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Conserved domains on  [gi|19113333|ref|NP_596541|]
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inositol polyphosphate phosphatase [Schizosaccharomyces pombe]

Protein Classification

SAC family polyphosphoinositide phosphatase( domain architecture ID 11474933)

SAC family polyphosphoinositide phosphatase catalyzes the hydrolysis of phosphatidylinositol (PtdIns) phosphates, such as PtdIns(3)P, PtdIns(4)P, and/or PtdIns(3,5)P2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
1-562 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


:

Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 697.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333   1 MVQFEANEKQFKLRRE----DCCLTIDRESGAVSFEPDELKPVARSKENSVTLFGSIKLKKDKYLILATEKSSAAQILGH 76
Cdd:COG5329  11 SIAIVSNNYALSFRRLgvknSERILCATELVGVRFEPDEGFSSLSSAHKIYGVIGLIKLKGDIYLIVITGASLVGVIPGH 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333  77 KIYRVHKFEVIPYRNLLADDQ---DELDLYNLLQN--HLKTGPFYFSYTWDLTNSLQRScTDEGKASPILRSDKRFFWNE 151
Cdd:COG5329  91 SIYKILDVDFISLNNNKWDDEleeDEANYDKLSELkkLLSNGTFYFSYDFDITNSLQKN-LSEGLEASVDRADLIFMWNS 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 152 FASKDFIDLIGAHSEVSL----FITPMIYGFITSASTIVKGRTITLALISRRSKQRAGTRYFTRGLDENGNPANFNETEQ 227
Cdd:COG5329 170 FLLEEFINHRSKLSSLEKqfdnFLTTVIRGFAETVDIKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQ 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 228 ITIVSdeksEVTYSHVQTRGSVPAFWAEVNNLRYKPLMVANSASMAAAAAKKHFDEQISIYGDQVVVNLVNCKGHELPIK 307
Cdd:COG5329 250 IVTDS----QYIFSFTQVRGSIPLFWEQSNLLYGPKIKVTRSSEAAQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLL 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 308 QLYENVIRRLDNPHIHYHYFDFHKECSHMRWDRVSLLLNEIQPELEEQGYTTLDTQKYRVLSRQNGVVRSNCMDCLDRTN 387
Cdd:COG5329 326 ELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFAYDINEGKSISEQDGVFRTNCLDCLDRTN 405

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 388 VVQSCIGrWVLTNQLRKCGIIGATHPlrsviPLDNIFCNIWSDNADYISLSYSGTGALKTDFTRTGIRTRKGAFNDFVNS 467
Cdd:COG5329 406 VIQSLIS-RVLLEQFRSEGVISDGYS-----PFLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKS 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 468 AKRYILNNFYDGARQDAYDLVLGQFRPDVNFRYrldlRPLTIRCVPYILLACLILFFMTLFSRSSSTILPPSILLILTFL 547
Cdd:COG5329 480 FSRYYINNFTDGQRQDAIDLLLGKFRPQEAFSY----RPLRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVLAVI 555

                       570
                ....*....|....*
gi 19113333 548 GIVASLYYCFAHGLQ 562
Cdd:COG5329 556 LIVLSKLYQFPHGRQ 570
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
1-562 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 697.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333   1 MVQFEANEKQFKLRRE----DCCLTIDRESGAVSFEPDELKPVARSKENSVTLFGSIKLKKDKYLILATEKSSAAQILGH 76
Cdd:COG5329  11 SIAIVSNNYALSFRRLgvknSERILCATELVGVRFEPDEGFSSLSSAHKIYGVIGLIKLKGDIYLIVITGASLVGVIPGH 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333  77 KIYRVHKFEVIPYRNLLADDQ---DELDLYNLLQN--HLKTGPFYFSYTWDLTNSLQRScTDEGKASPILRSDKRFFWNE 151
Cdd:COG5329  91 SIYKILDVDFISLNNNKWDDEleeDEANYDKLSELkkLLSNGTFYFSYDFDITNSLQKN-LSEGLEASVDRADLIFMWNS 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 152 FASKDFIDLIGAHSEVSL----FITPMIYGFITSASTIVKGRTITLALISRRSKQRAGTRYFTRGLDENGNPANFNETEQ 227
Cdd:COG5329 170 FLLEEFINHRSKLSSLEKqfdnFLTTVIRGFAETVDIKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQ 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 228 ITIVSdeksEVTYSHVQTRGSVPAFWAEVNNLRYKPLMVANSASMAAAAAKKHFDEQISIYGDQVVVNLVNCKGHELPIK 307
Cdd:COG5329 250 IVTDS----QYIFSFTQVRGSIPLFWEQSNLLYGPKIKVTRSSEAAQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLL 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 308 QLYENVIRRLDNPHIHYHYFDFHKECSHMRWDRVSLLLNEIQPELEEQGYTTLDTQKYRVLSRQNGVVRSNCMDCLDRTN 387
Cdd:COG5329 326 ELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFAYDINEGKSISEQDGVFRTNCLDCLDRTN 405

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 388 VVQSCIGrWVLTNQLRKCGIIGATHPlrsviPLDNIFCNIWSDNADYISLSYSGTGALKTDFTRTGIRTRKGAFNDFVNS 467
Cdd:COG5329 406 VIQSLIS-RVLLEQFRSEGVISDGYS-----PFLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKS 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 468 AKRYILNNFYDGARQDAYDLVLGQFRPDVNFRYrldlRPLTIRCVPYILLACLILFFMTLFSRSSSTILPPSILLILTFL 547
Cdd:COG5329 480 FSRYYINNFTDGQRQDAIDLLLGKFRPQEAFSY----RPLRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVLAVI 555

                       570
                ....*....|....*
gi 19113333 548 GIVASLYYCFAHGLQ 562
Cdd:COG5329 556 LIVLSKLYQFPHGRQ 570
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 49-333 3.04e-113

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 339.93  E-value: 3.04e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333    49 LFGSIKLKKDKYLILATEKSSAAQILGHKIYRVHKFEVIPYRNLLADDQ-------DELDLYNLLQNHLKTGPFYFSYTW 121
Cdd:pfam02383   3 ILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDTQlakkehpDEERLLKLLKLFLSSGSFYFSYDY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333   122 DLTNSLQRSCTDEgKASPILRSDKRFFWNEFASKDFIDLIGAHSEvslFITPMIYGFITSASTIVKGRTITLALISRRSK 201
Cdd:pfam02383  83 DLTNSLQRNLTRS-RSPSFDSLDDRFFWNRHLLKPLIDFQLDLDR---WILPLIQGFVEQGKLSVFGRSVTLTLISRRSR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333   202 QRAGTRYFTRGLDENGNPANFNETEQI-TIVSDEKSEVTYSHVQTRGSVPAFWAEVNNLRYKPLMVANSASMAAAAAKKH 280
Cdd:pfam02383 159 KRAGTRYLRRGIDDDGNVANFVETEQIvSLNTSNSEGKIFSFVQIRGSIPLFWSQDPNLKYKPKIQITRPEATQPAFKKH 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19113333   281 FDEQISIYGDQVVVNLVNCKGHELPIKQLYENVIRRL---DNPHIHYHYFDFHKEC 333
Cdd:pfam02383 239 FDDLIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLnqfLPDKLRYTAFDFHHEC 294
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
1-562 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 697.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333   1 MVQFEANEKQFKLRRE----DCCLTIDRESGAVSFEPDELKPVARSKENSVTLFGSIKLKKDKYLILATEKSSAAQILGH 76
Cdd:COG5329  11 SIAIVSNNYALSFRRLgvknSERILCATELVGVRFEPDEGFSSLSSAHKIYGVIGLIKLKGDIYLIVITGASLVGVIPGH 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333  77 KIYRVHKFEVIPYRNLLADDQ---DELDLYNLLQN--HLKTGPFYFSYTWDLTNSLQRScTDEGKASPILRSDKRFFWNE 151
Cdd:COG5329  91 SIYKILDVDFISLNNNKWDDEleeDEANYDKLSELkkLLSNGTFYFSYDFDITNSLQKN-LSEGLEASVDRADLIFMWNS 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 152 FASKDFIDLIGAHSEVSL----FITPMIYGFITSASTIVKGRTITLALISRRSKQRAGTRYFTRGLDENGNPANFNETEQ 227
Cdd:COG5329 170 FLLEEFINHRSKLSSLEKqfdnFLTTVIRGFAETVDIKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQ 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 228 ITIVSdeksEVTYSHVQTRGSVPAFWAEVNNLRYKPLMVANSASMAAAAAKKHFDEQISIYGDQVVVNLVNCKGHELPIK 307
Cdd:COG5329 250 IVTDS----QYIFSFTQVRGSIPLFWEQSNLLYGPKIKVTRSSEAAQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLL 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 308 QLYENVIRRLDNPHIHYHYFDFHKECSHMRWDRVSLLLNEIQPELEEQGYTTLDTQKYRVLSRQNGVVRSNCMDCLDRTN 387
Cdd:COG5329 326 ELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFAYDINEGKSISEQDGVFRTNCLDCLDRTN 405

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 388 VVQSCIGrWVLTNQLRKCGIIGATHPlrsviPLDNIFCNIWSDNADYISLSYSGTGALKTDFTRTGIRTRKGAFNDFVNS 467
Cdd:COG5329 406 VIQSLIS-RVLLEQFRSEGVISDGYS-----PFLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKS 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333 468 AKRYILNNFYDGARQDAYDLVLGQFRPDVNFRYrldlRPLTIRCVPYILLACLILFFMTLFSRSSSTILPPSILLILTFL 547
Cdd:COG5329 480 FSRYYINNFTDGQRQDAIDLLLGKFRPQEAFSY----RPLRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVLAVI 555

                       570
                ....*....|....*
gi 19113333 548 GIVASLYYCFAHGLQ 562
Cdd:COG5329 556 LIVLSKLYQFPHGRQ 570
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 49-333 3.04e-113

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 339.93  E-value: 3.04e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333    49 LFGSIKLKKDKYLILATEKSSAAQILGHKIYRVHKFEVIPYRNLLADDQ-------DELDLYNLLQNHLKTGPFYFSYTW 121
Cdd:pfam02383   3 ILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDTQlakkehpDEERLLKLLKLFLSSGSFYFSYDY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333   122 DLTNSLQRSCTDEgKASPILRSDKRFFWNEFASKDFIDLIGAHSEvslFITPMIYGFITSASTIVKGRTITLALISRRSK 201
Cdd:pfam02383  83 DLTNSLQRNLTRS-RSPSFDSLDDRFFWNRHLLKPLIDFQLDLDR---WILPLIQGFVEQGKLSVFGRSVTLTLISRRSR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113333   202 QRAGTRYFTRGLDENGNPANFNETEQI-TIVSDEKSEVTYSHVQTRGSVPAFWAEVNNLRYKPLMVANSASMAAAAAKKH 280
Cdd:pfam02383 159 KRAGTRYLRRGIDDDGNVANFVETEQIvSLNTSNSEGKIFSFVQIRGSIPLFWSQDPNLKYKPKIQITRPEATQPAFKKH 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19113333   281 FDEQISIYGDQVVVNLVNCKGHELPIKQLYENVIRRL---DNPHIHYHYFDFHKEC 333
Cdd:pfam02383 239 FDDLIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLnqfLPDKLRYTAFDFHHEC 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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