|
Name |
Accession |
Description |
Interval |
E-value |
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
435-858 |
4.14e-103 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 324.54 E-value: 4.14e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 435 LALLVMVSLLWATEAIPLFVTSFLVPFMTVFLKILRDengsplsgkestKVIFSSMWNPTIVLLLGGFTIAAALSKYHIA 514
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPP------------KEAFSGFSDPAVILFLAGFILGAALTRTGLA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 515 KRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAESDFakiLIVGIALASNVGGIASPI 594
Cdd:cd01115 69 KRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSR---LLMPLAFAASIGGMLTLI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 595 SSPQNIVALQNMDPAAGWGEWFAVSIPVSLLCIFSIWFLLSFgllkdehitlakirstkdtftgvqWFISIVTIGTIVLW 674
Cdd:cd01115 146 GTPPNLVASGYLESLGGQGFSFFEFTPIGLPLLIIGLLYLWF------------------------IFRLAVLIITIVLL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 675 CLERRFDEVFGDMGVIALVPIIVFFGTGLLTKEDFNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVSSLNTFR 754
Cdd:cd01115 202 AALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 755 VLLIFSALTLVVSSFISHIVAAMVVLPIVheVGSRLADP-HPRLFVLASGMMCSLAMALPTSGFPNMTAImmeneaGKRY 833
Cdd:cd01115 282 ILLLLCLLTLVLTNFISNTATAVLLAPIA--LSIALSLGlPPEALLLAVAIGASCAFMLPVGTPPNAIVL------GPGG 353
|
410 420
....*....|....*....|....*
gi 19113202 834 LKVSDFLKAGIPATLISFVILLLIG 858
Cdd:cd01115 354 YKFSDFAKVGLPLSILSLVVSVTMI 378
|
|
| COG5408 |
COG5408 |
SPX domain-containing protein [Signal transduction mechanisms]; |
1-301 |
1.39e-101 |
|
SPX domain-containing protein [Signal transduction mechanisms];
Pssm-ID: 227695 [Multi-domain] Cd Length: 296 Bit Score: 317.16 E-value: 1.39e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 1 MKFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAPDE-ETRLLEHERRSPDDRFMFALDKELQGIVEFYAP 79
Cdd:COG5408 1 MKFGHSLQFNAVPEWSSKYIDYKQLKKLIYSLQKDQLSSYHGVSDNdETRDEAGEPSNWRDRFNHALKKELSPLQANYVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 80 KEKEIadqygrIKGEFETYENEYMSQGNNINYPTPERLQKSSASRKSGRMARSQELPRITSSNREIYLNGQTSDGGYAAP 159
Cdd:COG5408 81 KFFEN------YISEEAIKLDEFYSQGQYIAYKKREFRKISSKFFYSERKALVQKEENTASSNYDTFLNLQTDEGAYVAD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 160 AISRAESTAIQPSEPHDVDTSKNGLSKK--QHSEAQPEVQGNDDEVEEEDDDDDDEDEDEDEDEDNNNnnRWLLIEQYPS 237
Cdd:COG5408 155 ARKRAEAKSYDPFDSLRIDTSKEGLTKRnlNLPDYEKIVSGTDEEVPSNDQDDEDQDFDYLAKKNDNT--ALLDLSQFNF 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113202 238 DIVAYENFVSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDKTLGSSLRESYMKRVNQAYP 301
Cdd:COG5408 233 KIVKYQKRSLLKKRIIELYIQLHQLKSFIELNYTGFSKITKKYDKTLHQNLRHEYMSRSVNEYY 296
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
499-863 |
1.08e-64 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 221.57 E-value: 1.08e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 499 LGGFTIAAALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAESD--FAKI 576
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRskFGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 577 LIVGIALASNVGGIASPISSPQNIVALQNMDPAAG----WGEWFAVSIPVSLLCIFSIWFLLSFgLLKDEHITLAK---- 648
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGipisFFEWMLVGLPVALVGLLLLWLVLYR-LLPPEIKEVPGskev 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 649 IRSTKDT---FTGVQWFISIVTIGTIVLWClerrFDEVFG-DMGVIALVPIIVFFGTGLLTKEDFNNFL-WTVIVLAMGG 723
Cdd:COG0471 160 IREELAElgpLSRREKIALAIFALTVLLWI----TGSLHGiPIAVVALLGAVLLLLTGVLTWKDAYKSIpWGVLLLFGGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 724 VALGKVVSSSGLLELIALKIGNAVSSLNTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGSRLaDPHPRLFVLASG 803
Cdd:COG0471 236 LALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL-GVNPLPLALAVA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 804 MMCSLAMALPTSGFPNmtAIMMeneaGKRYLKVSDFLKAGIPATLISFVILLLIGTPIMR 863
Cdd:COG0471 315 FAASCAFLLPVGTPPN--AIVY----GSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
|
|
| SPX_PHO87_PHO90_like |
cd14478 |
SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This ... |
2-282 |
1.17e-50 |
|
SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The SPX domain of the Saccharomyces cerevisiae membrane-localized low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2. Pho91 is involved in the export of inorganic phosphate from the vacuole to the cytosol. While both, Pho87 and Pho90, transport phosphate into the cell, only Pho87 appears to also function as a sensor for high extracellular phosphate concentrations.
Pssm-ID: 269899 [Multi-domain] Cd Length: 148 Bit Score: 174.65 E-value: 1.17e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAPDEE----TRLLEHERRSPDDRFMFALDKELQGIVEFY 77
Cdd:cd14478 1 KFSHSLQFNAVPEWSDHYIAYSNLKKLIYQLEKDQLQLQNGGDDEEeeesSLLLLSTDEDPDDVFVRALDKELEKIDSFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 78 APKEKEIADQYGRIKGEFETYENEYmsqgnninyptperlqkssasrksgrmarsqelpritssnreiylngqtsdggya 157
Cdd:cd14478 81 KEKEAELYAEVDELLKDVEEFEEEN------------------------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 158 apaisraestaiqpsephdvdtsknglskkqhseaqpevqgnddeveeeddddddededededednnnnnrwllieqyps 237
Cdd:cd14478 --------------------------------------------------------------------------------
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 19113202 238 diVAYENFVSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDK 282
Cdd:cd14478 106 --YLYDSRISLKKRIINLYVSLSELKSYIELNRTGFSKILKKYDK 148
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
435-860 |
1.44e-50 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 184.47 E-value: 1.44e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 435 LALLVMVSLLWATEAIPLFVTSFL-VPFMTVFLKILrdengsplsGKESTKVIFSSMWNPTIVLLLGGFTIAAALSKYHI 513
Cdd:TIGR00785 14 LAIFVAAIVGWILEPLPLPVTALLaIPIIAVLLGVL---------SAFKFKNALSGFADPTIWLFFGAFILATALVKTGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 514 AKRLATSILAHAG-RKPRSVLLTNMFVAMFASMWISNVAApvlCFSIIQPLLRNLPA---------ESDFAKILIVGIAL 583
Cdd:TIGR00785 85 GKRIAYKLVGKMGgTTLGLGYFLVFLETLLAPMWPSNTAR---AGGILLPIIKSLLPllgskpeksPRKIGKYLMLGIAY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 584 ASNVGGIASPISSPQNIVALQNMDPAAG----WGEWFAVSIPVSLLCIFSIWFLL-----SFGLLKDEHITLAKIR-STK 653
Cdd:TIGR00785 162 SASIGSSGFLTGSAPNALAAGILSKILGiqisWGDWFLAGLPLGIILLLLVPLLLyvlfpPELKLKDEVDLWAKEElEEM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 654 DTFTGVQWFISIVTIGTIVLWclerrfdeVFG-----DMGVIALVPIIVFFGTGLLTKEDF--NNFLWTVIVLAMGGVAL 726
Cdd:TIGR00785 242 GPMSFREKALLGIFLLALLLW--------IFGgslgiNASVVALLAVVLMLFLGIVTWKDIqkNKVAWNTLILFGGLIGL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 727 GKVVSSSGLLELIALKIGNAVSSL-NTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGSRLADPhPRLFVLASGMM 805
Cdd:TIGR00785 314 AGGLKKSGFIKWFSEKLVGILDGLsPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIP-LELLALALALS 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 19113202 806 CSLA-MALPTSGFPNMTAImmeneaGKRYLKVSDFLKAGIPATLISFVILLLIGTP 860
Cdd:TIGR00785 393 ASLMgFLTPYATPPNAIAY------GSGYVKIKDMWRVGAIIGIVGLIVLLLVGTL 442
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
443-801 |
5.98e-32 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 127.81 E-value: 5.98e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 443 LLWATEAIPLFVTSFLVPFMTVFLKILrdengsplsgkeSTKVIFSSMWNPTIVLLLGGFTIAAALSKYHIAKRLATSIL 522
Cdd:pfam03600 2 VLIITEKLPRDVVALLGAVLLVLLGVL------------TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 523 AHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLR--NLPaesdfAKILIVGIALASNVGGIASPISSPQNI 600
Cdd:pfam03600 70 RLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARrlGLP-----PSPLLIALAFAANIGGTATPIGDPPNI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 601 VALQNMDPAAGW---GEWFAVSIPVSLLCIFSIWFLLSFGLLKDEHITLAKIRSTKDTFTGVQWFISIVTIgtIVLWCLE 677
Cdd:pfam03600 145 IIASALGLSFGDfgfFMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALV--LALVILG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 678 RRFDEVFGDMGVIALVpiivfFGTGLLTKEDFNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVsslNTFRVLL 757
Cdd:pfam03600 223 FLLLSVLALAGALLLL-----LTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS---GLLVALA 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 19113202 758 IFSALTLVVSSFISHIVAAMVVLPIVHEV--GSRLADPHPRLFVLA 801
Cdd:pfam03600 295 LILWLSALLSAFISNVPTAALMAPIIVGMapAAGLGDPDPLAWALA 340
|
|
| SPX |
pfam03105 |
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ... |
1-296 |
8.63e-30 |
|
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.
Pssm-ID: 460807 [Multi-domain] Cd Length: 339 Bit Score: 121.13 E-value: 8.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 1 MKFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAP------------------------------------ 44
Cdd:pfam03105 1 MKFGKELEENLVPEWRDAYLDYKQLKKLIKKIQRELESTPPSSSpsssdsgsaaspsdsttslplrdplsrsssldrafg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 45 ------------------------------------------DEETRLLEHERRSPDDRFMFALDKELQGIVEFYAPKEK 82
Cdd:pfam03105 81 glvpsppssssssssdsssssnssssssssspsllrrlpsesDDSSESYETTPLDSEDEFFERLDSELNKVNKFYKEKEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 83 EIADQYGRIKGEFEtyeneymsqgNNINYptpeRLQKSSASRKSgrMARSQELPRITSSNREIYLNGQTSDGGyAAPAIS 162
Cdd:pfam03105 161 EFLERLEALNKQLE----------ALRDF----RIKLIRESKSD--LYRWREPFGLYSSDSSVFFSTSELDSG-NSSESS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 163 RAESTAIQPSEPHDVDTSKNGLSKKQHSEAQPEVQgnddeveeeddddddededededeDNNNNNRWLLIEQYPSDIVAY 242
Cdd:pfam03105 224 VDDEVEEELERNGWISPIKSKDKKKRPSEALDKVK------------------------TPDRTLKGFLDASRRDYLNRI 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 243 ENF------VSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDKTLGSSLRESYMKRV 296
Cdd:pfam03105 280 NKVnlrkakKKLKKAFIELYRGLELLKSYSELNRTAFRKILKKFDKVTSLNASKDYMKEV 339
|
|
| PLN00137 |
PLN00137 |
NHAD transporter family protein; Provisional |
495-594 |
1.25e-03 |
|
NHAD transporter family protein; Provisional
Pssm-ID: 215071 Cd Length: 424 Bit Score: 42.37 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 495 IVLLLGGFTIAAALSKYHIAKRLATSILAhagRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSiiqpLLRNLPAESDFA 574
Cdd:PLN00137 69 VFFLLGAMTIVEIVDAHQGFKLVTDSITT---RSPRTLLWVVGFITFFLSSILDNLTTTIVMVS----LLRKLVPPSEYR 141
|
90 100
....*....|....*....|
gi 19113202 575 KILIVGIALASNVGGIASPI 594
Cdd:PLN00137 142 KLLGAVVVVAANAGGAWTPI 161
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
435-858 |
4.14e-103 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 324.54 E-value: 4.14e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 435 LALLVMVSLLWATEAIPLFVTSFLVPFMTVFLKILRDengsplsgkestKVIFSSMWNPTIVLLLGGFTIAAALSKYHIA 514
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPP------------KEAFSGFSDPAVILFLAGFILGAALTRTGLA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 515 KRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAESDFakiLIVGIALASNVGGIASPI 594
Cdd:cd01115 69 KRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSR---LLMPLAFAASIGGMLTLI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 595 SSPQNIVALQNMDPAAGWGEWFAVSIPVSLLCIFSIWFLLSFgllkdehitlakirstkdtftgvqWFISIVTIGTIVLW 674
Cdd:cd01115 146 GTPPNLVASGYLESLGGQGFSFFEFTPIGLPLLIIGLLYLWF------------------------IFRLAVLIITIVLL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 675 CLERRFDEVFGDMGVIALVPIIVFFGTGLLTKEDFNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVSSLNTFR 754
Cdd:cd01115 202 AALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 755 VLLIFSALTLVVSSFISHIVAAMVVLPIVheVGSRLADP-HPRLFVLASGMMCSLAMALPTSGFPNMTAImmeneaGKRY 833
Cdd:cd01115 282 ILLLLCLLTLVLTNFISNTATAVLLAPIA--LSIALSLGlPPEALLLAVAIGASCAFMLPVGTPPNAIVL------GPGG 353
|
410 420
....*....|....*....|....*
gi 19113202 834 LKVSDFLKAGIPATLISFVILLLIG 858
Cdd:cd01115 354 YKFSDFAKVGLPLSILSLVVSVTMI 378
|
|
| COG5408 |
COG5408 |
SPX domain-containing protein [Signal transduction mechanisms]; |
1-301 |
1.39e-101 |
|
SPX domain-containing protein [Signal transduction mechanisms];
Pssm-ID: 227695 [Multi-domain] Cd Length: 296 Bit Score: 317.16 E-value: 1.39e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 1 MKFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAPDE-ETRLLEHERRSPDDRFMFALDKELQGIVEFYAP 79
Cdd:COG5408 1 MKFGHSLQFNAVPEWSSKYIDYKQLKKLIYSLQKDQLSSYHGVSDNdETRDEAGEPSNWRDRFNHALKKELSPLQANYVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 80 KEKEIadqygrIKGEFETYENEYMSQGNNINYPTPERLQKSSASRKSGRMARSQELPRITSSNREIYLNGQTSDGGYAAP 159
Cdd:COG5408 81 KFFEN------YISEEAIKLDEFYSQGQYIAYKKREFRKISSKFFYSERKALVQKEENTASSNYDTFLNLQTDEGAYVAD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 160 AISRAESTAIQPSEPHDVDTSKNGLSKK--QHSEAQPEVQGNDDEVEEEDDDDDDEDEDEDEDEDNNNnnRWLLIEQYPS 237
Cdd:COG5408 155 ARKRAEAKSYDPFDSLRIDTSKEGLTKRnlNLPDYEKIVSGTDEEVPSNDQDDEDQDFDYLAKKNDNT--ALLDLSQFNF 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113202 238 DIVAYENFVSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDKTLGSSLRESYMKRVNQAYP 301
Cdd:COG5408 233 KIVKYQKRSLLKKRIIELYIQLHQLKSFIELNYTGFSKITKKYDKTLHQNLRHEYMSRSVNEYY 296
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
499-863 |
1.08e-64 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 221.57 E-value: 1.08e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 499 LGGFTIAAALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAESD--FAKI 576
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRskFGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 577 LIVGIALASNVGGIASPISSPQNIVALQNMDPAAG----WGEWFAVSIPVSLLCIFSIWFLLSFgLLKDEHITLAK---- 648
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGipisFFEWMLVGLPVALVGLLLLWLVLYR-LLPPEIKEVPGskev 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 649 IRSTKDT---FTGVQWFISIVTIGTIVLWClerrFDEVFG-DMGVIALVPIIVFFGTGLLTKEDFNNFL-WTVIVLAMGG 723
Cdd:COG0471 160 IREELAElgpLSRREKIALAIFALTVLLWI----TGSLHGiPIAVVALLGAVLLLLTGVLTWKDAYKSIpWGVLLLFGGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 724 VALGKVVSSSGLLELIALKIGNAVSSLNTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGSRLaDPHPRLFVLASG 803
Cdd:COG0471 236 LALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL-GVNPLPLALAVA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 804 MMCSLAMALPTSGFPNmtAIMMeneaGKRYLKVSDFLKAGIPATLISFVILLLIGTPIMR 863
Cdd:COG0471 315 FAASCAFLLPVGTPPN--AIVY----GSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
443-857 |
1.17e-57 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 202.86 E-value: 1.17e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 443 LLWATEAIPLFVTSFLVPFMTVFLKILRDENgsplsgkestkvIFSSMWNPTIVLLLGGFTIAAALSKYHIAKRLATSIL 522
Cdd:cd00625 2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKE------------ALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 523 AhAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAesDFAKILIVGIALASNVGGIASPISSPQNIVA 602
Cdd:cd00625 70 R-ASKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGL--SPPVPLLLALAFAANIGGAATPIGNPPNLII 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 603 LQNMDPAAGWGEWFAVSIPVSLLCIFSIWFLLSFG--LLKDEHITLAKIRSTKDT-FTGVQWFISIVTIGTIVLWCLERR 679
Cdd:cd00625 147 ASLSGLGFLDFLAFMAPPALGLLLLLLGLLYLLFRkkLLLPDEDKLTVLAEPLPArPLLKKFLLLALLLLLLFVLLFFFL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 680 FDEVFGDMGVIALVPIIVFFgtGLLTKEDFNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIgNAVSSLNTFRVLLIF 759
Cdd:cd00625 227 IPLGLIALLGALLLLLLLVR--GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELL-VALVGLPPLAALLLI 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 760 SALTLVVSSFISHIVAAMVVLPIVHEVGSR----LADPHPRLFVLASGMMCSLAMALPTSGFPNMTAimmeneagkrYLK 835
Cdd:cd00625 304 GLLSALLSNFISNVPTVALLLPIAASLAPPepawLALALGSTLGGNLTLIGSLANLIPLGAAENAGV----------GIS 373
|
410 420
....*....|....*....|..
gi 19113202 836 VSDFLKAGIPATLISFVILLLI 857
Cdd:cd00625 374 FGEFLKVGLPLTLLSLVVSLLY 395
|
|
| SPX_PHO87_PHO90_like |
cd14478 |
SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This ... |
2-282 |
1.17e-50 |
|
SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The SPX domain of the Saccharomyces cerevisiae membrane-localized low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2. Pho91 is involved in the export of inorganic phosphate from the vacuole to the cytosol. While both, Pho87 and Pho90, transport phosphate into the cell, only Pho87 appears to also function as a sensor for high extracellular phosphate concentrations.
Pssm-ID: 269899 [Multi-domain] Cd Length: 148 Bit Score: 174.65 E-value: 1.17e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAPDEE----TRLLEHERRSPDDRFMFALDKELQGIVEFY 77
Cdd:cd14478 1 KFSHSLQFNAVPEWSDHYIAYSNLKKLIYQLEKDQLQLQNGGDDEEeeesSLLLLSTDEDPDDVFVRALDKELEKIDSFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 78 APKEKEIADQYGRIKGEFETYENEYmsqgnninyptperlqkssasrksgrmarsqelpritssnreiylngqtsdggya 157
Cdd:cd14478 81 KEKEAELYAEVDELLKDVEEFEEEN------------------------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 158 apaisraestaiqpsephdvdtsknglskkqhseaqpevqgnddeveeeddddddededededednnnnnrwllieqyps 237
Cdd:cd14478 --------------------------------------------------------------------------------
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 19113202 238 diVAYENFVSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDK 282
Cdd:cd14478 106 --YLYDSRISLKKRIINLYVSLSELKSYIELNRTGFSKILKKYDK 148
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
435-860 |
1.44e-50 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 184.47 E-value: 1.44e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 435 LALLVMVSLLWATEAIPLFVTSFL-VPFMTVFLKILrdengsplsGKESTKVIFSSMWNPTIVLLLGGFTIAAALSKYHI 513
Cdd:TIGR00785 14 LAIFVAAIVGWILEPLPLPVTALLaIPIIAVLLGVL---------SAFKFKNALSGFADPTIWLFFGAFILATALVKTGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 514 AKRLATSILAHAG-RKPRSVLLTNMFVAMFASMWISNVAApvlCFSIIQPLLRNLPA---------ESDFAKILIVGIAL 583
Cdd:TIGR00785 85 GKRIAYKLVGKMGgTTLGLGYFLVFLETLLAPMWPSNTAR---AGGILLPIIKSLLPllgskpeksPRKIGKYLMLGIAY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 584 ASNVGGIASPISSPQNIVALQNMDPAAG----WGEWFAVSIPVSLLCIFSIWFLL-----SFGLLKDEHITLAKIR-STK 653
Cdd:TIGR00785 162 SASIGSSGFLTGSAPNALAAGILSKILGiqisWGDWFLAGLPLGIILLLLVPLLLyvlfpPELKLKDEVDLWAKEElEEM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 654 DTFTGVQWFISIVTIGTIVLWclerrfdeVFG-----DMGVIALVPIIVFFGTGLLTKEDF--NNFLWTVIVLAMGGVAL 726
Cdd:TIGR00785 242 GPMSFREKALLGIFLLALLLW--------IFGgslgiNASVVALLAVVLMLFLGIVTWKDIqkNKVAWNTLILFGGLIGL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 727 GKVVSSSGLLELIALKIGNAVSSL-NTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGSRLADPhPRLFVLASGMM 805
Cdd:TIGR00785 314 AGGLKKSGFIKWFSEKLVGILDGLsPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIP-LELLALALALS 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 19113202 806 CSLA-MALPTSGFPNMTAImmeneaGKRYLKVSDFLKAGIPATLISFVILLLIGTP 860
Cdd:TIGR00785 393 ASLMgFLTPYATPPNAIAY------GSGYVKIKDMWRVGAIIGIVGLIVLLLVGTL 442
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
443-801 |
5.98e-32 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 127.81 E-value: 5.98e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 443 LLWATEAIPLFVTSFLVPFMTVFLKILrdengsplsgkeSTKVIFSSMWNPTIVLLLGGFTIAAALSKYHIAKRLATSIL 522
Cdd:pfam03600 2 VLIITEKLPRDVVALLGAVLLVLLGVL------------TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 523 AHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLR--NLPaesdfAKILIVGIALASNVGGIASPISSPQNI 600
Cdd:pfam03600 70 RLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARrlGLP-----PSPLLIALAFAANIGGTATPIGDPPNI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 601 VALQNMDPAAGW---GEWFAVSIPVSLLCIFSIWFLLSFGLLKDEHITLAKIRSTKDTFTGVQWFISIVTIgtIVLWCLE 677
Cdd:pfam03600 145 IIASALGLSFGDfgfFMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALV--LALVILG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 678 RRFDEVFGDMGVIALVpiivfFGTGLLTKEDFNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVsslNTFRVLL 757
Cdd:pfam03600 223 FLLLSVLALAGALLLL-----LTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS---GLLVALA 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 19113202 758 IFSALTLVVSSFISHIVAAMVVLPIVHEV--GSRLADPHPRLFVLA 801
Cdd:pfam03600 295 LILWLSALLSAFISNVPTAALMAPIIVGMapAAGLGDPDPLAWALA 340
|
|
| SPX |
pfam03105 |
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ... |
1-296 |
8.63e-30 |
|
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.
Pssm-ID: 460807 [Multi-domain] Cd Length: 339 Bit Score: 121.13 E-value: 8.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 1 MKFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAP------------------------------------ 44
Cdd:pfam03105 1 MKFGKELEENLVPEWRDAYLDYKQLKKLIKKIQRELESTPPSSSpsssdsgsaaspsdsttslplrdplsrsssldrafg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 45 ------------------------------------------DEETRLLEHERRSPDDRFMFALDKELQGIVEFYAPKEK 82
Cdd:pfam03105 81 glvpsppssssssssdsssssnssssssssspsllrrlpsesDDSSESYETTPLDSEDEFFERLDSELNKVNKFYKEKEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 83 EIADQYGRIKGEFEtyeneymsqgNNINYptpeRLQKSSASRKSgrMARSQELPRITSSNREIYLNGQTSDGGyAAPAIS 162
Cdd:pfam03105 161 EFLERLEALNKQLE----------ALRDF----RIKLIRESKSD--LYRWREPFGLYSSDSSVFFSTSELDSG-NSSESS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 163 RAESTAIQPSEPHDVDTSKNGLSKKQHSEAQPEVQgnddeveeeddddddededededeDNNNNNRWLLIEQYPSDIVAY 242
Cdd:pfam03105 224 VDDEVEEELERNGWISPIKSKDKKKRPSEALDKVK------------------------TPDRTLKGFLDASRRDYLNRI 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 243 ENF------VSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDKTLGSSLRESYMKRV 296
Cdd:pfam03105 280 NKVnlrkakKKLKKAFIELYRGLELLKSYSELNRTAFRKILKKFDKVTSLNASKDYMKEV 339
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
491-856 |
1.01e-29 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 122.93 E-value: 1.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 491 WNpTIVLLLGGFTIAAALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAE 570
Cdd:COG1055 53 WN-TILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLN 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 571 sdfAKILIVGIALASNVGGIASPISSPQNIVALQNMDPaaGWGEWFAVSIPVSLLCIFSIWFLLSFGLLKDEHITLAKIR 650
Cdd:COG1055 132 ---PVPFLIAIVFAANIGGAATPIGNPTNIMIASAGGL--SFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLED 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 651 STKDTFTGVQWF-ISIVTIGTIVLWCLerrFDEVFG-DMGVIALVPIIVFFgtgLLTKEDFNNFL----WTVIVLAMGGV 724
Cdd:COG1055 207 DPKEAIKDRRLLrISLLVLALLLVGFV---LHSFLGlPPALIALLGAAVLL---LLARVDVREVLkkvdWSTLLFFIGLF 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 725 ALGKVVSSSGLLELIALKIgNAVSSLNTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGsrlADPHPRLFVLASGM 804
Cdd:COG1055 281 VVVGGLENTGLLDLLAELL-ASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLG---ATGNPEPLWLALAL 356
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113202 805 MCSLAmalptsgfPNMTAI-------MMENEAgKRYLKVS--DFLKAGIPATLISFVILLL 856
Cdd:COG1055 357 GATLG--------GNLTPIgsaanviVLGIAE-KKGIKISfgEFLKVGLPLTLLTLLIALL 408
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
407-866 |
2.38e-26 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 113.62 E-value: 2.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 407 IATLITIIVIFILLLSFPV---IDNREQNnCLALLVMVSLLWATEAIPLFVTSF----LVPFMTVFLKILRDENGspLSG 479
Cdd:pfam00939 4 WWKLLALLAVLLIILLLPApdgLPSKAWH-LFAIFIATIVGWILEPLPMAVIALfaisLSAILIGTLLAKALSWA--LSG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 480 kestkviFSsmwNPTIVLLLGGFTIAAALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVamFASMWISNVAAPVLCFSI 559
Cdd:pfam00939 81 -------FS---STTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFS--DLLLAPATPSNTARAGGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 560 IQPLLRNLPA--ESDFAK--------ILIVGIALASNVGGIASPISSPQNIVALQNMDPAAG----WGEWFAVSIPVSLL 625
Cdd:pfam00939 149 VFPIIMSLPPafGSDPEKgserrigaYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGvtitWASWFLAAIPPGVI 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 626 CIFSIWFLLSFGLL-----KDEHITLAKIR-STKDTFTGVQWFISIVTIGTIVLWCLErrfDEVFGDMGVIALVPIIVFF 699
Cdd:pfam00939 229 LLLLAPLLLYVLYPpeiksVPDAKAIAKTElKELGPMTFREKALLGLFVLLLLLWIFG---GSLNIDATTVAIIGLALML 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 700 GTGLLTKEDF--NNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVSSLN----TFRVLLIFSALTLVVSSFISHI 773
Cdd:pfam00939 306 LLRILDWKDIvkNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSpamaFIIILSLFYLSHYLFASATAHT 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 774 VAamvVLPIVHEVGSRLADPHPRLFVLASGMMCSLA-MALPTSGFPNMTAImmeneaGKRYLKVSDFLKAGIPATLISFV 852
Cdd:pfam00939 386 AA---MLPIFAAVAQAIPGAPPLLAALLLGFAISLGgFLTPYGTGPGPIYF------GSGYLKVKDWWRIGAILTIIGLL 456
|
490
....*....|....
gi 19113202 853 ILLLIGTPIMRALG 866
Cdd:pfam00939 457 ILLLLGNWWWKPLG 470
|
|
| SPX |
cd14447 |
Domain found in Syg1, Pho81, XPR1, and related proteins; This region has been named the SPX ... |
2-92 |
3.75e-15 |
|
Domain found in Syg1, Pho81, XPR1, and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). This domain is found at the amino terminus of a variety of proteins. In the yeast protein Syg1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2. NUC-2 contains several ankyrin repeats. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with xenotropic and polytropic murine leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signaling and result in cell toxicity and death. The similarity between Syg1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, S. cerevisiae, and many other diverse organisms.
Pssm-ID: 269894 [Multi-domain] Cd Length: 143 Bit Score: 73.37 E-value: 3.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAPDEEtrLLEHERRSPDDRFMFALDKELQGIVEFYAPKE 81
Cdd:cd14447 1 KFGKRLREEAVPEWRDKYVDYKALKKLIKNLVASADEASNSSEALE--LSESGGEEFESEFFEALDAELEKVNEFYQELL 78
|
90
....*....|.
gi 19113202 82 KEIADQYGRIK 92
Cdd:cd14447 79 EELQELLKRLE 89
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
671-857 |
3.24e-14 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 75.36 E-value: 3.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 671 IVLWCLERRfdevfgDMGVIALVPIIVFFGTGLLTKED-FNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIgnAVSS 749
Cdd:cd00625 1 YVLIRPEKL------PRAVVALLGAVLLVLLGVVSPKEaLSAIDWETILLLFGMMILSAALEETGLFDRLAAKL--ARAS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 750 LNTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGSRLADPHPRLFVLASGMMCSLA-MALPTSGFPNMTAimmene 828
Cdd:cd00625 73 KGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGgAATPIGNPPNLII------ 146
|
170 180
....*....|....*....|....*....
gi 19113202 829 AGKRYLKVSDFLKAGIPATLISFVILLLI 857
Cdd:cd00625 147 ASLSGLGFLDFLAFMAPPALGLLLLLLGL 175
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
478-853 |
5.02e-13 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 71.90 E-value: 5.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 478 SGKESTKVIFSSMWNPTIVLLLGGFTIAAALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCF 557
Cdd:cd01116 33 TLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 558 SIIQPLLRNLPAesdFAKILIVGIALASNVGGIASPISSPQNIVALQNMDpaAGWGEWFAVSIPVSLLCIFSIwFLLSFG 637
Cdd:cd01116 113 PVTIRLCEVLGL---NPVPVLISEVIAANIGGAATLIGDPPNIMIGSAAG--LTFNDFLLHMLPSVVLALVVT-FILLYF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 638 LLKDEHITLAKIRSTKDTFT--------GVQWFISIVTIGTIVLWCLErrfDEVFGDMGVIALVPIIVFFGTGLltKEDF 709
Cdd:cd01116 187 LYRNILKAREEDVLALAELEpkypikdkVLLLKSLTILTLVIIGFVLH---SPLGVSLGWIALLGALLLLLLAD--KLDF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 710 NNFL----WTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVSSLNTFRVLLI--FSALtlvVSSFISHIVAAMVVLPIV 783
Cdd:cd01116 262 EDVLsrveWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILIlwISAL---LSAFIDNIPVTATMIPIV 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113202 784 HEVGSRL-ADPHPRLFVLASGmmCSLAMALPTSGFP-NMTAIMMENEAGkryLKVS--DFLKAGIPATLISFVI 853
Cdd:cd01116 339 KDLASQLgIPLLPLWWALALG--ACLGGNGTLIGASaNVVAAGIAEQHG---YKISfwEFLKVGFPIMLVSLIL 407
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
492-857 |
1.94e-12 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 70.00 E-value: 1.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 492 NPTIVLLLGGFTIAAALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNvaaPVLCFSIIqPL------LR 565
Cdd:cd01117 40 DLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRRLLFLLVLLSGILSALLTN---DTACLVFT-PIvlelarVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 566 NLPAesdfaKILIVGIALASNVGGIASPISSPQNIV--ALQNMDpaagWGEWFAVSIPVSLLCIFSIWFLLSF---GLLK 640
Cdd:cd01117 116 GLPP-----IPLLLALATAANIGSAATPIGNPQNLLiaSESGIS----FPFFLAAMAPLALLGLLLLLILLLVlfpGELK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 641 DEHITLAKIRSTKDTFTGVqWFISIVTIGTIVLWCLERRFDEVFgdmgVIALVPIIVFFGTGLLTKEDFNNFLWTVIVLA 720
Cdd:cd01117 187 GLPLDKATKEEGVGARKLA-VKLLVLILLLLVAFLALLGVIPLW----TAALVAAVLLLLTRLKPRRVLKKVDWGLLLFF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 721 MGGVALGKVVSSSGLLELIALkignavsSLNTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEvgsrlADPHPRLfvl 800
Cdd:cd01117 262 AGLFILVGGFAQGLPLEGLSR-------LLPLLDSVLSLFLVSIGLSQLISNVPAVLLLLPFLPS-----ADEKDWL--- 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113202 801 asgmmcSLAMALPTSGFPNMTA-----IMMENEAGKRY-LKVSDFLKAGIPATLISFVILLLI 857
Cdd:cd01117 327 ------LLAAGSTIAGNLTLLGsaanlIVAEAAERRGVrLSFGEFLKYGVPLTLLTAAIGILW 383
|
|
| SPX_GDE1_like |
cd14484 |
SPX domain of Gde1 and similar proteins; This region has been named the SPX domain after (Syg1, ... |
2-92 |
2.47e-11 |
|
SPX domain of Gde1 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The yeast protein Gde1/Ypl110c is similar to both, NUC-2 and Pho81, in sharing their multi-domain architecture, which includes the SPX N-terminal domain followed by several ankyrin repeats and a C-terminal glycerophosphodiester phosphodiesterase domain (GDPD). Gde1 hydrolyzes intracellular glycerophosphocholine into glycerolphosphate and choline, and plays a role in the utilization of glycerophosphocholine as a source for phosphate.
Pssm-ID: 269905 [Multi-domain] Cd Length: 134 Bit Score: 62.16 E-value: 2.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEHEQitlqqgAPDEETRLLEherrspddrFMFALDKELQGIVEFYAPKE 81
Cdd:cd14484 1 KFGKNLPRNQVPEWSSSYINYKGLKKLIKAIAEQQ------KEGVKVDLAE---------FFFALDRNLEDVDTFYNKKF 65
|
90
....*....|....*...
gi 19113202 82 KEIA-------DQYGRIK 92
Cdd:cd14484 66 AEYSrrlklllDRYGFSP 83
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
659-857 |
4.08e-10 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 62.84 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 659 VQWFISIVTIGTIVLWCLERRFdevfGDMGVIALVPIIVFFGTGLLTKED-FNNFLWTVIVLAMGGVALGKVVSSSGLLE 737
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPRG----LNRAVAALLGAALLLLLGVVSLEDaLEAIDWNTILFLLGMMIIVAILDESGFFE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 738 LIALKIGNAVSSlNTFRVLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGSRLADPhPRLFVLASGMMCSLA-MALPTSG 816
Cdd:COG1055 77 WLAIKLARRAKG-SPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLN-PVPFLIAIVFAANIGgAATPIGN 154
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 19113202 817 FPNmtaIMMENEAGkryLKVSDFLKAGIPATLISFVILLLI 857
Cdd:COG1055 155 PTN---IMIASAGG---LSFLDFLANLFPPSLVSLLVTLLV 189
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
434-634 |
4.25e-10 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 62.65 E-value: 4.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 434 CLALLVMVSLLWATEAIPLFVTSFLVPFMTVFLKILRDENgsplsgkestkVIFSSMWNpTIVLLLGGFTIAAALSKYHI 513
Cdd:cd00625 213 LLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEE-----------VLKSVDWG-TLLFFAGLFVLVGALESTGL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 514 AKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAApvlcFSIIQPLLrnlpAESDFAKILIVGIALASNVGGIASP 593
Cdd:cd00625 281 LEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPT----VALLLPIA----ASLAPPEPAWLALALGSTLGGNLTL 352
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 19113202 594 ISSPQNIVALQ---NMDPAAGWGEWFAVSIPVSLLCIFSIWFLL 634
Cdd:cd00625 353 IGSLANLIPLGaaeNAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| SPX_XPR1_like |
cd14477 |
SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins; ... |
2-145 |
4.62e-10 |
|
SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-terminus of the human XPR1 protein (xenotropic and polytropic retrovirus receptor 1) binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all members of this family are involved in G-protein associated signal transduction. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with xenotropic and polytropic murine leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signaling and result in cell toxicity and death. Similarity between Syg1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organisms.
Pssm-ID: 269898 [Multi-domain] Cd Length: 161 Bit Score: 59.22 E-value: 4.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKLIYsleheqiTLQQGAPDEETRLLEHERR---SPDDRFMFALDKELQGIVEFYA 78
Cdd:cd14477 1 KFGEHLSAHITPEWRKQYINYEELKAMLY-------AAVEQAPSPEVTDEDVVKRyfaKFEEEFFQECDKELAKVNTFFS 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19113202 79 PKEKEIADQYGRIKGEFETYENEymsqgnninyptperlQKSSASRKSGRMARSQELPRITSSNREI 145
Cdd:cd14477 74 EKLAEAQRKFATLKNELLSSLEA----------------QGESGAASSLIRRVFALLRKERVKPRKL 124
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
435-636 |
1.56e-08 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 57.47 E-value: 1.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 435 LALLVMVSLLWATEA---IPLFVTSFLVPFMTVFLKILrdengsplSGKESTKVIfssMWNpTIVLLLGGFTIAAALSKY 511
Cdd:COG0471 178 LAIFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVL--------TWKDAYKSI---PWG-VLLLFGGGLALGAALEKT 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 512 HIAKRLATSILAHAGRK-PRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAEsdfAKILIVGIALASNvGGI 590
Cdd:COG0471 246 GLAAWLADALLPLLGGLsPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVN---PLPLALAVAFAAS-CAF 321
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 19113202 591 ASPISSPQNIVALqnmdpAAGW---GEWFAVSIPVSLLCIFSIWFLLSF 636
Cdd:COG0471 322 LLPVGTPPNAIVY-----GSGYykfKDFLKVGLPLNLIGLVVLLLLGPL 365
|
|
| SPX_VTC2_like |
cd14480 |
SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been ... |
243-282 |
5.63e-08 |
|
SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. Vtc2 is part of the Saccharomyces cerevisiae membrane-integral VTC complex, together with Vtc1, Vtc3, and Vtc4. It contains an N-terminal SPX domain next to a central polyphosphate polymerase domain and a C-terminal domain of unknown function.
Pssm-ID: 269901 [Multi-domain] Cd Length: 135 Bit Score: 52.54 E-value: 5.63e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 19113202 243 ENFVSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDK 282
Cdd:cd14480 96 EDFKELEEELDDILADVHDLAKFTRLNYTGFLKIVKKHDK 135
|
|
| SPX_SYG1_like |
cd14475 |
SPX domain of the yeast plasma protein Syg1 and related proteins; This region has been named ... |
2-133 |
8.73e-08 |
|
SPX domain of the yeast plasma protein Syg1 and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. In the yeast protein Syg1, the N-terminus binds directly to the G-protein beta subunit and inhibits transduction of the mating pheromone signal, and it co-occurs with a C-terminal domain from the EXS family.
Pssm-ID: 269896 [Multi-domain] Cd Length: 139 Bit Score: 51.80 E-value: 8.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKLIYSLEheqitlqqgapdeetrlleherrspddrFMFALDKELQGIVEFYAPKE 81
Cdd:cd14475 1 KFAKYLEENLVPEWRKKYLDYKGGKKKIKARE----------------------------FFEFLDSELDKVESFYKEKE 52
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 19113202 82 KEIADQYGRIKGEFETYENEYMSQGNNINYPTPERLQKSSASRKSGRMARSQ 133
Cdd:cd14475 53 DEARERLDLLRDQLHELRDHRIQEADDGRRDYSRRPEQNAHDPVSYRSARRK 104
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
477-639 |
1.03e-07 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 55.13 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 477 LSGKESTKVIFSSMWNPTIVLLLGGFTIAAALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLC 556
Cdd:COG1055 255 LLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAAL 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 557 FSIIQPLlrnlpAESDFAKILIVGIALASNVGGIASPISSPQNIVALQNMDPAA---GWGEWFAVSIPVSLLCIFSIWFL 633
Cdd:COG1055 335 LPLIPDL-----GATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGikiSFGEFLKVGLPLTLLTLLIALLY 409
|
....*.
gi 19113202 634 LSFGLL 639
Cdd:COG1055 410 LLLLYF 415
|
|
| SPX_PHO1_like |
cd14476 |
SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain ... |
2-83 |
3.24e-07 |
|
SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The PHO1 gene family conserved in plants is involved in a variety of processes, most notably the transport of inorganic phosphate from the root to the shoot of the plant and mediating the response to low levels of inorganic phosphate. More recently it has become evident that PHO1 gene families have diverged in various plants and may play roles in stress response as well as the stomatal response to abscisic acid.
Pssm-ID: 269897 [Multi-domain] Cd Length: 139 Bit Score: 50.33 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKL---IYSLEHEQITLQQGAPDEETrllEHERrspddRFMFALDKELQGIVEFYA 78
Cdd:cd14476 1 KFGKEFESQMVPEWQEAYVDYKQLKKDlkrIQKFRDEYETTFLEAAEEGG---EYEL-----VFFRRLDDELNKVNKFYR 72
|
....*
gi 19113202 79 PKEKE 83
Cdd:cd14476 73 SKVEE 77
|
|
| SPX_PHO81_NUC-2_like |
cd14483 |
SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain ... |
2-83 |
6.01e-07 |
|
SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. NUC-2 plays an important role in the phosphate-regulated signal transduction pathway in N. crassa. It shows high similarity to a cyclin-dependent kinase inhibitory protein Pho81, which is part of the phosphate regulatory cascade in S. cerevisiae. Both, NUC-2 and Pho81, have multi-domain architecture, including the SPX N-terminal domain following by several ankyrin repeats and a putative C-terminal glycerophosphodiester phosphodiesterase domain (GDPD) with unknown function.
Pssm-ID: 269904 [Multi-domain] Cd Length: 162 Bit Score: 49.94 E-value: 6.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAV--PEWSESYIAYSNLKKLIYSLEHEQITLQQGAPDEETRLLEHERRSPD---------DRFMFALDKEL 70
Cdd:cd14483 1 KFGKYIQARQLelPEYSAYFLDYKALKKLIKSLAAPRVAAAAALLAGGRPLSPDGTDESDaqtslqankAAFFFKLEREL 80
|
90
....*....|...
gi 19113202 71 QGIVEFYAPKEKE 83
Cdd:cd14483 81 EKVNAFYLQKEAE 93
|
|
| SPX_VTC2_like |
cd14480 |
SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been ... |
2-118 |
1.17e-05 |
|
SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. Vtc2 is part of the Saccharomyces cerevisiae membrane-integral VTC complex, together with Vtc1, Vtc3, and Vtc4. It contains an N-terminal SPX domain next to a central polyphosphate polymerase domain and a C-terminal domain of unknown function.
Pssm-ID: 269901 [Multi-domain] Cd Length: 135 Bit Score: 45.61 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQFNAVPEWSESYIAYSNLKKLiysLEHEQITLQQGAPDEETRLLEherrspddrfmfALDKELQGIVEFYAPKE 81
Cdd:cd14480 1 KFGKTLKSSIYPPWKDYYIDYDKLKKL---LKERETDRGWWTEDDERFFVE------------LLEVELEKVYTFQKEKY 65
|
90 100 110
....*....|....*....|....*....|....*..
gi 19113202 82 KEIADqygRIKGEFETYENEYMSQGNNINYPTPERLQ 118
Cdd:cd14480 66 SELRR---RIDACEKKVKELVSNLDSSEDDPSEEDFK 99
|
|
| SPX_AtSPX1_like |
cd14481 |
SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX ... |
262-282 |
2.44e-05 |
|
SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. This family of plant proteins contains a single SPX domain. Arabidopsis thaliana SPX1 and SPX3 have been reported to play roles in the adaptation to low-phosphate conditions, SPX3 may be involved in the regulation of SPX1 activity. Oryza sativa SPX1 suppresses the regulation of expression of OsPT2, a low-affinity phosphate transporter, by the MYB-like OsPHR2.
Pssm-ID: 269902 [Multi-domain] Cd Length: 149 Bit Score: 44.95 E-value: 2.44e-05
10 20
....*....|....*....|.
gi 19113202 262 LISYVHLNYTGFSKILKKYDK 282
Cdd:cd14481 128 LENYSSLNYTGLVKILKKYDK 148
|
|
| SPX-MFS_plant |
cd14479 |
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ... |
1-87 |
2.47e-05 |
|
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.
Pssm-ID: 269900 [Multi-domain] Cd Length: 140 Bit Score: 44.97 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 1 MKFSHSLQFNAVPEWSESYIAYSNLKKLIyslehEQITLQQgapDEETRllehERRSPDDRFMFALDKELQGIVEFYAPK 80
Cdd:cd14479 1 VNFGKKLKEDQIPEWEGYYINYKLLKKKV-----KQYVQQT---QDGGQ----DRRDVLKDFSKLLDDQIEKIVLFLLEQ 68
|
....*..
gi 19113202 81 EKEIADQ 87
Cdd:cd14479 69 QGLLASR 75
|
|
| SPX_PHO81_NUC-2_like |
cd14483 |
SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain ... |
244-283 |
1.32e-04 |
|
SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. NUC-2 plays an important role in the phosphate-regulated signal transduction pathway in N. crassa. It shows high similarity to a cyclin-dependent kinase inhibitory protein Pho81, which is part of the phosphate regulatory cascade in S. cerevisiae. Both, NUC-2 and Pho81, have multi-domain architecture, including the SPX N-terminal domain following by several ankyrin repeats and a putative C-terminal glycerophosphodiester phosphodiesterase domain (GDPD) with unknown function.
Pssm-ID: 269904 [Multi-domain] Cd Length: 162 Bit Score: 43.39 E-value: 1.32e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 19113202 244 NFVSLKRKLTQLYVSIHDLISYVHLNYTGFSKILKKYDKT 283
Cdd:cd14483 121 SFVTLEEGFRQFERDLNKLQQFVELNATGFSKILKKWDKR 160
|
|
| SPX-MFS_plant |
cd14479 |
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ... |
261-285 |
1.43e-04 |
|
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.
Pssm-ID: 269900 [Multi-domain] Cd Length: 140 Bit Score: 42.66 E-value: 1.43e-04
10 20
....*....|....*....|....*
gi 19113202 261 DLISYVHLNYTGFSKILKKYDKTLG 285
Cdd:cd14479 111 KLLKFVELNATGLRKILKKFDKRFG 135
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
687-857 |
1.53e-04 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 44.94 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 687 MGVIALVPIIVFFGTGLLtKEDFNNFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNaVSSLNTFRVLLIFSALTLVV 766
Cdd:cd01116 21 AGALWLVILGLATLSPDL-ETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVK-ISKGRPWRLLLLLGLLTAFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 767 SSFISHIVAAMVVLPIVHEVGSRLA-DPHPRLF--VLASGMMcslAMALPTSGFPNmtaIMMENEAGkryLKVSDFLKAG 843
Cdd:cd01116 99 SAFLDNVTTVLLMVPVTIRLCEVLGlNPVPVLIseVIAANIG---GAATLIGDPPN---IMIGSAAG---LTFNDFLLHM 169
|
170
....*....|....
gi 19113202 844 IPATLISFVILLLI 857
Cdd:cd01116 170 LPSVVLALVVTFIL 183
|
|
| SPX_AtSPX1_like |
cd14481 |
SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX ... |
2-104 |
4.10e-04 |
|
SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. This family of plant proteins contains a single SPX domain. Arabidopsis thaliana SPX1 and SPX3 have been reported to play roles in the adaptation to low-phosphate conditions, SPX3 may be involved in the regulation of SPX1 activity. Oryza sativa SPX1 suppresses the regulation of expression of OsPT2, a low-affinity phosphate transporter, by the MYB-like OsPHR2.
Pssm-ID: 269902 [Multi-domain] Cd Length: 149 Bit Score: 41.48 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 2 KFSHSLQF---NAVPEWSESYIAYSNLKKLIYSLEHEQITLQQGAPDEETRLLEHERRSPDDRFMFALDKELQGIVEFYA 78
Cdd:cd14481 1 KFGKSLKRqieETLPEWRDKFLSYKELKKLLKLISPGNADKPNSKRDRRGGGAARAMTKEEADFVRLLNAELDKFNAFFV 80
|
90 100 110
....*....|....*....|....*....|...
gi 19113202 79 PKE-------KEIADQYGRIKGEFETYENEYMS 104
Cdd:cd14481 81 EKEeeyvirlKELQDRVAEAKETPRDSNEELMR 113
|
|
| PLN00137 |
PLN00137 |
NHAD transporter family protein; Provisional |
495-594 |
1.25e-03 |
|
NHAD transporter family protein; Provisional
Pssm-ID: 215071 Cd Length: 424 Bit Score: 42.37 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 495 IVLLLGGFTIAAALSKYHIAKRLATSILAhagRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSiiqpLLRNLPAESDFA 574
Cdd:PLN00137 69 VFFLLGAMTIVEIVDAHQGFKLVTDSITT---RSPRTLLWVVGFITFFLSSILDNLTTTIVMVS----LLRKLVPPSEYR 141
|
90 100
....*....|....*....|
gi 19113202 575 KILIVGIALASNVGGIASPI 594
Cdd:PLN00137 142 KLLGAVVVVAANAGGAWTPI 161
|
|
| PLN00136 |
PLN00136 |
silicon transporter; Provisional |
487-601 |
4.82e-03 |
|
silicon transporter; Provisional
Pssm-ID: 215070 [Multi-domain] Cd Length: 482 Bit Score: 40.36 E-value: 4.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 487 FSSMWNPTIVLLLGGFTIAAALSKYHIAKRLATsILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLL-- 564
Cdd:PLN00136 58 YASIDLPILGLLFATMVVGSYLKNAGMFKHLGR-LLAWRSQGGRDLLCRVCVVTALASALFTNDTCCVVLTEFVLELAae 136
|
90 100 110
....*....|....*....|....*....|....*..
gi 19113202 565 RNLPAesdfaKILIVGIALASNVGGIASPISSPQNIV 601
Cdd:PLN00136 137 RNLPA-----KPFLLALASSANIGSSATPIGNPQNLV 168
|
|
| GntT |
COG2610 |
H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and ... |
495-817 |
6.16e-03 |
|
H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and metabolism];
Pssm-ID: 442022 [Multi-domain] Cd Length: 440 Bit Score: 40.10 E-value: 6.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 495 IVLLLGGfTIAAALSKYHIAKRLATSILAHAGRKpRSVLltnmfvAMFASMWIsnVAAPVLC---FSIIQPLLRNLPAES 571
Cdd:COG2610 64 LVIGLGA-MLGKLLEDSGAAERIADTIIKKFGEK-RAPL------ALVLAGFI--LGIPVFFdvgFVILAPLAFSLARRA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 572 DFAKILIVG-IALASNVG-GIASPISSPQNIVALQNMDPAAGWGEWFAVSIPVSLLC-IFSIWFLLSFGLLKDEHITLAK 648
Cdd:COG2610 134 GISKLLIGLaLAAGLSTThMLVPPTPGPLAAAGILGADLGAVILLGLIVAIPALIVGyLYAKWLGKKAPVPAPEGLAGEE 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 649 IRSTKDTFTGVQWFISIVTIGT-IVLWCLERRFDEVFGDMGVIALV-----PII-----VFFGTGLL----TKEDFNNFL 713
Cdd:COG2610 214 DEEEEDDEELPSFGLALLPILLpIVLILLGTIADLLPKDSALVQVLafigdPIIalligVLVAILLLrrglSREELMKIL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113202 714 WT------VIVLAMG-GVALGKVVSSSGllelIALKIGNAVSSLNTFRVLLIFsaltlVVSSFI-----SHIVAAMVVLP 781
Cdd:COG2610 294 NEglkpagLILLITGaGGAFGAVLAASG----IGDAIADALSGLGLPPLLLAF-----LIAALLrgatgSATVAMITAAG 364
|
330 340 350
....*....|....*....|....*....|....*.
gi 19113202 782 IVHEVGSRLaDPHPRLFVLASGMMCSLAMALPTSGF 817
Cdd:COG2610 365 ILAPLLLAL-GVSPELLVLAIGAGSGGLSHVNDSGF 399
|
|
| SPX_PHO1_like |
cd14476 |
SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain ... |
245-285 |
8.27e-03 |
|
SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The PHO1 gene family conserved in plants is involved in a variety of processes, most notably the transport of inorganic phosphate from the root to the shoot of the plant and mediating the response to low levels of inorganic phosphate. More recently it has become evident that PHO1 gene families have diverged in various plants and may play roles in stress response as well as the stomatal response to abscisic acid.
Pssm-ID: 269897 [Multi-domain] Cd Length: 139 Bit Score: 37.62 E-value: 8.27e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 19113202 245 FVSLKRKLT--QLYVSIHDLISYVHLNYTGFSKILKKYDKTLG 285
Cdd:cd14476 92 LIAFRVKVEnpQFYRKLRLLKSYSFLNMLAFSKILKKYDKVTS 134
|
|
| |
