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Conserved domains on  [gi|19113225|ref|NP_596433|]
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mitochondrial matrix protein, YjgF family protein Mmf1, reactive intermediate imine deaminase A homolog Mmf1 [Schizosaccharomyces pombe]

Protein Classification

RidA family protein( domain architecture ID 817)

RidA (reactive intermediate/imine deaminase A) family protein

PubMed:  25975565

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjgF_YER057c_UK114_family super family cl10015
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 39-162 2.04e-49

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


The actual alignment was detected with superfamily member TIGR00004:

Pssm-ID: 447879  Cd Length: 124  Bit Score: 155.15  E-value: 2.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225    39 KTPINSPKLSSA-GPYNQAIKANGVIYCSGQIPV--ANGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLAD 115
Cdd:TIGR00004   1 KKIISTDKAPAAiGPYSQAVKVGNTVYVSGQIPLdpSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 19113225   116 MDDFAAVNKVYTEVLPDPKPARSCVAVKTVPLstqGVKIEIECIALE 162
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPK---GVLVEIEAIAVK 124
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 39-162 2.04e-49

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 155.15  E-value: 2.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225    39 KTPINSPKLSSA-GPYNQAIKANGVIYCSGQIPV--ANGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLAD 115
Cdd:TIGR00004   1 KKIISTDKAPAAiGPYSQAVKVGNTVYVSGQIPLdpSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 19113225   116 MDDFAAVNKVYTEVLPDPKPARSCVAVKTVPLstqGVKIEIECIALE 162
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPK---GVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 38-160 1.15e-48

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 153.02  E-value: 1.15e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  38 TKTPINSPKLSSAGPYNQAIKANGVIYCSGQIPV-ANGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADM 116
Cdd:COG0251   2 TRELINPPAPAPIGPYSQAVRVGNLVFVSGQVPLdPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 19113225 117 DDFAAVNKVYTEVLPDPKPARSCVAVKTVPLstqGVKIEIECIA 160
Cdd:COG0251  82 ADFAAVNEVYAEYFGEGRPARTAVGVAALPK---GALVEIEAIA 122
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 47-160 8.40e-47

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 148.22  E-value: 8.40e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225    47 LSSAGPYNQAIKANGVIYCSGQIPVA--NGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNK 124
Cdd:pfam01042   3 PAAAGPYSQAVKAGNLVYVSGQIPLDpdTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVNE 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 19113225   125 VYTEVLPDPK-PARSCVAVKTVPLstqGVKIEIECIA 160
Cdd:pfam01042  83 VYAEYFDADKaPARSAVGVAALPL---GALVEIEAIA 116
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 53-160 1.01e-43

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 140.00  E-value: 1.01e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  53 YNQAIKANGVIYCSGQIPV-ANGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNKVYTEVLP 131
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLdPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100       110
                ....*....|....*....|....*....|
gi 19113225 132 D-PKPARSCVAVKTVPLstqGVKIEIECIA 160
Cdd:cd00448  81 EgPPPARTAVGVAALPP---GALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
51-161 1.36e-20

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 82.04  E-value: 1.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225   51 GPYNQAIKANGVIYCSGQIPVA--NGKVIEGTVgDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNKVYTE 128
Cdd:PRK11401  15 GPYVQGVDLGSMVFTSGQIPVCpqTGEIPADVQ-DQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDFATINEVYKQ 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 19113225  129 VLPDPK---PARSCVAVKTVPlstQGVKIEIECIAL 161
Cdd:PRK11401  94 FFDEHQatyPTRSCVQVARLP---KDVKLEIEAIAV 126
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 39-162 2.04e-49

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 155.15  E-value: 2.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225    39 KTPINSPKLSSA-GPYNQAIKANGVIYCSGQIPV--ANGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLAD 115
Cdd:TIGR00004   1 KKIISTDKAPAAiGPYSQAVKVGNTVYVSGQIPLdpSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 19113225   116 MDDFAAVNKVYTEVLPDPKPARSCVAVKTVPLstqGVKIEIECIALE 162
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPK---GVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 38-160 1.15e-48

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 153.02  E-value: 1.15e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  38 TKTPINSPKLSSAGPYNQAIKANGVIYCSGQIPV-ANGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADM 116
Cdd:COG0251   2 TRELINPPAPAPIGPYSQAVRVGNLVFVSGQVPLdPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 19113225 117 DDFAAVNKVYTEVLPDPKPARSCVAVKTVPLstqGVKIEIECIA 160
Cdd:COG0251  82 ADFAAVNEVYAEYFGEGRPARTAVGVAALPK---GALVEIEAIA 122
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 47-160 8.40e-47

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 148.22  E-value: 8.40e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225    47 LSSAGPYNQAIKANGVIYCSGQIPVA--NGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNK 124
Cdd:pfam01042   3 PAAAGPYSQAVKAGNLVYVSGQIPLDpdTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVNE 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 19113225   125 VYTEVLPDPK-PARSCVAVKTVPLstqGVKIEIECIA 160
Cdd:pfam01042  83 VYAEYFDADKaPARSAVGVAALPL---GALVEIEAIA 116
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 53-160 1.01e-43

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 140.00  E-value: 1.01e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  53 YNQAIKANGVIYCSGQIPV-ANGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNKVYTEVLP 131
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLdPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100       110
                ....*....|....*....|....*....|
gi 19113225 132 D-PKPARSCVAVKTVPLstqGVKIEIECIA 160
Cdd:cd00448  81 EgPPPARTAVGVAALPP---GALVEIEAIA 107
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 53-160 8.60e-28

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 99.53  E-value: 8.60e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  53 YNQAIKANGVIYCSGQipVANGKviEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNKVYTEVLPD 132
Cdd:cd06150   3 MSQAVVHNGTVYLAGQ--VADDT--SADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWVPP 78

                        90       100
                ....*....|....*....|....*....
gi 19113225 133 -PKPARSCVAVKtvpLSTQGVKIEIECIA 160
Cdd:cd06150  79 gHAPARACVEAK---LADPGYLVEIVVTA 104
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 53-160 4.16e-21

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 82.60  E-value: 4.16e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  53 YNQAIKANGVIYCSGQIPVA-NGKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNKVYTEVLP 131
Cdd:cd06154  13 YSRAVRVGNWVFVSGTTGYDyDGMVMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEVFG 92

                        90       100
                ....*....|....*....|....*....
gi 19113225 132 DPKPARSCVAVKtvPLSTQGVKIEIECIA 160
Cdd:cd06154  93 DIRPAATMVVVS--LLVDPEMLVEIEVTA 119
PRK11401 PRK11401
enamine/imine deaminase;
51-161 1.36e-20

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 82.04  E-value: 1.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225   51 GPYNQAIKANGVIYCSGQIPVA--NGKVIEGTVgDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNKVYTE 128
Cdd:PRK11401  15 GPYVQGVDLGSMVFTSGQIPVCpqTGEIPADVQ-DQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDFATINEVYKQ 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 19113225  129 VLPDPK---PARSCVAVKTVPlstQGVKIEIECIAL 161
Cdd:PRK11401  94 FFDEHQatyPTRSCVQVARLP---KDVKLEIEAIAV 126
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 74-161 1.23e-17

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 73.45  E-value: 1.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  74 GKVIEGTVGDQTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADMDDFAAVNKVYTEVLPDPKP-ARSCVAVKtvplSTQGV 152
Cdd:cd06155  17 ASESDETVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNPpSRVCVECG----LPEGC 92


                ....*....
gi 19113225 153 KIEIECIAL 161
Cdd:cd06155  93 DVQLSCVAA 101
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 53-160 2.47e-17

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 72.68  E-value: 2.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  53 YNQAIKANGVIYCSGQIpvanGKVIEGTVGD----QTRQCLLNLQEVLTEAGSSLNKIVKVNIFLADM-DDFAAVNKVYT 127
Cdd:cd02198   3 YSPAVRVGDTLFVSGQV----GSDADGSVAEdfeaQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKD 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 19113225 128 EVLPDPKPARSCVAVKTvpLSTQGVKIEIECIA 160
Cdd:cd02198  79 EYFKEPYPAWTAVGVAW--LARPGLLVEIKVVA 109
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 50-160 3.07e-11

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 57.86  E-value: 3.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  50 AGPYNQAIKANGVIYCSGQIPVANGK-VIEGTVGDQ---------TRQCLLNLQEVLTEAGSSLNKI---VKVNIFLADM 116
Cdd:cd02199  13 VGNYVPAVRTGNLLYVSGQLPRVDGKlVYTGKVGADlsveegqeaARLCALNALAALKAALGDLDRVkrvVRLTGFVNSA 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 19113225 117 DDF----AAVN---KVYTEVLPD-PKPARSCVAVKTVPLstqGVKIEIECIA 160
Cdd:cd02199  93 PDFteqpKVANgasDLLVEVFGEaGRHARSAVGVASLPL---NAAVEVEAIV 141
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 53-160 2.30e-09

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 52.31  E-value: 2.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  53 YNQAIKANGVIYCSGQ---IPvaNGKVIEGTVGDQTRQCLLNLQEVLTEAG-SSLNKIVKVNIFLADMDD---FAAVNKV 125
Cdd:cd06152   3 YSQAVRIGDRIEISGQggwDP--DTGKIPEDLEEEIDQAFDNVELALKAAGgKGWEQVYKVNSYHVDIKNeeaFGLMVEN 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 19113225 126 YTEVLPDPKPARSCVAVKTVPLstQGVKIEIECIA 160
Cdd:cd06152  81 FKKWMPNHQPIWTCVGVTALGL--PGMRVEIEVDA 113
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 62-160 2.49e-07

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 46.93  E-value: 2.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  62 VIYCSGQIP-VANGKVIEGTV---GD---QTRQCLLNLQEVLTEAGSSLNKIVKVNIFL-AD--MD---DFAAVNKVYTE 128
Cdd:cd06151  13 TIYLSGTVPaVVNASAPKGSParyGDtetQTISVLKRIETILQSQGLTMGDVVKMRVFLvADpaLDgkmDFAGFMKAYRQ 92

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 19113225 129 VLPDP----KPARSCVAVktVPLSTQGVKIEIECIA 160
Cdd:cd06151  93 FFGTAeqpnKPARSTLQV--AGLVNPGWLVEIEVVA 126
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 71-160 1.43e-04

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 39.16  E-value: 1.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113225  71 VANGKVIEGTVGDQTRQCLLNLQEVLTEAG-----SSLNKIVKVNIFLADMDDFAAVNKVYTEVLPDPKPArscvAVKTV 145
Cdd:cd06153  24 VGHGTVHPGDVEAQTRETLENIEALLEAAGrgggaQFLADLLRLKVYLRDREDLPAVRAILAARLGPAVPA----VFLQA 99

                        90
                ....*....|....*
gi 19113225 146 PLSTQGVKIEIECIA 160
Cdd:cd06153 100 DVCRPDLLVEIEAVA 114
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 53-114 5.48e-04

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 37.69  E-value: 5.48e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113225  53 YNQAIKANGVIYCSGQIPV--ANGKVIEGTVGDQTRQCLLNLQEVLteagsslnKIVKVNIFLA 114
Cdd:cd06156   1 YSQAIVVPKVAYISGQIGLipATMTLLEGGITLQAVLSLQHLERVA--------KAMNVQWVLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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