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Conserved domains on  [gi|19113595|ref|NP_596803|]
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mitochondrial translation initiation factor [Schizosaccharomyces pombe]

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 960)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Gene Ontology:  GO:0003723|GO:0003743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF1_SUI1_like super family cl00229
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 12-179 1.49e-48

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


The actual alignment was detected with superfamily member TIGR01159:

Pssm-ID: 469673  Cd Length: 173  Bit Score: 155.80  E-value: 1.49e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595    12 VLYCDVCTLPVEYCEFEGTLKKCKEWLKSSHPDVYDKLYGEQDLSKDLENTLNVSGTKDSNAEEQPAKLTKEEKRVEREE 91
Cdd:TIGR01159   4 VLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAQEEKGEKDLLGIQKAQEAREGGKK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595    92 AKRMASKVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTADKKDEIVVQGDLNYDIFDFILEKFK 171
Cdd:TIGR01159  84 KKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSKSVTGKEEIVIQGDVMDDIEDYIHEKWP 163


                  ....*...
gi 19113595   172 EVPEDNIK 179
Cdd:TIGR01159 164 EVGDKDIK 171
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 12-179 1.49e-48

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 155.80  E-value: 1.49e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595    12 VLYCDVCTLPVEYCEFEGTLKKCKEWLKSSHPDVYDKLYGEQDLSKDLENTLNVSGTKDSNAEEQPAKLTKEEKRVEREE 91
Cdd:TIGR01159   4 VLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAQEEKGEKDLLGIQKAQEAREGGKK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595    92 AKRMASKVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTADKKDEIVVQGDLNYDIFDFILEKFK 171
Cdd:TIGR01159  84 KKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSKSVTGKEEIVIQGDVMDDIEDYIHEKWP 163


                  ....*...
gi 19113595   172 EVPEDNIK 179
Cdd:TIGR01159 164 EVGDKDIK 171
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 97-182 1.56e-40

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 132.30  E-value: 1.56e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595  97 SKVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTADKKDEIVVQGDLNYDIFDFILEKFKEVPED 176
Cdd:cd11607   1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKGAEGKDEIVIQGDVTDDIVDLILEKWPEIDED 80


                ....*.
gi 19113595 177 NIKIVE 182
Cdd:cd11607  81 NIEILG 86
SUI1 pfam01253
Translation initiation factor SUI1;
97-169 1.40e-20

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 80.94  E-value: 1.40e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113595    97 SKVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTaDKKDEIVVQGDLNYDIFDFILEK 169
Cdd:pfam01253   2 PKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKD-GGGEEIQVQGDQRDKVAELLTEK 73
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
98-179 1.65e-04

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 39.14  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595   98 KVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVtktadKKDEIVVQGDLNYDIFDFILEkfKEVPEDN 177
Cdd:PRK00939  25 RIKIKVDKRRYGKEVTIIEGIDPKDIDLKELAKKLKSKLACGGTV-----KDGRIELQGDHRERVKELLIK--MGFSEEN 97


                 ..
gi 19113595  178 IK 179
Cdd:PRK00939  98 IE 99
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 12-179 1.49e-48

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 155.80  E-value: 1.49e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595    12 VLYCDVCTLPVEYCEFEGTLKKCKEWLKSSHPDVYDKLYGEQDLSKDLENTLNVSGTKDSNAEEQPAKLTKEEKRVEREE 91
Cdd:TIGR01159   4 VLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAQEEKGEKDLLGIQKAQEAREGGKK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595    92 AKRMASKVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTADKKDEIVVQGDLNYDIFDFILEKFK 171
Cdd:TIGR01159  84 KKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSKSVTGKEEIVIQGDVMDDIEDYIHEKWP 163


                  ....*...
gi 19113595   172 EVPEDNIK 179
Cdd:TIGR01159 164 EVGDKDIK 171
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 97-182 1.56e-40

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 132.30  E-value: 1.56e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595  97 SKVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTADKKDEIVVQGDLNYDIFDFILEKFKEVPED 176
Cdd:cd11607   1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKGAEGKDEIVIQGDVTDDIVDLILEKWPEIDED 80


                ....*.
gi 19113595 177 NIKIVE 182
Cdd:cd11607  81 NIEILG 86
SUI1 pfam01253
Translation initiation factor SUI1;
97-169 1.40e-20

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 80.94  E-value: 1.40e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113595    97 SKVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTaDKKDEIVVQGDLNYDIFDFILEK 169
Cdd:pfam01253   2 PKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKD-GGGEEIQVQGDQRDKVAELLTEK 73
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 98-171 2.50e-10

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 54.49  E-value: 2.50e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19113595  98 KVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVTKTADKKD--EIVVQGDLNYDIFDFILEKFK 171
Cdd:cd11608   1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSPLPGKKKgvEVQVQGNQVKFVAKLLTEKYG 76
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 98-180 5.96e-09

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 50.89  E-value: 5.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595  98 KVLIKTIERTKRKRVTTVQGLDAFgIETKKAAKMLANKFATGASVTktaDKKDEIVVQGDLNYDIFDFILEKFKEVpeDN 177
Cdd:cd00474   1 KIHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSVE---GEKMEIEIQGDHTDQIIVALEEKGIDK--DW 74


                ...
gi 19113595 178 IKI 180
Cdd:cd00474  75 VEL 77
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 97-180 3.03e-08

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 49.07  E-value: 3.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595  97 SKVLIKTIERTKRKRVTTVQGLDAfGIETKKAAKMLANKFATGASVTKTADKKDEIVVQGDLNYDIFDFILEKfKEVPED 176
Cdd:cd11566   1 GYIHIRIQQRNGRKTLTTVQGLPE-EFDLKKILKAFKKEFACNGTVVEDPEYGEVIQLQGDQRKNIKEFLLEE-GIAKKD 78


                ....
gi 19113595 177 NIKI 180
Cdd:cd11566  79 NIKV 82
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 104-157 1.80e-05

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 41.31  E-value: 1.80e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19113595 104 IERTKRKR----VTTVQGLDAFGIETKKAAKMLANKFATGASVtktadKKDEIVVQGD 157
Cdd:cd11567   5 VRLEKRGRggktVTVIEGLPLSEEDLKELAKELKKKCGCGGTV-----KDGEIELQGD 57
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
98-179 1.65e-04

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 39.14  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113595   98 KVLIKTIERTKRKRVTTVQGLDAFGIETKKAAKMLANKFATGASVtktadKKDEIVVQGDLNYDIFDFILEkfKEVPEDN 177
Cdd:PRK00939  25 RIKIKVDKRRYGKEVTIIEGIDPKDIDLKELAKKLKSKLACGGTV-----KDGRIELQGDHRERVKELLIK--MGFSEEN 97


                 ..
gi 19113595  178 IK 179
Cdd:PRK00939  98 IE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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