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Conserved domains on  [gi|24584187|ref|NP_609675|]
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secretory 71 [Drosophila melanogaster]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 13-1580 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1042.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    13 IVRALEKILADKDIRRshHSQLKKSCDSALEQIKAELISAGQI--AEGNELPCAALPLPKNDAA----SIINAETYFLPF 86
Cdd:PLN03076   14 VSPALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPGPLHDGGsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    87 ELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGCFSgpQTDEAVQLQIIKALLTVVTSQHV 166
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   167 EIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIFARMENQVYELP-----------PPNSNPTNGSIhSEDC 235
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPiqpivvaelmePAEKSDSDTSM-TQFV 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   236 NGSGEESLRDSDEVIASEL-LAEIISAAYNEAMKDQESVGEPEPT--LNGND-------------YSSHSDHDSVELHS- 298
Cdd:PLN03076  249 QGFITKIMQDIDGVLNPATaGKSSGSGAHDGAFETTATVETTNPAdlLDSTDkdmldakyweismYKSALEGRKGELADg 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   299 --ENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLP-DGHPDPKSheLRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIK 375
Cdd:PLN03076  329 evEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPkEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIK 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   376 QYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILE-ANSSSFEHKWMVIQALTRICADAQS 454
Cdd:PLN03076  407 QYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLEnVAQPNFQQKMIVLRFLDKLCVDSQI 486

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   455 VVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQA-LELGANPMQEKSMRIRGLECLVSILKCMVEW-SKDLYV-NPNMPV 531
Cdd:PLN03076  487 LVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPgVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLpDPASLK 566

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   532 PPMQVQ-SPTSTEQDQADTTIQTMHSGS-SHSLNSNQEQLQdlpEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQL 609
Cdd:PLN03076  567 KLDAVEnNLEPGSLPVANGNGDENGEGSdSHSELSSETSDA---ATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANK 643

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   610 LGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFA 689
Cdd:PLN03076  644 VGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFA 723

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   690 SRYCECNPKnqLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKsDLPEEYLSSIYDEISEHEIKM 769
Cdd:PLN03076  724 ERYCKCNPK--AFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGK-DLPEEFMRSLYERISKNEIKM 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   770 KNNSGMLQQAKPTGKQAF--------ITEKRRKLLWNMEM--EVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAW 839
Cdd:PLN03076  801 KEDDLVPQQKQSANSNRIlgldsilnIVIRKRGEDSYMETsdDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCW 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   840 TPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPInemKAKNIDTIKTLIMVA 919
Cdd:PLN03076  881 APMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIA 957

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   920 HTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQ--FLSGAQTTL------KDSLNPSVKEH------------------ 973
Cdd:PLN03076  958 DEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDatFFAAPQNESdkskqaKSPILPVLKRKgpgklqyaaaavrrgsyd 1037

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   974 ---IGETSSQSVV-------------------VAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQ-QQPRMFSLQKIV 1030
Cdd:PLN03076 1038 sagVGGKASGVVTseqmnnlvsnlnmleqvgsFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSpSDPRVFSLTKIV 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1031 EISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASP 1110
Cdd:PLN03076 1118 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1197

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1111 AIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEF 1190
Cdd:PLN03076 1198 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAF 1277

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1191 ATARF-PDTSMEAIRLVRTCAQCVHE-------------APQLfAEHAG----MENDASVAEEDRVWVrgWFPMLFSLSC 1252
Cdd:PLN03076 1278 TNSRFnKDISLNAIAFLRFCATKLAEgdlgsssrnkdkeAPPS-SPQSGkdgkQESGEFTDKDDHLYF--WFPLLAGLSE 1354

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1253 VVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKDLFN-VIFRIFDNMKlpeHVTEKSE--------------------W 1311
Cdd:PLN03076 1355 LSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFEsVLFPIFDYVR---HAIDPSGgdepegqgvdgdqgeldqdaW 1431

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1312 MTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAqLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDI 1391
Cdd:PLN03076 1432 LYETCTLALQLVVDLFVKFYPTVNPLLKKVLML-LVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEA 1510

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1392 FNATLPQdlLSWRPKAHSSNNIPQEHNHfealhircvvqleliqtMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQS 1471
Cdd:PLN03076 1511 ANATLPD--FSYVVSGEYMPAENIQDSE-----------------NAEAASSSTADNDAEAERSRRLYAAISDAKCRAAV 1571

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1472 QLLECQ--REEQGMYG-YLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVK-PNLLKQETSSLACVLRIF 1547
Cdd:PLN03076 1572 QLLLIQavMEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFL 1651

                        1690      1700      1710
                  ....*....|....*....|....*....|...
gi 24584187  1548 FKMYGDENRRSDWPGIEQELVQVCKEALGYYLS 1580
Cdd:PLN03076 1652 QNLILDKPPLAKEAEVESRLVELCEEVLQFYIE 1684
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 13-1580 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1042.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    13 IVRALEKILADKDIRRshHSQLKKSCDSALEQIKAELISAGQI--AEGNELPCAALPLPKNDAA----SIINAETYFLPF 86
Cdd:PLN03076   14 VSPALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPGPLHDGGsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    87 ELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGCFSgpQTDEAVQLQIIKALLTVVTSQHV 166
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   167 EIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIFARMENQVYELP-----------PPNSNPTNGSIhSEDC 235
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPiqpivvaelmePAEKSDSDTSM-TQFV 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   236 NGSGEESLRDSDEVIASEL-LAEIISAAYNEAMKDQESVGEPEPT--LNGND-------------YSSHSDHDSVELHS- 298
Cdd:PLN03076  249 QGFITKIMQDIDGVLNPATaGKSSGSGAHDGAFETTATVETTNPAdlLDSTDkdmldakyweismYKSALEGRKGELADg 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   299 --ENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLP-DGHPDPKSheLRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIK 375
Cdd:PLN03076  329 evEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPkEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIK 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   376 QYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILE-ANSSSFEHKWMVIQALTRICADAQS 454
Cdd:PLN03076  407 QYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLEnVAQPNFQQKMIVLRFLDKLCVDSQI 486

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   455 VVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQA-LELGANPMQEKSMRIRGLECLVSILKCMVEW-SKDLYV-NPNMPV 531
Cdd:PLN03076  487 LVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPgVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLpDPASLK 566

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   532 PPMQVQ-SPTSTEQDQADTTIQTMHSGS-SHSLNSNQEQLQdlpEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQL 609
Cdd:PLN03076  567 KLDAVEnNLEPGSLPVANGNGDENGEGSdSHSELSSETSDA---ATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANK 643

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   610 LGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFA 689
Cdd:PLN03076  644 VGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFA 723

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   690 SRYCECNPKnqLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKsDLPEEYLSSIYDEISEHEIKM 769
Cdd:PLN03076  724 ERYCKCNPK--AFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGK-DLPEEFMRSLYERISKNEIKM 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   770 KNNSGMLQQAKPTGKQAF--------ITEKRRKLLWNMEM--EVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAW 839
Cdd:PLN03076  801 KEDDLVPQQKQSANSNRIlgldsilnIVIRKRGEDSYMETsdDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCW 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   840 TPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPInemKAKNIDTIKTLIMVA 919
Cdd:PLN03076  881 APMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIA 957

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   920 HTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQ--FLSGAQTTL------KDSLNPSVKEH------------------ 973
Cdd:PLN03076  958 DEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDatFFAAPQNESdkskqaKSPILPVLKRKgpgklqyaaaavrrgsyd 1037

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   974 ---IGETSSQSVV-------------------VAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQ-QQPRMFSLQKIV 1030
Cdd:PLN03076 1038 sagVGGKASGVVTseqmnnlvsnlnmleqvgsFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSpSDPRVFSLTKIV 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1031 EISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASP 1110
Cdd:PLN03076 1118 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1197

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1111 AIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEF 1190
Cdd:PLN03076 1198 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAF 1277

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1191 ATARF-PDTSMEAIRLVRTCAQCVHE-------------APQLfAEHAG----MENDASVAEEDRVWVrgWFPMLFSLSC 1252
Cdd:PLN03076 1278 TNSRFnKDISLNAIAFLRFCATKLAEgdlgsssrnkdkeAPPS-SPQSGkdgkQESGEFTDKDDHLYF--WFPLLAGLSE 1354

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1253 VVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKDLFN-VIFRIFDNMKlpeHVTEKSE--------------------W 1311
Cdd:PLN03076 1355 LSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFEsVLFPIFDYVR---HAIDPSGgdepegqgvdgdqgeldqdaW 1431

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1312 MTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAqLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDI 1391
Cdd:PLN03076 1432 LYETCTLALQLVVDLFVKFYPTVNPLLKKVLML-LVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEA 1510

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1392 FNATLPQdlLSWRPKAHSSNNIPQEHNHfealhircvvqleliqtMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQS 1471
Cdd:PLN03076 1511 ANATLPD--FSYVVSGEYMPAENIQDSE-----------------NAEAASSSTADNDAEAERSRRLYAAISDAKCRAAV 1571

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1472 QLLECQ--REEQGMYG-YLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVK-PNLLKQETSSLACVLRIF 1547
Cdd:PLN03076 1572 QLLLIQavMEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFL 1651

                        1690      1700      1710
                  ....*....|....*....|....*....|...
gi 24584187  1548 FKMYGDENRRSDWPGIEQELVQVCKEALGYYLS 1580
Cdd:PLN03076 1652 QNLILDKPPLAKEAEVESRLVELCEEVLQFYIE 1684
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 582-767 2.43e-92

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 296.68  E-value: 2.43e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    582 RKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEV 661
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    662 VAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKnqLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNR 741
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*.
gi 24584187    742 GISDSKsDLPEEYLSSIYDEISEHEI 767
Cdd:pfam01369  159 GINDGK-DFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 582-767 2.16e-88

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 285.27  E-value: 2.16e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  582 RKEVMETGIELFNRKPQKGVQFLQEKQLL-GATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQME 660
Cdd:cd00171    1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  661 VVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPkNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMN 740
Cdd:cd00171   81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNP-GIFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                        170       180
                 ....*....|....*....|....*..
gi 24584187  741 RGISDSKsDLPEEYLSSIYDEISEHEI 767
Cdd:cd00171  160 RGINDGE-DFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 580-767 1.05e-73

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 243.74  E-value: 1.05e-73
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187     580 KMRKEVMETGIELFNRKPQKGVQFLQEKQLLG-ATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQ 658
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187     659 MEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIK 738
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*....
gi 24584187     739 MNRGISDSKsDLPEEYLSSIYDEISEHEI 767
Cdd:smart00222  162 NVRGSNDGE-DLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 13-1580 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1042.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    13 IVRALEKILADKDIRRshHSQLKKSCDSALEQIKAELISAGQI--AEGNELPCAALPLPKNDAA----SIINAETYFLPF 86
Cdd:PLN03076   14 VSPALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPGPLHDGGsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    87 ELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGCFSgpQTDEAVQLQIIKALLTVVTSQHV 166
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   167 EIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIFARMENQVYELP-----------PPNSNPTNGSIhSEDC 235
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPiqpivvaelmePAEKSDSDTSM-TQFV 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   236 NGSGEESLRDSDEVIASEL-LAEIISAAYNEAMKDQESVGEPEPT--LNGND-------------YSSHSDHDSVELHS- 298
Cdd:PLN03076  249 QGFITKIMQDIDGVLNPATaGKSSGSGAHDGAFETTATVETTNPAdlLDSTDkdmldakyweismYKSALEGRKGELADg 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   299 --ENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLP-DGHPDPKSheLRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIK 375
Cdd:PLN03076  329 evEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPkEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIK 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   376 QYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILE-ANSSSFEHKWMVIQALTRICADAQS 454
Cdd:PLN03076  407 QYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLEnVAQPNFQQKMIVLRFLDKLCVDSQI 486

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   455 VVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQA-LELGANPMQEKSMRIRGLECLVSILKCMVEW-SKDLYV-NPNMPV 531
Cdd:PLN03076  487 LVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPgVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLpDPASLK 566

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   532 PPMQVQ-SPTSTEQDQADTTIQTMHSGS-SHSLNSNQEQLQdlpEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQL 609
Cdd:PLN03076  567 KLDAVEnNLEPGSLPVANGNGDENGEGSdSHSELSSETSDA---ATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANK 643

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   610 LGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFA 689
Cdd:PLN03076  644 VGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFA 723

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   690 SRYCECNPKnqLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKsDLPEEYLSSIYDEISEHEIKM 769
Cdd:PLN03076  724 ERYCKCNPK--AFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGK-DLPEEFMRSLYERISKNEIKM 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   770 KNNSGMLQQAKPTGKQAF--------ITEKRRKLLWNMEM--EVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAW 839
Cdd:PLN03076  801 KEDDLVPQQKQSANSNRIlgldsilnIVIRKRGEDSYMETsdDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCW 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   840 TPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPInemKAKNIDTIKTLIMVA 919
Cdd:PLN03076  881 APMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIA 957

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   920 HTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQ--FLSGAQTTL------KDSLNPSVKEH------------------ 973
Cdd:PLN03076  958 DEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDatFFAAPQNESdkskqaKSPILPVLKRKgpgklqyaaaavrrgsyd 1037

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   974 ---IGETSSQSVV-------------------VAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQ-QQPRMFSLQKIV 1030
Cdd:PLN03076 1038 sagVGGKASGVVTseqmnnlvsnlnmleqvgsFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSpSDPRVFSLTKIV 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1031 EISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASP 1110
Cdd:PLN03076 1118 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1197

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1111 AIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEF 1190
Cdd:PLN03076 1198 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAF 1277

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1191 ATARF-PDTSMEAIRLVRTCAQCVHE-------------APQLfAEHAG----MENDASVAEEDRVWVrgWFPMLFSLSC 1252
Cdd:PLN03076 1278 TNSRFnKDISLNAIAFLRFCATKLAEgdlgsssrnkdkeAPPS-SPQSGkdgkQESGEFTDKDDHLYF--WFPLLAGLSE 1354

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1253 VVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKDLFN-VIFRIFDNMKlpeHVTEKSE--------------------W 1311
Cdd:PLN03076 1355 LSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFEsVLFPIFDYVR---HAIDPSGgdepegqgvdgdqgeldqdaW 1431

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1312 MTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAqLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDI 1391
Cdd:PLN03076 1432 LYETCTLALQLVVDLFVKFYPTVNPLLKKVLML-LVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEA 1510

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1392 FNATLPQdlLSWRPKAHSSNNIPQEHNHfealhircvvqleliqtMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQS 1471
Cdd:PLN03076 1511 ANATLPD--FSYVVSGEYMPAENIQDSE-----------------NAEAASSSTADNDAEAERSRRLYAAISDAKCRAAV 1571

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  1472 QLLECQ--REEQGMYG-YLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVK-PNLLKQETSSLACVLRIF 1547
Cdd:PLN03076 1572 QLLLIQavMEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFL 1651

                        1690      1700      1710
                  ....*....|....*....|....*....|...
gi 24584187  1548 FKMYGDENRRSDWPGIEQELVQVCKEALGYYLS 1580
Cdd:PLN03076 1652 QNLILDKPPLAKEAEVESRLVELCEEVLQFYIE 1684
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 582-767 2.43e-92

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 296.68  E-value: 2.43e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    582 RKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEV 661
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    662 VAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKnqLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNR 741
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*.
gi 24584187    742 GISDSKsDLPEEYLSSIYDEISEHEI 767
Cdd:pfam01369  159 GINDGK-DFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 582-767 2.16e-88

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 285.27  E-value: 2.16e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  582 RKEVMETGIELFNRKPQKGVQFLQEKQLL-GATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQME 660
Cdd:cd00171    1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187  661 VVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPkNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMN 740
Cdd:cd00171   81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNP-GIFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                        170       180
                 ....*....|....*....|....*..
gi 24584187  741 RGISDSKsDLPEEYLSSIYDEISEHEI 767
Cdd:cd00171  160 RGINDGE-DFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 580-767 1.05e-73

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 243.74  E-value: 1.05e-73
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187     580 KMRKEVMETGIELFNRKPQKGVQFLQEKQLLG-ATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQ 658
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187     659 MEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIK 738
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*....
gi 24584187     739 MNRGISDSKsDLPEEYLSSIYDEISEHEI 767
Cdd:smart00222  162 NVRGSNDGE-DLPREFLEELYDSIKNNEI 189
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 312-467 1.10e-47

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 167.67  E-value: 1.10e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    312 LQKDAFLVFRALCKLS-MKPLPDghPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVALSNNGVSLV 390
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24584187    391 PEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEaNSSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFS 467
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1428-1640 1.62e-44

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 159.33  E-value: 1.62e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   1428 VVQLELIQTMDNIVffpatsrkedaetlaqaaadltggrsgsqsqllecqreeQGMYGYLRTRQLLTLADCLMQSHRFAK 1507
Cdd:pfam20252    1 VVQLLLIQTVNEIL---------------------------------------DEHYESLPSDHLLRLLDCLEKSYTFAR 41

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   1508 RFNADHDQRSLLWRAGFkGSVKPNLLKQETSSLACVLRIFFKMYGDENRRSD-WPGIEQELVQVCKEALGYYLSL-QSEA 1585
Cdd:pfam20252   42 SFNSDLELRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEPRTSqREEVEERLIPLCEDILEYYLSLdEEEK 120

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24584187   1586 HRD--AWTSLLLLILTRLLKMSDARFATHVSNYYSLLCEMMCFDLKPELRSVLRRVF 1640
Cdd:pfam20252  121 QRElaAWTPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFF 177
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1080-1161 7.42e-38

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 136.85  E-value: 7.42e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187   1080 KFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQ 1159
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 24584187   1160 TT 1161
Cdd:pfam09324   81 IL 82
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 30-211 4.78e-33

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 126.22  E-value: 4.78e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187     30 HHSQLKKSCDSALEQIKAELIS-AGQIAEGNELPCAALPLPKNDAASIIN----AETYFLPFELACKSRSPRIVVTALDC 104
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRkYPPVKEASEKGILRLRTVHSSSPLMQNllsaSEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584187    105 LQKLIAYGHLTGSiqdsanpghlLIDRIVVTIYGCFSGPQTdeaVQLQIIKALLTVVTSQHVeIHEFTLLQAVRTCYDIY 184
Cdd:pfam16213   81 LQKLISHDAISQS----------AAPYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 24584187    185 LsSKNLVNQTTARATLTQMLNVIFARM 211
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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