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Conserved domains on  [gi|19112157|ref|NP_595365|]
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enoyl reductase [Schizosaccharomyces pombe]

Protein Classification

steroid 5-alpha reductase family protein( domain architecture ID 708466)

steroid 5-alpha reductase family protein similar to Homo sapiens very-long-chain enoyl-CoA reductase and trans-2,3-enoyl-CoA reductase-like

EC:  1.3.1.-
Gene Ontology:  GO:0016491|GO:0042761

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02560 super family cl28409
enoyl-CoA reductase
 1-294 4.54e-66

enoyl-CoA reductase


The actual alignment was detected with superfamily member PLN02560:

Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 208.81  E-value: 4.54e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157    1 MSITLSSR-GRKIrkLPKSLEFPLDGSIDKLRDEVSSVTR--LPvERLRFST------ADGTTLLPNTTLRKYGVGPGAT 71
Cdd:PLN02560   1 MKVTVVSRsGREI--IKGGLEVPDSATVADLKKAIHKRKKkyYP-SRQRLTLplppgkTRPTVLDDSKSLKDYGLGDGGT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157   72 IWVKDLGPQIGWRTVFMIEYLGPLVIHL---FFILNYKWI-YRKDYNLCLNQKIAFVLVMLHFMKREYESIFVHRFSLAT 147
Cdd:PLN02560  78 VVFKDLGPQVSYRTLFFFEYLGPLLIYPlfyFFPQVYKYFgYPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHAT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157  148 MPLRNIFKNCAHYHLLsGLFLAYFIYGPwhanDYIKPNHLLfLIVGWAFAV---LSNFRTHIILRDLR-PAGSKKRVIPT 223
Cdd:PLN02560 158 SPLFNVFRNCAYYWTF-GAYIAYFVNHP----LYTPVSETQ-MKVGFGFGLvcqLANFYCHIILRNLRkPDGKGGYQIPR 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19112157  224 GYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVWAKKKHARYLKEF------PNYPRSRKIMIPFF 294
Cdd:PLN02560 232 GFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFdgkdgrPKYPRRWVILPPFL 308
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 1-294 4.54e-66

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 208.81  E-value: 4.54e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157    1 MSITLSSR-GRKIrkLPKSLEFPLDGSIDKLRDEVSSVTR--LPvERLRFST------ADGTTLLPNTTLRKYGVGPGAT 71
Cdd:PLN02560   1 MKVTVVSRsGREI--IKGGLEVPDSATVADLKKAIHKRKKkyYP-SRQRLTLplppgkTRPTVLDDSKSLKDYGLGDGGT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157   72 IWVKDLGPQIGWRTVFMIEYLGPLVIHL---FFILNYKWI-YRKDYNLCLNQKIAFVLVMLHFMKREYESIFVHRFSLAT 147
Cdd:PLN02560  78 VVFKDLGPQVSYRTLFFFEYLGPLLIYPlfyFFPQVYKYFgYPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHAT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157  148 MPLRNIFKNCAHYHLLsGLFLAYFIYGPwhanDYIKPNHLLfLIVGWAFAV---LSNFRTHIILRDLR-PAGSKKRVIPT 223
Cdd:PLN02560 158 SPLFNVFRNCAYYWTF-GAYIAYFVNHP----LYTPVSETQ-MKVGFGFGLvcqLANFYCHIILRNLRkPDGKGGYQIPR 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19112157  224 GYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVWAKKKHARYLKEF------PNYPRSRKIMIPFF 294
Cdd:PLN02560 232 GFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFdgkdgrPKYPRRWVILPPFL 308
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 146-295 2.38e-59

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 186.46  E-value: 2.38e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157   146 ATMPLRNIFKNCAhYHLLSGLFLAY--FIYGPWhANDYIKPNHLLFLIVGWAFAVLSNFRTHIILRDLRPAGSKKRVIPT 223
Cdd:pfam02544   1 ATMPLTIVAKAFA-FCTLNGLIQGRynSYYQPY-AEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19112157   224 GYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVWAKKKHARYLKEFPNYPRSRKIMIPFFL 295
Cdd:pfam02544  79 GGLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 3-77 1.69e-13

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 64.62  E-value: 1.69e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19112157   3 ITLSSRGRkiRKLPKSLEFPLDGSIDKLRDEVSSVTR-LPVERLRFST--ADGTTLLPNTTLRKYGVGPGATIWVKDL 77
Cdd:cd01801   2 IEVVSRKG--GKQIITLEVSSSATVADLKKAIHKKKKkLYPERQRLRLevPKGKVLKDDKTLSSYGVKDGSTLYFKDL 77
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
 1-74 2.86e-03

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563 [Multi-domain]  Cd Length: 72  Bit Score: 35.70  E-value: 2.86e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19112157      1 MSITLSSRGRKIRKLpkslEFPLDGSIDKLRDEVSSVTRLPVERLRFsTADGTTLLPNTTLRKYGVGPGATIWV 74
Cdd:smart00213   1 IELTVKTLDGKTITL----EVKPSDTVSELKEKIAELTGIPPEQQRL-IYKGKVLEDDRTLADYGIQDGSTIHL 69
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 1-294 4.54e-66

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 208.81  E-value: 4.54e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157    1 MSITLSSR-GRKIrkLPKSLEFPLDGSIDKLRDEVSSVTR--LPvERLRFST------ADGTTLLPNTTLRKYGVGPGAT 71
Cdd:PLN02560   1 MKVTVVSRsGREI--IKGGLEVPDSATVADLKKAIHKRKKkyYP-SRQRLTLplppgkTRPTVLDDSKSLKDYGLGDGGT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157   72 IWVKDLGPQIGWRTVFMIEYLGPLVIHL---FFILNYKWI-YRKDYNLCLNQKIAFVLVMLHFMKREYESIFVHRFSLAT 147
Cdd:PLN02560  78 VVFKDLGPQVSYRTLFFFEYLGPLLIYPlfyFFPQVYKYFgYPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHAT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157  148 MPLRNIFKNCAHYHLLsGLFLAYFIYGPwhanDYIKPNHLLfLIVGWAFAV---LSNFRTHIILRDLR-PAGSKKRVIPT 223
Cdd:PLN02560 158 SPLFNVFRNCAYYWTF-GAYIAYFVNHP----LYTPVSETQ-MKVGFGFGLvcqLANFYCHIILRNLRkPDGKGGYQIPR 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19112157  224 GYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVWAKKKHARYLKEF------PNYPRSRKIMIPFF 294
Cdd:PLN02560 232 GFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFdgkdgrPKYPRRWVILPPFL 308
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 146-295 2.38e-59

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 186.46  E-value: 2.38e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157   146 ATMPLRNIFKNCAhYHLLSGLFLAY--FIYGPWhANDYIKPNHLLFLIVGWAFAVLSNFRTHIILRDLRPAGSKKRVIPT 223
Cdd:pfam02544   1 ATMPLTIVAKAFA-FCTLNGLIQGRynSYYQPY-AEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19112157   224 GYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVWAKKKHARYLKEFPNYPRSRKIMIPFFL 295
Cdd:pfam02544  79 GGLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 3-77 1.69e-13

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 64.62  E-value: 1.69e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19112157   3 ITLSSRGRkiRKLPKSLEFPLDGSIDKLRDEVSSVTR-LPVERLRFST--ADGTTLLPNTTLRKYGVGPGATIWVKDL 77
Cdd:cd01801   2 IEVVSRKG--GKQIITLEVSSSATVADLKKAIHKKKKkLYPERQRLRLevPKGKVLKDDKTLSSYGVKDGSTLYFKDL 77
PLN02392 PLN02392
probable steroid reductase DET2
 220-294 9.28e-12

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 63.68  E-value: 9.28e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19112157  220 VIPTGYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVWAKKKHARYLKEF-PNYPRSRKIMIPFF 294
Cdd:PLN02392 184 KVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKFgEDYPKGRKAVIPFL 259
PLN03164 PLN03164
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional
 123-293 1.19e-08

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional


Pssm-ID: 215610 [Multi-domain]  Cd Length: 323  Bit Score: 55.21  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157  123 FVLVML--HFMKREYESIFVHRFS-LATMPLRNIFKNCAHY-----HLLSGLFLAYFIYG-------------PWHAN-- 179
Cdd:PLN03164 116 FLLLLMeiHVLRRLYESLYVFKYSpSARMHILGYLTGLFFYvaaplSLCCNCAPEVAKFVgnqvaefivkgksAMSAIef 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112157  180 ---DYIKPnhllFLIVGW---------AFAVLSNFRTHIILRDLR--PAGSKKRVIPTGYGFNLVSFPNYFFESLgwLFF 245
Cdd:PLN03164 196 dwwDFVSP----LMKLGWfqwigaaifLWGWIHQYRCHAILGSLRehKKQADEYVIPYGDWFEMVSCPHYLAEIV--IYA 269

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 19112157  246 ALLTKSWAS----W-IFLFVGSAQMFVwAKKKHARYLKEFPNYPRSRKIMIPF 293
Cdd:PLN03164 270 GLLIASGGTdltiWlLFGFVVANLTFA-AAETHRWYLQKFENYPRNRYAIIPF 321
Ubl_IQUB cd17061
ubiquitin-like (Ubl) domain found in IQ and ubiquitin-like domain-containing protein (IQUB) ...
 19-72 5.37e-04

ubiquitin-like (Ubl) domain found in IQ and ubiquitin-like domain-containing protein (IQUB) and similar proteins; IQUB is an IQ motif and ubiquitin domain-containing protein that may play roles in cilia formation and/or maintenance. It contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340581  Cd Length: 79  Bit Score: 38.01  E-value: 5.37e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 19112157  19 LEFPLDGSIDKLRDEVSSVTRLPVERLRFsTADGTTLLPNTTLRKYGVGPGATI 72
Cdd:cd17061  18 LAFTLGQTIGELKEHFSSELKIPPDVLQI-MFDGKLVEDNTTLVDLGVRPNGTI 70
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog) ...
 11-72 1.47e-03

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog), Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 459726 [Multi-domain]  Cd Length: 72  Bit Score: 36.38  E-value: 1.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19112157    11 KIRKLPKS---LEFPLDGSIDKLRDEVSSVTRLPVERLRFSTAdGTTLLPNTTLRKYGVGPGATI 72
Cdd:pfam00240   2 TVKTLDGKkitLEVDPTDTVLELKEKIAEKEGVPPEQQRLIYS-GKVLEDDQTLGEYGIEDGSTI 65
Ubl_ubiquitin_like cd17039
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ...
 18-74 1.57e-03

ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340559 [Multi-domain]  Cd Length: 68  Bit Score: 36.42  E-value: 1.57e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19112157  18 SLEFPLDGSIDKLRDEVSSVTRLPVE--RLRFstaDGTTLLPNTTLRKYGVGPGATIWV 74
Cdd:cd17039  12 TVEVDPDDTVADLKEKIEEKTGIPVEqqRLIY---NGKELKDDKTLSDYGIKDGSTIHL 67
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
 1-74 2.86e-03

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563 [Multi-domain]  Cd Length: 72  Bit Score: 35.70  E-value: 2.86e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19112157      1 MSITLSSRGRKIRKLpkslEFPLDGSIDKLRDEVSSVTRLPVERLRFsTADGTTLLPNTTLRKYGVGPGATIWV 74
Cdd:smart00213   1 IELTVKTLDGKTITL----EVKPSDTVSELKEKIAELTGIPPEQQRL-IYKGKVLEDDRTLADYGIQDGSTIHL 69
Ubl_UBFD1 cd17047
ubiquitin-like (Ubl) domain found in ubiquitin domain-containing protein UBFD1 and similar ...
 19-74 3.30e-03

ubiquitin-like (Ubl) domain found in ubiquitin domain-containing protein UBFD1 and similar proteins; UBFD1, also termed ubiquitin-binding protein homolog (UBPH), is a polyubiquitin binding protein containing a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. It may play a role as nuclear factor-kappaB (NF-kappaB) regulator.


Pssm-ID: 340567  Cd Length: 70  Bit Score: 35.68  E-value: 3.30e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19112157  19 LEFPLDGSIDKLRDEVSSVTRLPV--ERLRFStadgtTLLP-NTTLRKYGVGPGATIWV 74
Cdd:cd17047  14 VKFPLDSTIAELKEHIETLTGVPPamQKLMYK-----GLLKdDKTLRELKVTKGAKVMV 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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