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Conserved domains on  [gi|24584690|ref|NP_609809|]
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pickpocket 17, isoform A [Drosophila melanogaster]

Protein Classification

amiloride-sensitive sodium channel family protein( domain architecture ID 235)

amiloride-sensitive sodium channel family protein such as vertebrate acid-sensing ion channels which are cation channels with high affinity for sodium; may be partial

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASC super family cl47603
Amiloride-sensitive sodium channel;
22-358 2.23e-10

Amiloride-sensitive sodium channel;


The actual alignment was detected with superfamily member pfam00858:

Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 62.19  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690    22 LVLFACCIVVIVQLYECFakLYNPPISTHSYYSLNETIEMPSVTICREPPYKEEVLTRLSGGACPHPKYATCWMKYPFGE 101
Cdd:pfam00858  30 LASLIFLIYLISLLFEKY--LSYPVITVIEEILYVWNVPFPAVTICNLNPFRYSALKELSLFYDNLSFLLYLKFKFLEKI 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   102 ISLDEFFENSTHDSGDTFVFYGLNEDKNNVVMNSSLHFY---------------------------MGRCYTL--RPKES 152
Cdd:pfam00858 108 LKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLGLRcedlivscsfggekedcsanftpilteYGNCYTFnsKDNGS 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   153 AKRVSKAVGY------SIMLeHSMLTTSVSDVDTGSVGWHVFIHDKKEnFTEINMKGsgrveyVFVGVNEEIEIKLQTQY 226
Cdd:pfam00858 188 KLYPRRLKGAgsgrglSLIL-NIQQSETYSPLDYQAAGFKVSIHSPGE-PPDVDKRG------FSVPPGTETSVGIQPTE 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   227 FSNVQTREEAC-SDDEN------YSDLKCGEQCIWQDLADNMQCSGPWMheIASEPCNDSLSMRKLISDYKDVYENEDDF 299
Cdd:pfam00858 260 ITTLKRPYGNCtFDDEKllyfksYSQSNCLLECRQNYILKLCGCVPFFY--PLPPGTKTGADIPCLLNYEDHLLEVNEGL 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   300 DC-DCVQPCQSRIYTTFI---------------------QNRKAFNQPEPRTQIYIYYTTKLISMIEERPSYDTTQFIAD 357
Cdd:pfam00858 338 SCqDCLPPCNETEYETEIsystwpslssqlfllyyelstYNNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSS 417

                  .
gi 24584690   358 V 358
Cdd:pfam00858 418 I 418
 
Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
22-358 2.23e-10

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 62.19  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690    22 LVLFACCIVVIVQLYECFakLYNPPISTHSYYSLNETIEMPSVTICREPPYKEEVLTRLSGGACPHPKYATCWMKYPFGE 101
Cdd:pfam00858  30 LASLIFLIYLISLLFEKY--LSYPVITVIEEILYVWNVPFPAVTICNLNPFRYSALKELSLFYDNLSFLLYLKFKFLEKI 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   102 ISLDEFFENSTHDSGDTFVFYGLNEDKNNVVMNSSLHFY---------------------------MGRCYTL--RPKES 152
Cdd:pfam00858 108 LKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLGLRcedlivscsfggekedcsanftpilteYGNCYTFnsKDNGS 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   153 AKRVSKAVGY------SIMLeHSMLTTSVSDVDTGSVGWHVFIHDKKEnFTEINMKGsgrveyVFVGVNEEIEIKLQTQY 226
Cdd:pfam00858 188 KLYPRRLKGAgsgrglSLIL-NIQQSETYSPLDYQAAGFKVSIHSPGE-PPDVDKRG------FSVPPGTETSVGIQPTE 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   227 FSNVQTREEAC-SDDEN------YSDLKCGEQCIWQDLADNMQCSGPWMheIASEPCNDSLSMRKLISDYKDVYENEDDF 299
Cdd:pfam00858 260 ITTLKRPYGNCtFDDEKllyfksYSQSNCLLECRQNYILKLCGCVPFFY--PLPPGTKTGADIPCLLNYEDHLLEVNEGL 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   300 DC-DCVQPCQSRIYTTFI---------------------QNRKAFNQPEPRTQIYIYYTTKLISMIEERPSYDTTQFIAD 357
Cdd:pfam00858 338 SCqDCLPPCNETEYETEIsystwpslssqlfllyyelstYNNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSS 417

                  .
gi 24584690   358 V 358
Cdd:pfam00858 418 I 418
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
142-314 5.56e-05

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 45.61  E-value: 5.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   142 GRCYTLRPKESAKRVSKAVG--YSIMLehsMLTTSVSDV--DTGSVGWHVFIHDKKEN-FTEINmkG-SGRVEYV-FVGV 214
Cdd:TIGR00867 334 GNCYTFNYNRSVNLSSSRAGpmYGLRL---LLFVNQSDYlpTTEAAGVRLTIHDKDEFpFPDTF--GySAPTGYIsSFGV 408
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   215 NEEIEIKLQTQYFSNVQTREEACS--DDENYSDLKCGEQCIWQDLADNMQCSGP-----WMHEIASEPCNDSLS-MRKLI 286
Cdd:TIGR00867 409 RLKQMSRLPAPYGNCVDTGKDSSYiyKGYIYSPEGCHRSCFQRLIIAKCGCADPrfpvpEGTRHCQAFNKTDREcLETLT 488
                         170       180
                  ....*....|....*....|....*...
gi 24584690   287 SDYKDVYENEddFDCDCVQPCQSRIYTT 314
Cdd:TIGR00867 489 GDLGELHHSI--FKCRCQQPCQESIYTT 514
 
Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
22-358 2.23e-10

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 62.19  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690    22 LVLFACCIVVIVQLYECFakLYNPPISTHSYYSLNETIEMPSVTICREPPYKEEVLTRLSGGACPHPKYATCWMKYPFGE 101
Cdd:pfam00858  30 LASLIFLIYLISLLFEKY--LSYPVITVIEEILYVWNVPFPAVTICNLNPFRYSALKELSLFYDNLSFLLYLKFKFLEKI 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   102 ISLDEFFENSTHDSGDTFVFYGLNEDKNNVVMNSSLHFY---------------------------MGRCYTL--RPKES 152
Cdd:pfam00858 108 LKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLGLRcedlivscsfggekedcsanftpilteYGNCYTFnsKDNGS 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   153 AKRVSKAVGY------SIMLeHSMLTTSVSDVDTGSVGWHVFIHDKKEnFTEINMKGsgrveyVFVGVNEEIEIKLQTQY 226
Cdd:pfam00858 188 KLYPRRLKGAgsgrglSLIL-NIQQSETYSPLDYQAAGFKVSIHSPGE-PPDVDKRG------FSVPPGTETSVGIQPTE 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   227 FSNVQTREEAC-SDDEN------YSDLKCGEQCIWQDLADNMQCSGPWMheIASEPCNDSLSMRKLISDYKDVYENEDDF 299
Cdd:pfam00858 260 ITTLKRPYGNCtFDDEKllyfksYSQSNCLLECRQNYILKLCGCVPFFY--PLPPGTKTGADIPCLLNYEDHLLEVNEGL 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   300 DC-DCVQPCQSRIYTTFI---------------------QNRKAFNQPEPRTQIYIYYTTKLISMIEERPSYDTTQFIAD 357
Cdd:pfam00858 338 SCqDCLPPCNETEYETEIsystwpslssqlfllyyelstYNNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSS 417

                  .
gi 24584690   358 V 358
Cdd:pfam00858 418 I 418
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
142-314 5.56e-05

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 45.61  E-value: 5.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   142 GRCYTLRPKESAKRVSKAVG--YSIMLehsMLTTSVSDV--DTGSVGWHVFIHDKKEN-FTEINmkG-SGRVEYV-FVGV 214
Cdd:TIGR00867 334 GNCYTFNYNRSVNLSSSRAGpmYGLRL---LLFVNQSDYlpTTEAAGVRLTIHDKDEFpFPDTF--GySAPTGYIsSFGV 408
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584690   215 NEEIEIKLQTQYFSNVQTREEACS--DDENYSDLKCGEQCIWQDLADNMQCSGP-----WMHEIASEPCNDSLS-MRKLI 286
Cdd:TIGR00867 409 RLKQMSRLPAPYGNCVDTGKDSSYiyKGYIYSPEGCHRSCFQRLIIAKCGCADPrfpvpEGTRHCQAFNKTDREcLETLT 488
                         170       180
                  ....*....|....*....|....*...
gi 24584690   287 SDYKDVYENEddFDCDCVQPCQSRIYTT 314
Cdd:TIGR00867 489 GDLGELHHSI--FKCRCQQPCQESIYTT 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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