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Conserved domains on  [gi|19920666|ref|NP_608817|]
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uncharacterized protein Dmel_CG2955 [Drosophila melanogaster]

Protein Classification

RP/EB family microtubule-associated protein( domain architecture ID 1000504)

RP/EB family microtubule-associated protein may play important roles in microtubule dynamic regulation, cytokinesis, mitotic spindle positioning, and episome segregation

Gene Ontology:  GO:0008017|GO:0051301
PubMed:  10188731

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BIM1 super family cl34944
Microtubule-binding protein involved in cell cycle control [Cell division and chromosome ...
 10-116 7.58e-09

Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton];


The actual alignment was detected with superfamily member COG5217:

Pssm-ID: 227542 [Multi-domain]  Cd Length: 342  Bit Score: 57.70  E-value: 7.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920666  10 GNSASRRRILGWINNNLGTTYVRLEELRTGAEYCRMLHKLQPSaIRLKRVFKEPKSHYECVQNMKLLQKSLLKQGVEKQI 89
Cdd:COG5217   4 ALVESREELLFWENVVVRLDLQRIEDCGEGFAMQQIHDSIYVD-LPDSLVRFPWIAEYKHPGNGKILQLLFSDYGIDKAV 82

                        90       100
                ....*....|....*....|....*..
gi 19920666  90 PIQRLVSRGNSESLEFAQWFKAFYDHN 116
Cdd:COG5217  83 LVLVLVRCKLQDNLEFLQWLKDHWVRN 109
 
Name Accession Description Interval E-value
BIM1 COG5217
Microtubule-binding protein involved in cell cycle control [Cell division and chromosome ...
 10-116 7.58e-09

Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton];


Pssm-ID: 227542 [Multi-domain]  Cd Length: 342  Bit Score: 57.70  E-value: 7.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920666  10 GNSASRRRILGWINNNLGTTYVRLEELRTGAEYCRMLHKLQPSaIRLKRVFKEPKSHYECVQNMKLLQKSLLKQGVEKQI 89
Cdd:COG5217   4 ALVESREELLFWENVVVRLDLQRIEDCGEGFAMQQIHDSIYVD-LPDSLVRFPWIAEYKHPGNGKILQLLFSDYGIDKAV 82

                        90       100
                ....*....|....*....|....*..
gi 19920666  90 PIQRLVSRGNSESLEFAQWFKAFYDHN 116
Cdd:COG5217  83 LVLVLVRCKLQDNLEFLQWLKDHWVRN 109
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 15-87 7.57e-05

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 41.94  E-value: 7.57e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920666  15 RRRILGWINNNLGTTYVR-----LEELRTGAEYCRMLHKLQPSAIrlKRVFKEPKSHYECVQNMKLLQKSLLKQGVEK 87
Cdd:cd00014   1 EEELLKWINEVLGEELPVsitdlFESLRDGVLLCKLINKLSPGSI--PKINKKPKSPFKKRENINLFLNACKKLGLPE 76
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 14-87 1.62e-04

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 41.12  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920666    14 SRRRILGWINNNLGTTYVRL------EELRTGAEYCRMLHKLQPSAIRLKRVfkePKSHYECVQNMKL-LQKSLLKQGVE 86
Cdd:pfam00307   3 LEKELLRWINSHLAEYGPGVrvtnftTDLRDGLALCALLNKLAPGLVDKKKL---NKSEFDKLENINLaLDVAEKKLGVP 79


                  .
gi 19920666    87 K 87
Cdd:pfam00307  80 K 80
 
Name Accession Description Interval E-value
BIM1 COG5217
Microtubule-binding protein involved in cell cycle control [Cell division and chromosome ...
 10-116 7.58e-09

Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton];


Pssm-ID: 227542 [Multi-domain]  Cd Length: 342  Bit Score: 57.70  E-value: 7.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920666  10 GNSASRRRILGWINNNLGTTYVRLEELRTGAEYCRMLHKLQPSaIRLKRVFKEPKSHYECVQNMKLLQKSLLKQGVEKQI 89
Cdd:COG5217   4 ALVESREELLFWENVVVRLDLQRIEDCGEGFAMQQIHDSIYVD-LPDSLVRFPWIAEYKHPGNGKILQLLFSDYGIDKAV 82

                        90       100
                ....*....|....*....|....*..
gi 19920666  90 PIQRLVSRGNSESLEFAQWFKAFYDHN 116
Cdd:COG5217  83 LVLVLVRCKLQDNLEFLQWLKDHWVRN 109
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 15-87 7.57e-05

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 41.94  E-value: 7.57e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920666  15 RRRILGWINNNLGTTYVR-----LEELRTGAEYCRMLHKLQPSAIrlKRVFKEPKSHYECVQNMKLLQKSLLKQGVEK 87
Cdd:cd00014   1 EEELLKWINEVLGEELPVsitdlFESLRDGVLLCKLINKLSPGSI--PKINKKPKSPFKKRENINLFLNACKKLGLPE 76
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 14-87 1.62e-04

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 41.12  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920666    14 SRRRILGWINNNLGTTYVRL------EELRTGAEYCRMLHKLQPSAIRLKRVfkePKSHYECVQNMKL-LQKSLLKQGVE 86
Cdd:pfam00307   3 LEKELLRWINSHLAEYGPGVrvtnftTDLRDGLALCALLNKLAPGLVDKKKL---NKSEFDKLENINLaLDVAEKKLGVP 79


                  .
gi 19920666    87 K 87
Cdd:pfam00307  80 K 80
CH_betaPIX cd21266
calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak ...
 36-74 5.35e-03

calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409115  Cd Length: 112  Bit Score: 36.82  E-value: 5.35e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 19920666  36 LRTGAEYCRMLHKLQPSAIrlKRVFKEPKSHYECVQNMK 74
Cdd:cd21266  33 LKDGVVLCRLLERLLPGSI--DKVYPEPRTESECLSNIR 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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