 280
Cdd:cd17325 160 ALLALVLALLLLPEPR 175
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 106-272 1.33e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 59.90  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 106 SLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCA 185
Cdd:cd17504   2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 186 QNIWTLVILRFFQGFFGST-PLsnCGGTLSDLFTPiQRTYVLPGFCTFPF-LGPIFGPIIGDFICQsYLGWCWVFWINMI 263
Cdd:cd17504  82 PNLPVLIAGRALQGIGGAVfPL--AFALVREEFPP-ERVPVAQGILSATFgIGAGIGLPLGGWIVQ-HLGWRWIFWTAAP 157


                ....*....
gi 19112107 264 MGAVVIVII 272
Cdd:cd17504 158 VAVLLAALV 166
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 99-278 1.99e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 59.68  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107    99 WIVVVQISLIAFVVTFGSSVYSSGIGNVSMDFGVS-ISVSSLGSCVfLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTL 177
Cdd:TIGR00895  16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDpVQLGFLFSAG-LIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   178 FQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLpgfcTFPFLGPIFGPIIGDFICQ---SYLGW 254
Cdd:TIGR00895  95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAV----GLMFCGYPIGAAVGGFLAGwliPVFGW 170

                         170       180
                  ....*....|....*....|....
gi 19112107   255 CWVFWINMIMGAVVIVIIFFFMPE 278
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLMRFLPE 194
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 118-279 3.26e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 58.75  E-value: 3.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 118 VYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFF 197
Cdd:cd17365  17 VMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 198 QGFFGSTPLSNCGGTLSDLFTPIQR-TYVLPGFCTFPfLGPIFGPIIGDFICQSYlGWCWVFWInmimGAVVIVIIFFFM 276
Cdd:cd17365  97 TGLGLGAAMPNAITLVSEYAPARRRsLAVTLMFCGYP-LGAALGGFLAAALIPAF-GWRSVFLL----GGVPPLILLPLL 170


                ...
gi 19112107 277 PET 279
Cdd:cd17365 171 RGT 173
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
97-279 3.72e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.74  E-value: 3.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  97 KKWIVVVqISLIAFVVTFGS-SVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMF 175
Cdd:COG2223   2 GRWRVLL-LATLAFFLAFGVwYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 176 TLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYlGWC 255
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-GWR 159

                       170       180
                ....*....|....*....|....
gi 19112107 256 WVFWINMIMGAVVIVIIFFFMPET 279
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDP 183
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 129-277 6.02e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 57.97  E-value: 6.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 129 DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSN 208
Cdd:cd17319  32 DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPG 111

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19112107 209 CGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFIcQSYLGWCWVFWINMIMGAVVIVIIFFFMP 277
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
129-372 1.06e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 54.13  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  129 DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGffgstpLSN 208
Cdd:PRK11043  35 DLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQA------VGV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  209 CGGTLS------DLFTPIQRTYVlpgFCT-FPF--LGPIFGPIIGDFICQSYlGWCWVFWINMIMGAVVIVIIFFFMPE- 278
Cdd:PRK11043 109 CSAAVIwqalviDRYPAQKANRV---FATiMPLvaLSPALAPLLGAWLLNHF-GWQAIFATLFAITLLLILPTLRLKPSk 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  279 ---THGDTILDYKArYLRNKTR--NMkwhtiherqrnprsAIYQACTDSvsllitepivvcFTLYLTvvyiigyidfeGY 353
Cdd:PRK11043 185 karKQSQDALTFKQ-LLKSKTYlgNV--------------LIFAACSAA------------FFAWLT-----------GS 226

                        250
                 ....*....|....*....
gi 19112107  354 PIVFAKYSFDQGEIGLSFI 372
Cdd:PRK11043 227 PFILEQMGYSPADIGLSYV 245
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 107-280 6.41e-07

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 51.81  E-value: 6.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 107 LIAFVVTFGSSVYSSGIG-----------NVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMF 175
Cdd:cd17358   2 LATFVANLGSFSFGIAVGwsspalpslmsDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 176 TLFQIGGGCAQNIWTLVILRFFQGFfgstplsnCGGTLSdlftpiqrtYVLP-------------GFCTFPFLGPIFGPI 242
Cdd:cd17358  82 ILGWLLIAFAKDVWMLYLGRFLAGF--------GGGAAS---------VVVPvyiaeiapknvrgALGSLNQLLVNIGIL 144

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 19112107 243 IGdFICQSYLGWCWVFWINMIMgAVVIVIIFFFMPETH 280
Cdd:cd17358 145 LG-YVLGSFLPWRTLALIGAIP-PVVFLILLFFIPESP 180
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 139-279 1.26e-06

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 50.84  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   139 LGSCvFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFT 218
Cdd:TIGR00881  35 LLSS-FSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFS 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19112107   219 PIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYLGWCWVFWINMIMGAVVIVIIFFFMPET 279
Cdd:TIGR00881 114 RSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 129-277 1.94e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.88  E-value: 1.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 129 DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTpLSN 208
Cdd:cd17330  28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSV 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 209 CGGTLSDLFTPIQRTYVLpGFCTFPF-LGPIFGPIIGDFICQSYlGWCWVFWINMIMGAVVIVIIFFFMP 277
Cdd:cd17330 107 AQAYIADITDEEERAKAF-GIISAAFgLGFILGPALGGFLSTPY-GYALPFLVAAALALLNLVLVLFFLP 174
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 129-271 2.13e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 129 DFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFF--GSTPL 206
Cdd:cd17316  30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGigGEYPG 109

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19112107 207 SNcggTLSDLFTPI-QRTYVLPGFCTFPFLGPIFGPIIGDFICQSY---LGWCWVFWINMIMGAVVIVI 271
Cdd:cd17316 110 AS---TYVAEFAPSkRRGFALGLLQSGWALGALLAALVASLLIPLLsgdWGWRILFLIGALPALLALLL 175
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 114-279 8.28e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 48.07  E-value: 8.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 114 FGSSVYSSGIGNVSMDFGVS-ISVSSLGScVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLV 192
Cdd:cd17371  13 FDLLLLGLVLPALIAEFGLDeAEAGLLGT-VTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 193 ILRFFQGFfGSTPLSNCGGTL-SDLFTPIQRTYVLPGFCTFPFLGPIF-----GPIIGDFicQSYLGWCWVFWINMImGA 266
Cdd:cd17371  92 ILRALAGL-GFGGEWAAGAALmAEYVPARHRGKALGYVQSGWAVGWLLatllaALLFPLL--PPEIAWRVLFLLGAL-PA 167

                       170
                ....*....|...
gi 19112107 267 VVIVIIFFFMPET 279
Cdd:cd17371 168 LLVLFIRRFVKEP 180
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 105-276 1.07e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 47.64  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:cd17476   3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTP-IQRTYVLPGF----CTFPFLGPIFGPIIGDFIcqsylGWCWVFW 259
Cdd:cd17476  83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFgataPLGFALGGVFGGLFAQLA-----WWPWIFW 157

                       170
                ....*....|....*..
gi 19112107 260 INMIMGAVVIVIIFFFM 276
Cdd:cd17476 158 FLAILAAIVAVAAIFWT 174
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
100-279 3.14e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 3.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 100 IVVVQISLIAFVVtFGSSVYSSGIGN-----VSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRF--VVYFCTL 172
Cdd:COG2271 177 LALLRFWLLALAY-FLVYFALYGFLTwlptyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGL 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 173 LMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFtPIQRTYVLPGFC-TFPFLGPIFGPIIGDFICQSY 251
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF-PKKARGTASGLVnTFGFLGGALGPLLVGYLLDAT 334

                       170       180
                ....*....|....*....|....*...
gi 19112107 252 lGWCWVFWINMIMGAVVIVIIFFFMPET 279
Cdd:COG2271 335 -GYQAAFLLLAALALLAALLALLLLRET 361
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 148-274 3.70e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.05  E-value: 3.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 148 FGFGSLPFAPLSGI----YGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGfFGSTPLSNCGGTLSDLFTPIQRT 223
Cdd:cd17489  40 FTLAALLARPFAGRlldrFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHG-IGWGAFTTAAATLVADIIPPSRR 118

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 19112107 224 -YVLPGFCTFPFLGPIFGPIIGDFIcQSYLGWCWVFWINMIMGAVVIVIIFF 274
Cdd:cd17489 119 gEGIGYYGLATTLAMALGPALGLFL-YQHLGFAVLFIVAAVLALLALLLVFL 169
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 130-278 3.92e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.07  E-value: 3.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 130 FGVSISVS-------SLGSCVFLVG-----FGFGSLPFAPLSG----IYGR-FVVYFCTLLMFTLFQIGGgCAQNIWTLV 192
Cdd:cd17390  10 FGVSMILPllsthirSLGASPTVIGligsvYGALQLFSSPLVGswsdVVGRrPVLLICLLLTALGYVLLG-FSTSLALLF 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 193 ILRFFQGFFGSTpLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYLGWCWVFWINMIMGAVVIVII 272
Cdd:cd17390  89 LSRIPLGIFKHT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLV 167


                ....*.
gi 19112107 273 FFFMPE 278
Cdd:cd17390 168 WFLLSK 173
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 140-295 5.19e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 45.67  E-value: 5.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 140 GSCVFLVGFGFGS---------LPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTplSNCG 210
Cdd:cd17472  28 GATPTLIGLALGIygltqaifqIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS--SVVM 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 211 GTLSDLFTPIQRT----YVLPGFCTFPFLGPIFGPIIGDFicqsyLGWCWVFWINMIMGAVVIVIIFFFMPE-----THG 281
Cdd:cd17472 106 ALLADLTREENRTkamaLIGASIGIAFAISMVLGPLLAAH-----LGVSGLFLITAILSLVSLLILLFFVPDppkivQIS 180

                       170
                ....*....|....
gi 19112107 282 DTILDYKARYLRNK 295
Cdd:cd17472 181 EKEKKKLKKLLKNK 194
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
125-282 5.31e-05

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 45.70  E-value: 5.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  125 NVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQG----F 200
Cdd:PRK15402  38 AVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGiglcF 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  201 FGSTPLSncggTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQsYLGWCWVFWINMIMGAVVIVIIFFFMPETH 280
Cdd:PRK15402 118 IGAVGYA----AIQESFEEADAIKITALMANVALLAPLLGPLVGAALIH-VLPWRGMFVLFAALAALSFFGLWRAMPETA 192


                 ..
gi 19112107  281 GD 282
Cdd:PRK15402 193 GR 194
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 138-321 7.78e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 45.32  E-value: 7.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 138 SLGSCVFLVGFGFGSLPFAPLSGIYG-RFVVYFCTLLmFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDL 216
Cdd:cd17327  44 NWGNTVFYVGYIIFELPGNLLLQRFPpSKWLSVFIVL-WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 217 FTPIQRTYVLPGFCTFPFLGPIFGPIIGdFICQSYL------GWCWVFWINMIMGAVVIVIIFFFMPETHGDTIL--DYK 288
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSIFGGLLA-YGVFKILgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFltEEE 201

                       170       180       190
                ....*....|....*....|....*....|...
gi 19112107 289 ARYLRNKTRNMkwHTIHERQRNPRSAIYQACTD 321
Cdd:cd17327 202 KELAVERLRAN--QTGKGDQKFKWKQIKEAFKD 232
emrD PRK11652
multidrug transporter EmrD;
107-279 1.02e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 44.90  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  107 LIAFVVTFGS---SVYSSGIGNVSMDFGVSIS-VSSLGSCvFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGG 182
Cdd:PRK11652  12 MLVLLVAVGQmaqTIYVPAIADMARDLNVREGaVQAVMAA-YLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  183 GCAQNIWTLVILRFFQGFfGStplsNCGGTLS-----DLF--TPIQRTYVLPGFCTFpfLGPIFGPIIGDFIcQSYLGWC 255
Cdd:PRK11652  91 LFAHSLTVLIAASAIQGL-GT----GVGGVMArtlprDLYegTQLRHANSLLNMGIL--VSPLLAPLIGGLL-TTLFGWR 162

                        170       180
                 ....*....|....*....|....
gi 19112107  256 WVFWINMIMGAVVIVIIFFFMPET 279
Cdd:PRK11652 163 ACYLFLLLLGAGVTFSMARWMPET 186
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 95-279 2.19e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  95 MWKKWIVVVQISLIAFVVTFGSSVYssgignVSMDFGVSISVSSLgscvFLVGFGFGSLPFAPLSG----IYGRFVVYFC 170
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWPFMAIY------LHQQLGLSASIVGL----VLALSAVAGIVASLIGGrladRFGRKPVMLA 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 171 TLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQS 250
Cdd:cd17329  71 GLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150

                       170       180
                ....*....|....*....|....*....
gi 19112107 251 YLGwcWVFWINMIMGAVVIVIIFFFMPET 279
Cdd:cd17329 151 SFR--LLFLAAAVLFLLAALVLLFLLPET 177
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 102-273 3.15e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.97  E-value: 3.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 102 VVQISLIAFVVTFGSSVYSSGIGNV-SMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQI 180
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 181 GGGCA--QNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRtYVLPGFCT-FPFLGPIFGPIIGDFICQSYLGWCWV 257
Cdd:cd17316 259 PLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR-ATGVGLSYnLGRLGGGGAPPLIALLLASTGGTGVP 337

                       170
                ....*....|....*.
gi 19112107 258 FWINMIMGAVVIVIIF 273
Cdd:cd17316 338 ALILALLAIVALIVAL 353
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
105-283 3.50e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 3.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 105 ISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:COG0738  13 IYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 185 AQNIWTLVILRFFQGFFGSTpLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYLG--WCWVFWINM 262
Cdd:COG0738  93 APSYPLLLLALFLLGLGLGL-LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlsWHLPYLILA 171

                       170       180
                ....*....|....*....|..
gi 19112107 263 IMGAVVIVIIFFF-MPETHGDT 283
Cdd:COG0738 172 VLLLLLALLFLRSkLPEIEEEE 193
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 172-276 3.59e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 43.03  E-value: 3.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 172 LLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSY 251
Cdd:cd17312  75 LLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY 154

                        90       100
                ....*....|....*....|....*
gi 19112107 252 lGWCWVFWINMIMGAVVIVIIFFFM 276
Cdd:cd17312 155 -GWRAAFLVPGIVGLVVAIILFFFL 178
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 150-280 3.98e-04

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 43.19  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   150 FGSLPFAPLSGIYGR-----FVVYFCTLLMFTLFQIGGGCAqnIWtLVILRFFQGFfGSTPLSNC-GGTLSDLFTPIQRT 223
Cdd:TIGR00894  91 IIQIPVGYLAGKYVFkwsigIGMFLSSVISIVIPWAAGGGI--AL-VVFCRVIQGL-AQGSVSPAtHKIIVKWAPPKERS 166

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19112107   224 ----YVLPGFCTFPFlgpIFGPIIGdFICQSYLGWCWVFWINMIMGAVVIVIIFFFM---PETH 280
Cdd:TIGR00894 167 rllgMSTSGFQLGTF---IFLPISG-WLCESWGGWPMIFYVFGIVGCAWSLLWFVFPaddPSIH 226
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 141-278 4.21e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 43.08  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   141 SCVFlVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTpLSNCGGTLSDLFTPI 220
Cdd:TIGR00898 134 SCFF-VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGG-IWVQAVVLNTEFLPK 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   221 -QRTYVLPGFCTFPFLGPIFGPIIGDFIcqsyLGWCWV-FWINmiMGAVVIVIIFFFMPE 278
Cdd:TIGR00898 212 kQRAIVGTLIQVFFSLGLVLLPLVAYFI----PDWRWLqLAVS--LPTFLFFLLSWFVPE 265
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 138-204 5.70e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 42.18  E-value: 5.70e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19112107 138 SLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGST 204
Cdd:cd17317  28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAG 94
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 133-279 9.84e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.54  E-value: 9.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 133 SISVSSLGSCVFLVGFGF--GSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCG 210
Cdd:cd17333  27 NLNVADVSVIFSSQNAGYliGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGAN 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19112107 211 GTLSDLF--TPIQRTYVLPGFCTFpflGPIFGPIIGDFICQSYLGWCWVFWI-NMIMGAVVIVIIFFFMPET 279
Cdd:cd17333 107 TFVGALFeeSSATRLNVLHGFFGL---GALIGPLIATSLLTSELSWSWAYLIiGLIYLLLAILILLTLFPEL 175
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 135-280 1.02e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.48  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 135 SVSSLGSCVFLVGFGFGS-----LPFAPLSGI----YGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFF-GST 204
Cdd:cd17391  27 GVTSGGLVELWSGLAFSStflvsAIFSPIWGRladrYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFsGYV 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19112107 205 PLSNcggTLSDLFTPIQRT-YVLPGFCTFPFLGPIFGPIIGDFICQSYlGWCWVFWINMIMGAVVIVIIFFFMPETH 280
Cdd:cd17391 107 PNAT---ALIASQTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLF-GIRNVFFITGGLLFLAFLLTLFFVKEDF 179
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 99-275 1.07e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.40  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  99 WIVVVQISLIafvvtfgssVYSSGIGNVSMdFGVSISVSSLGSCVflvgfgfGSLPFAPLSGIYGRFVVYFCTLLMFTLF 178
Cdd:cd17473 214 YVIPIQLPFL---------LQERGGGSAAL-IGLALAIASLAGAI-------GALLFGRLKRRLGKRRLLAIGFALMALG 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 179 QIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYLGWCWVF 258
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAF 356

                       170
                ....*....|....*..
gi 19112107 259 WINMIMGAVVIVIIFFF 275
Cdd:cd17473 357 LILGVLALVLAIVLLLL 373
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 102-275 1.48e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 102 VVQISLIAFVVTFGSS-------VYSSGIGNVS-MDFGVSISVSSLGSCVFLVGFGFgslpfapLSGIYGRFVVYFCTLL 173
Cdd:cd17325 201 LLALFLAIFVLAFAFGalepflpLYAAELGGLSpAQIGLLFGAQGLASALSQPPAGK-------LSDRIGRKPLILIGLL 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 174 MFTLFQIGGGCAQNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFICQSYlG 253
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-G 352

                       170       180
                ....*....|....*....|..
gi 19112107 254 WCWVFWINMIMGAVVIVIIFFF 275
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFLLL 374
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 143-388 2.03e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 40.70  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 143 VFLVGFGFGSLPFAP----LSGIYGRFVVYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGSTpLSNCGGTLSDLFT 218
Cdd:cd17388  42 VLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGAT-GAVAAAYIADVTP 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 219 PIQRT--YVLPGFCtfpF-LGPIFGPIIGdficqsylGWCWV------FWINMIMGAVVIVIIFFFMPETHgdtildyka 289
Cdd:cd17388 121 PEQRArnFGLLGAA---FgLGFIAGPALG--------GLLGEisprapFLVAAGLNGLNFLLGLFVLPESL--------- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 290 rylrNKTRNMKWHTiheRQRNPRSaiyqactdSVSLLITEPIVVCFTLYLTVVYIIGYIDFEGYPI-VFAKYSFDQGEIG 368
Cdd:cd17388 181 ----PPERRRAFRW---RRANPFG--------SLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLfTEDRFDWSPTMVG 245

                       250       260
                ....*....|....*....|..
gi 19112107 369 LSFIGIGI--GIVLAGACTPII 388
Cdd:cd17388 246 LSLAVFGLlhALFQAFVTGPIA 267
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
87-200 2.49e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 40.24  E-value: 2.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  87 PLNPKNWPMWKKWIVVVQISLIAFVVTFGSSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFV 166
Cdd:COG2807   5 SSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 19112107 167 VYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGF 200
Cdd:COG2807  85 TLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA 118
Sugar_tr pfam00083
Sugar (and other) transporter;
105-279 3.12e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 39.95  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   105 ISLIAFVVTFGSSVYSSgignvsmDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQIGGGC 184
Cdd:pfam00083  23 LTLIDFFKNFGLSKSVS-------SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   185 A---QNIWTLVILRFFQGFFgstplsnCGG--TLSDLFTPIQRTYVLPGFC-TFPFLGPIFGPIIGDFI------CQSYL 252
Cdd:pfam00083  96 AkgkWSVYQLIVGRVLVGIG-------VGGasVLAPMYISEIAPKKLRGALgSLYQLAITFGILLAYIFglglnkTSNSD 168

                         170       180
                  ....*....|....*....|....*..
gi 19112107   253 GWCWVFWINMIMgAVVIVIIFFFMPET 279
Cdd:pfam00083 169 GWRIPLGLQLVP-ALLLIIGLLFLPES 194
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 107-279 3.41e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 39.86  E-value: 3.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 107 LIAFVVTFG-------SSVYSSGIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLFQ 179
Cdd:cd17359   1 LISLVAALGgllfgydTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107 180 IGGGCAQNIWTLVILRFFQGFF--GSTPLS----------NCGGTLSDLFtpiQRTYVLPGFCTFpflgpIFGPIIGDFI 247
Cdd:cd17359  81 LGSAFSPNFTIFIIARIIGGLAvgGASALVpmyiaevapaEIRGRLVSLN---QLMIVFGQLLAY-----IVNYLIANAG 152

                       170       180       190
                ....*....|....*....|....*....|....*
gi 19112107 248 CQSYL---GWCWVFWINMIMgAVVIVIIFFFMPET 279
Cdd:cd17359 153 GADWLgaeGWRWMLGLEAIP-AILFLLGMLFIPES 186
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
122-279 3.53e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 39.81  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  122 GIGNVSMDFGVSISVSSLGSCVFLVGFGFGSLPFAPLSGIYGRFVVYFCTLLMFTLfqiggGCAQNIWT-----LVILRF 196
Cdd:PRK15403  38 GIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTL-----ACAATLFTtsmtqFLIARF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  197 FQG----FFGSTPLSncggTLSDLFTPIQRTYVLPGFCTFPFLGPIFGPIIGDFIcQSYLGWCWVFWINMIMGAVVIVII 272
Cdd:PRK15403 113 IQGtsicFIATVGYV----TVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAAL-MHFVHWKVLFAIIAVMGLIAFVGL 187


                 ....*..
gi 19112107  273 FFFMPET 279
Cdd:PRK15403 188 LLAMPET 194
PRK10504 PRK10504
putative transporter; Provisional
 167-277 3.59e-03

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 40.10  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  167 VYFCTLLMFTLFQIGGGCAQNIWTLVILRFFQGFFGStplsncggtlsdLFTPIQRTYVLP-----------GFCTFPF- 234
Cdd:PRK10504  77 IFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGA------------MMVPVGRLTVMKivpreqymaamTFVTLPGq 144

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 19112107  235 LGPIFGPIIGDFICQsYLGWCWVFWINMIMGAVVIVIIFFFMP 277
Cdd:PRK10504 145 VGPLLGPALGGLLVE-YASWHWIFLINIPVGIIGAIATLMLMP 186
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 168-277 5.26e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 39.30  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107  168 YFCTLL-----MFTLFQIGGGcaqNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLpGFC-TFPFLGPIFGP 241
Cdd:PRK03893 344 YVCSLLisqllIIPVFAIGGA---NVWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGL-GFTyNVGALGGALAP 419

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 19112107  242 IIGDFICQSY-LGWCwVFWINMIMGAVVIVIIFFFMP 277
Cdd:PRK03893 420 ILGALIAQRLdLGTA-LASLSFSLTFVVILLIGLDMP 455
Sugar_tr pfam00083
Sugar (and other) transporter;
121-283 7.97e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.79  E-value: 7.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   121 SGIgNVSMDFGVSISVSSLGSCVFLVGFGFGSLPF-APLSGIYG------RFVVYFCTLLMFTLFQIGGGCA-------- 185
Cdd:pfam00083 268 TGI-NAIFYYSTTIFENLGLSDSFLVTIIVGVVNFvFTFIAIFLvdrfgrRPLLLLGAAGMAICFVILGIVAllgvsksd 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112107   186 -QNIWTLVILRFFQGFFGSTPLSNCGGTLSDLFTPIQRTYVLP-GFCT---FPFLGPIFGPIIGDFIcqsylGWCWVFWI 260
Cdd:pfam00083 347 wAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMAlATAAnwlANFLIGFLFPIITDAI-----GLGYTFFI 421

                         170       180
                  ....*....|....*....|...
gi 19112107   261 NMIMGAVVIVIIFFFMPETHGDT 283
Cdd:pfam00083 422 FAGLLVLFIIFVFFFVPETKGRT 444
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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