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Conserved domains on  [gi|45550341|ref|NP_609786|]
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uncharacterized protein Dmel_CG17328, isoform A [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10657792)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 8-80 1.67e-13

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 214871  Cd Length: 73  Bit Score: 65.23  E-value: 1.67e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45550341      8 ICRVCLEELHPVTSIYSTDFAMMPSVMLMQCAKIRVFKTDGLPSVICNNCIYRLGVAFHFKQECENSDLRLRQ 80
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-213 2.65e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.65e-04
                          10        20
                  ....*....|....*....|....*
gi 45550341   189 NLKVHERTHTGDKPFQCEICSKQFS 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
146-211 6.69e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.69e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550341 146 PHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQK--YNLKVHERTHTGDKPFQCEICSKQ 211
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.30e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 45550341   245 DLSKHMITHTGIKNHHCDVCGKAFSR 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 8-80 1.67e-13

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 65.23  E-value: 1.67e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45550341      8 ICRVCLEELHPVTSIYSTDFAMMPSVMLMQCAKIRVFKTDGLPSVICNNCIYRLGVAFHFKQECENSDLRLRQ 80
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 8-81 1.25e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.39  E-value: 1.25e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45550341     8 ICRVCLEELHPVTSIY-STDFAMMPSVMLMQCAKIRVFKTDGLPSVICNNCIYRLGVAFHFKQECENSDLRLRQY 81
Cdd:pfam07776   1 VCRLCLDESDELIPIFdPSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-213 2.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.65e-04
                          10        20
                  ....*....|....*....|....*
gi 45550341   189 NLKVHERTHTGDKPFQCEICSKQFS 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-211 6.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.69e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550341 146 PHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQK--YNLKVHERTHTGDKPFQCEICSKQ 211
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
162-186 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*
gi 45550341   162 LTQHIRTHTGEKPYQCSFCIQRFAQ 186
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 45550341   245 DLSKHMITHTGIKNHHCDVCGKAFSR 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 8-80 1.67e-13

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 65.23  E-value: 1.67e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45550341      8 ICRVCLEELHPVTSIYSTDFAMMPSVMLMQCAKIRVFKTDGLPSVICNNCIYRLGVAFHFKQECENSDLRLRQ 80
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 8-81 1.25e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.39  E-value: 1.25e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45550341     8 ICRVCLEELHPVTSIY-STDFAMMPSVMLMQCAKIRVFKTDGLPSVICNNCIYRLGVAFHFKQECENSDLRLRQY 81
Cdd:pfam07776   1 VCRLCLDESDELIPIFdPSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-213 2.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.65e-04
                          10        20
                  ....*....|....*....|....*
gi 45550341   189 NLKVHERTHTGDKPFQCEICSKQFS 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-211 6.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.69e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550341 146 PHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQK--YNLKVHERTHTGDKPFQCEICSKQ 211
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
162-186 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*
gi 45550341   162 LTQHIRTHTGEKPYQCSFCIQRFAQ 186
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 45550341   245 DLSKHMITHTGIKNHHCDVCGKAFSR 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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