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Conserved domains on  [gi|19920472|ref|NP_608531|]
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translocator protein [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TspO_MBR pfam03073
TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that ...
 16-161 1.25e-56

TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.


:

Pssm-ID: 460795  Cd Length: 144  Bit Score: 175.09  E-value: 1.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920472    16 AVILPNLGGIYNGRLTRQHLQSWYANLKFPSFKPPNSVFAPMWISLYAGMGYGSYLVWRDGGGFAgeaAKLPLIAYGTQL 95
Cdd:pfam03073   1 AVALPLAVGLLGGLFTRSSISDWYASLKKPPWTPPNWVFPPVWTVLYILMGIAAYLVWRAGGGSG---RKLALGLYGLQL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19920472    96 ALNWAWTPIFFGQHNIKGGLIDIVALTAAASACGVLFYRVNKTAGLLFVPYVAWLGFATALNYAIW 161
Cdd:pfam03073  78 ALNLLWSPLFFGLRSPGLALVDILALWGLVLATILAFYRISKLAALLLVPYLLWLSFATYLNYGIW 143
 
Name Accession Description Interval E-value
TspO_MBR pfam03073
TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that ...
 16-161 1.25e-56

TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.


Pssm-ID: 460795  Cd Length: 144  Bit Score: 175.09  E-value: 1.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920472    16 AVILPNLGGIYNGRLTRQHLQSWYANLKFPSFKPPNSVFAPMWISLYAGMGYGSYLVWRDGGGFAgeaAKLPLIAYGTQL 95
Cdd:pfam03073   1 AVALPLAVGLLGGLFTRSSISDWYASLKKPPWTPPNWVFPPVWTVLYILMGIAAYLVWRAGGGSG---RKLALGLYGLQL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19920472    96 ALNWAWTPIFFGQHNIKGGLIDIVALTAAASACGVLFYRVNKTAGLLFVPYVAWLGFATALNYAIW 161
Cdd:pfam03073  78 ALNLLWSPLFFGLRSPGLALVDILALWGLVLATILAFYRISKLAALLLVPYLLWLSFATYLNYGIW 143
TSPO_MBR cd15904
Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family ...
 13-161 2.87e-56

Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.


Pssm-ID: 320706  Cd Length: 142  Bit Score: 173.84  E-value: 2.87e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920472  13 IAGAVILPNLGGIyngrLTRQHLQSWYANLKFPSFKPPNSVFAPMWISLYAGMGYGSYLVWRDGGGfagEAAKLPLIAYG 92
Cdd:cd15904   1 LALALAVGLLGGL----LTGSSIGEWYASLNKPSWTPPNWVFGPVWTILYILMGIAAYLVWRAGGF---AGRKLALALYA 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19920472  93 TQLALNWAWTPIFFGQHNIKGGLIDIVALTAAASACGVLFYRVNKTAGLLFVPYVAWLGFATALNYAIW 161
Cdd:cd15904  74 VQLALNLLWSPLFFGLHRPGLALVVILALWLLILATIVAFWRVSRLAALLLLPYLAWVSFATYLNYSIW 142
TspO COG3476
Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog) ...
 9-164 1.82e-51

Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms];


Pssm-ID: 442699  Cd Length: 152  Bit Score: 162.30  E-value: 1.82e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920472   9 NILRIAGAVILPNLGGIYNGRLTrQHLQSWYANLKFPSFKPPNSVFAPMWISLYAGMGYGSYLVWRDGGGfagEAAKLPL 88
Cdd:COG3476   1 SWLALILFLAAVLAAGALGGLLT-PSDGEWYASLNKPSWTPPNWVFGPVWTVLYILMAVAAWLVWRAAGS---SERRLAL 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19920472  89 IAYGTQLALNWAWTPIFFGQHNIKGGLIDIVALTAAASACGVLFYRVNKTAGLLFVPYVAWLGFATALNYAIWKLN 164
Cdd:COG3476  77 ALFALQLVLNALWSPLFFGLHSLGLALIVILLLWLLILATILAFWRVSRLAALLLLPYLLWVSFATYLNAAIWRLN 152
 
Name Accession Description Interval E-value
TspO_MBR pfam03073
TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that ...
 16-161 1.25e-56

TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.


Pssm-ID: 460795  Cd Length: 144  Bit Score: 175.09  E-value: 1.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920472    16 AVILPNLGGIYNGRLTRQHLQSWYANLKFPSFKPPNSVFAPMWISLYAGMGYGSYLVWRDGGGFAgeaAKLPLIAYGTQL 95
Cdd:pfam03073   1 AVALPLAVGLLGGLFTRSSISDWYASLKKPPWTPPNWVFPPVWTVLYILMGIAAYLVWRAGGGSG---RKLALGLYGLQL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19920472    96 ALNWAWTPIFFGQHNIKGGLIDIVALTAAASACGVLFYRVNKTAGLLFVPYVAWLGFATALNYAIW 161
Cdd:pfam03073  78 ALNLLWSPLFFGLRSPGLALVDILALWGLVLATILAFYRISKLAALLLVPYLLWLSFATYLNYGIW 143
TSPO_MBR cd15904
Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family ...
 13-161 2.87e-56

Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.


Pssm-ID: 320706  Cd Length: 142  Bit Score: 173.84  E-value: 2.87e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920472  13 IAGAVILPNLGGIyngrLTRQHLQSWYANLKFPSFKPPNSVFAPMWISLYAGMGYGSYLVWRDGGGfagEAAKLPLIAYG 92
Cdd:cd15904   1 LALALAVGLLGGL----LTGSSIGEWYASLNKPSWTPPNWVFGPVWTILYILMGIAAYLVWRAGGF---AGRKLALALYA 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19920472  93 TQLALNWAWTPIFFGQHNIKGGLIDIVALTAAASACGVLFYRVNKTAGLLFVPYVAWLGFATALNYAIW 161
Cdd:cd15904  74 VQLALNLLWSPLFFGLHRPGLALVVILALWLLILATIVAFWRVSRLAALLLLPYLAWVSFATYLNYSIW 142
TspO COG3476
Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog) ...
 9-164 1.82e-51

Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms];


Pssm-ID: 442699  Cd Length: 152  Bit Score: 162.30  E-value: 1.82e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920472   9 NILRIAGAVILPNLGGIYNGRLTrQHLQSWYANLKFPSFKPPNSVFAPMWISLYAGMGYGSYLVWRDGGGfagEAAKLPL 88
Cdd:COG3476   1 SWLALILFLAAVLAAGALGGLLT-PSDGEWYASLNKPSWTPPNWVFGPVWTVLYILMAVAAWLVWRAAGS---SERRLAL 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19920472  89 IAYGTQLALNWAWTPIFFGQHNIKGGLIDIVALTAAASACGVLFYRVNKTAGLLFVPYVAWLGFATALNYAIWKLN 164
Cdd:COG3476  77 ALFALQLVLNALWSPLFFGLHSLGLALIVILLLWLLILATILAFWRVSRLAALLLLPYLLWVSFATYLNAAIWRLN 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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