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Conserved domains on  [gi|19113508|ref|NP_596716|]
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F-box protein Pof12 [Schizosaccharomyces pombe]

Protein Classification

F-box protein( domain architecture ID 10584247)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
PubMed:  10581972|31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 16-55 1.30e-07

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.86  E-value: 1.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19113508    16 HETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHNLY 55
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 16-55 1.30e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.86  E-value: 1.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19113508    16 HETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHNLY 55
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
17-54 4.11e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.50  E-value: 4.11e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 19113508     17 ETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHNL 54
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
 17-57 7.91e-04

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 37.16  E-value: 7.91e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 19113508  17 ETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHNLYLS 57
Cdd:cd22141   7 EISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLLIS 47
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 16-55 1.30e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.86  E-value: 1.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19113508    16 HETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHNLY 55
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
17-54 4.11e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.50  E-value: 4.11e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 19113508     17 ETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHNL 54
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
 17-57 7.91e-04

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 37.16  E-value: 7.91e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 19113508  17 ETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHNLYLS 57
Cdd:cd22141   7 EISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLLIS 47
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 12-46 8.90e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 36.65  E-value: 8.90e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 19113508  12 SIFSHETLLHVLNDLSAHDLAALERVSRSWNSIVR 46
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 16-53 1.54e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.36  E-value: 1.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19113508    16 HETLLHVLNDLSAHDLAALERVSRSWNSIVRRSSVWHN 53
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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