NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|20129055|ref|NP_608335|]
View 

required for cell differentiation 1, isoform B [Drosophila melanogaster]

Protein Classification

Rcd1-like cell differentiation family protein( domain architecture ID 10513525)

Rcd1-like cell differentiation family protein such as CCR4-NOT transcription complex subunit 9 (CNOT9), which is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Rcd1 pfam04078
Cell differentiation family, Rcd1-like; Two of the members in this family have been ...
 32-288 1.51e-170

Cell differentiation family, Rcd1-like; Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.


:

Pssm-ID: 461160  Cd Length: 259  Bit Score: 472.83  E-value: 1.51e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055    32 WINELAHPDTRETALLELSKKRET--DLAPMLWNSFGTACALLQEIVNIYPSITPPTLTAHQSNRVCNALALLQCVASHP 109
Cdd:pfam04078   1 LILDLTDPEKREEALLELSKKRESfpDLAPLLWHSFGTMAALLQEIVSIYPLLSPPTLTERESNRVCNALALLQCVASHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055   110 ETRTAFLQAQIPLYLYPFLSTTSKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIVPLCLSIMDSGSELSKTVATF 189
Cdd:pfam04078  81 ETRSLFLRAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALVKTDDPEVINFLLDTEIVPLCLRIMESGSELSKTVATF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055   190 IIQKILLDESGLSYICQTYERFSHVAITLGKMVIQLAKDPCARLLKHVVRCYLRLSDNTRARKALGQCLPDQLRDGTFAL 269
Cdd:pfam04078 161 ILQKILSDDDGLNYICQTPDRFSAVAQVLNSMVVQLVEQPSPRLLKHVIRCYLRLSDNPRAREALRSCLPELLKDGTFSS 240

                         250
                  ....*....|....*....
gi 20129055   270 CLQEDKSTKQWLQMLLKNL 288
Cdd:pfam04078 241 LLKDDPETKRWLKQLLHNL 259
 
Name Accession Description Interval E-value
Rcd1 pfam04078
Cell differentiation family, Rcd1-like; Two of the members in this family have been ...
 32-288 1.51e-170

Cell differentiation family, Rcd1-like; Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.


Pssm-ID: 461160  Cd Length: 259  Bit Score: 472.83  E-value: 1.51e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055    32 WINELAHPDTRETALLELSKKRET--DLAPMLWNSFGTACALLQEIVNIYPSITPPTLTAHQSNRVCNALALLQCVASHP 109
Cdd:pfam04078   1 LILDLTDPEKREEALLELSKKRESfpDLAPLLWHSFGTMAALLQEIVSIYPLLSPPTLTERESNRVCNALALLQCVASHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055   110 ETRTAFLQAQIPLYLYPFLSTTSKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIVPLCLSIMDSGSELSKTVATF 189
Cdd:pfam04078  81 ETRSLFLRAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALVKTDDPEVINFLLDTEIVPLCLRIMESGSELSKTVATF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055   190 IIQKILLDESGLSYICQTYERFSHVAITLGKMVIQLAKDPCARLLKHVVRCYLRLSDNTRARKALGQCLPDQLRDGTFAL 269
Cdd:pfam04078 161 ILQKILSDDDGLNYICQTPDRFSAVAQVLNSMVVQLVEQPSPRLLKHVIRCYLRLSDNPRAREALRSCLPELLKDGTFSS 240

                         250
                  ....*....|....*....
gi 20129055   270 CLQEDKSTKQWLQMLLKNL 288
Cdd:pfam04078 241 LLKDDPETKRWLKQLLHNL 259
RCD1 COG5209
Uncharacterized protein involved in cell differentiation/sexual development [General function ...
 25-290 2.28e-118

Uncharacterized protein involved in cell differentiation/sexual development [General function prediction only];


Pssm-ID: 227534  Cd Length: 315  Bit Score: 342.66  E-value: 2.28e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055  25 EQEKVYQWINELAHPDTRETALLELSKKRET--DLAPMLWNSFGTACALLQEIVNIYPSITPPTLTAHQSNRVCNALALL 102
Cdd:COG5209  45 RQALVYSWICQLVVGNPKEQALDELFRKREQspDLALELWRSDGVMTFLLQEIISVYPILSPSKLDERESNRVCNALNLL 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055 103 QCVASHPETRTAFLQAQIPLYLYPFLSTTSKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIVPLCLSIMDSGSEL 182
Cdd:COG5209 125 QCLASHPETKKVFLDAHIPLFLYPFLNTSSSNSKFEYLRLTSLGVIGALVKNDSQYVIKFLLTTEIVPLCLRIMELGSEL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055 183 SKTVATFIIQKILLDESGLSYICQTYERFSHVAITLGKMVIQLAKDPCARLLKHVVRCYLRLSDNTRARKALGQCLPDQL 262
Cdd:COG5209 205 SKTVAIFIFQKILGDDVGLQYICQTFERFYAVNLVLNSMVSQLVSLGSTRLLKHAIRCYLRLSDKPHARALLSSKLPDGL 284

                       250       260
                ....*....|....*....|....*...
gi 20129055 263 RDGTFALCLQEDKSTKQWLQMLLKNLEL 290
Cdd:COG5209 285 RDDTFSLVLADDGGSKECLAQLLTFLNL 312
 
Name Accession Description Interval E-value
Rcd1 pfam04078
Cell differentiation family, Rcd1-like; Two of the members in this family have been ...
 32-288 1.51e-170

Cell differentiation family, Rcd1-like; Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.


Pssm-ID: 461160  Cd Length: 259  Bit Score: 472.83  E-value: 1.51e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055    32 WINELAHPDTRETALLELSKKRET--DLAPMLWNSFGTACALLQEIVNIYPSITPPTLTAHQSNRVCNALALLQCVASHP 109
Cdd:pfam04078   1 LILDLTDPEKREEALLELSKKRESfpDLAPLLWHSFGTMAALLQEIVSIYPLLSPPTLTERESNRVCNALALLQCVASHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055   110 ETRTAFLQAQIPLYLYPFLSTTSKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIVPLCLSIMDSGSELSKTVATF 189
Cdd:pfam04078  81 ETRSLFLRAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALVKTDDPEVINFLLDTEIVPLCLRIMESGSELSKTVATF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055   190 IIQKILLDESGLSYICQTYERFSHVAITLGKMVIQLAKDPCARLLKHVVRCYLRLSDNTRARKALGQCLPDQLRDGTFAL 269
Cdd:pfam04078 161 ILQKILSDDDGLNYICQTPDRFSAVAQVLNSMVVQLVEQPSPRLLKHVIRCYLRLSDNPRAREALRSCLPELLKDGTFSS 240

                         250
                  ....*....|....*....
gi 20129055   270 CLQEDKSTKQWLQMLLKNL 288
Cdd:pfam04078 241 LLKDDPETKRWLKQLLHNL 259
RCD1 COG5209
Uncharacterized protein involved in cell differentiation/sexual development [General function ...
 25-290 2.28e-118

Uncharacterized protein involved in cell differentiation/sexual development [General function prediction only];


Pssm-ID: 227534  Cd Length: 315  Bit Score: 342.66  E-value: 2.28e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055  25 EQEKVYQWINELAHPDTRETALLELSKKRET--DLAPMLWNSFGTACALLQEIVNIYPSITPPTLTAHQSNRVCNALALL 102
Cdd:COG5209  45 RQALVYSWICQLVVGNPKEQALDELFRKREQspDLALELWRSDGVMTFLLQEIISVYPILSPSKLDERESNRVCNALNLL 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055 103 QCVASHPETRTAFLQAQIPLYLYPFLSTTSKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIVPLCLSIMDSGSEL 182
Cdd:COG5209 125 QCLASHPETKKVFLDAHIPLFLYPFLNTSSSNSKFEYLRLTSLGVIGALVKNDSQYVIKFLLTTEIVPLCLRIMELGSEL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129055 183 SKTVATFIIQKILLDESGLSYICQTYERFSHVAITLGKMVIQLAKDPCARLLKHVVRCYLRLSDNTRARKALGQCLPDQL 262
Cdd:COG5209 205 SKTVAIFIFQKILGDDVGLQYICQTFERFYAVNLVLNSMVSQLVSLGSTRLLKHAIRCYLRLSDKPHARALLSSKLPDGL 284

                       250       260
                ....*....|....*....|....*...
gi 20129055 263 RDGTFALCLQEDKSTKQWLQMLLKNLEL 290
Cdd:COG5209 285 RDDTFSLVLADDGGSKECLAQLLTFLNL 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH