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Conserved domains on  [gi|19924097|ref|NP_598006|]
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synapsin-1 isoform Ib [Homo sapiens]

Protein Classification

ATP-grasp domain-containing protein; acetate--CoA ligase family protein( domain architecture ID 10301346)

ATP-grasp domain-containing protein may be related to carbamoyl phosphate synthetase and predicted to be involved in the biosynthesis of a ribonucleoside involved in stress response| acetate--CoA ligase family protein similar to ADP-forming acetate--CoA ligase that catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CPSase_L_D2 super family cl17255
Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase ...
 214-416 6.02e-138

Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase catalyzes the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.


The actual alignment was detected with superfamily member pfam02750:

Pssm-ID: 473076  Cd Length: 203  Bit Score: 401.74  E-value: 6.02e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   214 NSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIAS 293
Cdd:pfam02750   1 NSLESIYNFCDKPWVFAQLIAIFHSLGGEKFPLIEQTFFPNHKEMLTAPNFPVVIKIGHAHAGMGKIKVENHHDFQDIAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   294 VVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVE 373
Cdd:pfam02750  81 VVALAKTYATAEAFIDSKYDIRIQKIGNNYKAYMRTSISGNWKANTGSAMLEQIAMSDRYKLWVDSCSEMFGGLDICAVK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19924097   374 ALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQ 416
Cdd:pfam02750 161 AVHGKDGKDYIFEVMDCSMPLIGEHQEEDKQLIADLVISKMNQ 203
Synapsin pfam02078
Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.
 115-212 9.30e-61

Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.


:

Pssm-ID: 460438  Cd Length: 97  Bit Score: 197.87  E-value: 9.30e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   115 VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFsmAR 194
Cdd:pfam02078   2 TLLVIDDQHTDWSKYFRGKKIHGDYDIRVEQAEFSELNLTAYADGGCVVDMQVIRNGTKVVRSFRPDFVLVRQHAR--DA 79

                          90
                  ....*....|....*...
gi 19924097   195 NGDYRSLVIGLQYAGIPS 212
Cdd:pfam02078  80 GEDYRNLLLGLQYGGVPS 97
Synapsin_N super family cl11206
Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at ...
 1-27 9.40e-12

Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin.


The actual alignment was detected with superfamily member pfam10581:

Pssm-ID: 463155  Cd Length: 32  Bit Score: 59.81  E-value: 9.40e-12
                          10        20
                  ....*....|....*....|....*..
gi 19924097     1 MNYLRRRLSDSNFMANLPNGYMTDLQR 27
Cdd:pfam10581   1 MNYLRRRLSDSNFMSNLPNGYMSDLQR 27
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 498-669 2.58e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   498 PPAG--SPLPQRLPSPTSAPQQPASQAAPptqgqgrqSRPVAGGPGAPPAARPPASPSPQRQAG---PPQATRQTSVSGP 572
Cdd:PHA03247 2771 PPAApaAGPPRRLTRPAVASLSESRESLP--------SPWDPADPPAAVLAPAAALPPAASPAGplpPPTSAQPTAPPPP 2842

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   573 APPKASGAPPGG--------QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSgPGPAGRPKPQLAQKPSQDV 644
Cdd:PHA03247 2843 PGPPPPSLPLGGsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPPQPQP 2921

                         170       180
                  ....*....|....*....|....*
gi 19924097   645 PPPATAAAGGPPHPQLKaSPAQAQP 669
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPR-PQPPLAP 2945
 
Name Accession Description Interval E-value
Synapsin_C pfam02750
Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function ...
 214-416 6.02e-138

Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function unknown.


Pssm-ID: 308403  Cd Length: 203  Bit Score: 401.74  E-value: 6.02e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   214 NSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIAS 293
Cdd:pfam02750   1 NSLESIYNFCDKPWVFAQLIAIFHSLGGEKFPLIEQTFFPNHKEMLTAPNFPVVIKIGHAHAGMGKIKVENHHDFQDIAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   294 VVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVE 373
Cdd:pfam02750  81 VVALAKTYATAEAFIDSKYDIRIQKIGNNYKAYMRTSISGNWKANTGSAMLEQIAMSDRYKLWVDSCSEMFGGLDICAVK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19924097   374 ALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQ 416
Cdd:pfam02750 161 AVHGKDGKDYIFEVMDCSMPLIGEHQEEDKQLIADLVISKMNQ 203
Synapsin pfam02078
Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.
 115-212 9.30e-61

Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.


Pssm-ID: 460438  Cd Length: 97  Bit Score: 197.87  E-value: 9.30e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   115 VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFsmAR 194
Cdd:pfam02078   2 TLLVIDDQHTDWSKYFRGKKIHGDYDIRVEQAEFSELNLTAYADGGCVVDMQVIRNGTKVVRSFRPDFVLVRQHAR--DA 79

                          90
                  ....*....|....*...
gi 19924097   195 NGDYRSLVIGLQYAGIPS 212
Cdd:pfam02078  80 GEDYRNLLLGLQYGGVPS 97
Synapsin_N pfam10581
Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at ...
 1-27 9.40e-12

Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin.


Pssm-ID: 463155  Cd Length: 32  Bit Score: 59.81  E-value: 9.40e-12
                          10        20
                  ....*....|....*....|....*..
gi 19924097     1 MNYLRRRLSDSNFMANLPNGYMTDLQR 27
Cdd:pfam10581   1 MNYLRRRLSDSNFMSNLPNGYMSDLQR 27
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 161-420 5.15e-10

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 61.11  E-value: 5.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097 161 FSVDMEVLRNGVKVVRSLKPDFVLIRQ----HAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKpwvFAQMVRLH 236
Cdd:COG0189  38 LTLDLGRAPELYRGEDLSEFDAVLPRIdppfYGLALLRQ---------LEAAGVPVVNDPEAIRRARDK---LFTLQLLA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097 237 KK-LGTeefP--LIdqTFYPNH-KEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQD-IASVVALTKTYATAEPFIDAK 311
Cdd:COG0189 106 RAgIPV---PptLV--TRDPDDlRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESiLEALTELGSEPVLVQEFIPEE 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097 312 --YDVRVqkI---GQNYKAYMRTSVSGNWKTNT---GSAmlEQIAMSDRYKLWVDTCSEIFgGLDICAVEALHGKDGRdH 383
Cdd:COG0189 181 dgRDIRV--LvvgGEPVAAIRRIPAEGEFRTNLargGRA--EPVELTDEERELALRAAPAL-GLDFAGVDLIEDDDGP-L 254

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 19924097 384 IIEVvgSSMPLIGDHQDEDKQLIVELVVNKMAQALPR 420
Cdd:COG0189 255 VLEV--NVTPGFRGLERATGVDIAEAIADYLEARAAR 289
PHA03247 PHA03247
large tegument protein UL36; Provisional
 498-669 2.58e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   498 PPAG--SPLPQRLPSPTSAPQQPASQAAPptqgqgrqSRPVAGGPGAPPAARPPASPSPQRQAG---PPQATRQTSVSGP 572
Cdd:PHA03247 2771 PPAApaAGPPRRLTRPAVASLSESRESLP--------SPWDPADPPAAVLAPAAALPPAASPAGplpPPTSAQPTAPPPP 2842

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   573 APPKASGAPPGG--------QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSgPGPAGRPKPQLAQKPSQDV 644
Cdd:PHA03247 2843 PGPPPPSLPLGGsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPPQPQP 2921

                         170       180
                  ....*....|....*....|....*
gi 19924097   645 PPPATAAAGGPPHPQLKaSPAQAQP 669
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPR-PQPPLAP 2945
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 505-669 6.30e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 6.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   505 PQRLPSPTSaPQQPASQAAPPTQGqgrqsrpvaggpgappaarppaspspqrqagPPQATRQTSVSGPAPPKASGAPPGG 584
Cdd:pfam03154 239 PQRLPSPHP-PLQPMTQPPPPSQV-------------------------------SPQPLPQPSLHGQMPPMPHSLQTGP 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   585 QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQlaQKPSQDVPPPATAaaggpPHPQLKASP 664
Cdd:pfam03154 287 SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQ--QPPREQPLPPAPL-----SMPHIKPPP 359


                  ....*
gi 19924097   665 AQAQP 669
Cdd:pfam03154 360 TTPIP 364
rimK_fam TIGR00768
alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione ...
 179-396 3.45e-04

alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).


Pssm-ID: 273261 [Multi-domain]  Cd Length: 276  Bit Score: 43.10  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   179 KPDFVLIR----QHAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKPWVFAqmvrlhkKLGTEEFPLIDQTFYPN 254
Cdd:TIGR00768  48 ELDVVIVRivsmFRGLAVLRY---------LESLGVPVINSSDAILNAGDKFLSHQ-------LLAKAGIPLPRTGLAGS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   255 HKE---MLSSTTYPVVVKMGHAHSGMGKVKVDnqhDFQDIASVV-ALTKTYATAEPFIDAKY-------DVRVQKIGQNY 323
Cdd:TIGR00768 112 PEEalkLIEEIGFPVVLKPVFGSWGRGVSLAR---DRQAAESLLeHFEQLNGPQNLFLVQEYikkpggrDIRVFVVGDEV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   324 KAYMRTSVSGNWKTNT---GSAM-------LEQIAMSdryklwvdtCSEIFgGLDICAVEALHGKDGrdHIIEVVGSSMP 393
Cdd:TIGR00768 189 VAAIYRITSGHWRSNLargGKAEpcslteeIEELAIK---------AAKAL-GLDVAGVDLLESEDG--LLVNEVNANPE 256


                  ...
gi 19924097   394 LIG 396
Cdd:TIGR00768 257 FKN 259
 
Name Accession Description Interval E-value
Synapsin_C pfam02750
Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function ...
 214-416 6.02e-138

Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function unknown.


Pssm-ID: 308403  Cd Length: 203  Bit Score: 401.74  E-value: 6.02e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   214 NSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIAS 293
Cdd:pfam02750   1 NSLESIYNFCDKPWVFAQLIAIFHSLGGEKFPLIEQTFFPNHKEMLTAPNFPVVIKIGHAHAGMGKIKVENHHDFQDIAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   294 VVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVE 373
Cdd:pfam02750  81 VVALAKTYATAEAFIDSKYDIRIQKIGNNYKAYMRTSISGNWKANTGSAMLEQIAMSDRYKLWVDSCSEMFGGLDICAVK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19924097   374 ALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQ 416
Cdd:pfam02750 161 AVHGKDGKDYIFEVMDCSMPLIGEHQEEDKQLIADLVISKMNQ 203
Synapsin pfam02078
Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.
 115-212 9.30e-61

Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.


Pssm-ID: 460438  Cd Length: 97  Bit Score: 197.87  E-value: 9.30e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   115 VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFsmAR 194
Cdd:pfam02078   2 TLLVIDDQHTDWSKYFRGKKIHGDYDIRVEQAEFSELNLTAYADGGCVVDMQVIRNGTKVVRSFRPDFVLVRQHAR--DA 79

                          90
                  ....*....|....*...
gi 19924097   195 NGDYRSLVIGLQYAGIPS 212
Cdd:pfam02078  80 GEDYRNLLLGLQYGGVPS 97
Synapsin_N pfam10581
Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at ...
 1-27 9.40e-12

Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin.


Pssm-ID: 463155  Cd Length: 32  Bit Score: 59.81  E-value: 9.40e-12
                          10        20
                  ....*....|....*....|....*..
gi 19924097     1 MNYLRRRLSDSNFMANLPNGYMTDLQR 27
Cdd:pfam10581   1 MNYLRRRLSDSNFMSNLPNGYMSDLQR 27
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 161-420 5.15e-10

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 61.11  E-value: 5.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097 161 FSVDMEVLRNGVKVVRSLKPDFVLIRQ----HAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKpwvFAQMVRLH 236
Cdd:COG0189  38 LTLDLGRAPELYRGEDLSEFDAVLPRIdppfYGLALLRQ---------LEAAGVPVVNDPEAIRRARDK---LFTLQLLA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097 237 KK-LGTeefP--LIdqTFYPNH-KEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQD-IASVVALTKTYATAEPFIDAK 311
Cdd:COG0189 106 RAgIPV---PptLV--TRDPDDlRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESiLEALTELGSEPVLVQEFIPEE 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097 312 --YDVRVqkI---GQNYKAYMRTSVSGNWKTNT---GSAmlEQIAMSDRYKLWVDTCSEIFgGLDICAVEALHGKDGRdH 383
Cdd:COG0189 181 dgRDIRV--LvvgGEPVAAIRRIPAEGEFRTNLargGRA--EPVELTDEERELALRAAPAL-GLDFAGVDLIEDDDGP-L 254

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 19924097 384 IIEVvgSSMPLIGDHQDEDKQLIVELVVNKMAQALPR 420
Cdd:COG0189 255 VLEV--NVTPGFRGLERATGVDIAEAIADYLEARAAR 289
PHA03247 PHA03247
large tegument protein UL36; Provisional
 498-669 2.58e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   498 PPAG--SPLPQRLPSPTSAPQQPASQAAPptqgqgrqSRPVAGGPGAPPAARPPASPSPQRQAG---PPQATRQTSVSGP 572
Cdd:PHA03247 2771 PPAApaAGPPRRLTRPAVASLSESRESLP--------SPWDPADPPAAVLAPAAALPPAASPAGplpPPTSAQPTAPPPP 2842

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   573 APPKASGAPPGG--------QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSgPGPAGRPKPQLAQKPSQDV 644
Cdd:PHA03247 2843 PGPPPPSLPLGGsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPPQPQP 2921

                         170       180
                  ....*....|....*....|....*
gi 19924097   645 PPPATAAAGGPPHPQLKaSPAQAQP 669
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPR-PQPPLAP 2945
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 494-669 3.42e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 53.45  E-value: 3.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  494 SGLGPPAGSPLPQRLPSPT-----SAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSpqrQAGPPQATRQTS 568
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPEeaarpAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKH---VAVPDASDGGDG 668

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  569 VSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPA 648
Cdd:PRK07764 669 WPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                        170       180
                 ....*....|....*....|.
gi 19924097  649 TAAAGGPPHPQLKASPAQAQP 669
Cdd:PRK07764 749 PDPAGAPAQPPPPPAPAPAAA 769
PHA03247 PHA03247
large tegument protein UL36; Provisional
 419-669 7.85e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 7.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   419 PRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGpplqqrpppqgqqhlsglGP 498
Cdd:PHA03247 2571 PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS------------------PS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   499 PAGSPLPQRLPSPTSAPQQPASQAAPptqgqGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKAS 578
Cdd:PHA03247 2633 PAANEPDPHPPPTVPPPERPRDDPAP-----GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   579 GAP-PGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGP-----PTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAA 652
Cdd:PHA03247 2708 PEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                         250
                  ....*....|....*..
gi 19924097   653 GGPPHPQLKASPAQAQP 669
Cdd:PHA03247 2788 VASLSESRESLPSPWDP 2804
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
498-669 5.31e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  498 PPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSrpvaggpgappAARPPASPSPQRQAGPPQATRQtSVSGPAPPKA 577
Cdd:PRK12323 392 PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS-----------PAPEALAAARQASARGPGGAPA-PAPAPAAAPA 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  578 SGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQP-RPSGPGPAgRPKPQLAQKPSQDVPPPATAAAGGPP 656
Cdd:PRK12323 460 AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPpEFASPAPA-QPDAAPAGWVAESIPDPATADPDDAF 538

                        170
                 ....*....|...
gi 19924097  657 HPQLKASPAQAQP 669
Cdd:PRK12323 539 ETLAPAPAAAPAP 551
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 497-669 1.26e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.44  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  497 GPPAGSPLPQRLPSPTSAP-----QQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSP----QRQAGPPQATRQT 567
Cdd:PRK07764 603 PASSGPPEEAARPAAPAAPaapaaPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGgdgwPAKAGGAAPAAPP 682

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  568 SVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPP 647
Cdd:PRK07764 683 PAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPP 762

                        170       180
                 ....*....|....*....|..
gi 19924097  648 ATAAAGGPPHPQLKASPAQAQP 669
Cdd:PRK07764 763 APAPAAAPAAAPPPSPPSEEEE 784
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 509-669 2.69e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  509 PSPTSAPQQPASQAAPPTQGQGrqsrpvaggpgappaarppaspspqrQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQ 588
Cdd:PRK07764 390 GAGAPAAAAPSAAAAAPAAAPA--------------------------PAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPS 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  589 GPPQKPPGPAGPTRQASQAGPVPRTGPPttqqprpSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLKASPAQAQ 668
Cdd:PRK07764 444 PAGNAPAGGAPSPPPAAAPSAQPAPAPA-------AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERW 516


                 .
gi 19924097  669 P 669
Cdd:PRK07764 517 P 517
PHA03247 PHA03247
large tegument protein UL36; Provisional
 497-667 4.54e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   497 GPPAgsPLPQRLPSPTSAPQQPASQAAPPTQG---QGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPA 573
Cdd:PHA03247 2550 DPPP--PLPPAAPPAAPDRSVPPPRPAPRPSEpavTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   574 PPKAS------------GAPPGGQQRQGPPQKPPGPAGPTRQASQA--------GPVPRTGPPT----TQQPRPSGPGPA 629
Cdd:PHA03247 2628 PPSPSpaanepdphpppTVPPPERPRDDPAPGRVSRPRRARRLGRAaqassppqRPRRRAARPTvgslTSLADPPPPPPT 2707

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 19924097   630 GRPKPQLAQKPSQDVPPPATAAAGGPPHPQLKASPAQA 667
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP 2745
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 512-669 6.12e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 6.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  512 TSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPP-------GG 584
Cdd:PRK07764 587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVavpdasdGG 666

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  585 QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDV---PPPATAAAGGPPHPQLK 661
Cdd:PRK07764 667 DGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQgasAPSPAADDPVPLPPEPD 746


                 ....*...
gi 19924097  662 ASPAQAQP 669
Cdd:PRK07764 747 DPPDPAGA 754
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 505-669 6.30e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 6.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   505 PQRLPSPTSaPQQPASQAAPPTQGqgrqsrpvaggpgappaarppaspspqrqagPPQATRQTSVSGPAPPKASGAPPGG 584
Cdd:pfam03154 239 PQRLPSPHP-PLQPMTQPPPPSQV-------------------------------SPQPLPQPSLHGQMPPMPHSLQTGP 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   585 QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQlaQKPSQDVPPPATAaaggpPHPQLKASP 664
Cdd:pfam03154 287 SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQ--QPPREQPLPPAPL-----SMPHIKPPP 359


                  ....*
gi 19924097   665 AQAQP 669
Cdd:pfam03154 360 TTPIP 364
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 505-666 8.81e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.80  E-value: 8.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   505 PQRLPSPTSAPQQPAsQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQA-TRQTSVSGPAPPKASGAPPG 583
Cdd:pfam09770 208 KKPAQQPAPAPAQPP-AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIlQRPQSPQPDPAQPSIQPQAQ 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   584 GQQRQGppqkppgpagptrqasqagpvprtgPPTTQQPR-----PSGPGPAGRPKPQLAQKPSQDVPP-PATAAAGGPPH 657
Cdd:pfam09770 287 QFHQQP-------------------------PPVPVQPTqilqnPNRLSAARVGYPQNPQPGVQPAPAhQAHRQQGSFGR 341

                         170
                  ....*....|
gi 19924097   658 -PQLKASPAQ 666
Cdd:pfam09770 342 qAPIITHPQQ 351
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 504-663 9.06e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 9.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  504 LPQRLPSPTSApQQPASQAAPPTQGQGRQSrpvaggpgappaaRpPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPG 583
Cdd:PRK07764 374 LLARLERLERR-LGVAGGAGAPAAAAPSAA-------------A-AAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPA 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  584 GQQRQGPPQKPPGPAGPTRQASQAGPVPRtgpPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLKAS 663
Cdd:PRK07764 439 PAPPSPAGNAPAGGAPSPPPAAAPSAQPA---PAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRER 515
PHA03378 PHA03378
EBNA-3B; Provisional
 499-659 1.97e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  499 PAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRqSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKAs 578
Cdd:PHA03378 691 PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGR-ARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA- 768

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  579 gAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQ---------KPSQDVPPPAT 649
Cdd:PHA03378 769 -AAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQlltggvkrgRPSLKKPAALE 847

                        170
                 ....*....|..
gi 19924097  650 --AAAGGPPHPQ 659
Cdd:PHA03378 848 rqAAAGPTPSPG 859
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 558-669 3.23e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 43.90  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  558 AGPPQATrqtSVSGPAPPKASGAPPGGQQRQGPPqkppgpagptrqASQAGPVPRTGPPTTqqprpsgPGPAGRPKPQLa 637
Cdd:PRK14959 378 ASAPSGS---AAEGPASGGAATIPTPGTQGPQGT------------APAAGMTPSSAAPAT-------PAPSAAPSPRV- 434

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 19924097  638 qkPSQDVpPPATAAAGGPPHPQLK---ASPAQAQP 669
Cdd:PRK14959 435 --PWDDA-PPAPPRSGIPPRPAPRmpeASPVPGAP 466
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 498-646 3.40e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   498 PPAGSPLPQRLPSPTSAPQQPasQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKa 577
Cdd:PRK10263  364 PGPQTGEPVIAPAPEGYPQQS--QYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQ- 440

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   578 sgaPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQ-KPSQdvPP 646
Cdd:PRK10263  441 ---PVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEEtKPAR--PP 505
rimK_fam TIGR00768
alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione ...
 179-396 3.45e-04

alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).


Pssm-ID: 273261 [Multi-domain]  Cd Length: 276  Bit Score: 43.10  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   179 KPDFVLIR----QHAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKPWVFAqmvrlhkKLGTEEFPLIDQTFYPN 254
Cdd:TIGR00768  48 ELDVVIVRivsmFRGLAVLRY---------LESLGVPVINSSDAILNAGDKFLSHQ-------LLAKAGIPLPRTGLAGS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   255 HKE---MLSSTTYPVVVKMGHAHSGMGKVKVDnqhDFQDIASVV-ALTKTYATAEPFIDAKY-------DVRVQKIGQNY 323
Cdd:TIGR00768 112 PEEalkLIEEIGFPVVLKPVFGSWGRGVSLAR---DRQAAESLLeHFEQLNGPQNLFLVQEYikkpggrDIRVFVVGDEV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   324 KAYMRTSVSGNWKTNT---GSAM-------LEQIAMSdryklwvdtCSEIFgGLDICAVEALHGKDGrdHIIEVVGSSMP 393
Cdd:TIGR00768 189 VAAIYRITSGHWRSNLargGKAEpcslteeIEELAIK---------AAKAL-GLDVAGVDLLESEDG--LLVNEVNANPE 256


                  ...
gi 19924097   394 LIG 396
Cdd:TIGR00768 257 FKN 259
PHA03247 PHA03247
large tegument protein UL36; Provisional
 498-662 4.30e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   498 PPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGP--PQATRQTSVSGPAPP 575
Cdd:PHA03247 2813 APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPaaPARPPVRRLARPAVS 2892

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   576 KASGA---PPGGQQRQGppqkppGpagptrqaSQAGPVPRTGPPTTQQPRPS-GPGPAGRPKPQLAQKPSqdvPPPATAA 651
Cdd:PHA03247 2893 RSTESfalPPDQPERPP------Q--------PQAPPPPQPQPQPPPPPQPQpPPPPPPRPQPPLAPTTD---PAGAGEP 2955

                         170
                  ....*....|.
gi 19924097   652 AGGPPHPQLKA 662
Cdd:PHA03247 2956 SGAVPQPWLGA 2966
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 497-659 5.14e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  497 GPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSR---------PVAGGPGAPPAARPPASPSPQRQAGPPQATRQT 567
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDggdgwpakaGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPA 706

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  568 SVSGPAP-PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPP 646
Cdd:PRK07764 707 ATPPAGQaDDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMA 786

                        170
                 ....*....|...
gi 19924097  647 PATAAAGGPPHPQ 659
Cdd:PRK07764 787 EDDAPSMDDEDRR 799
PHA03247 PHA03247
large tegument protein UL36; Provisional
 500-669 5.73e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   500 AGSPLPqrLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASg 579
Cdd:PHA03247  303 AGAPLA--LPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRAS- 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   580 aPPGGQQRQgppqkppgpagpTRQAsqAGPVPRtGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPAT-AAAGGPPHP 658
Cdd:PHA03247  380 -LPTRKRRS------------ARHA--ATPFAR-GPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATpLPSAEPGSD 443

                         170
                  ....*....|.
gi 19924097   659 QLKASPAQAQP 669
Cdd:PHA03247  444 DGPAPPPERQP 454
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 495-626 6.93e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 6.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  495 GLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAP 574
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 19924097  575 PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGP 626
Cdd:PRK07764 466 PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWP 517
PHA03378 PHA03378
EBNA-3B; Provisional
 498-668 9.56e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 9.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  498 PPAGSPLPQR----LPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPA 573
Cdd:PHA03378 625 PMPLRPIPMRplrmQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPM 704

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  574 PPKAsgAPPGGQQRQgppqkppgpagptrQASQAGPVPRTGPPTTQQPRPSGPGPAGRPK--PQLAQKPSQ---DVPPPA 648
Cdd:PHA03378 705 RPPA--APPGRAQRP--------------AAATGRARPPAAAPGRARPPAAAPGRARPPAaaPGRARPPAAapgRARPPA 768

                        170       180
                 ....*....|....*....|
gi 19924097  649 TAAAGGPPHPQLKASPAQAQ 668
Cdd:PHA03378 769 AAPGAPTPQPPPQAPPAPQQ 788
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
497-668 1.22e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  497 GPPAGSPLPQRL-PSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAP- 574
Cdd:PRK07003 404 GAAGAALAPKAAaAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASd 483

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  575 ----------PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPS-------------------- 624
Cdd:PRK07003 484 appdaafepaPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAaraggaaaaldvlrnagmrv 563

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 19924097  625 ----GPGPAGRPKPQLAQ---------KPSQDVPPPATAAAGGPPHPQLKASPAQAQ 668
Cdd:PRK07003 564 ssdrGARAAAAAKPAAAPaaapkpaapRVAVQVPTPRARAATGDAPPNGAARAEQAA 620
PHA03378 PHA03378
EBNA-3B; Provisional
 432-657 1.47e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  432 SHGQTPSPgaLPLGRQTSQQPAgppaQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGP---PAGSPLPQRL 508
Cdd:PHA03378 591 SYAQTPWP--VPHPSQTPEPPT----TQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPhqpPQVEITPYKP 664

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  509 -----------PSPTSA-----PQQPASQAAPPTQGQGRqSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGP 572
Cdd:PHA03378 665 twtqighipyqPSPTGAntmlpIQWAPGTMQPPPRAPTP-MRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGR 743

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  573 APPKAsgAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRpsgPGPAGRPKPQLAQKPSQDVPPPATAAA 652
Cdd:PHA03378 744 ARPPA--AAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPR---GAPTPQPPPQAGPTSMQLMPRAAPGQQ 818


                 ....*
gi 19924097  653 GGPPH 657
Cdd:PHA03378 819 GPTKQ 823
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
494-669 2.02e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  494 SGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGrqsrPVAGGPGAPPAARPPASPSPQRQAGPPQAT--------R 565
Cdd:PRK07003 364 GGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVT----AVTGAAGAALAPKAAAAAAATRAEAPPAAPappatadrG 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097  566 QTSVSGPAPPKASGAPPGgqqRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPsgpgPAGRPKPQlAQKPSQDVP 645
Cdd:PRK07003 440 DDAADGDAPVPAKANARA---SADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAP----RAAAPSAA-TPAAVPDAR 511

                        170       180
                 ....*....|....*....|....
gi 19924097  646 PPATAAAGGPPHPQLKASPAQAQP 669
Cdd:PRK07003 512 APAAASREDAPAAAAPPAPEARPP 535
PHA03247 PHA03247
large tegument protein UL36; Provisional
 498-634 2.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   498 PPAGSPLP----QRLPSPTSAPQQPASQAAPPTqgqgrqSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPA 573
Cdd:PHA03247 2851 PLGGSVAPggdvRRRPPSRSPAAKPAAPARPPV------RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19924097   574 PPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPT----------TQQPRPSGPGPAGRPKP 634
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVpgrvavprfrVPQPAPSREAPASSTPP 2995
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 603-669 2.21e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 41.27  E-value: 2.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19924097  603 QASQAGPVPRTGPPTTQQPRPSGPGPAgrpkPQLAQKPSqdvPPPATAAAGGPPHPQLKASPAQAQP 669
Cdd:PRK14965 388 AWGAPTPAAPAAPPPAAAPPVPPAAPA----RPAAARPA---PAPAPPAAAAPPARSADPAAAASAG 447
PHA03247 PHA03247
large tegument protein UL36; Provisional
 419-658 3.05e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   419 PRQRQRDASPG--RGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQrpppqgqqhlSGL 496
Cdd:PHA03247 2592 PPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAP----------GRV 2661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   497 GPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPpQATRQTSvsgPAPPK 576
Cdd:PHA03247 2662 SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGP-AAARQAS---PALPA 2737

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   577 ASGAPPggqqrqgPPQKPPGPAGPTRQASQA------GPVPRTGPPTTQQPR----------------PSGPGPAGRPKP 634
Cdd:PHA03247 2738 APAPPA-------VPAGPATPGGPARPARPPttagppAPAPPAAPAAGPPRRltrpavaslsesreslPSPWDPADPPAA 2810

                         250       260       270
                  ....*....|....*....|....*....|..
gi 19924097   635 QLA--------QKPSQDVPPPATAAAGGPPHP 658
Cdd:PHA03247 2811 VLApaaalppaASPAGPLPPPTSAQPTAPPPP 2842
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 570-669 3.93e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.64  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   570 SGPAPPKASGAPPGGQqrqgppqkppgpagptrqASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPqlAQKPSQDVPPPAT 649
Cdd:PRK12270   40 STAAPTAAAAAAAAAA------------------SAPAAAPAAKAPAAPAPAPPAAAAPAAPPKP--AAAAAAAAAPAAP 99

                          90       100
                  ....*....|....*....|
gi 19924097   650 AAAGGPPHPQLKASPAQAQP 669
Cdd:PRK12270  100 PAAAAAAAPAAAAVEDEVTP 119
PHA03247 PHA03247
large tegument protein UL36; Provisional
 415-667 5.56e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   415 AQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLS 494
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   495 GLGPP-AGSPLPQRLPSPTSAPQQPASQAAPPtqgqGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPA 573
Cdd:PHA03247 2827 PLPPPtSAQPTAPPPPPGPPPPSLPLGGSVAP----GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPP 2902

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   574 PPKASGAPPGGQQR---QGPPQKPPGPAGPTRQA--SQAGPVPRTGPPTTQQPRPSGPGP-AGRPKPQLAQKPSQDVPPP 647
Cdd:PHA03247 2903 DQPERPPQPQAPPPpqpQPQPPPPPQPQPPPPPPprPQPPLAPTTDPAGAGEPSGAVPQPwLGALVPGRVAVPRFRVPQP 2982

                         250       260
                  ....*....|....*....|.
gi 19924097   648 A-TAAAGGPPHPQLKASPAQA 667
Cdd:PHA03247 2983 ApSREAPASSTPPLTGHSLSR 3003
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 556-669 8.13e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.38  E-value: 8.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   556 RQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPrtGPPTTQQPRPSGPGPAGRPKPQ 635
Cdd:PHA03307  773 ALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDG--GSESSGPARPPGAAARPPPARS 850

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 19924097   636 LAQKPSQDVPPPATAAAGGP-----PHPQLKASPAQAQP 669
Cdd:PHA03307  851 SESSKSKPAAAGGRARGKNGrrrprPPEPRARPGAAAPP 889
Androgen_recep pfam02166
Androgen receptor;
571-665 9.96e-03

Androgen receptor;


Pssm-ID: 426632 [Multi-domain]  Cd Length: 501  Bit Score: 39.14  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924097   571 GPAPPKASG--APPGG-----QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSgPGPAG--------RPKPQ 635
Cdd:pfam02166  33 GPRHPEAAGgaAPPGArlqhqQQQQQQVPQQPQQQESSPRQPQASVQPQQAGDDGSPPAHN-RGPAGylaleddeQPQPS 111

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19924097   636 LAQKPSQD------VPPPATAAAGGPPHPQLKASPA 665
Cdd:pfam02166 112 QAQPAAECcpengcVPEPGAAAAAGKGLPQQAVAPA 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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