transcription initiation factor TFIID subunit 9B [Rattus norvegicus]
transcription initiation factor TFIID subunit 9 family protein( domain architecture ID 11130032)
transcription initiation factor TFIID subunit 9 family protein similar to Homo sapiens transcription initiation factor TFIID subunit 9 (TAF9), which is a component of the TFIID basal transcription factor complex that plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription
List of domain hits
Name | Accession | Description | Interval | E-value | |||
TFIID-31kDa | pfam02291 | Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of ... |
5-125 | 2.88e-73 | |||
Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of the 31kD subunit (42kD in drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation. : Pssm-ID: 460525 Cd Length: 122 Bit Score: 218.92 E-value: 2.88e-73
|
|||||||
Name | Accession | Description | Interval | E-value | |||
TFIID-31kDa | pfam02291 | Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of ... |
5-125 | 2.88e-73 | |||
Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of the 31kD subunit (42kD in drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation. Pssm-ID: 460525 Cd Length: 122 Bit Score: 218.92 E-value: 2.88e-73
|
|||||||
HFD_TAF9 | cd07979 | histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and ... |
8-102 | 1.54e-52 | |||
histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and similar proteins; The family includes TAF9 (also called TATA Binding Protein (TBP) associated factor 9, RNA polymerase II TBP-associated factor subunit G, STAF31/32, transcription initiation factor TFIID 31 kDa subunit, TAFII-31, TAFII31, transcription initiation factor TFIID 32 kDa subunit, TAFII-32, or TAFII32) and TAF9-like (also called transcription initiation factor TFIID subunit 9B, neuronal cell death-related protein 7, DN-7, or transcription-associated factor TAFII31L), which are essential for cell viability. They are involved in transcriptional activation as well as the repression of distinct but overlapping sets of genes. They may have roles in gene regulation associated with apoptosis. Both TAF9 and TAF9-like are TAFs that are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. TAF9 interacts directly with different transcription factors such as p53, herpes simplex virus activator vp16, and the basal transcription factor TFIIB. Pssm-ID: 467024 Cd Length: 95 Bit Score: 165.47 E-value: 1.54e-52
|
|||||||
TAF9 | COG5094 | Transcription initiation factor TFIID, subunit TAF9 (also component of histone ... |
8-124 | 3.62e-35 | |||
Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription]; Pssm-ID: 227425 Cd Length: 145 Bit Score: 122.78 E-value: 3.62e-35
|
|||||||
Name | Accession | Description | Interval | E-value | |||
TFIID-31kDa | pfam02291 | Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of ... |
5-125 | 2.88e-73 | |||
Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of the 31kD subunit (42kD in drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation. Pssm-ID: 460525 Cd Length: 122 Bit Score: 218.92 E-value: 2.88e-73
|
|||||||
HFD_TAF9 | cd07979 | histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and ... |
8-102 | 1.54e-52 | |||
histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and similar proteins; The family includes TAF9 (also called TATA Binding Protein (TBP) associated factor 9, RNA polymerase II TBP-associated factor subunit G, STAF31/32, transcription initiation factor TFIID 31 kDa subunit, TAFII-31, TAFII31, transcription initiation factor TFIID 32 kDa subunit, TAFII-32, or TAFII32) and TAF9-like (also called transcription initiation factor TFIID subunit 9B, neuronal cell death-related protein 7, DN-7, or transcription-associated factor TAFII31L), which are essential for cell viability. They are involved in transcriptional activation as well as the repression of distinct but overlapping sets of genes. They may have roles in gene regulation associated with apoptosis. Both TAF9 and TAF9-like are TAFs that are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. TAF9 interacts directly with different transcription factors such as p53, herpes simplex virus activator vp16, and the basal transcription factor TFIIB. Pssm-ID: 467024 Cd Length: 95 Bit Score: 165.47 E-value: 1.54e-52
|
|||||||
TAF9 | COG5094 | Transcription initiation factor TFIID, subunit TAF9 (also component of histone ... |
8-124 | 3.62e-35 | |||
Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription]; Pssm-ID: 227425 Cd Length: 145 Bit Score: 122.78 E-value: 3.62e-35
|
|||||||
HFD_SF | cd00076 | histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally ... |
13-71 | 2.98e-08 | |||
histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally conserved interaction motif involved in heterodimerization of the core histones and their assembly into the nucleosome octamer. Histone fold heterodimers play crucial roles in gene regulation. The minimal HFD consists of three alpha helices connected by two short, unstructured loops. The HFD is found in core histones, TATA box-binding protein-associated factors (TAFs), and many other transcription factors. HFD plays a role in the nucleosomal core particle by conserving histone interactions; these contain more than one HFD. The structure of the nucleosome core particle has two modes that have the largest interaction surfaces, and these are the H3-H4 and H2A-H2B heterodimer interactions. Several TAFs interact via histone-fold (HF) motifs. Five HF-containing TAF pairs have been described in transcription factor II D (TFIID): TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10. Pssm-ID: 467021 Cd Length: 63 Bit Score: 49.14 E-value: 2.98e-08
|
|||||||
HFD_CENP-S | cd22919 | histone-fold domain found in centromere protein S (CENP-S) and similar proteins; CENP-S, also ... |
26-68 | 3.42e-04 | |||
histone-fold domain found in centromere protein S (CENP-S) and similar proteins; CENP-S, also called MHF1, apoptosis-inducing TAF9-like domain-containing protein 1 (APITD1), FANCM-associated histone fold protein 1, FANCM-interacting histone fold protein 1, or Fanconi anemia-associated polypeptide of 16 kDa (FAAP16), is a DNA-binding component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. CENP-S, together with CENP-X, forms the MHF heterodimer, which can further assemble to form tetrameric structures. CENP-S acts as a crucial cofactor for FANCM, in both binding and ATP-dependent remodeling of DNA. It can stabilize FANCM. CENP-S also forms a discrete complex with FANCM and CENP-X, called FANCM-MHF. This interaction leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. In complex with CENP-T, CENP-W and CENP-X (CENP-T-W-S-X heterotetramer), CENP-S is involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, CENP-S binds DNA and bends it to form a nucleosome-like structure. Its DNA-binding function is fulfilled in the presence of CENP-X. It does not bind DNA on its own. Pssm-ID: 467044 Cd Length: 77 Bit Score: 38.31 E-value: 3.42e-04
|
|||||||
Bromo_TP | pfam07524 | Bromodomain associated; This domain is predicted to bind DNA and is often found associated ... |
12-71 | 7.74e-03 | |||
Bromodomain associated; This domain is predicted to bind DNA and is often found associated with pfam00439 and in transcription factors. It has a histone-like fold. Pssm-ID: 400073 Cd Length: 77 Bit Score: 34.61 E-value: 7.74e-03
|
|||||||
Blast search parameters | ||||
|