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Conserved domains on  [gi|45550124|ref|NP_608861|]
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uncharacterized protein Dmel_CG15628, isoform A [Drosophila melanogaster]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10552919)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; similar to the C-terminal region of the D. melanogaster hypothetical protein FR47

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|9175471|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 196-281 1.21e-38

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


:

Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 132.84  E-value: 1.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124   196 GLGIFRKETGELAAWMVHSYYGAMFSMQTRPDFRRMGYGIRLAKSLTQLVIERGYTPFVVIRPGNDASRSLYTKLGYEKA 275
Cdd:pfam08445   1 VLGIYRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKLGFRKI 80


                  ....*.
gi 45550124   276 FETCRV 281
Cdd:pfam08445  81 DETYWV 86
 
Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 196-281 1.21e-38

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 132.84  E-value: 1.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124   196 GLGIFRKETGELAAWMVHSYYGAMFSMQTRPDFRRMGYGIRLAKSLTQLVIERGYTPFVVIRPGNDASRSLYTKLGYEKA 275
Cdd:pfam08445   1 VLGIYRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKLGFRKI 80


                  ....*.
gi 45550124   276 FETCRV 281
Cdd:pfam08445  81 DETYWV 86
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
208-286 2.96e-11

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 59.15  E-value: 2.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124 208 AAWMVHSYYGAMFS-MQTRPDFRRMGYGIRLAKSLTQLVIERGY-TPFVVIRPGNDASRSLYTKLGYEKAFETCRVRMTP 285
Cdd:COG3393   6 AGVRAESPGVAEISgVYTHPEYRGRGLASALVAALAREALARGArTPFLYVDADNPAARRLYERLGFRPVGEYATVLFRK 85


                .
gi 45550124 286 D 286
Cdd:COG3393  86 P 86
PRK03624 PRK03624
putative acetyltransferase; Provisional
 217-273 1.21e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 44.53  E-value: 1.21e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 45550124  217 GAMFSMQTRPDFRRMGYGIRLAKSLTQLVIERGyTPFV--VIRPGNDASRSLYTKLGYE 273
Cdd:PRK03624  69 GWAYYLAVHPDFRGRGIGRALVARLEKKLIARG-CPKInlQVREDNDAVLGFYEALGYE 126
 
Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 196-281 1.21e-38

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 132.84  E-value: 1.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124   196 GLGIFRKETGELAAWMVHSYYGAMFSMQTRPDFRRMGYGIRLAKSLTQLVIERGYTPFVVIRPGNDASRSLYTKLGYEKA 275
Cdd:pfam08445   1 VLGIYRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKLGFRKI 80


                  ....*.
gi 45550124   276 FETCRV 281
Cdd:pfam08445  81 DETYWV 86
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
208-286 2.96e-11

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 59.15  E-value: 2.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124 208 AAWMVHSYYGAMFS-MQTRPDFRRMGYGIRLAKSLTQLVIERGY-TPFVVIRPGNDASRSLYTKLGYEKAFETCRVRMTP 285
Cdd:COG3393   6 AGVRAESPGVAEISgVYTHPEYRGRGLASALVAALAREALARGArTPFLYVDADNPAARRLYERLGFRPVGEYATVLFRK 85


                .
gi 45550124 286 D 286
Cdd:COG3393  86 P 86
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 174-272 1.52e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.44  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124   174 DLYPANEIECVQLFDILVRKLPGLGIFRKETGELAAWMV------HSYYGAMFSMQTRPDFRRMGYGIRLAKSLTQLVIE 247
Cdd:pfam00583  11 EFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASlsiiddEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE 90

                          90       100
                  ....*....|....*....|....*.
gi 45550124   248 RGYT-PFVVIRPGNDASRSLYTKLGY 272
Cdd:pfam00583  91 RGCErIFLEVAADNLAAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 216-293 8.50e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 43.88  E-value: 8.50e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550124 216 YGAMFSMQTRPDFRRMGYGIRLAKSLTQLVIERGYTP-FVVIRPGNDASRSLYTKLGYEkafetcRVRMTPDCYEDSTV 293
Cdd:COG0456  13 EAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRlRLEVREDNEAAIALYEKLGFE------EVGERPNYYGDDAL 85
PRK03624 PRK03624
putative acetyltransferase; Provisional
 217-273 1.21e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 44.53  E-value: 1.21e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 45550124  217 GAMFSMQTRPDFRRMGYGIRLAKSLTQLVIERGyTPFV--VIRPGNDASRSLYTKLGYE 273
Cdd:PRK03624  69 GWAYYLAVHPDFRGRGIGRALVARLEKKLIARG-CPKInlQVREDNDAVLGFYEALGYE 126
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 150-274 4.32e-05

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 43.45  E-value: 4.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124 150 LELEPL-PEDAE--MRLLNLDNVQGIHDLYPANEIECVQLFDILVR--KLPG---LGIFRKETGELAAWMvhSYYG---- 217
Cdd:COG1670   8 LRLRPLrPEDAEalAELLNDPEVARYLPGPPYSLEEARAWLERLLAdwADGGalpFAIEDKEDGELIGVV--GLYDidra 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45550124 218 ---AMFSMQTRPDFRRMGYGIRLAKSLTQLVIER-GYTPFV-VIRPGNDASRSLYTKLGYEK 274
Cdd:COG1670  86 nrsAEIGYWLAPAYWGKGYATEALRALLDYAFEElGLHRVEaEVDPDNTASIRVLEKLGFRL 147
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
225-274 4.45e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.44  E-value: 4.45e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 45550124 225 RPDFRRMGYGIRLAKSLTQLVIERGY-TPFVVIRPGNDASRSLYTKLGYEK 274
Cdd:COG1247  89 DPDARGRGIGRALLEALIERARARGYrRLVAVVLADNEASIALYEKLGFEE 139
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 222-274 2.21e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 40.81  E-value: 2.21e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 45550124 222 MQTRPDFRRMGYGIRLAKSLTQLVIERGYTPF-VVIRPGNDASRSLYTKLGYEK 274
Cdd:COG0454  64 LYVLPEYRGKGIGKALLEALLEWARERGCTALeLDTLDGNPAAIRFYERLGFKE 117
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 150-273 5.38e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 39.64  E-value: 5.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124   150 LELEPL-PEDAEmRLLNLDN---VQGIHDLYPANEIECVQLFDILVRKLP-----GLGIFRKETGELAA----WMVHSYY 216
Cdd:pfam13302   2 LLLRPLtEEDAE-ALFELLSdpeVMRYGVPWPLTLEEAREWLARIWAADEaergyGWAIELKDTGFIGSiglyDIDGEPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 45550124   217 GAMFSMQTRPDFRRMGYGIRLAKSLTQLVIERGYTPFVVIR--PGNDASRSLYTKLGYE 273
Cdd:pfam13302  81 RAELGYWLGPDYWGKGYATEAVRALLEYAFEELGLPRLVARidPENTASRRVLEKLGFK 139
Eis COG4552
Predicted acetyltransferase [General function prediction only];
197-286 9.33e-04

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 41.04  E-value: 9.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550124 197 LGIFrkETGELAAwMVHSY------YGAMFSMQ------TRPDFRRMGYGIRL-AKSLTQLViERGYtPFVVIRPgndAS 263
Cdd:COG4552  44 LGVF--DDGELVG-TLALYpftlnvGGARVPMAgitgvaVAPEHRRRGVARALlREALAELR-ERGQ-PLSALYP---FE 115

                        90       100
                ....*....|....*....|...
gi 45550124 264 RSLYTKLGYEKAFETCRVRMTPD 286
Cdd:COG4552 116 PGFYRRFGYELAGDRRRYTIPPE 138
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
225-288 5.64e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 36.99  E-value: 5.64e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45550124 225 RPDFRRMGYGIRLAKSLTQLVIERGYTPFVVIrpGNDASRSLYTKLGYEKAfETCRVRMTPDCY 288
Cdd:COG3153  76 DPEYRGQGIGRALMRAALEAARERGARAVVLL--GDPSLLPFYERFGFRPA-GELGLTLGPDEV 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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