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Conserved domains on  [gi|19113041|ref|NP_596249|]
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cystathionine gamma-synthase [Schizosaccharomyces pombe]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 297-610 4.46e-32

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member cd00614:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 369  Bit Score: 127.70  E-value: 4.46e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 297 FLFPTGMSAIYNThrILRLVLDDSRKsVCFGFCYVDTL----KILQKWGSGCYFYGLGNDEQLDEFEKrlesgEKVMALF 372
Cdd:cd00614  59 LAFSSGMAAISTV--LLALLKAGDHV-VASDDLYGGTYrlfeRLLPKLGIEVTFVDPDDPEALEAAIK-----PETKLVY 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 373 CEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNpSSRYYSR 451
Cdd:cd00614 131 VESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFATPYLQRPLELgADIVVHSATKYIGGHSDVIAGVVVGS-GEALIQR 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 452 IKDAMKALYEDLLYDEDALTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGYGGL 531
Cdd:cd00614 210 LRFLRLALGTILSPFDAWLLL-RGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQH-ELAKKQMSGYGGV 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 532 LSV-VFHNPEDARQFYDKIQVAK-GPSLGTNFTLASPYAILAHYQELDWA-GENGIDRNLVRVSVGMEPSEHLKNVFINA 608
Cdd:cd00614 288 FSFeLKGGLEAAKKFLNALKLFSlAVSLGGVESLVEHPASMTHSQLPPEErAAAGITPGLVRLSVGIEDVEDLIADLEQA 367


                ..
gi 19113041 609 LS 610
Cdd:cd00614 368 LK 369
 
Name Accession Description Interval E-value
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 297-610 4.46e-32

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 127.70  E-value: 4.46e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 297 FLFPTGMSAIYNThrILRLVLDDSRKsVCFGFCYVDTL----KILQKWGSGCYFYGLGNDEQLDEFEKrlesgEKVMALF 372
Cdd:cd00614  59 LAFSSGMAAISTV--LLALLKAGDHV-VASDDLYGGTYrlfeRLLPKLGIEVTFVDPDDPEALEAAIK-----PETKLVY 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 373 CEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNpSSRYYSR 451
Cdd:cd00614 131 VESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFATPYLQRPLELgADIVVHSATKYIGGHSDVIAGVVVGS-GEALIQR 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 452 IKDAMKALYEDLLYDEDALTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGYGGL 531
Cdd:cd00614 210 LRFLRLALGTILSPFDAWLLL-RGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQH-ELAKKQMSGYGGV 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 532 LSV-VFHNPEDARQFYDKIQVAK-GPSLGTNFTLASPYAILAHYQELDWA-GENGIDRNLVRVSVGMEPSEHLKNVFINA 608
Cdd:cd00614 288 FSFeLKGGLEAAKKFLNALKLFSlAVSLGGVESLVEHPASMTHSQLPPEErAAAGITPGLVRLSVGIEDVEDLIADLEQA 367


                ..
gi 19113041 609 LS 610
Cdd:cd00614 368 LK 369
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 297-609 1.02e-29

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 120.80  E-value: 1.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   297 FLFPTGMSAIYNTHRIL-----RLVLDDSrksvCFGFCYVDTLKILQKWGSGCYFYGLGNdeqLDEFEKRLesGEKVMAL 371
Cdd:pfam01053  66 LAFSSGMAAITAAILALlkagdHIVATDD----LYGGTYRLFNKVLPRFGIEVTFVDTSD---PEDLEAAI--KPNTKAV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   372 FCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNpSSRYYS 450
Cdd:pfam01053 137 YLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLgADIVVHSATKYIGGHSDVVGGVIVVN-GEELGK 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   451 RIKDAMKALyEDLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGYGG 530
Cdd:pfam01053 216 ELYFLQNAT-GAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGH-ELAKRQMKGFGG 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   531 LLSVVFHNPED-ARQFYDKIQV-AKGPSLGTNFTLASPYAILAHYQELDWAGEN-GIDRNLVRVSVGMEPSEHLKNVFIN 607
Cdd:pfam01053 294 MLSFELKGGLEaAKKFLDNLKLfSLAVSLGGVESLISHPATMTHASIPPEEREAaGITDDLIRLSVGIEDVDDLIADLKQ 373


                  ..
gi 19113041   608 AL 609
Cdd:pfam01053 374 AL 375
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 297-610 6.81e-28

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 115.92  E-value: 6.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 297 FLFPTGMSAIYNThrIL-------RLVLDDSrksvCFGFCYVDTLKILQKWGSGCYFYGLGNdeqLDEFEKRLESGEKVm 369
Cdd:COG0626  77 LAFASGMAAISAV--LLallkagdHVVASDD----LYGGTRRLLDKVLARFGIEVTFVDPTD---LAAVEAAIRPNTKL- 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 370 aLFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIG---NFvnvevLPL---ADVVVSSLTKIFSGDSNVMGGSMVLN 443
Cdd:COG0626 147 -VFLETPSNPTLEVVDIAAIAAIAHAAGALLVVDNTFAtplLQ-----RPLelgADIVVHSATKYLGGHSDVLGGAVVGR 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 444 pSSRYYSRIKDAMKALyedllydEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRR 523
Cdd:COG0626 221 -DEELAERLRFLQNALgav-lspFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGH-ELAKR 297

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 524 ENGGYGGLLSVVFH-NPEDARQFYDKIQVAK-GPSLGTNFTLASPYAILAH--YQELDWAgENGIDRNLVRVSVGMEPSE 599
Cdd:COG0626 298 QMSGFGGMLSFELKgGREAARRFLDALKLFTlAVSLGGVESLITHPATMTHrsLPPEERA-ALGITDGLVRLSVGLEDVD 376

                       330
                ....*....|.
gi 19113041 600 HLKNVFINALS 610
Cdd:COG0626 377 DLIADLEQALA 387
PRK08249 PRK08249
cystathionine gamma-synthase family protein;
299-601 8.94e-26

cystathionine gamma-synthase family protein;


Pssm-ID: 236202 [Multi-domain]  Cd Length: 398  Bit Score: 109.83  E-value: 8.94e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  299 FPTGMSAIYNThriLRLVLDDSRKSVCFGFCYVDTLKI----LQKWGSGCYFYGLGNDEQLdefEKRLESGEKVmaLFCE 374
Cdd:PRK08249  85 FSTGMAAISNT---LYTFLKPGDRVVSIKDTYGGTNKIftefLPRMGVDVTLCETGDHEQI---EAEIAKGCDL--LYLE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  375 FPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGsMVLNPSS-----RY 448
Cdd:PRK08249 157 TPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALgADLVIHSATKFLSGHADALGG-VVCGSKElmeqvYH 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  449 YSRIK----DAMKALyedllydedaLTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHFEACRRE 524
Cdd:PRK08249 236 YREINgatmDPMSAY----------LIL-RGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQM 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  525 NGgYGGLLSVVFHNPEDA-RQFYDKIQVA-KGPSLGTNFTLASPYAILAHYQ-ELDWAGENGIDRNLVRVSVGMEPSEHL 601
Cdd:PRK08249 305 RG-FGGILSFVLKGGMDTvKRLLPKLRYAhRAANLGAVETIYGPARTTSHVEnTLEERAALGIPEGLVRISVGIEDTEDL 383
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 355-609 8.55e-12

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 67.16  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   355 LDEFEKRLesGEKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDS 433
Cdd:TIGR01329 121 LDKVKAAL--GPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVVDNTMMSPLLCNPLELgADIVYHSATKFLAGHS 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   434 NVMGGSMVLNP---SSRYYSRIKDAMKALYEDllydeDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPK 510
Cdd:TIGR01329 199 DVMAGVLAVKGeeiAKKVYFLQNSTGSGLAPF-----DCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAG 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   511 YNtSKEHFEACRRENGGYGGLLSVVFHNPEDARQF-----YDKIQVAKGP--SLGTNFTLASPYAILAHYQEldwagENG 583
Cdd:TIGR01329 274 LP-SHPGFHLHFSQAKGAGSVLSFETGSVALSKRLveatkLFSITVSFGSvnSLISMPCFMSHASIPAEVRE-----ERG 347

                         250       260
                  ....*....|....*....|....*.
gi 19113041   584 IDRNLVRVSVGMEPSEHLKNVFINAL 609
Cdd:TIGR01329 348 LPEDLVRLSVGIEDVDDLISDLDIAF 373
 
Name Accession Description Interval E-value
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 297-610 4.46e-32

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 127.70  E-value: 4.46e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 297 FLFPTGMSAIYNThrILRLVLDDSRKsVCFGFCYVDTL----KILQKWGSGCYFYGLGNDEQLDEFEKrlesgEKVMALF 372
Cdd:cd00614  59 LAFSSGMAAISTV--LLALLKAGDHV-VASDDLYGGTYrlfeRLLPKLGIEVTFVDPDDPEALEAAIK-----PETKLVY 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 373 CEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNpSSRYYSR 451
Cdd:cd00614 131 VESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFATPYLQRPLELgADIVVHSATKYIGGHSDVIAGVVVGS-GEALIQR 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 452 IKDAMKALYEDLLYDEDALTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGYGGL 531
Cdd:cd00614 210 LRFLRLALGTILSPFDAWLLL-RGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQH-ELAKKQMSGYGGV 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 532 LSV-VFHNPEDARQFYDKIQVAK-GPSLGTNFTLASPYAILAHYQELDWA-GENGIDRNLVRVSVGMEPSEHLKNVFINA 608
Cdd:cd00614 288 FSFeLKGGLEAAKKFLNALKLFSlAVSLGGVESLVEHPASMTHSQLPPEErAAAGITPGLVRLSVGIEDVEDLIADLEQA 367


                ..
gi 19113041 609 LS 610
Cdd:cd00614 368 LK 369
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 297-609 1.02e-29

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 120.80  E-value: 1.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   297 FLFPTGMSAIYNTHRIL-----RLVLDDSrksvCFGFCYVDTLKILQKWGSGCYFYGLGNdeqLDEFEKRLesGEKVMAL 371
Cdd:pfam01053  66 LAFSSGMAAITAAILALlkagdHIVATDD----LYGGTYRLFNKVLPRFGIEVTFVDTSD---PEDLEAAI--KPNTKAV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   372 FCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNpSSRYYS 450
Cdd:pfam01053 137 YLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLgADIVVHSATKYIGGHSDVVGGVIVVN-GEELGK 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   451 RIKDAMKALyEDLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGYGG 530
Cdd:pfam01053 216 ELYFLQNAT-GAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGH-ELAKRQMKGFGG 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   531 LLSVVFHNPED-ARQFYDKIQV-AKGPSLGTNFTLASPYAILAHYQELDWAGEN-GIDRNLVRVSVGMEPSEHLKNVFIN 607
Cdd:pfam01053 294 MLSFELKGGLEaAKKFLDNLKLfSLAVSLGGVESLISHPATMTHASIPPEEREAaGITDDLIRLSVGIEDVDDLIADLKQ 373


                  ..
gi 19113041   608 AL 609
Cdd:pfam01053 374 AL 375
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 297-610 6.81e-28

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 115.92  E-value: 6.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 297 FLFPTGMSAIYNThrIL-------RLVLDDSrksvCFGFCYVDTLKILQKWGSGCYFYGLGNdeqLDEFEKRLESGEKVm 369
Cdd:COG0626  77 LAFASGMAAISAV--LLallkagdHVVASDD----LYGGTRRLLDKVLARFGIEVTFVDPTD---LAAVEAAIRPNTKL- 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 370 aLFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIG---NFvnvevLPL---ADVVVSSLTKIFSGDSNVMGGSMVLN 443
Cdd:COG0626 147 -VFLETPSNPTLEVVDIAAIAAIAHAAGALLVVDNTFAtplLQ-----RPLelgADIVVHSATKYLGGHSDVLGGAVVGR 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 444 pSSRYYSRIKDAMKALyedllydEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRR 523
Cdd:COG0626 221 -DEELAERLRFLQNALgav-lspFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGH-ELAKR 297

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 524 ENGGYGGLLSVVFH-NPEDARQFYDKIQVAK-GPSLGTNFTLASPYAILAH--YQELDWAgENGIDRNLVRVSVGMEPSE 599
Cdd:COG0626 298 QMSGFGGMLSFELKgGREAARRFLDALKLFTlAVSLGGVESLITHPATMTHrsLPPEERA-ALGITDGLVRLSVGLEDVD 376

                       330
                ....*....|.
gi 19113041 600 HLKNVFINALS 610
Cdd:COG0626 377 DLIADLEQALA 387
PRK08249 PRK08249
cystathionine gamma-synthase family protein;
299-601 8.94e-26

cystathionine gamma-synthase family protein;


Pssm-ID: 236202 [Multi-domain]  Cd Length: 398  Bit Score: 109.83  E-value: 8.94e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  299 FPTGMSAIYNThriLRLVLDDSRKSVCFGFCYVDTLKI----LQKWGSGCYFYGLGNDEQLdefEKRLESGEKVmaLFCE 374
Cdd:PRK08249  85 FSTGMAAISNT---LYTFLKPGDRVVSIKDTYGGTNKIftefLPRMGVDVTLCETGDHEQI---EAEIAKGCDL--LYLE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  375 FPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGsMVLNPSS-----RY 448
Cdd:PRK08249 157 TPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALgADLVIHSATKFLSGHADALGG-VVCGSKElmeqvYH 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  449 YSRIK----DAMKALyedllydedaLTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHFEACRRE 524
Cdd:PRK08249 236 YREINgatmDPMSAY----------LIL-RGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQM 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  525 NGgYGGLLSVVFHNPEDA-RQFYDKIQVA-KGPSLGTNFTLASPYAILAHYQ-ELDWAGENGIDRNLVRVSVGMEPSEHL 601
Cdd:PRK08249 305 RG-FGGILSFVLKGGMDTvKRLLPKLRYAhRAANLGAVETIYGPARTTSHVEnTLEERAALGIPEGLVRISVGIEDTEDL 383
PRK08574 PRK08574
cystathionine gamma-synthase family protein;
372-610 1.88e-21

cystathionine gamma-synthase family protein;


Pssm-ID: 236298 [Multi-domain]  Cd Length: 385  Bit Score: 96.67  E-value: 1.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  372 FCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETignFVN-VEVLPL---ADVVVSSLTKIFSGDSNVMGGSMVLnpSSR 447
Cdd:PRK08574 142 FIETMTNPTLKVIDVPEVAKAAKELGAILVVDNT---FATpLLYRPLrhgADFVVHSLTKYIAGHNDVVGGVAVA--WSG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  448 YYSRIKDAMKALYEDLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHFEACRR-ENG 526
Cdd:PRK08574 217 EFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLfGKD 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  527 GYGGLLSV-VFHNPEDARQFYDKIQVAK-GPSLGTNFTLAS-PYAILAHYQELDWAGENGIDRNLVRVSVGMEPSEHLKN 603
Cdd:PRK08574 297 LYGGVVSFrVKGGRDAVLKFLRSLKLIKpSPSLGGVESLATyPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIE 376


                 ....*..
gi 19113041  604 VFINALS 610
Cdd:PRK08574 377 DLDQALG 383
PRK06176 PRK06176
cystathionine gamma-synthase;
335-601 8.12e-21

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 94.58  E-value: 8.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  335 KILQKWGSGCYFYGLGNDEQLdefEKRLESGEKvmALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGN-FVNVE 413
Cdd:PRK06176 107 KVLVKNGLSCTIIDTSDLSQI---KKAIKPNTK--ALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATpYYQNP 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  414 VLPLADVVVSSLTKIFSGDSNVMGGSMVLN--PSSRYYSRIKDAMKAlyedLLYDEDALTLERNSRDFAERSQVINHNAE 491
Cdd:PRK06176 182 LLLGADIVVHSGTKYLGGHSDVVAGLVTTNneALAQEIAFFQNAIGG----VLGPQDSWLLQRGIKTLGLRMEAHQKNAL 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  492 TICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGYGGLLSVVFHNPEDARQFYDKIQV-AKGPSLGTNFTLASPYAIL 570
Cdd:PRK06176 258 CVAEFLEKHPKVEKVYYPGLPTHPNH-ELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLfILGESLGGVESLVGIPAFM 336

                        250       260       270
                 ....*....|....*....|....*....|....
gi 19113041  571 AHY---QELDWAGenGIDRNLVRVSVGMEPSEHL 601
Cdd:PRK06176 337 THAcipKEQREAA--GIRDGLVRLSVGIEHEQDL 368
PRK07671 PRK07671
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
297-610 8.38e-21

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;


Pssm-ID: 181076 [Multi-domain]  Cd Length: 377  Bit Score: 94.79  E-value: 8.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  297 FLFPTGMSAIYNTHRILR----LVLDDSrksvCFGFCYVDTLKILQKWGSGCYFYGLGNdeqLDEFEKRLESGEKvmALF 372
Cdd:PRK07671  69 FAFGSGMAAITAVMMLFSsgdhVILTDD----VYGGTYRVMTKVLNRFGIEHTFVDTSN---LEEVEEAIRPNTK--AIY 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  373 CEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNPssryysr 451
Cdd:PRK07671 140 VETPTNPLLKITDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLgADIVLHSATKYLGGHSDVVAGLVVVNS------- 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  452 ikdamKALYEDL----------LYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEAC 521
Cdd:PRK07671 213 -----PELAEDLhfvqnstggiLGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNH-ELA 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  522 RRENGGYGGLLSVVFHNPEDARQFYDKIQV-AKGPSLGTNFTLASPYAILAHYQ-ELDWAGENGIDRNLVRVSVGMEPSE 599
Cdd:PRK07671 287 KEQANGFGGMISFDVGSEETANKVLERLQYfTLAESLGAVESLISIPSQMTHASiPADRRKELGITDGLIRISVGIEDGE 366

                        330
                 ....*....|.
gi 19113041  600 HLKNVFINALS 610
Cdd:PRK07671 367 DLIEDLAQALA 377
PRK08045 PRK08045
cystathionine gamma-synthase; Provisional
 301-601 3.61e-20

cystathionine gamma-synthase; Provisional


Pssm-ID: 169194 [Multi-domain]  Cd Length: 386  Bit Score: 93.04  E-value: 3.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  301 TGMSAIyntHRILRLVLDDSRKSVCFGFCYVDTLKILQKWGS-GCY---FYGLGNDEQLDEfekrlESGEKVMALFCEFP 376
Cdd:PRK08045  75 TGMSAI---HLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKrGCYrvlFVDQGDEQALRA-----ALAEKPKLVLVESP 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  377 SNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNPS------SRYY 449
Cdd:PRK08045 147 SNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPALQNPLALgADLVLHSCTKYLNGHSDVVAGVVIAKDPdvvtelAWWA 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  450 SRIKDAMKALyedllydeDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHFEACRRENgGYG 529
Cdd:PRK08045 227 NNIGVTGGAF--------DSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQK-GFG 297

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113041  530 GLLSVVFHNPEDA-RQFYDKIQV-AKGPSLGTNFTLASPYAILAHYQELDWA-GENGIDRNLVRVSVGMEPSEHL 601
Cdd:PRK08045 298 AMLSFELDGDEQTlRRFLGGLSLfTLAESLGGVESLISHAATMTHAGMAPEArAAAGISETLLRISTGIEDGEDL 372
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 374-601 8.11e-20

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 91.63  E-value: 8.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  374 EFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNpssryysri 452
Cdd:PRK07811 153 ETPTNPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALgADVVVHSTTKYIGGHSDVVGGALVTN--------- 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  453 kDAmkALYEDLLYDEDA-----------LTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEAC 521
Cdd:PRK07811 224 -DE--ELDEAFAFLQNGagavpgpfdayLTL-RGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGH-EVA 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  522 RRENGGYGGLLSVVFH-NPEDARQFYDKIQVakgpslgtnFTLASPY----AILAHYQELDWAGENG----IDRNLVRVS 592
Cdd:PRK07811 299 ARQMRGFGGMVSVRLAgGEEAARDFCARTKV---------FTLAESLggveSLIEHPSAMTHASTAGsqleVPDDLVRLS 369


                 ....*....
gi 19113041  593 VGMEPSEHL 601
Cdd:PRK07811 370 VGIEDVADL 378
PRK06460 PRK06460
hypothetical protein; Provisional
 299-610 8.98e-20

hypothetical protein; Provisional


Pssm-ID: 235807 [Multi-domain]  Cd Length: 376  Bit Score: 91.43  E-value: 8.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  299 FPTGMSAIYNThrILRLVLDDSRKSV---CFGFCYVDTLKILQKWGSGCYFYGLGNDEQLdefEKRLESGEKVmaLFCEF 375
Cdd:PRK06460  66 FSSGMGAISTT--ALALLKPGNSVLVhrdMFGRSYRFFTDYLKNWGVNVDASNPGSDNII---EKAKSKRYDV--VFVEN 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  376 PSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGsmVLNPSSRYYSRIKD 454
Cdd:PRK06460 139 ITNPLLRVVDITELSKVCKENGSILIVDATFSTPINQKPLELgADIVVHSASKFLAGHNDVIAG--LAAGYGKLLNVIDQ 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  455 AMKALYEDLlyDEDALTL-ERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGYGGLLS 533
Cdd:PRK06460 217 MRRTLGTSL--DPHAAYLtLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDY-EIARRVLKGFGGVLS 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  534 vvFHNPEDARQFYDKIQVAK----GPSL-GTNFTLASPYAILAHYQELDWAGENGIDRNLVRVSVGMEPSEHLKNVFINA 608
Cdd:PRK06460 294 --FEVNGGQESALKVMKSLKliipAQTLgGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRA 371


                 ..
gi 19113041  609 LS 610
Cdd:PRK06460 372 LS 373
PRK08776 PRK08776
O-succinylhomoserine (thiol)-lyase;
374-601 1.01e-17

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181554 [Multi-domain]  Cd Length: 405  Bit Score: 85.81  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  374 EFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVlnpssryysrI 452
Cdd:PRK08776 152 ETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFgADLVLHSTTKYINGHSDVVGGAVV----------A 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  453 KDAmkALYEDLLYDEDALTLE----------RNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHFEACR 522
Cdd:PRK08776 222 RDA--ELHQQLVWWANALGLTgspfdafltlRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAAR 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  523 RENgGYGGLLSVVFHNPEDA-RQFYDKIQ-VAKGPSLGTNFTLASPYAILAHYQELDWAGEN-GIDRNLVRVSVGMEPSE 599
Cdd:PRK08776 300 QQK-GFGAMLSFELEGGEAAvRAFVDGLRyFTLAESLGGVESLIAHPASMTHAAMTAEARAAaGISDGLLRLSVGIESAE 378


                 ..
gi 19113041  600 HL 601
Cdd:PRK08776 379 DL 380
PRK08064 PRK08064
cystathionine beta-lyase MetC;
297-610 2.31e-17

cystathionine beta-lyase MetC;


Pssm-ID: 236146 [Multi-domain]  Cd Length: 390  Bit Score: 84.44  E-value: 2.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  297 FLFPTGMSAIYNTHRILR-----LVLDDsrksvCFGFCYVDTLKILQKWGSGCYFYGLGNdeqLDEFEKRLESGEKVmaL 371
Cdd:PRK08064  73 FAFASGMAAISTAFLLLSkgdhvLISED-----VYGGTYRMITEVLSRFGIEHTFVDMTN---LEEVAQNIKPNTKL--F 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  372 FCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNPS--SRY 448
Cdd:PRK08064 143 YVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLgADVVLHSATKFLAGHSDVLAGLAVVKDEelAQK 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  449 YSRIKDAMKAlyedLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGGY 528
Cdd:PRK08064 223 LYFLQNSFGA----VLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGF-DIQQSQATSA 297

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  529 GGLLSVVFHNPEDARQFYDKIQVakgP----SLGTNFTLASPYAILAH----YQELDwagENGIDRNLVRVSVGMEPSEH 600
Cdd:PRK08064 298 GAVLSFTLQSEEAVRQFVSHVKL---PvfavSLGAVESILSYPAKMSHaampKEERD---ERGITDGLLRLSVGLENVDD 371

                        330
                 ....*....|
gi 19113041  601 LKNVFINALS 610
Cdd:PRK08064 372 LIADFEQALS 381
PRK07810 PRK07810
O-succinylhomoserine sulfhydrylase; Provisional
 301-601 6.58e-17

O-succinylhomoserine sulfhydrylase; Provisional


Pssm-ID: 236103 [Multi-domain]  Cd Length: 403  Bit Score: 83.24  E-value: 6.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  301 TGMSAIYNTHRIL-----RLVLDDSrksvCFGFCYVDTLKILQKWGSGCYFYglgNDEQLDEFEKRLesGEKVMALFCEF 375
Cdd:PRK07810  93 SGMSAVFTALGALlgagdRLVAARS----LFGSCFVVCNEILPRWGVETVFV---DGEDLSQWEEAL--SVPTQAVFFET 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  376 PSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSmVLNPSSRYYSRIKD 454
Cdd:PRK07810 164 PSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLgADVVVYSGTKHIDGQGRVLGGA-ILGDREYIDGPVQK 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  455 AMKALYEDlLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPkYNTSKEHFEACRRENGGYGGLLSV 534
Cdd:PRK07810 243 LMRHTGPA-LSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYP-FLPSHPQYDLAKRQMSGGGTVVTF 320

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113041  535 VFHNPED-----ARQFYDKIQVAK-GPSLGTNFTLASPYAILAHyQELDWAGEN--GIDRNLVRVSVGMEPSEHL 601
Cdd:PRK07810 321 ELDAPEDaakkrAFEVLDKLRVIDiSNNLGDAKSLITHPATTTH-RAMGPEGRAaiGLGDGVVRLSVGLEDTDDL 394
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 365-601 7.45e-16

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 79.85  E-value: 7.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  365 GEKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVln 443
Cdd:PRK07503 148 SDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELgADLVVHSATKYLGGHGDITAGLVV-- 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  444 PSSRYYSRIK-DAMKALYEDLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACR 522
Cdd:PRK07503 226 GGKALADRIRlEGLKDMTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQH-ALAQ 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  523 RENGGYGGLLSVVFHNPEDA-RQFYDKIQ-VAKGPSLGTNFTLASPYAILAH--YQELDWAgENGIDRNLVRVSVGMEPS 598
Cdd:PRK07503 305 RQMALPGGMIAFELKGGIAAgRRFMNALQlFARAVSLGDAESLAQHPASMTHstYTPEERA-EHGISEGLVRLSVGLEDV 383


                 ...
gi 19113041  599 EHL 601
Cdd:PRK07503 384 ADI 386
PRK05939 PRK05939
cystathionine gamma-synthase family protein;
371-610 1.33e-15

cystathionine gamma-synthase family protein;


Pssm-ID: 235650 [Multi-domain]  Cd Length: 397  Bit Score: 78.96  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  371 LFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGN---FVNVEVLplADVVVSSLTKIFSGDSNVMGGSMV---LNP 444
Cdd:PRK05939 135 VFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSpwlFRPKDVG--ASLVINSLSKYIAGHGNALGGAVTdtgLFD 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  445 SSRY------YSRIKDAM--------KALyEDL---LYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLY 507
Cdd:PRK05939 213 WSAYpnifpaYRKGDPQQwgltqirkKGL-RDMgatLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVY 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  508 YPKYNTSKEHFEAcRRENGGYGGLLSVVFHNPEDARQFYDKIQ-VAKGPSLGTNFTLASPYAILAHYQeldwAG-----E 581
Cdd:PRK05939 292 YPGLASHPQHARA-TELFRHYGGLLSFELADGIDCFDFLNRLKlVIKATHLGDTRTLVIPVAPTIYYE----MGaerraS 366

                        250       260
                 ....*....|....*....|....*....
gi 19113041  582 NGIDRNLVRVSVGMEPSEHLKNVFINALS 610
Cdd:PRK05939 367 MGIADSLIRVSVGIEDEADLIADFEQALD 395
PRK06434 PRK06434
cystathionine gamma-lyase; Validated
 299-610 3.72e-15

cystathionine gamma-lyase; Validated


Pssm-ID: 102374 [Multi-domain]  Cd Length: 384  Bit Score: 77.64  E-value: 3.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  299 FPTGMSAIynTHRILRLVLDDSRksvcfgfcyvdTLKILQKWGSGCYFYG-----LGNDEQLDEFEkRLESGE----KVM 369
Cdd:PRK06434  85 FSSGMGAI--TSAILSLIKKGKR-----------ILSISDLYGQTFYFFNkvlktLGIHVDYIDTD-RLNSLDfdpsNYD 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  370 ALFCEFPSNPLLNSPDlvrIRKLAD-SYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNpSSR 447
Cdd:PRK06434 151 LIYAESITNPTLKVPD---IKNVSSfCHENDVIVDATFASPYNQNPLDLgADVVIHSATKYISGHSDVVMGVAGTN-NKS 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  448 YYSRIKDAMKALYEDLLYDEDALTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKehfeacrRENGG 527
Cdd:PRK06434 227 IFNNLVERRKTLGSNPDPIQAYLAL-RGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDTEIGK-------KVLRG 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  528 YGGLLSVVFHNPEDARQFYDKIQV-AKGPSLGTNFTLASPYAILAHYQELDWAGEN-GIDRNLVRVSVGMEPSEHLKNVF 605
Cdd:PRK06434 299 FGGMLSFELRSMEDVHKFIRNLEIpMVAASLGGVESLITLPVETSHSSLSPEERERlGISDNLVRFSIGIEDIDDLIKDI 378


                 ....*
gi 19113041  606 INALS 610
Cdd:PRK06434 379 ENALS 383
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 355-599 4.31e-13

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 71.40  E-value: 4.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  355 LDEFEKRLESGEKVMALfcEFPSNPLLNSPDLVRIRKLADSY--DFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSG 431
Cdd:PRK06234 139 LEEVRNALKANTKVVYL--ETPANPTLKVTDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLgADVVVHSATKYLNG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  432 DSNVMGGSMVLNpsSRYYSRIK-DAMKALYEDLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPK 510
Cdd:PRK06234 217 HGDVIAGFVVGK--EEFINQVKlFGIKDMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPG 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  511 YNTSkEHFEACRRENGGYGGLLSV-VFHNPEDARQFYDKIQVAK-GPSLGTNFTLASPYAILAH--YQELDWAgENGIDR 586
Cdd:PRK06234 295 LESF-EYYELAKKQMSLPGAMISFeLKGGVEEGKVVMNNVKLATlAVSLGDAETLIQHPASMTHspYTAEERK-EAGISD 372

                        250
                 ....*....|...
gi 19113041  587 NLVRVSVGMEPSE 599
Cdd:PRK06234 373 GLVRLSVGLEDVD 385
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
371-601 5.40e-13

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 71.08  E-value: 5.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  371 LFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVlnpssryy 449
Cdd:PRK08861 142 ILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELgADFVIHSTTKYINGHSDVIGGVLI-------- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  450 srIKDAMKAlyEDLLY-----------DEDALTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHf 518
Cdd:PRK08861 214 --TKTKEHA--EELAWwgncigatgtpFDSYMTL-RGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGH- 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  519 EACRRENGGYGGLLSVVFHNP-EDARQFYDKIQV-AKGPSLGTNFTLASPYAILAHYQELDWA-GENGIDRNLVRVSVGM 595
Cdd:PRK08861 288 EIAKKQQSGFGSMLSFEFAGSfEQLKVFVKALALfSLAESLGGVESLICHPASMTHRAMGEEAlAEAGVSQQLLRLSVGL 367


                 ....*.
gi 19113041  596 EPSEHL 601
Cdd:PRK08861 368 EDAQDL 373
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
338-610 1.22e-12

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 69.73  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  338 QKWGSGCYFYglgNDEQLDEFEKRLEsgEKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIgnFVNVEVLPL 417
Cdd:PRK08247 112 KKWNVRFVYV---NTASLKAIEQAIT--PNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLLLIVDNTF--YTPVLQRPL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  418 ---ADVVVSSLTKIFSGDSNVMGGSMVlnpssryysrIKDamKALYEDLLYDE----------DALTLERNSRDFAERSQ 484
Cdd:PRK08247 185 eegADIVIHSATKYLGGHNDVLAGLVV----------AKG--QELCERLAYYQnaagavlspfDSWLLIRGMKTLALRMR 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  485 VINHNAETICNLLYQNPKIKTLYYPkyntskehfeacrrengGYGGLLSVVFHNPEDARQFYDKIQ-VAKGPSLGTNFTL 563
Cdd:PRK08247 253 QHEENAKAIAAFLNEQPGVTDVLYP-----------------GRGGMLSFRLQDEEWVNPFLKSLKlITFAESLGGVESF 315

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 19113041  564 ASPYAILAHY---QELDWAgeNGIDRNLVRVSVGMEPSEHLKNVFINALS 610
Cdd:PRK08247 316 ITYPATQTHAdipEEIRIA--NGVCNRLLRFSVGIENVEDLIADLKQAFK 363
PRK06767 PRK06767
methionine gamma-lyase; Provisional
 371-599 4.49e-12

methionine gamma-lyase; Provisional


Pssm-ID: 180685 [Multi-domain]  Cd Length: 386  Bit Score: 67.94  E-value: 4.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  371 LFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPLA-DVVVSSLTKIFSGDSNVMGGSMVLNpsSRYY 449
Cdd:PRK06767 150 IFVETPINPTMKLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGcDAVVHSATKYIGGHGDVVAGVTICK--TRAL 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  450 SRIKDAMKALYEDLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYntskehfEACRRENGGYG 529
Cdd:PRK06767 228 AEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEG-------ELASRQMKRGG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113041  530 GLLSV-VFHNPEDARQFYDKIQ-VAKGPSLGTNFTLASPYAILAHY---QELdwAGENGIDRNLVRVSVGMEPSE 599
Cdd:PRK06767 301 GVISFsIKGGKEETQAFINDLHfITIAVSLGDTETLIQHPATMTHAaipAEL--RQEMGIYDNLIRLSVGLESWE 373
PRK07269 PRK07269
cystathionine gamma-synthase; Reviewed
 366-610 5.20e-12

cystathionine gamma-synthase; Reviewed


Pssm-ID: 235983  Cd Length: 364  Bit Score: 67.54  E-value: 5.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  366 EKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMVLNP 444
Cdd:PRK07269 135 EDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELgADIVLHSATKYLSGHNDVLAGVVVTND 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  445 ssryysrikdamKALYEDLLYDE----------DALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPkynts 514
Cdd:PRK07269 215 ------------LELYEKLFYNLnttgavlspfDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT----- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  515 kehfeacrrengGYGGLLSVVFHNPEDARQFYDKIQVAK-GPSLGTNFTLASPYAILAHYQ-ELDWAGENGIDRNLVRVS 592
Cdd:PRK07269 278 ------------GKGGMISFKVADETRIPHILNSLKVFTfAESLGGVESLITYPTTQTHADiPAEVRHSYGLTDDLLRLS 345

                        250
                 ....*....|....*...
gi 19113041  593 VGMEPSEHLKNVFINALS 610
Cdd:PRK07269 346 IGIEDARDLIADLKQALE 363
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 355-609 8.55e-12

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 67.16  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   355 LDEFEKRLesGEKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDS 433
Cdd:TIGR01329 121 LDKVKAAL--GPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVVDNTMMSPLLCNPLELgADIVYHSATKFLAGHS 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   434 NVMGGSMVLNP---SSRYYSRIKDAMKALYEDllydeDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPK 510
Cdd:TIGR01329 199 DVMAGVLAVKGeeiAKKVYFLQNSTGSGLAPF-----DCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAG 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   511 YNtSKEHFEACRRENGGYGGLLSVVFHNPEDARQF-----YDKIQVAKGP--SLGTNFTLASPYAILAHYQEldwagENG 583
Cdd:TIGR01329 274 LP-SHPGFHLHFSQAKGAGSVLSFETGSVALSKRLveatkLFSITVSFGSvnSLISMPCFMSHASIPAEVRE-----ERG 347

                         250       260
                  ....*....|....*....|....*.
gi 19113041   584 IDRNLVRVSVGMEPSEHLKNVFINAL 609
Cdd:TIGR01329 348 LPEDLVRLSVGIEDVDDLISDLDIAF 373
PLN02509 PLN02509
cystathionine beta-lyase
 351-601 7.25e-11

cystathionine beta-lyase


Pssm-ID: 178125 [Multi-domain]  Cd Length: 464  Bit Score: 64.66  E-value: 7.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  351 NDEQLDEFEKRLesGEKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIF 429
Cdd:PLN02509 203 NTTNLDEVAAAI--GPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELgADIVMHSATKFI 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  430 SGDSNVMGGSMVLNPSSryysrikdamkaLYEDLLYDEDA-----------LTLeRNSRDFAERSQVINHNAETICNLLY 498
Cdd:PLN02509 281 AGHSDVMAGVLAVKGEK------------LAKEVYFLQNSegsglapfdcwLCL-RGIKTMALRIEKQQENARKIAMYLS 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  499 QNPKIKTLYY---PKYNTSKEHFEACRrengGYGGLLSVVFHNPEDARQF-----YDKIQVAKGP--SLGTNFTLASPYA 568
Cdd:PLN02509 348 SHPRVKKVYYaglPDHPGHHLHFSQAK----GAGSVFSFITGSVALSKHLvettkYFSIAVSFGSvkSLISMPCFMSHAS 423

                        250       260       270
                 ....*....|....*....|....*....|...
gi 19113041  569 ILAHYQEldwagENGIDRNLVRVSVGMEPSEHL 601
Cdd:PLN02509 424 IPAEVRE-----ARGLTEDLVRISAGIEDVDDL 451
PRK07504 PRK07504
O-succinylhomoserine sulfhydrylase; Reviewed
 326-609 1.06e-09

O-succinylhomoserine sulfhydrylase; Reviewed


Pssm-ID: 168979 [Multi-domain]  Cd Length: 398  Bit Score: 60.92  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  326 FGFC--YVDTLkiLQKWGSGCyfyGLGNDEQLDEFEKRLESGEKVMalFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVD 403
Cdd:PRK07504 114 FGSCryVVETL--LPRYGIES---TLVDGLDLDNWEKAVRPNTKVF--FLESPTNPTLEVIDIAAVAKIANQAGAKLVVD 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  404 etignfvNVEVLPL--------ADVVVSSLTKIFSGDSNVMGGsMVLNPSSRYYSRIKDAMKALYEDlLYDEDALTLERN 475
Cdd:PRK07504 187 -------NVFATPLfqkplelgAHIVVYSATKHIDGQGRCLGG-VVLSDKAWIEEHLQDYFRHTGPS-LSPFNAWTLLKG 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  476 SRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKyntSKEHFEACRRENGGYGGLLSVVFH---NPEDARQFYDKIQVA 552
Cdd:PRK07504 258 LETLPVRVRQQTESAAAIADFLAGHPKVARVIYPG---RADHPQADIIAKQMTGGSTLVAFElkgGKEAAFRFLNALKIV 334

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19113041  553 K-GPSLGTNFTLASPYAILAHYQELDWA-GENGIDRNLVRVSVGMEPSEHLKNVFINAL 609
Cdd:PRK07504 335 RiSNNLGDAKSLITHPATTTHKNLSPEArAELGISEGFLRLSAGLEDTDDLIEDLAAAL 393
PRK05968 PRK05968
hypothetical protein; Provisional
 299-610 2.46e-09

hypothetical protein; Provisional


Pssm-ID: 168320 [Multi-domain]  Cd Length: 389  Bit Score: 59.71  E-value: 2.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  299 FPTGMSAIYNThrILRLVLDDSRkSVCFGFCYVDTL----KILQKWGSGCYFYGlGNDEqlDEFEKRLeSGEKVmaLFCE 374
Cdd:PRK05968  84 FASGMAAISST--VLSFVEPGDR-IVAVRHVYPDAFrlfeTILKRMGVEVDYVD-GRDE--EAVAKAL-PGAKL--LYLE 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  375 FPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPLA-DVVVSSLTKIFSGDSNVMGGsmVLNPSSRYYSRIK 453
Cdd:PRK05968 155 SPTSWVFELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGvDLVIHSASKYLGGHSDTVAG--VVAGSKEHIARIN 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  454 DAMKALYEDLLYDEDALTLERNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNtskEHFEACRRengGYGGLLS 533
Cdd:PRK05968 233 AEAYPYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALA---NHPPAGLS---GTSGLFS 306

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113041  534 VVFHNPEDARQFYDKIQVAK-GPSLGTNFTLASP-YAILAHYQELDWAGENGIDRNLVRVSVGMEPSEHLKNVFINALS 610
Cdd:PRK05968 307 FIFREGIDVRAFADALKLFRlGVSWGGHESLVVPaEVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALA 385
PLN02242 PLN02242
methionine gamma-lyase
 363-594 7.05e-09

methionine gamma-lyase


Pssm-ID: 215134  Cd Length: 418  Bit Score: 58.24  E-value: 7.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  363 ESGEKVmaLFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVnveVLPL---ADVVVSSLTKIFSGDSNVMGGS 439
Cdd:PLN02242 161 PGKTKV--LYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFAPMV---LSPArlgADVVVHSISKFISGGADIIAGA 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  440 mVLNPSSryysrIKDAMKALYedllydEDALTL---ERNSRDFAERSQVINHNAETI---CN--LLYQNpKIKTL----Y 507
Cdd:PLN02242 236 -VCGPAE-----LVNSMMDLH------HGALMLlgpTMNPKVAFELSERLPHLSLRMkehCRraMEYAK-RMKELglkvI 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  508 YPKYNTSKEH--FEACRRENGGYGGLLSVVFHNPEDARQFYDKIQVAKG-----PSLGTNFTLASPYAIlAHYQELDWAG 580
Cdd:PLN02242 303 YPGLEDHPQHalLKSMANKGYGFGGLLCLDMDTEERANRLMRYLQNSTQfgfmaVSLGYYETLMSCSGS-STSSELDPEE 381

                        250
                 ....*....|....*.
gi 19113041  581 EN--GIDRNLVRVSVG 594
Cdd:PLN02242 382 KAaaGISPGLVRMSVG 397
PRK08133 PRK08133
O-succinylhomoserine sulfhydrylase; Validated
 335-603 9.66e-09

O-succinylhomoserine sulfhydrylase; Validated


Pssm-ID: 181244 [Multi-domain]  Cd Length: 390  Bit Score: 57.70  E-value: 9.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  335 KILQKWGSGCYFYGLGNdeqLDEFEKRLESGEKVmaLFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDetigNFVNVEV 414
Cdd:PRK08133 119 KIFARFGIETTFVDLTD---LDAWRAAVRPNTKL--FFLETPSNPLTELADIAALAEIAHAAGALLVVD----NCFCTPA 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  415 L--PL---ADVVVSSLTKIFSGDSNVMGGSMVLNpssryysriKDAMKALYEDL------LYDEDALTLERNSRDFAERS 483
Cdd:PRK08133 190 LqqPLklgADVVIHSATKYLDGQGRVLGGAVVGS---------KELMEEVFGFLrtagptLSPFNAWVFLKGLETLSLRM 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  484 QVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHFEACRRENGGyGGLLS-VVFHNPEDARQFYDKIQVAkgpSLGTNF- 561
Cdd:PRK08133 261 EAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGG-GAIVSfEVKGGREAAWRVIDATRLI---SITANLg 336

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 19113041  562 ----TLASPyAILAH---YQELDWAGenGIDRNLVRVSVGMEPSEHLKN 603
Cdd:PRK08133 337 dtktTITHP-ATTTHgrlSPEARAAA--GITEGLIRVAVGLEDVADIKA 382
PRK07050 PRK07050
cystathionine beta-lyase; Provisional
 371-601 1.12e-08

cystathionine beta-lyase; Provisional


Pssm-ID: 180810 [Multi-domain]  Cd Length: 394  Bit Score: 57.43  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  371 LFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGnfVNVEVLPLA---DVVVSSLTKIFSGDSNVMGGSmVLNPSSR 447
Cdd:PRK07050 154 IWLEAPGSVTMEVPDVPAITAAARARGVVTAIDNTYS--AGLAFKPFEhgvDISVQALTKYQSGGSDVLMGA-TITADAE 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  448 YYSRIKDAMKALYEDLLYDEDALTLeRNSRDFAERSQVINHNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACRRENGG 527
Cdd:PRK07050 231 LHAKLKLARMRLGIGVSADDCSLVL-RGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGH-AFWMRDFTG 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  528 YGGLLSVVFHNPEDARQ---FYDKIQV-AKGPSLGTNFTLASPYAIlAHYQELDW--AGEngidrnLVRVSVGMEPSEHL 601
Cdd:PRK07050 309 AGGLFSVVFDERYSPAQvdaFVEALELfAIGWSWGGACSLAMPYDV-ASMRTAKWphRGT------LVRLYIGLEDEADL 381
MET17 COG2873
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ...
 355-441 7.68e-07

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 442120 [Multi-domain]  Cd Length: 428  Bit Score: 51.95  E-value: 7.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 355 LDEFEKRLesGEKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEvlPL---ADVVVSSLTKIFSG 431
Cdd:COG2873 138 PEAFEAAI--DPNTKAIFGETIGNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCR--PIehgADIVVHSATKYIGG 213

                        90
                ....*....|
gi 19113041 432 DSNVMGGSMV 441
Cdd:COG2873 214 HGTSIGGVIV 223
PRK05613 PRK05613
O-acetylhomoserine/O-acetylserine sulfhydrylase;
370-596 2.95e-06

O-acetylhomoserine/O-acetylserine sulfhydrylase;


Pssm-ID: 168128 [Multi-domain]  Cd Length: 437  Bit Score: 49.87  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  370 ALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGSMV------- 441
Cdd:PRK05613 158 AFFGETFANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELgADVVVASLTKFYTGNGSGLGGVLIdggkfdw 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  442 -------------LNPSSRYYS-RIKD------AMKAlYEDLLYDEDALTLERNSRDFAE-------RSQVINHNAETIC 494
Cdd:PRK05613 238 tverdgkpvfpyfVTPDPAYHGlKYADlgapafGLKA-RAGLLRDTGATLSPFNAWVTAQgldtlslRLERHNENAIKVA 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  495 NLLYQNPKIKTLYYPKYNTSKEHfeaCRRENGGY---GGLLSVVFHNPED-ARQFYDKIQVAKG-PSLGTNFTLASPYAI 569
Cdd:PRK05613 317 EFLNNHEKVAKVNFAGLKDSPWY---ATKEKLGLkytGSVLSFDIKGGKDeAWAFIDALKLHSNlANIGDVRSLVVHPAT 393

                        250       260
                 ....*....|....*....|....*....
gi 19113041  570 LAHYQElDWAG--ENGIDRNLVRVSVGME 596
Cdd:PRK05613 394 TTHSQS-DEAGlaRAGITQATVRLSVGIE 421
PRK07582 PRK07582
cystathionine gamma-lyase; Validated
 371-601 5.15e-06

cystathionine gamma-lyase; Validated


Pssm-ID: 236061  Cd Length: 366  Bit Score: 48.84  E-value: 5.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  371 LFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEVLPL-ADVVVSSLTKIFSGDSNVMGGsMVLNPSSRYY 449
Cdd:PRK07582 136 VLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELgADLVVASDTKALTGHSDLLLG-YVAGRDPELM 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  450 SRIKD------AMKALYEDLLYDEDALTLE-RnsrdFAERSQvinhNAETICNLLYQNPKIKTLYYPKYNTSKEHfEACR 522
Cdd:PRK07582 215 AAVERwrllagAIPGPFEAWLAHRSLGTLGlR----FARQCA----NALAVAELLAGHPAVRGVRYPGLPGDPAH-EVAA 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041  523 RENGGYGGLLSVVFHNPEDARQFYDKIQ-VAKGPSLGTNFTLASPYAilahyqelDWAgeNGIDRNLVRVSVGMEPSEHL 601
Cdd:PRK07582 286 RQMRRFGGLVSFELADAAAAERFVAASRlVVAATSFGGVHTSADRRA--------RWG--DAVPEGFVRLSCGIEDTDDL 355
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 272-430 2.17e-05

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 46.95  E-value: 2.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 272 DLQKALpkegSQYLREVKGL--SHDDVFLFPTGMSAIYNthrILRLVLDDSRKSVCFGFCYVDTLKILQKWGSGCYFYGL 349
Cdd:cd00609  40 ELREAI----AEWLGRRGGVdvPPEEIVVTNGAQEALSL---LLRALLNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 350 GNDEQLDEFEKRLES--GEKVMALFCEFPSNP---LLNSPDLVRIRKLADSYDFAVVVDETIGNFV----NVEVLPLAD- 419
Cdd:cd00609 113 DEEGGFLLDLELLEAakTPKTKLLYLNNPNNPtgaVLSEEELEELAELAKKHGILIISDEAYAELVydgePPPALALLDa 192

                       170
                ....*....|....*
gi 19113041 420 ----VVVSSLTKIFS 430
Cdd:cd00609 193 yervIVLRSFSKTFG 207
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 351-441 5.28e-04

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 41.21  E-value: 5.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041 351 NDEQLDEFEKRLESGEKVMALFCEFPSNPLLNsPDLVRIRKLADSYDFAVVVDET--IGNFVNVEVLPL---ADVVVSSL 425
Cdd:cd01494  77 GGLDVAILEELKAKPNVALIVITPNTTSGGVL-VPLKEIRKIAKEYGILLLVDAAsaGGASPAPGVLIPeggADVVTFSL 155

                        90
                ....*....|....*.
gi 19113041 426 TKIFsgdsNVMGGSMV 441
Cdd:cd01494 156 HKNL----GGEGGGVV 167
PRK05994 PRK05994
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 366-441 1.42e-03

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 180344 [Multi-domain]  Cd Length: 427  Bit Score: 41.24  E-value: 1.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113041  366 EKVMALFCEFPSNPLLNSPDLVRIRKLADSYDFAVVVDETIGNFVNVEvlPL---ADVVVSSLTKIFSGDSNVMGGSMV 441
Cdd:PRK05994 147 PRTKAIFIESIANPGGTVTDIAAIAEVAHRAGLPLIVDNTLASPYLIR--PIehgADIVVHSLTKFLGGHGNSMGGIIV 223
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
355-430 6.38e-03

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 39.21  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113041   355 LDEFEKRLESGEKVMALFCefPSNP---LLNSPDLVRIRKLADSYDFAVVVDETIGNFV-----NVEVLPLAD-----VV 421
Cdd:pfam00155 126 FDALEAALKEKPKVVLHTS--PHNPtgtVATLEELEKLLDLAKEHNILLLVDEAYAGFVfgspdAVATRALLAegpnlLV 203


                  ....*....
gi 19113041   422 VSSLTKIFS 430
Cdd:pfam00155 204 VGSFSKAFG 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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