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Conserved domains on  [gi|19113264|ref|NP_596472|]
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RNase P subunit Rpr2 [Schizosaccharomyces pombe]

Protein Classification

ribonuclease P Rpr2/Rpp21/SNM1 subunit( domain architecture ID 10513160)

ribonuclease P (RNAse P) Rpr2/Rpp21/SNM1 subunit is a component of RNAse P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends; ribonuclease P protein component 4 is part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends

EC:  3.1.26.5
Gene Ontology:  GO:0046872|GO:0006278|GO:0004526|GO:0030677
PubMed:  21930585|14550630

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 11-96 1.35e-26

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


:

Pssm-ID: 427665  Cd Length: 88  Bit Score: 93.90  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113264    11 RVSYLYQASQLLfRNVQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIRFEEPSRKN--PSIDR 88
Cdd:pfam04032   1 RLNFLYQAAHLL-ARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTVRIENKSKGGkkPWADV 79


                  ....*...
gi 19113264    89 VLWICKKC 96
Cdd:pfam04032  80 LVYTCLTC 87
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 11-96 1.35e-26

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 93.90  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113264    11 RVSYLYQASQLLfRNVQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIRFEEPSRKN--PSIDR 88
Cdd:pfam04032   1 RLNFLYQAAHLL-ARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTVRIENKSKGGkkPWADV 79


                  ....*...
gi 19113264    89 VLWICKKC 96
Cdd:pfam04032  80 LVYTCLTC 87
RPR2 COG2023
Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];
11-75 1.72e-11

Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441626  Cd Length: 90  Bit Score: 55.22  E-value: 1.72e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113264  11 RVSYLYQASQLLFRNvQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIR 75
Cdd:COG2023   5 RIEILFELAEEAARE-GNPELARRYVELARRIAMKYRVRLPRELKRRFCKKCDAPLVPGVNARVR 68
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 11-75 2.66e-05

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 40.21  E-value: 2.66e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113264   11 RVSYLYQASQLLFRnvQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIR 75
Cdd:PRK03954  21 RIDTLFTLAERVFP--YSPELANRYVELALAVQQKAKVKLPRKWKRRYCKRCHSFLVPGVNARVR 83
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 11-96 1.35e-26

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 93.90  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113264    11 RVSYLYQASQLLfRNVQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIRFEEPSRKN--PSIDR 88
Cdd:pfam04032   1 RLNFLYQAAHLL-ARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTVRIENKSKGGkkPWADV 79


                  ....*...
gi 19113264    89 VLWICKKC 96
Cdd:pfam04032  80 LVYTCLTC 87
RPR2 COG2023
Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];
11-75 1.72e-11

Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441626  Cd Length: 90  Bit Score: 55.22  E-value: 1.72e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113264  11 RVSYLYQASQLLFRNvQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIR 75
Cdd:COG2023   5 RIEILFELAEEAARE-GNPELARRYVELARRIAMKYRVRLPRELKRRFCKKCDAPLVPGVNARVR 68
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 11-75 2.66e-05

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 40.21  E-value: 2.66e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113264   11 RVSYLYQASQLLFRnvQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIR 75
Cdd:PRK03954  21 RIDTLFTLAERVFP--YSPELANRYVELALAVQQKAKVKLPRKWKRRYCKRCHSFLVPGVNARVR 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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