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Conserved domains on  [gi|19112252|ref|NP_595460|]
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phosphoribosylaminoimidazolesuccinocarboxamide synthase [Schizosaccharomyces pombe]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10105458)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 14-294 2.65e-152

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


:

Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 426.96  E-value: 2.65e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  14 KIATGKVRDLYECVEfpDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPHVQTHLITSRWEELPPvITKH 93
Cdd:cd01414   1 LIYSGKVRDVYDLGD--GRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDIIPNHLISTDVEDLPE-IKEP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  94 EELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLNVPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPDEVS 173
Cdd:cd01414  78 EDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVCGIKLPEGLREAQKLPEPIFTPSTKAEEGHDENISFEEAV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 174 KIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVLTPDSSRFWLASDYTVGKSPDSFDK 253
Cdd:cd01414 158 EIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDE-NGEIILIDEVLTPDSSRFWPADSYEPGKEQPSFDK 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19112252 254 QYLRNWLTAN--NLANKPNVSLPEDVVEATRRKYVEAYEMITG 294
Cdd:cd01414 237 QFVRDWLEASgwDKQDPPPPPLPAEVIEKTSARYIEAYERITG 279
 
Name Accession Description Interval E-value
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 14-294 2.65e-152

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 426.96  E-value: 2.65e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  14 KIATGKVRDLYECVEfpDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPHVQTHLITSRWEELPPvITKH 93
Cdd:cd01414   1 LIYSGKVRDVYDLGD--GRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDIIPNHLISTDVEDLPE-IKEP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  94 EELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLNVPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPDEVS 173
Cdd:cd01414  78 EDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVCGIKLPEGLREAQKLPEPIFTPSTKAEEGHDENISFEEAV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 174 KIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVLTPDSSRFWLASDYTVGKSPDSFDK 253
Cdd:cd01414 158 EIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDE-NGEIILIDEVLTPDSSRFWPADSYEPGKEQPSFDK 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19112252 254 QYLRNWLTAN--NLANKPNVSLPEDVVEATRRKYVEAYEMITG 294
Cdd:cd01414 237 QFVRDWLEASgwDKQDPPPPPLPAEVIEKTSARYIEAYERITG 279
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-298 3.65e-152

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 427.31  E-value: 3.65e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    1 MALLKTSLdAPFTKIATGKVRDLYECVEfpDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPHVQTHLIT 80
Cdd:PRK13961   2 STLMESDL-PSLPLLGRGKVRDIYAVDD--DRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAHIVPNHLTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   81 SRWEELPPVITKhEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLNVPTGMKEAEAFPEPLFTPSTKAA 160
Cdd:PRK13961  79 IDVDDVVPADEA-DQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPIFTPATKAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  161 EG-HDENIHPDEVSKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVLTPDSSRFWLA 239
Cdd:PRK13961 158 LGdHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDE-DGTLTLMDEVLTPDSSRFWPA 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19112252  240 SDYTVGKSPDSFDKQYLRNWLTA---NNLANKPNvsLPEDVVEATRRKYVEAYEMITGKKWS 298
Cdd:PRK13961 237 DSYQPGTSQPSFDKQFVRDWLETsgwDKTAPAPP--LPADVIEKTRAKYREALERLTGKSLD 296
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 13-296 5.12e-109

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 316.25  E-value: 5.12e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  13 TKIATGKVRDLYEcveFPDD-LLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPH-VQTHLItsrweelppvi 90
Cdd:COG0152   5 ELLYEGKVKDVYA---TDDDtLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIgIPTHFI----------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  91 tkhEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKqgtvhGLNVPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPD 170
Cdd:COG0152  71 ---ETLSGREMLVKKLEMIPVEVVVRNYAAGSLWKRYQA-----GIALPLGLEEGTKLPEPIFEPSTKADEGHDPNISEE 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 171 EV--SKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVlTPDSSRFWLASDYtvgksp 248
Cdd:COG0152 143 HIvaLGLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDA-DGEIVLADEI-TPDSSRLWDADTY------ 214

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112252 249 DSFDKQYLRNWLTANnlankpnvslpedvveaTRRKYVEAYEMITGKK 296
Cdd:COG0152 215 ESLDKDRFRDWLGGN-----------------TSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 14-266 1.02e-105

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 306.98  E-value: 1.02e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    14 KIATGKVRDLYECVEfPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPH-VQTHLItsrweelppvitk 92
Cdd:pfam01259   1 LLYEGKVKDVYETDD-PDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAgIPTHFI------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    93 hEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAEGHDENIHPDEV 172
Cdd:pfam01259  67 -KSLSGREMLVKKVKIIPLEVVVRNYAAGSLGKRLP------------GLKEGTKLPEPIFEPSTKADALGDPNINEEHI 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   173 S--KIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVlTPDSSRFWLASDYTvgKSPDS 250
Cdd:pfam01259 134 ValGLATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDS-DGEIVLADEI-TPDSSRFWDADTYE--KSQES 209

                         250
                  ....*....|....*.
gi 19112252   251 FDKQYLRNWLTANNLA 266
Cdd:pfam01259 210 LDKDRFRDDLGDVEEA 225
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 14-294 3.32e-63

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 199.16  E-value: 3.32e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    14 KIATGKVRDLYEcVEFPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLkphvqthlitsrwEELppVITKH 93
Cdd:TIGR00081   8 KLYSGKAKDIYE-TDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKL-------------EEA--GIPTH 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    94 EE--LKDRSMLVKKYKILPIEAIVRGYITGSAWKEYqkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAE--GHDENIHP 169
Cdd:TIGR00081  72 YIdlIEDREMLVKKLDIIPLEVIVRNIAAGSLLKRL-------------GIPEGLELEQPLVEFIFKPDEvgDPMLNESY 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   170 DEVSKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDETTNkIVLVDEVlTPDSSRFWLASDYTVGKSPd 249
Cdd:TIGR00081 139 AEALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGN-LILADEV-SPDTCRLWDKETYEVGAPK- 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 19112252   250 sfdkqylrnwltannlankpnvsLPEDVVEATRRKYVEAYEMITG 294
Cdd:TIGR00081 216 -----------------------LDKDIFRRTLGKLIEAYETVAR 237
 
Name Accession Description Interval E-value
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 14-294 2.65e-152

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 426.96  E-value: 2.65e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  14 KIATGKVRDLYECVEfpDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPHVQTHLITSRWEELPPvITKH 93
Cdd:cd01414   1 LIYSGKVRDVYDLGD--GRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDIIPNHLISTDVEDLPE-IKEP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  94 EELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLNVPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPDEVS 173
Cdd:cd01414  78 EDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVCGIKLPEGLREAQKLPEPIFTPSTKAEEGHDENISFEEAV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 174 KIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVLTPDSSRFWLASDYTVGKSPDSFDK 253
Cdd:cd01414 158 EIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDE-NGEIILIDEVLTPDSSRFWPADSYEPGKEQPSFDK 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19112252 254 QYLRNWLTAN--NLANKPNVSLPEDVVEATRRKYVEAYEMITG 294
Cdd:cd01414 237 QFVRDWLEASgwDKQDPPPPPLPAEVIEKTSARYIEAYERITG 279
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-298 3.65e-152

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 427.31  E-value: 3.65e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    1 MALLKTSLdAPFTKIATGKVRDLYECVEfpDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPHVQTHLIT 80
Cdd:PRK13961   2 STLMESDL-PSLPLLGRGKVRDIYAVDD--DRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAHIVPNHLTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   81 SRWEELPPVITKhEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLNVPTGMKEAEAFPEPLFTPSTKAA 160
Cdd:PRK13961  79 IDVDDVVPADEA-DQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPIFTPATKAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  161 EG-HDENIHPDEVSKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVLTPDSSRFWLA 239
Cdd:PRK13961 158 LGdHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDE-DGTLTLMDEVLTPDSSRFWPA 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19112252  240 SDYTVGKSPDSFDKQYLRNWLTA---NNLANKPNvsLPEDVVEATRRKYVEAYEMITGKKWS 298
Cdd:PRK13961 237 DSYQPGTSQPSFDKQFVRDWLETsgwDKTAPAPP--LPADVIEKTRAKYREALERLTGKSLD 296
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 13-296 5.12e-109

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 316.25  E-value: 5.12e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  13 TKIATGKVRDLYEcveFPDD-LLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPH-VQTHLItsrweelppvi 90
Cdd:COG0152   5 ELLYEGKVKDVYA---TDDDtLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIgIPTHFI----------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  91 tkhEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKqgtvhGLNVPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPD 170
Cdd:COG0152  71 ---ETLSGREMLVKKLEMIPVEVVVRNYAAGSLWKRYQA-----GIALPLGLEEGTKLPEPIFEPSTKADEGHDPNISEE 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 171 EV--SKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVlTPDSSRFWLASDYtvgksp 248
Cdd:COG0152 143 HIvaLGLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDA-DGEIVLADEI-TPDSSRLWDADTY------ 214

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112252 249 DSFDKQYLRNWLTANnlankpnvslpedvveaTRRKYVEAYEMITGKK 296
Cdd:COG0152 215 ESLDKDRFRDWLGGN-----------------TSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 14-266 1.02e-105

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 306.98  E-value: 1.02e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    14 KIATGKVRDLYECVEfPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPH-VQTHLItsrweelppvitk 92
Cdd:pfam01259   1 LLYEGKVKDVYETDD-PDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAgIPTHFI------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    93 hEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAEGHDENIHPDEV 172
Cdd:pfam01259  67 -KSLSGREMLVKKVKIIPLEVVVRNYAAGSLGKRLP------------GLKEGTKLPEPIFEPSTKADALGDPNINEEHI 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   173 S--KIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVlTPDSSRFWLASDYTvgKSPDS 250
Cdd:pfam01259 134 ValGLATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDS-DGEIVLADEI-TPDSSRFWDADTYE--KSQES 209

                         250
                  ....*....|....*.
gi 19112252   251 FDKQYLRNWLTANNLA 266
Cdd:pfam01259 210 LDKDRFRDDLGDVEEA 225
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 18-296 5.63e-87

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 262.52  E-value: 5.63e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   18 GKVRDLYEcveFPDDLL-FVATDRISAYDFIMEnGIPEKGKVLTKISEFWFDVLKPHVQTHLItsrweELP-PVITkhee 95
Cdd:PRK12607  21 GKVRDNYD---LPDGRRvMVATDRISAFDRVLP-AIPYKGQVLNQTAAFWFEATKDICPNHVL-----AVPdPNVV---- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   96 lkdrsmLVKKYKILPIEAIVRGYITGSAWKEYQK-QGTVHGLNVPTGMKEAEAFPEPLFTPSTKAAE-GHDENIHPDEV- 172
Cdd:PRK12607  88 ------VGKRCEPFPVEMVVRGYLAGSTWRLYKAgKREMYGVTLPDGLRENQKLPEPIITPTTKAEEgGHDEPISPEEIl 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  173 -SKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVLTPDSSRFWLASDY----TVGKS 247
Cdd:PRK12607 162 aQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDA-DGRIVLIDEIHTPDSSRYWYADGYeerfAAGEP 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 19112252  248 PDSFDKQYLRNWLTANNlaNKPNVSLPE---DVVEATRRKYVEAYEMITGKK 296
Cdd:PRK12607 241 QEQLDKEFVRQWLIERC--GPYGQEIPEipdEVIVSVSERYIELYEKITGET 290
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 14-294 3.32e-63

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 199.16  E-value: 3.32e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    14 KIATGKVRDLYEcVEFPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLkphvqthlitsrwEELppVITKH 93
Cdd:TIGR00081   8 KLYSGKAKDIYE-TDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKL-------------EEA--GIPTH 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252    94 EE--LKDRSMLVKKYKILPIEAIVRGYITGSAWKEYqkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAE--GHDENIHP 169
Cdd:TIGR00081  72 YIdlIEDREMLVKKLDIIPLEVIVRNIAAGSLLKRL-------------GIPEGLELEQPLVEFIFKPDEvgDPMLNESY 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   170 DEVSKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDETTNkIVLVDEVlTPDSSRFWLASDYTVGKSPd 249
Cdd:TIGR00081 139 AEALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGN-LILADEV-SPDTCRLWDKETYEVGAPK- 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 19112252   250 sfdkqylrnwltannlankpnvsLPEDVVEATRRKYVEAYEMITG 294
Cdd:TIGR00081 216 -----------------------LDKDIFRRTLGKLIEAYETVAR 237
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 16-296 1.99e-60

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 196.58  E-value: 1.99e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   16 ATGKVRDLYECvefPDDLLFVATDRISAYDFIMENgIPEKGKVLTKISEFWFDVLKPHVQTHLITSrweelP-PVITkhe 94
Cdd:PLN02544  79 RRGKVRDIYDL---GDYLVLVTTDRQSAFDRVLAS-IPFKGQVLNQTSAWWFNNTKHITPNALVSS-----PdPNVT--- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   95 elkdrsmLVKKYKILPIEAIVRGYITGSA----WKEYQKQGTVH-GLNVPTGMKEAEAFPEPLFTPSTKAAEgHDENIHP 169
Cdd:PLN02544 147 -------IAKKCSVFPVEFVVRGYMTGSTstslWTVYNKGVRNYcGNDLPDGMVKNQKLPANILTPTTKAAD-HDVPISP 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  170 DEvskIVGPELAKQ-----VAETSVKLYKIARDVALKKGIIIADTKFEFGVDETtNKIVLVDEVLTPDSSRFWLASDY-- 242
Cdd:PLN02544 219 EE---IVEEGLMTQedfdeVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDAD-GTILLIDEVHTPDSSRYWLADSYee 294

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  243 --TVGKSPDSFDKQYLRNWLTANNLANKPNVsLPED----VVEATRRkYVEAYEMITGKK 296
Cdd:PLN02544 295 rhAAGLEPENIDKEFLRLWFKENCDPYKDEV-LPEApaelVCELSWR-YIKLYETITGEK 352
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 14-293 8.41e-56

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 179.97  E-value: 8.41e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  14 KIATGKVRDLYECVEfpDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVL-KPHVQTHLItsrweelppvitk 92
Cdd:cd00476   1 TLYRGKTKIVYETKD--GVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLsEAGIPTHFV------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  93 hEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAEGHDENIHPD-- 170
Cdd:cd00476  66 -ERLGPRTLLVDKLK*IPLEVVVRNRATGSFVKRYG------------GFKEGREFPPPLVEFFYKDDAEHDPIVSEDql 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 171 EVSKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVLtPDSSRFWLASDYTVGKSPDs 250
Cdd:cd00476 133 ERLGFIGKVDVER*KELAVKINTVLKKLFSPAGLELWDFKLEFGLDE-EGEIVLGDEIS-PDSSRLWRKGGEPYDKDLF- 209

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19112252 251 fdkqylrnwltannlankpnvsLPEDVVEATRRKYVEAYEMIT 293
Cdd:cd00476 210 ----------------------RRRASLGQIIEKYEEVAELVR 230
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 17-296 4.31e-33

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 124.82  E-value: 4.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   17 TGKVRDLYECVE-------------FPDDL---LFVATDRISAYDFIME-----NGIPEKGKVLTKISEFWFDVLKphvQ 75
Cdd:PRK13960  24 SGKVRSVYWLTEedsrrlikekgynVPADAplaIMVISDRISAFDCIWHgegglNGVPGKGAALNAISNHWFKLFK---E 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   76 THLITSRWEELP-PVItkheelkdrsMLVKKYKILPIEAIVRGYITGSAWKEYQK-QGTVHGLNVPTGMKEAEAFPEPLF 153
Cdd:PRK13960 101 NGLADSHILDIPhPFV----------WIVQKARPVMIEAICRQYITGSMWRAYSKgEREFCGITLPEGLEKDQKLPELLI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  154 TPSTKA--------AEGHDENIHPDEVSKIVGPELAKQVAETSV--KLYKIARDV---ALKK-GIIIADTKFEFGVDETT 219
Cdd:PRK13960 171 TPSTKGiltgipgvPEADDVNISRSDIEANYQAFNFSSADDIDLyeKLLKEGFKVisdALAKlDQIFVDTKFEFGYVTDA 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  220 N---KIVLVDEVLTPDSSRFWLASDYTVGK----SPDSFDKQYLRNWLTANNLANKPNV----------SLPEDVVEATR 282
Cdd:PRK13960 251 AgneKLIYMDEVGTPDSSRIWDGAAYRDGKivenSKEGFRQFLLNHFPDPDILLNKDRMperealardnALPLEAMMDVS 330

                        330
                 ....*....|....
gi 19112252  283 RKYVEAYEMITGKK 296
Cdd:PRK13960 331 RTYTGIAEKITGAK 344
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 14-258 2.32e-28

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 108.69  E-value: 2.32e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  14 KIATGKVRDLYECVEfPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPH-VQTHLItsrweelppvitk 92
Cdd:cd01415   1 LLYEGKAKIVYATDD-PDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENgIKTHFI------------- 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  93 hEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYqkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAEGHDENIHPDEV 172
Cdd:cd01415  67 -EKLSDREQLVKKVEIIPLEVVVRNIAAGSLVKRL-------------GIEEGTVLDPPIVEFYYKNDELGDPLINEDHI 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 173 S--KIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVlTPDSSRFWlasDytvGKSPDS 250
Cdd:cd01415 133 LalGLATEEELKEIKELALKINEVLSEFFAEIGIILVDFKLEFGRDK-DGEIVLADEI-SPDTCRLW---D---KETGEK 204


                ....*...
gi 19112252 251 FDKQYLRN 258
Cdd:cd01415 205 LDKDRFRR 212
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 13-258 7.91e-28

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 107.50  E-value: 7.91e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   13 TKIATGKVRDLYECVEfPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPH-VQTHLItsrweelppvit 91
Cdd:PRK09362   5 ELLYEGKAKIVYSTDD-PDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAgIPTHFI------------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   92 khEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYqkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAEGHDENIHPDE 171
Cdd:PRK09362  72 --EKLSDREQLVKKVEIIPLEVVVRNVAAGSLVKRL-------------GIEEGTVLPPPIVEFYYKNDALGDPMINEDH 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  172 VS--KIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDEtTNKIVLVDEVlTPDSSRFWLAsdytvgKSPD 249
Cdd:PRK09362 137 ILalGWATPEELAEIKELALKINDVLKGLFAGAGIRLVDFKLEFGRDK-DGEIVLADEI-SPDTCRLWDK------ETNE 208


                 ....*....
gi 19112252  250 SFDKQYLRN 258
Cdd:PRK09362 209 KLDKDRFRR 217
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 17-297 4.17e-24

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 99.75  E-value: 4.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   17 TGKVRDLY----ECVEFPDDLLFVATDRISAYDF-IMENGIPEKGKVLTKISEFWFDVL-KPHVQTHLItsRWEELPPVI 90
Cdd:PRK13959   1 MGSVKDFYvdeePTETDLGRGRFVFSDRYSVFDWgIMPDEIPDKGASLCTMGAYNFELLeEEGIKTHYI--GVVEDGEVV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252   91 TKHE-ELKDRSMLVKKYKI------------------------LPIEAIVRGYI-TGSAWKEYQKQGTV----HGLNVPT 140
Cdd:PRK13959  79 RLAEaSEPPNEMAVKLTQVpdlpfeggsydydayheaagenylIPLEVIFRNYVpVGSSLRDRIKEGKIkpedLGLDADE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  141 GMKEAEAFPEPLFTPSTKAaEGHDENIHPDEVSKIVGPELAK--QVAETSVKLYKIARDVALKKGIIIADTKFEFGVDET 218
Cdd:PRK13959 159 WPEEGVKLPEPIVEFSTKY-EEQDRYLSRKEADEIAGLSRAEieELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  219 TNkIVLVDEVLTPDSSRFwlasdytvgkspdSFD---------KQYLRN--WLTANNLANKPNVS------------LPE 275
Cdd:PRK13959 238 RE-IRVVDVVGTFDENRF-------------SYEgqelskevvRQYYRRteWVEAVKEAKEEDVAdwrslcepdpppLPD 303

                        330       340
                 ....*....|....*....|..
gi 19112252  276 DVVEATRRKYVEAYEMITGKKW 297
Cdd:PRK13959 304 EVVEAVSDLYKAGTNAYTGREW 325
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 13-267 4.65e-17

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 78.87  E-value: 4.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  13 TKIATGKVRDLYECVEFPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLK-PHVQTHLITsrweelppvit 91
Cdd:cd01416   5 KKLIEGKTKIVYELPDQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQeAGIKTHFVK----------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252  92 KHEElkdRSMLVKKYKILPIEAIVRGYITGSAWKEYQkqgtvhglnvptGMKEAEAFPEPLFTPSTKAAEGHDENIHPDE 171
Cdd:cd01416  74 QCSP---TAFIARKCEMIPIEWVCRRIATGSFLKRNP------------GVKEGYRFSPPKLEFFYKDDANHDPQWSEEQ 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112252 172 V--------SKIVGPELAKQVAETSVKLYKIARDVALKKGIIIADTKFEFGVDETTNKIVLVDeVLTPDSSRFWLASDYT 243
Cdd:cd01416 139 LleaklncgGLKIGKKEVDIMTKSTIAIFEILEKAWATQDCTLVDMKIEFGVDVTTGEILLAD-VIDNDSWRLWPSGDKR 217

                       250       260
                ....*....|....*....|....*.
gi 19112252 244 VGKspdsfDKQYLRN--WLTANNLAN 267
Cdd:cd01416 218 LMK-----DKQVYRNlkEVTDEALQE 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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