NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24643654|ref|NP_608439|]
View 

uncharacterized protein Dmel_CG1724 [Drosophila melanogaster]

Protein Classification

Tim17/Tim22/Tim23/Pmp24 domain-containing protein( domain architecture ID 1013)

Tim17/Tim22/Tim23/Pmp24 domain-containing protein similar to Homo sapiens NADH:ubiquinone oxidoreductase subunit A11 and translocase of inner mitochondrial membrane 17B

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TIM22 super family cl02381
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 1-147 1.56e-66

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member TIGR00980:

Pssm-ID: 470560  Cd Length: 170  Bit Score: 201.22  E-value: 1.56e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654     1 MEEYSREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGLKRRfaGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSL 80
Cdd:TIGR00980   1 MEEYTREPCPYRILDDFGGAFAMGTIGGSIFQAFKGFRNSPKGEKLV--GAMRAIKTRAPVLGGNFAVWGGLFSTIDCAV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24643654    81 VHLRKKEDPWNSIMSGAIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQFRNSDPQ 147
Cdd:TIGR00980  79 VAIRKKEDPWNSIISGFLTGAALAVRGGPRAMRGSAILGACILAVIEGVGLVLTRWAAAQMDPTAPE 145
 
Name Accession Description Interval E-value
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 1-147 1.56e-66

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 201.22  E-value: 1.56e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654     1 MEEYSREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGLKRRfaGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSL 80
Cdd:TIGR00980   1 MEEYTREPCPYRILDDFGGAFAMGTIGGSIFQAFKGFRNSPKGEKLV--GAMRAIKTRAPVLGGNFAVWGGLFSTIDCAV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24643654    81 VHLRKKEDPWNSIMSGAIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQFRNSDPQ 147
Cdd:TIGR00980  79 VAIRKKEDPWNSIISGFLTGAALAVRGGPRAMRGSAILGACILAVIEGVGLVLTRWAAAQMDPTAPE 145
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 1-140 7.98e-58

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 178.70  E-value: 7.98e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654    1 MEEYSREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGLkrRFAGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSL 80
Cdd:PTZ00236   3 ERDLSREPCPDRIIEDMGGAFSMGCIGGFIWHFLKGMRNSPKGE--RFSGGFYLLRKRAPILGGNFAIWGGLFSTFDCTL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654   81 VHLRKKEDPWNSIMSGAIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQ 140
Cdd:PTZ00236  81 QYLRGKEDHWNAIASGFFTGGVLAIRGGWRSAVRNAIFGGILLGIIELVSIGMNRRQMRT 140
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 13-121 1.23e-29

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 104.95  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654    13 IVDDCGGAFTMGCFGGGLFQGLKGFRNAP--QGLKRRFAGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSLVHLRKKEDPW 90
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNRPppLTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPW 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 24643654    91 NSIMSGAIAGGILssRNGVAAMFGSAIIGGV 121
Cdd:pfam02466  81 NSIAAGALTGALL--RGGPRAAAVGGAVGAA 109
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 5-140 7.03e-16

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 71.81  E-value: 7.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654   5 SREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGlkRRFAGGLAAVKSRSPTIGGNFAA-WGCVFSIVDCSLVHL 83
Cdd:COG5596  26 ERDPCPLEKLADFMKAFSYSCIGKSALSGLKGFRLGGPS--GGFSSSLAYGTGLVHLLGLNFGGvWGGLFSTIDCTPFRL 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24643654  84 RKKEDPWNSIMSG-------AIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQ 140
Cdd:COG5596 104 QLKEQLNNAGKRGfftgknlGVLGLIYAGINSIITALRAKHDIANAIAAGAFTGAALASSAGPQ 167
 
Name Accession Description Interval E-value
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 1-147 1.56e-66

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 201.22  E-value: 1.56e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654     1 MEEYSREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGLKRRfaGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSL 80
Cdd:TIGR00980   1 MEEYTREPCPYRILDDFGGAFAMGTIGGSIFQAFKGFRNSPKGEKLV--GAMRAIKTRAPVLGGNFAVWGGLFSTIDCAV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24643654    81 VHLRKKEDPWNSIMSGAIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQFRNSDPQ 147
Cdd:TIGR00980  79 VAIRKKEDPWNSIISGFLTGAALAVRGGPRAMRGSAILGACILAVIEGVGLVLTRWAAAQMDPTAPE 145
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 1-140 7.98e-58

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 178.70  E-value: 7.98e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654    1 MEEYSREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGLkrRFAGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSL 80
Cdd:PTZ00236   3 ERDLSREPCPDRIIEDMGGAFSMGCIGGFIWHFLKGMRNSPKGE--RFSGGFYLLRKRAPILGGNFAIWGGLFSTFDCTL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654   81 VHLRKKEDPWNSIMSGAIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQ 140
Cdd:PTZ00236  81 QYLRGKEDHWNAIASGFFTGGVLAIRGGWRSAVRNAIFGGILLGIIELVSIGMNRRQMRT 140
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 13-121 1.23e-29

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 104.95  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654    13 IVDDCGGAFTMGCFGGGLFQGLKGFRNAP--QGLKRRFAGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSLVHLRKKEDPW 90
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNRPppLTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPW 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 24643654    91 NSIMSGAIAGGILssRNGVAAMFGSAIIGGV 121
Cdd:pfam02466  81 NSIAAGALTGALL--RGGPRAAAVGGAVGAA 109
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 5-140 7.03e-16

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 71.81  E-value: 7.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654   5 SREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGlkRRFAGGLAAVKSRSPTIGGNFAA-WGCVFSIVDCSLVHL 83
Cdd:COG5596  26 ERDPCPLEKLADFMKAFSYSCIGKSALSGLKGFRLGGPS--GGFSSSLAYGTGLVHLLGLNFGGvWGGLFSTIDCTPFRL 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24643654  84 RKKEDPWNSIMSG-------AIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQ 140
Cdd:COG5596 104 QLKEQLNNAGKRGfftgknlGVLGLIYAGINSIITALRAKHDIANAIAAGAFTGAALASSAGPQ 167
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 18-124 3.86e-08

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 50.22  E-value: 3.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643654    18 GGAFTMGC-FGG--GLFQGLKGFRNAPQGlKRRFAGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSLVHLRKKEDPWNSIM 94
Cdd:TIGR00983  39 GTCYLTGLaIGAlnGLRLGLKETQSMPWT-KLRLNQILNMVTRRGPFWGNTLGILALVYNGINSIIEATRGKHDDFNSVA 117

                          90       100       110
                  ....*....|....*....|....*....|
gi 24643654    95 SGAIAGGILSSRNGVAAMFGSAIIGGVLLS 124
Cdd:TIGR00983 118 AGALTGALYKSTRGLRGMARSGALGATAAG 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH