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Conserved domains on  [gi|19921286|ref|NP_609671|]
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uncharacterized protein Dmel_CG16890, isoform A [Drosophila melanogaster]

Protein Classification

FRA10AC1 family protein( domain architecture ID 10560741)

FRA10AC1 family protein similar to human FRA10AC1, which may be involved and the cause of folate-sensitive fragile site FRA10A expression characterized by chromosomal breakage under specific cell culture conditions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fra10Ac1 pfam09725
Folate-sensitive fragile site protein Fra10Ac1; This entry represents the full-length proteins ...
 42-160 1.39e-71

Folate-sensitive fragile site protein Fra10Ac1; This entry represents the full-length proteins in which, in higher eukaryotes, the nested domain EDSLL lies. Fra10Ac1 is a highly conserved protein, of unknown function that is nuclear and highly expressed in brain.


:

Pssm-ID: 462858  Cd Length: 117  Bit Score: 214.71  E-value: 1.39e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921286    42 RDIDVIRENHRFLWEDDELDSDTlsWEQRLALRYYRKLFKEYCIADLSRYKENKIALRWRTEQEVVTGTGQFQCGSRHCG 121
Cdd:pfam09725   1 TDFDVLKENHRFLRDDEDDDDSS--WEKRLAKKYYDKLFKEYAIADLSRYKEGKIALRWRTEKEVVSGKGQFTCGNKRCD 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 19921286   122 ERDNLRSWEVNFRYIEKGEPLNALVKVRLCPTHTDQLNY 160
Cdd:pfam09725  79 EHEGLKSWEVNFGYVEHGEKKNALVKVRLCPRCSKKLNY 117
 
Name Accession Description Interval E-value
Fra10Ac1 pfam09725
Folate-sensitive fragile site protein Fra10Ac1; This entry represents the full-length proteins ...
 42-160 1.39e-71

Folate-sensitive fragile site protein Fra10Ac1; This entry represents the full-length proteins in which, in higher eukaryotes, the nested domain EDSLL lies. Fra10Ac1 is a highly conserved protein, of unknown function that is nuclear and highly expressed in brain.


Pssm-ID: 462858  Cd Length: 117  Bit Score: 214.71  E-value: 1.39e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921286    42 RDIDVIRENHRFLWEDDELDSDTlsWEQRLALRYYRKLFKEYCIADLSRYKENKIALRWRTEQEVVTGTGQFQCGSRHCG 121
Cdd:pfam09725   1 TDFDVLKENHRFLRDDEDDDDSS--WEKRLAKKYYDKLFKEYAIADLSRYKEGKIALRWRTEKEVVSGKGQFTCGNKRCD 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 19921286   122 ERDNLRSWEVNFRYIEKGEPLNALVKVRLCPTHTDQLNY 160
Cdd:pfam09725  79 EHEGLKSWEVNFGYVEHGEKKNALVKVRLCPRCSKKLNY 117
 
Name Accession Description Interval E-value
Fra10Ac1 pfam09725
Folate-sensitive fragile site protein Fra10Ac1; This entry represents the full-length proteins ...
 42-160 1.39e-71

Folate-sensitive fragile site protein Fra10Ac1; This entry represents the full-length proteins in which, in higher eukaryotes, the nested domain EDSLL lies. Fra10Ac1 is a highly conserved protein, of unknown function that is nuclear and highly expressed in brain.


Pssm-ID: 462858  Cd Length: 117  Bit Score: 214.71  E-value: 1.39e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921286    42 RDIDVIRENHRFLWEDDELDSDTlsWEQRLALRYYRKLFKEYCIADLSRYKENKIALRWRTEQEVVTGTGQFQCGSRHCG 121
Cdd:pfam09725   1 TDFDVLKENHRFLRDDEDDDDSS--WEKRLAKKYYDKLFKEYAIADLSRYKEGKIALRWRTEKEVVSGKGQFTCGNKRCD 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 19921286   122 ERDNLRSWEVNFRYIEKGEPLNALVKVRLCPTHTDQLNY 160
Cdd:pfam09725  79 EHEGLKSWEVNFGYVEHGEKKNALVKVRLCPRCSKKLNY 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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