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Conserved domains on  [gi|221472890|ref|NP_608971|]
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uncharacterized protein Dmel_CG9044, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIP1 super family cl24471
LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It ...
 1-96 1.00e-31

LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.


The actual alignment was detected with superfamily member pfam15904:

Pssm-ID: 464931  Cd Length: 90  Bit Score: 119.13  E-value: 1.00e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890     1 MDPQK-ITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTLIADTEIgtgagylQPQSFQVVKPINAKSSVFPDLQL 79
Cdd:pfam15904    1 SDPEPlVHSLANLLRNNGDLVLDGSSTLTLSASSLQHLTRSFEQHLLPRS-------HQHGFLALPSHPADTSSLLQLQF 73

                           90
                   ....*....|....*..
gi 221472890    80 VHDFVQKTTLLKLTYFP 96
Cdd:pfam15904   74 LFDMLQKTTSLKLIHVP 90
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-302 7.28e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 7.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  176 NSLRSVDtALEFAQHLQHLNLRHNKLTSVAAIKWLPHLKTLDLSYNC---------LTHLPQFHMEA------------- 233
Cdd:cd21340    34 NKITKIE-NLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRisvveglenLTNLEELHIENqrlppgekltfdp 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221472890  234 ------CKRLQLLNISNNYVEELLDVAKLDALYNLDLSDNCLLEHSQLL-PLSALMSLIVLNLQGNPLACNPKHRQ 302
Cdd:cd21340   113 rslaalSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRD 188
 
Name Accession Description Interval E-value
LIP1 pfam15904
LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It ...
 1-96 1.00e-31

LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.


Pssm-ID: 464931  Cd Length: 90  Bit Score: 119.13  E-value: 1.00e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890     1 MDPQK-ITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTLIADTEIgtgagylQPQSFQVVKPINAKSSVFPDLQL 79
Cdd:pfam15904    1 SDPEPlVHSLANLLRNNGDLVLDGSSTLTLSASSLQHLTRSFEQHLLPRS-------HQHGFLALPSHPADTSSLLQLQF 73

                           90
                   ....*....|....*..
gi 221472890    80 VHDFVQKTTLLKLTYFP 96
Cdd:pfam15904   74 LFDMLQKTTSLKLIHVP 90
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-302 7.28e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 7.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  176 NSLRSVDtALEFAQHLQHLNLRHNKLTSVAAIKWLPHLKTLDLSYNC---------LTHLPQFHMEA------------- 233
Cdd:cd21340    34 NKITKIE-NLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRisvveglenLTNLEELHIENqrlppgekltfdp 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221472890  234 ------CKRLQLLNISNNYVEELLDVAKLDALYNLDLSDNCLLEHSQLL-PLSALMSLIVLNLQGNPLACNPKHRQ 302
Cdd:cd21340   113 rslaalSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRD 188
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-294 5.14e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 5.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890   85 QKTTLLKLTYFPSEHYFEGAIDIAKFRALRRLEVNKINIGQVVGIQPLRGQLQHLICVKSLTSVDDIITRCGGDNSNGFV 164
Cdd:COG4886    32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  165 WNELKTADFSYNSLRSVDTALEFAQHLQHLNLRHNKLTSV-AAIKWLPHLKTLDLSYNCLTHLPQFhMEACKRLQLLNIS 243
Cdd:COG4886   112 LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 221472890  244 NNYVEEL-LDVAKLDALYNLDLSDNCLlehSQL-LPLSALMSLIVLNLQGNPL 294
Cdd:COG4886   191 NNQITDLpEPLGNLTNLEELDLSGNQL---TDLpEPLANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
189-245 2.01e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 2.01e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 221472890   189 QHLQHLNLRHNKLTSV--AAIKWLPHLKTLDLSYNCLTHLPQFHMEACKRLQLLNISNN 245
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
166-349 8.04e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 8.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  166 NELKTADFSYNSLRSVDTALefAQHLQHLNLRHNKLTSVAAiKWLPHLKTLDLSYNCLTHLPQFHMEAckrLQLLNISNN 245
Cdd:PRK15370  283 EELRYLSVYDNSIRTLPAHL--PSGITHLNVQSNSLTALPE-TLPPGLKTLEAGENALTSLPASLPPE---LQVLDVSKN 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  246 YVEELLDVAKlDALYNLDLSDNCLLEHSQLLPlsalMSLIVLNLQGNPLACNPkhrQATAQYLHKNSATVKFVLDFEPLT 325
Cdd:PRK15370  357 QITVLPETLP-PTITTLDVSRNALTNLPENLP----AALQIMQASRNNLVRLP---ESLPHFRGEGPQPTRIIVEYNPFS 428

                         170       180
                  ....*....|....*....|....
gi 221472890  326 kaEKALTGSQkwRYISGLSHRSPR 349
Cdd:PRK15370  429 --ERTIQNMQ--RLMSSVGYQGPR 448
 
Name Accession Description Interval E-value
LIP1 pfam15904
LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It ...
 1-96 1.00e-31

LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.


Pssm-ID: 464931  Cd Length: 90  Bit Score: 119.13  E-value: 1.00e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890     1 MDPQK-ITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTLIADTEIgtgagylQPQSFQVVKPINAKSSVFPDLQL 79
Cdd:pfam15904    1 SDPEPlVHSLANLLRNNGDLVLDGSSTLTLSASSLQHLTRSFEQHLLPRS-------HQHGFLALPSHPADTSSLLQLQF 73

                           90
                   ....*....|....*..
gi 221472890    80 VHDFVQKTTLLKLTYFP 96
Cdd:pfam15904   74 LFDMLQKTTSLKLIHVP 90
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-302 7.28e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 7.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  176 NSLRSVDtALEFAQHLQHLNLRHNKLTSVAAIKWLPHLKTLDLSYNC---------LTHLPQFHMEA------------- 233
Cdd:cd21340    34 NKITKIE-NLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRisvveglenLTNLEELHIENqrlppgekltfdp 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221472890  234 ------CKRLQLLNISNNYVEELLDVAKLDALYNLDLSDNCLLEHSQLL-PLSALMSLIVLNLQGNPLACNPKHRQ 302
Cdd:cd21340   113 rslaalSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRD 188
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-294 5.14e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 5.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890   85 QKTTLLKLTYFPSEHYFEGAIDIAKFRALRRLEVNKINIGQVVGIQPLRGQLQHLICVKSLTSVDDIITRCGGDNSNGFV 164
Cdd:COG4886    32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  165 WNELKTADFSYNSLRSVDTALEFAQHLQHLNLRHNKLTSV-AAIKWLPHLKTLDLSYNCLTHLPQFhMEACKRLQLLNIS 243
Cdd:COG4886   112 LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 221472890  244 NNYVEEL-LDVAKLDALYNLDLSDNCLlehSQL-LPLSALMSLIVLNLQGNPL 294
Cdd:COG4886   191 NNQITDLpEPLGNLTNLEELDLSGNQL---TDLpEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
168-314 3.77e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  168 LKTADFSYNSLRSVDTALEFAQHLQHLNLRHNKLTSVAAIKWLPHLKTLDLSYNCLTHLPQFhmEACKRLQLLNISNNYV 247
Cdd:COG4886   207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQL 284

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221472890  248 EElLDVAKLDALYNLDLSDNCLLEHSQLLPLSALMSLIVLNLQGNPLACNPKHRQATAQYLHKNSAT 314
Cdd:COG4886   285 TD-LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR_8 pfam13855
Leucine rich repeat;
189-245 2.01e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 2.01e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 221472890   189 QHLQHLNLRHNKLTSV--AAIKWLPHLKTLDLSYNCLTHLPQFHMEACKRLQLLNISNN 245
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
166-349 8.04e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 8.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  166 NELKTADFSYNSLRSVDTALefAQHLQHLNLRHNKLTSVAAiKWLPHLKTLDLSYNCLTHLPQFHMEAckrLQLLNISNN 245
Cdd:PRK15370  283 EELRYLSVYDNSIRTLPAHL--PSGITHLNVQSNSLTALPE-TLPPGLKTLEAGENALTSLPASLPPE---LQVLDVSKN 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  246 YVEELLDVAKlDALYNLDLSDNCLLEHSQLLPlsalMSLIVLNLQGNPLACNPkhrQATAQYLHKNSATVKFVLDFEPLT 325
Cdd:PRK15370  357 QITVLPETLP-PTITTLDVSRNALTNLPENLP----AALQIMQASRNNLVRLP---ESLPHFRGEGPQPTRIIVEYNPFS 428

                         170       180
                  ....*....|....*....|....
gi 221472890  326 kaEKALTGSQkwRYISGLSHRSPR 349
Cdd:PRK15370  429 --ERTIQNMQ--RLMSSVGYQGPR 448
LRR_8 pfam13855
Leucine rich repeat;
211-267 3.35e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 3.35e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 221472890   211 PHLKTLDLSYNCLTHLPQFHMEACKRLQLLNISNNYVEELLDVA--KLDALYNLDLSDN 267
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 189-221 3.84e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 3.84e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 221472890   189 QHLQHLNLRHNKLTSVAAIKWLPHLKTLDLSYN 221
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
167-221 1.52e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.52e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 221472890   167 ELKTADFSYNSLRSV-DTALEFAQHLQHLNLRHNKLTSV--AAIKWLPHLKTLDLSYN 221
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGN 59
LRR_9 pfam14580
Leucine-rich repeat;
194-302 3.58e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.83  E-value: 3.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890   194 LNLRHNKLTSVAAI-KWLPHLKTLDLSYNCLTHLPQF-HMeacKRLQLLNISNN---YVEELLDVAkLDALYNLDLSDNC 268
Cdd:pfam14580   24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFpLL---RRLKTLLLNNNricRIGEGLGEA-LPNLTELILTNNN 99

                           90       100       110
                   ....*....|....*....|....*....|....
gi 221472890   269 LLEHSQLLPLSALMSLIVLNLQGNPLACNPKHRQ 302
Cdd:pfam14580  100 LQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRL 133
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 205-294 6.92e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 6.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  205 AAIKWLPHLKTLDLSYNCLT-HLPQFHMEACKRLQLLNISNNYVEELLDVAKLDALYNLDLSDNcLLEHSQLLPLSALMS 283
Cdd:PLN00113   87 SAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNN-MLSGEIPNDIGSFSS 165

                          90
                  ....*....|.
gi 221472890  284 LIVLNLQGNPL 294
Cdd:PLN00113  166 LKVLDLGGNVL 176
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 102-302 4.21e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  102 EGAIDIAK-FRALRRLEvnKINIGQvvgiQPLRGQLQHLICvksltsvddiitRCGGDNSNgfvwneLKTADFSYNSLRS 180
Cdd:cd00116   152 ASCEALAKaLRANRDLK--ELNLAN----NGIGDAGIRALA------------EGLKANCN------LEVLDLNNNGLTD 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221472890  181 -----VDTALEFAQHLQHLNLRHNKLTSV-------AAIKWLPHLKTLDLSYNCLThlpqfhMEACKRLQllnisnnyve 248
Cdd:cd00116   208 egasaLAETLASLKSLEVLNLGDNNLTDAgaaalasALLSPNISLLTLSLSCNDIT------DDGAKDLA---------- 271

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 221472890  249 ELLDVAKLdaLYNLDLSDNCLLEHSQllplsALMSLIVLNLQGNPLACNPKHRQ 302
Cdd:cd00116   272 EVLAEKES--LLELDLRGNKFGEEGA-----QLLAESLLEPGNELESLWVKDDS 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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