NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19526880|ref|NP_598467|]
View 

sigma intracellular receptor 2 [Mus musculus]

Protein Classification

EXPERA domain-containing protein( domain architecture ID 10526086)

EXPERA (EXPanded EBP superfamily) domain-containing protein such as Homo sapiens 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and emopamil-binding protein (EBP)-like may be involved in sterol metabolism or the regulation of cholesterol homeostasis

Gene Ontology:  GO:0016020|GO:0032934
PubMed:  25566323

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EBP pfam05241
EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved ...
 43-150 6.60e-19

EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved among the following protein families: TM6SF1 (Transmembrane 6 Superfamily Member 1), TM6SF2 (Transmembrane 6 Superfamily Member 2), MAC30 (Meningioma-associated protein 30 also known as TMEM97, or Transmembrane protein 97), and EBP (Emopamil binding protein). EBP is an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring. Mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.


:

Pssm-ID: 461600  Cd Length: 112  Bit Score: 77.19  E-value: 6.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526880    43 FSNLLRWYSKEFKDPLMQEPpvWFKSFLLCELVFQLPFFPIAAYAFFKgscRWIRIPAIIYAAHTITTLIPILYTLLFED 122
Cdd:pfam05241   2 LAQLWKEYLADTSDPFVAGP--PFVSFELLEAFFQGPLFFLAAYALLK---SPWRLLLLRYALQTATTTLQCYGDVLYFA 76

                          90       100
                  ....*....|....*....|....*...
gi 19526880   123 FSkavAFKGQRPESFRERLTLVGVYAPY 150
Cdd:pfam05241  77 TE---WLEGGLSLSRPFWVYLVFLNLPW 101
 
Name Accession Description Interval E-value
EBP pfam05241
EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved ...
 43-150 6.60e-19

EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved among the following protein families: TM6SF1 (Transmembrane 6 Superfamily Member 1), TM6SF2 (Transmembrane 6 Superfamily Member 2), MAC30 (Meningioma-associated protein 30 also known as TMEM97, or Transmembrane protein 97), and EBP (Emopamil binding protein). EBP is an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring. Mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.


Pssm-ID: 461600  Cd Length: 112  Bit Score: 77.19  E-value: 6.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526880    43 FSNLLRWYSKEFKDPLMQEPpvWFKSFLLCELVFQLPFFPIAAYAFFKgscRWIRIPAIIYAAHTITTLIPILYTLLFED 122
Cdd:pfam05241   2 LAQLWKEYLADTSDPFVAGP--PFVSFELLEAFFQGPLFFLAAYALLK---SPWRLLLLRYALQTATTTLQCYGDVLYFA 76

                          90       100
                  ....*....|....*....|....*...
gi 19526880   123 FSkavAFKGQRPESFRERLTLVGVYAPY 150
Cdd:pfam05241  77 TE---WLEGGLSLSRPFWVYLVFLNLPW 101
 
Name Accession Description Interval E-value
EBP pfam05241
EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved ...
 43-150 6.60e-19

EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved among the following protein families: TM6SF1 (Transmembrane 6 Superfamily Member 1), TM6SF2 (Transmembrane 6 Superfamily Member 2), MAC30 (Meningioma-associated protein 30 also known as TMEM97, or Transmembrane protein 97), and EBP (Emopamil binding protein). EBP is an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring. Mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.


Pssm-ID: 461600  Cd Length: 112  Bit Score: 77.19  E-value: 6.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526880    43 FSNLLRWYSKEFKDPLMQEPpvWFKSFLLCELVFQLPFFPIAAYAFFKgscRWIRIPAIIYAAHTITTLIPILYTLLFED 122
Cdd:pfam05241   2 LAQLWKEYLADTSDPFVAGP--PFVSFELLEAFFQGPLFFLAAYALLK---SPWRLLLLRYALQTATTTLQCYGDVLYFA 76

                          90       100
                  ....*....|....*....|....*...
gi 19526880   123 FSkavAFKGQRPESFRERLTLVGVYAPY 150
Cdd:pfam05241  77 TE---WLEGGLSLSRPFWVYLVFLNLPW 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH