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Conserved domains on  [gi|19920412|ref|NP_608450|]
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uncharacterized protein Dmel_CG1486, isoform A [Drosophila melanogaster]

Protein Classification

pyridoxal phosphate-dependent decarboxylase family protein( domain architecture ID 1903557)

pyridoxal phosphate-dependent decarboxylase family protein is primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but it is also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GadA super family cl43018
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 157-410 4.44e-19

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


The actual alignment was detected with superfamily member COG0076:

Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 91.05  E-value: 4.44e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 157 ATRWLGTLFHFAhpassfhaDNADAVLRT---------VRLAIVARCPGYL-EGGIPALAQPTFYISENTtpmrlHY--- 223
Cdd:COG0076 112 VVRWLADLLGLP--------EGAGGVFTSggteanllaLLAARDRALARRVrAEGLPGAPRPRIVVSEEA-----HSsvd 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 224 -ACRQLGIPLEAIKVIPeHSQSGTMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLHASG 302
Cdd:COG0076 179 kAARLLGLGRDALRKVP-VDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDA 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 303 -HGLAALVCAQNQGH---VEEVlHSMALNLGSWLGVP-SLPIVLL-HRPLQNSALSaFESD----------------PIL 360
Cdd:COG0076 258 aYGGFALPSPELRHLldgIERA-DSITVDPHKWLYVPyGCGAVLVrDPELLREAFS-FHASylgpaddgvpnlgdytLEL 335

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 19920412 361 SRRLNALSLWTSLQALGRKAIAERLHVAFQTCSILFEIASKCEGIRVLSH 410
Cdd:COG0076 336 SRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP 385
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 157-410 4.44e-19

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 91.05  E-value: 4.44e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 157 ATRWLGTLFHFAhpassfhaDNADAVLRT---------VRLAIVARCPGYL-EGGIPALAQPTFYISENTtpmrlHY--- 223
Cdd:COG0076 112 VVRWLADLLGLP--------EGAGGVFTSggteanllaLLAARDRALARRVrAEGLPGAPRPRIVVSEEA-----HSsvd 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 224 -ACRQLGIPLEAIKVIPeHSQSGTMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLHASG 302
Cdd:COG0076 179 kAARLLGLGRDALRKVP-VDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDA 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 303 -HGLAALVCAQNQGH---VEEVlHSMALNLGSWLGVP-SLPIVLL-HRPLQNSALSaFESD----------------PIL 360
Cdd:COG0076 258 aYGGFALPSPELRHLldgIERA-DSITVDPHKWLYVPyGCGAVLVrDPELLREAFS-FHASylgpaddgvpnlgdytLEL 335

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 19920412 361 SRRLNALSLWTSLQALGRKAIAERLHVAFQTCSILFEIASKCEGIRVLSH 410
Cdd:COG0076 336 SRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP 385
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 159-384 1.61e-13

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 72.62  E-value: 1.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 159 RWLGTLFHFAHPASS--FHADNADAVLRTVRLAIVARCPGYLEGGIPALAQPTFYISENTtpmrlHY----ACRQLGIPL 232
Cdd:cd06450  45 NWLAKLFGLPSEDADgvFTSGGSESNLLALLAARDRARKRLKAGGGRGIDKLVIVCSDQA-----HVsvekAAAYLDVKV 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 233 EAIKVIPEHsqsgTMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLH---ASghGLAALV 309
Cdd:cd06450 120 RLVPVDEDG----RMDPEALEAAIDEDKAEGLNPIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHvdaAY--GGFLLP 193

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920412 310 CAQNQGH---VEEVlHSMALNLGSWLGVpslpivllhrPLQNSAlsafesdpILSRrlnALSLWTSLQALGRKAIAER 384
Cdd:cd06450 194 FPEPRHLdfgIERV-DSISVDPHKYGLV----------PLGCSA--------VLVR---ALKLWATLRRFGRDGYGEH 249
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
192-379 2.36e-11

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 66.29  E-value: 2.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412   192 ARCPGYLEGGIPAlaQPTFYISENTtpmrlHY----ACRQLGIPLEAIKVipehSQSGTMDVTLLQKQIQQDVGNNRTPL 267
Cdd:pfam00282 132 AAGKPADSSGILA--KLVAYTSDQA-----HSsiekAALYGGVKLREIPS----DDNGKMRGMDLEKAIEEDKENGLIPF 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412   268 LVVADIGASLCGYVDNLLRLRDVCKAHNMWLH---ASGHGlaALVCAQNQGHVE--EVLHSMALNLGSWLGVP---SLPI 339
Cdd:pfam00282 201 FVVATLGTTGSGAFDDLQELGDICAKHNLWLHvdaAYGGS--AFICPEFRHWLFgiERADSITFNPHKWMLVLldcSAVW 278

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 19920412   340 V----LLHRPLQNSALSAFESDPI---------LSRRLNALSLWTSLQALGRK 379
Cdd:pfam00282 279 VkdkeALQQAFQFNPLYLGHTDSAydtghkqipLSRRFRILKLWFVIRSLGVE 331
PLN02880 PLN02880
tyrosine decarboxylase
 201-377 2.33e-06

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 51.06  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412  201 GIPALAQPTFYISENTTPMrLHYACRQLGIPLEAIKVIPEHSQSG-TMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCG 279
Cdd:PLN02880 175 GKNALEKLVVYASDQTHSA-LQKACQIAGIHPENCRLLKTDSSTNyALAPELLSEAISTDLSSGLIPFFLCATVGTTSST 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412  280 YVDNLLRLRDVCKAHNMWLHA-SGHGLAALVCAQNQGHVE--EVLHSMALNLGSW-------------------LGVPSL 337
Cdd:PLN02880 254 AVDPLLELGKIAKSNGMWFHVdAAYAGSACICPEYRHYIDgvEEADSFNMNAHKWfltnfdcsllwvkdrnaliQSLSTN 333

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 19920412  338 PIVLLHRPLQNSALSAFESDPI-LSRRLNALSLWTSLQALG 377
Cdd:PLN02880 334 PEFLKNKASQANSVVDYKDWQIpLGRRFRSLKLWMVLRLYG 374
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 157-410 4.44e-19

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 91.05  E-value: 4.44e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 157 ATRWLGTLFHFAhpassfhaDNADAVLRT---------VRLAIVARCPGYL-EGGIPALAQPTFYISENTtpmrlHY--- 223
Cdd:COG0076 112 VVRWLADLLGLP--------EGAGGVFTSggteanllaLLAARDRALARRVrAEGLPGAPRPRIVVSEEA-----HSsvd 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 224 -ACRQLGIPLEAIKVIPeHSQSGTMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLHASG 302
Cdd:COG0076 179 kAARLLGLGRDALRKVP-VDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDA 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 303 -HGLAALVCAQNQGH---VEEVlHSMALNLGSWLGVP-SLPIVLL-HRPLQNSALSaFESD----------------PIL 360
Cdd:COG0076 258 aYGGFALPSPELRHLldgIERA-DSITVDPHKWLYVPyGCGAVLVrDPELLREAFS-FHASylgpaddgvpnlgdytLEL 335

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 19920412 361 SRRLNALSLWTSLQALGRKAIAERLHVAFQTCSILFEIASKCEGIRVLSH 410
Cdd:COG0076 336 SRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP 385
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 159-384 1.61e-13

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 72.62  E-value: 1.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 159 RWLGTLFHFAHPASS--FHADNADAVLRTVRLAIVARCPGYLEGGIPALAQPTFYISENTtpmrlHY----ACRQLGIPL 232
Cdd:cd06450  45 NWLAKLFGLPSEDADgvFTSGGSESNLLALLAARDRARKRLKAGGGRGIDKLVIVCSDQA-----HVsvekAAAYLDVKV 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412 233 EAIKVIPEHsqsgTMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLH---ASghGLAALV 309
Cdd:cd06450 120 RLVPVDEDG----RMDPEALEAAIDEDKAEGLNPIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHvdaAY--GGFLLP 193

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920412 310 CAQNQGH---VEEVlHSMALNLGSWLGVpslpivllhrPLQNSAlsafesdpILSRrlnALSLWTSLQALGRKAIAER 384
Cdd:cd06450 194 FPEPRHLdfgIERV-DSISVDPHKYGLV----------PLGCSA--------VLVR---ALKLWATLRRFGRDGYGEH 249
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
192-379 2.36e-11

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 66.29  E-value: 2.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412   192 ARCPGYLEGGIPAlaQPTFYISENTtpmrlHY----ACRQLGIPLEAIKVipehSQSGTMDVTLLQKQIQQDVGNNRTPL 267
Cdd:pfam00282 132 AAGKPADSSGILA--KLVAYTSDQA-----HSsiekAALYGGVKLREIPS----DDNGKMRGMDLEKAIEEDKENGLIPF 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412   268 LVVADIGASLCGYVDNLLRLRDVCKAHNMWLH---ASGHGlaALVCAQNQGHVE--EVLHSMALNLGSWLGVP---SLPI 339
Cdd:pfam00282 201 FVVATLGTTGSGAFDDLQELGDICAKHNLWLHvdaAYGGS--AFICPEFRHWLFgiERADSITFNPHKWMLVLldcSAVW 278

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 19920412   340 V----LLHRPLQNSALSAFESDPI---------LSRRLNALSLWTSLQALGRK 379
Cdd:pfam00282 279 VkdkeALQQAFQFNPLYLGHTDSAydtghkqipLSRRFRILKLWFVIRSLGVE 331
PLN02880 PLN02880
tyrosine decarboxylase
 201-377 2.33e-06

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 51.06  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412  201 GIPALAQPTFYISENTTPMrLHYACRQLGIPLEAIKVIPEHSQSG-TMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCG 279
Cdd:PLN02880 175 GKNALEKLVVYASDQTHSA-LQKACQIAGIHPENCRLLKTDSSTNyALAPELLSEAISTDLSSGLIPFFLCATVGTTSST 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920412  280 YVDNLLRLRDVCKAHNMWLHA-SGHGLAALVCAQNQGHVE--EVLHSMALNLGSW-------------------LGVPSL 337
Cdd:PLN02880 254 AVDPLLELGKIAKSNGMWFHVdAAYAGSACICPEYRHYIDgvEEADSFNMNAHKWfltnfdcsllwvkdrnaliQSLSTN 333

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 19920412  338 PIVLLHRPLQNSALSAFESDPI-LSRRLNALSLWTSLQALG 377
Cdd:PLN02880 334 PEFLKNKASQANSVVDYKDWQIpLGRRFRSLKLWMVLRLYG 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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