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Conserved domains on  [gi|320544596|ref|NP_608998|]
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tectonic [Drosophila melanogaster]

Protein Classification

tectonic family protein( domain architecture ID 10544302)

tectonic family protein is a DUF1619 domain-containing protein similar to Homo sapiens tectonic proteins which are components of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 117-403 1.90e-61

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


:

Pssm-ID: 462260  Cd Length: 315  Bit Score: 207.40  E-value: 1.90e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  117 CSCDLQAGRCDLNCCCDNDCPLETRQVFN-------------CLPNSLLPQLESrleDFQYTHGLPTCQINDGWLCVFRS 183
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFSsclvgvvsgdsqlCSQKSAIFRSNL---PPQRLFGLVTDQINPDLFCVQSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  184 NTKATKTQ--------PPDMNIDTSQYRKWKDNLEYQESDYAQSRPSagHYKFGQTLQLWQPETkQLATLELPAAYESPN 255
Cdd:pfam07773  78 NNNSPLGSffqpptsvPTPSNFEDSLYKKFTGFSFASESDVSSSTSS--GYKVGDPIQTYNPSS-SVGYLTLPQSSLSGQ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  256 CQLKQSVWHLQPIRHVC------RMKDSAQLQesIWSLLNQTSNYEIlskpRDLEEPEVNGLIVQV-CLRGANKSMRCLE 328
Cdd:pfam07773 155 CVDNNPVAFLQNQSTSCtrrvtdLLDSCTTLP--ALSAASYTSNFIL----PAVPNSQVVPVTVQStYLQSLNSGLLTTL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  329 RGNDTQLDV-----------IVDHVELQLIHNFT-NILEAKLFLEEAKLAEDDNePLWLRYNVEFVTLN-ESLTKPTSGP 395
Cdd:pfam07773 229 TSTSLRGSPspllnngtcrnVVLEVKYVITYNGTgGITEATVSLVLANVSASQL-PLQQRFQVSFLSANsESASESRSGN 307


                  ....*...
gi 320544596  396 LGYLSGAP 403
Cdd:pfam07773 308 PGYVVGKP 315
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 33-112 3.11e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.14  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596   33 SPTASTTTEAP-ATTGAPSSETVSSISTLPEAEVTTTTPAITFPPRVQQKPKVAVASPTMSTALP-LNSTEVNSTLSVSG 110
Cdd:pfam05109 508 SPTSAVTTPTPnATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPtLGKTSPTSAVTTPT 587


                  ..
gi 320544596  111 DN 112
Cdd:pfam05109 588 PN 589
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 117-403 1.90e-61

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 207.40  E-value: 1.90e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  117 CSCDLQAGRCDLNCCCDNDCPLETRQVFN-------------CLPNSLLPQLESrleDFQYTHGLPTCQINDGWLCVFRS 183
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFSsclvgvvsgdsqlCSQKSAIFRSNL---PPQRLFGLVTDQINPDLFCVQSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  184 NTKATKTQ--------PPDMNIDTSQYRKWKDNLEYQESDYAQSRPSagHYKFGQTLQLWQPETkQLATLELPAAYESPN 255
Cdd:pfam07773  78 NNNSPLGSffqpptsvPTPSNFEDSLYKKFTGFSFASESDVSSSTSS--GYKVGDPIQTYNPSS-SVGYLTLPQSSLSGQ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  256 CQLKQSVWHLQPIRHVC------RMKDSAQLQesIWSLLNQTSNYEIlskpRDLEEPEVNGLIVQV-CLRGANKSMRCLE 328
Cdd:pfam07773 155 CVDNNPVAFLQNQSTSCtrrvtdLLDSCTTLP--ALSAASYTSNFIL----PAVPNSQVVPVTVQStYLQSLNSGLLTTL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  329 RGNDTQLDV-----------IVDHVELQLIHNFT-NILEAKLFLEEAKLAEDDNePLWLRYNVEFVTLN-ESLTKPTSGP 395
Cdd:pfam07773 229 TSTSLRGSPspllnngtcrnVVLEVKYVITYNGTgGITEATVSLVLANVSASQL-PLQQRFQVSFLSANsESASESRSGN 307


                  ....*...
gi 320544596  396 LGYLSGAP 403
Cdd:pfam07773 308 PGYVVGKP 315
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 33-112 3.11e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.14  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596   33 SPTASTTTEAP-ATTGAPSSETVSSISTLPEAEVTTTTPAITFPPRVQQKPKVAVASPTMSTALP-LNSTEVNSTLSVSG 110
Cdd:pfam05109 508 SPTSAVTTPTPnATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPtLGKTSPTSAVTTPT 587


                  ..
gi 320544596  111 DN 112
Cdd:pfam05109 588 PN 589
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 117-403 1.90e-61

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 207.40  E-value: 1.90e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  117 CSCDLQAGRCDLNCCCDNDCPLETRQVFN-------------CLPNSLLPQLESrleDFQYTHGLPTCQINDGWLCVFRS 183
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFSsclvgvvsgdsqlCSQKSAIFRSNL---PPQRLFGLVTDQINPDLFCVQSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  184 NTKATKTQ--------PPDMNIDTSQYRKWKDNLEYQESDYAQSRPSagHYKFGQTLQLWQPETkQLATLELPAAYESPN 255
Cdd:pfam07773  78 NNNSPLGSffqpptsvPTPSNFEDSLYKKFTGFSFASESDVSSSTSS--GYKVGDPIQTYNPSS-SVGYLTLPQSSLSGQ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  256 CQLKQSVWHLQPIRHVC------RMKDSAQLQesIWSLLNQTSNYEIlskpRDLEEPEVNGLIVQV-CLRGANKSMRCLE 328
Cdd:pfam07773 155 CVDNNPVAFLQNQSTSCtrrvtdLLDSCTTLP--ALSAASYTSNFIL----PAVPNSQVVPVTVQStYLQSLNSGLLTTL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596  329 RGNDTQLDV-----------IVDHVELQLIHNFT-NILEAKLFLEEAKLAEDDNePLWLRYNVEFVTLN-ESLTKPTSGP 395
Cdd:pfam07773 229 TSTSLRGSPspllnngtcrnVVLEVKYVITYNGTgGITEATVSLVLANVSASQL-PLQQRFQVSFLSANsESASESRSGN 307


                  ....*...
gi 320544596  396 LGYLSGAP 403
Cdd:pfam07773 308 PGYVVGKP 315
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 33-112 3.11e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.14  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544596   33 SPTASTTTEAP-ATTGAPSSETVSSISTLPEAEVTTTTPAITFPPRVQQKPKVAVASPTMSTALP-LNSTEVNSTLSVSG 110
Cdd:pfam05109 508 SPTSAVTTPTPnATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPtLGKTSPTSAVTTPT 587


                  ..
gi 320544596  111 DN 112
Cdd:pfam05109 588 PN 589
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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