NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19921694|ref|NP_610217|]
View 

Flavin-containing monooxygenase 2 [Drosophila melanogaster]

Protein Classification

flavin-containing monooxygenase( domain architecture ID 1750397)

flavin-containing monooxygenase (FMO) may act as an xenobiotic-metabolising enzyme that catalyzes the oxygenation of nucleophilic nitrogen, sulphur, phosphorus and selenium atoms in a range of structurally diverse compounds by using an NADPH cofactor and FAD prosthetic group

EC:  1.14.13.8
Gene Ontology:  GO:0004499|GO:0050661|GO:0050660
PubMed:  9538688

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02172 super family cl40780
flavin-containing monooxygenase FMO GS-OX
 3-384 1.87e-69

flavin-containing monooxygenase FMO GS-OX


The actual alignment was detected with superfamily member PLN02172:

Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 227.05  E-value: 1.87e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    3 KTSVDKRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSeemPKDEYDE---------VHSSMYEGLRTNL 73
Cdd:PLN02172   5 QNPINSQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYT---PKSESDPlsldptrsiVHSSVYESLRTNL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   74 PKEVMGYPDYSY---PDDITES---FITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLDDWEVyvWDHSTDTC--D 145
Cdd:PLN02172  82 PRECMGYRDFPFvprFDDESRDsrrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVEPVDGKWRV--QSKNSGGFskD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  146 PVYyDFVYVCNGHYTEPDLPEVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLSHHlST 225
Cdd:PLN02172 160 EIF-DAVVVCNGHYTEPNVAHIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASR-AS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  226 TPNT-----AFMGNVTQKPDVKRFTKDGA-VFTDGSTESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCININ 299
Cdd:PLN02172 238 ESDTyeklpVPQNNLWMHSEIDTAHEDGSiVFKNGKVVYADTIVHCTGYKYHFPFLETNGYMRIDENRVEPLYKHVFPPA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  300 -HPTMAFVGLPFNVIPTHIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVrNQKKAHQMGERQFVYYNELA 378
Cdd:PLN02172 318 lAPGLSFIGLPAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLEALGI-PKRYTHKLGKIQSEYLNWIA 396


                 ....*.
gi 19921694  379 SIAGIE 384
Cdd:PLN02172 397 EECGCP 402
 
Name Accession Description Interval E-value
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-384 1.87e-69

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 227.05  E-value: 1.87e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    3 KTSVDKRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSeemPKDEYDE---------VHSSMYEGLRTNL 73
Cdd:PLN02172   5 QNPINSQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYT---PKSESDPlsldptrsiVHSSVYESLRTNL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   74 PKEVMGYPDYSY---PDDITES---FITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLDDWEVyvWDHSTDTC--D 145
Cdd:PLN02172  82 PRECMGYRDFPFvprFDDESRDsrrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVEPVDGKWRV--QSKNSGGFskD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  146 PVYyDFVYVCNGHYTEPDLPEVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLSHHlST 225
Cdd:PLN02172 160 EIF-DAVVVCNGHYTEPNVAHIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASR-AS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  226 TPNT-----AFMGNVTQKPDVKRFTKDGA-VFTDGSTESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCININ 299
Cdd:PLN02172 238 ESDTyeklpVPQNNLWMHSEIDTAHEDGSiVFKNGKVVYADTIVHCTGYKYHFPFLETNGYMRIDENRVEPLYKHVFPPA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  300 -HPTMAFVGLPFNVIPTHIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVrNQKKAHQMGERQFVYYNELA 378
Cdd:PLN02172 318 lAPGLSFIGLPAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLEALGI-PKRYTHKLGKIQSEYLNWIA 396


                 ....*.
gi 19921694  379 SIAGIE 384
Cdd:PLN02172 397 EECGCP 402
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 8-382 4.77e-60

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 204.24  E-value: 4.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694     8 KRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMpkdeyDEVHSSMYEGLRTNLPKEVMGYPDYSYPD 87
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENV-----EEGRASIYKSVITNTSKEMSCFSDFPFPE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    88 DITeSFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DWEVyVWDHSTDTCDPVyYDFVYVCNGHYTEP 162
Cdd:pfam00743  76 DYP-NFMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDfstsgQWEV-VTEHEGKQESAV-FDAVMVCTGHHTNP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   163 DLP--EVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLS-------------------- 220
Cdd:pfam00743 153 HLPleSFPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLStrrgswvlsrvsdhgypwdm 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   221 -----------HHLSTT--------------------------------------PNTAFMGNVTQKPDVKRFTKDGAVF 251
Cdd:pfam00743 233 lfstrftsflrNILPTSisnwlmekqmnrrfnhenyglkpknralskepvvnddlPNRILCGAVKVKPNVKEFTETSAIF 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   252 TDGSTE-SFDHVMFCTGYKYTFPCLStDVGVQVIDNFVQpLWKHCI--NINHPTMAFVGL--PF-NVIPThiFDMQVRFT 325
Cdd:pfam00743 313 EDGTVEeDIDVVIFATGYTFAFPFLE-ESLVKVENNKVS-LYKYVFppNLEKPTLAIIGLiqPLgSIIPT--VELQARWA 388

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19921694   326 LKFFTGQRKFPSREQMIADLEQeigerwgcgvRNQKKAHQMGERQ--------FVYYNELASIAG 382
Cdd:pfam00743 389 TRVFKGLCTLPSQSEMMAEINK----------RQEKKIKRFGDSQshtiqtdyIDYMDELALFIG 443
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-324 1.08e-57

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 194.70  E-value: 1.08e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   4 TSVDKRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWifseempkdeydevHSSMYEGLRTNLPKEVMGYPDY 83
Cdd:COG2072   2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW--------------RDNRYPGLRLDTPSHLYSLPFF 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  84 SYPDDiTESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLDD--WEVyvwdhSTDTCDPVYYDFVYVCNGHYTE 161
Cdd:COG2072  68 PNWSD-DPDFPTGDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEADgrWTV-----TTDDGETLTARFVVVATGPLSR 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694 162 PDLPEVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLS----------HHLST------ 225
Cdd:COG2072 142 PKIPDIPGLEDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFqrtppwvlprPNYDPergrpa 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694 226 ------------------------------------TPNTAFM----------------GNVTQKPD-VKRFTKDGAVFT 252
Cdd:COG2072 222 nylgleappalnrrdarawlrrllraqvkdpelgllTPDYPPGckrpllstdyyealrrGNVELVTGgIERITEDGVVFA 301

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19921694 253 DGSTESFDHVMFCTGYKYTFPCLSTDvGVQVIDNFVQP-LWKHCININHPTMAFVGLPFNVIP---THIFDMQVRF 324
Cdd:COG2072 302 DGTEHEVDVIVWATGFRADLPWLAPL-DVRGRDGRSGPrAYLGVVVPGFPNLFFLGPNSPSGHsslTLGAERQARY 376
 
Name Accession Description Interval E-value
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-384 1.87e-69

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 227.05  E-value: 1.87e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    3 KTSVDKRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSeemPKDEYDE---------VHSSMYEGLRTNL 73
Cdd:PLN02172   5 QNPINSQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYT---PKSESDPlsldptrsiVHSSVYESLRTNL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   74 PKEVMGYPDYSY---PDDITES---FITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLDDWEVyvWDHSTDTC--D 145
Cdd:PLN02172  82 PRECMGYRDFPFvprFDDESRDsrrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVEPVDGKWRV--QSKNSGGFskD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  146 PVYyDFVYVCNGHYTEPDLPEVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLSHHlST 225
Cdd:PLN02172 160 EIF-DAVVVCNGHYTEPNVAHIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASR-AS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  226 TPNT-----AFMGNVTQKPDVKRFTKDGA-VFTDGSTESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCININ 299
Cdd:PLN02172 238 ESDTyeklpVPQNNLWMHSEIDTAHEDGSiVFKNGKVVYADTIVHCTGYKYHFPFLETNGYMRIDENRVEPLYKHVFPPA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  300 -HPTMAFVGLPFNVIPTHIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVrNQKKAHQMGERQFVYYNELA 378
Cdd:PLN02172 318 lAPGLSFIGLPAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLEALGI-PKRYTHKLGKIQSEYLNWIA 396


                 ....*.
gi 19921694  379 SIAGIE 384
Cdd:PLN02172 397 EECGCP 402
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 8-382 4.77e-60

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 204.24  E-value: 4.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694     8 KRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMpkdeyDEVHSSMYEGLRTNLPKEVMGYPDYSYPD 87
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENV-----EEGRASIYKSVITNTSKEMSCFSDFPFPE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    88 DITeSFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DWEVyVWDHSTDTCDPVyYDFVYVCNGHYTEP 162
Cdd:pfam00743  76 DYP-NFMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDfstsgQWEV-VTEHEGKQESAV-FDAVMVCTGHHTNP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   163 DLP--EVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLS-------------------- 220
Cdd:pfam00743 153 HLPleSFPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLStrrgswvlsrvsdhgypwdm 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   221 -----------HHLSTT--------------------------------------PNTAFMGNVTQKPDVKRFTKDGAVF 251
Cdd:pfam00743 233 lfstrftsflrNILPTSisnwlmekqmnrrfnhenyglkpknralskepvvnddlPNRILCGAVKVKPNVKEFTETSAIF 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   252 TDGSTE-SFDHVMFCTGYKYTFPCLStDVGVQVIDNFVQpLWKHCI--NINHPTMAFVGL--PF-NVIPThiFDMQVRFT 325
Cdd:pfam00743 313 EDGTVEeDIDVVIFATGYTFAFPFLE-ESLVKVENNKVS-LYKYVFppNLEKPTLAIIGLiqPLgSIIPT--VELQARWA 388

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19921694   326 LKFFTGQRKFPSREQMIADLEQeigerwgcgvRNQKKAHQMGERQ--------FVYYNELASIAG 382
Cdd:pfam00743 389 TRVFKGLCTLPSQSEMMAEINK----------RQEKKIKRFGDSQshtiqtdyIDYMDELALFIG 443
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-324 1.08e-57

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 194.70  E-value: 1.08e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   4 TSVDKRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWifseempkdeydevHSSMYEGLRTNLPKEVMGYPDY 83
Cdd:COG2072   2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW--------------RDNRYPGLRLDTPSHLYSLPFF 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  84 SYPDDiTESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLDD--WEVyvwdhSTDTCDPVYYDFVYVCNGHYTE 161
Cdd:COG2072  68 PNWSD-DPDFPTGDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEADgrWTV-----TTDDGETLTARFVVVATGPLSR 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694 162 PDLPEVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLS----------HHLST------ 225
Cdd:COG2072 142 PKIPDIPGLEDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFqrtppwvlprPNYDPergrpa 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694 226 ------------------------------------TPNTAFM----------------GNVTQKPD-VKRFTKDGAVFT 252
Cdd:COG2072 222 nylgleappalnrrdarawlrrllraqvkdpelgllTPDYPPGckrpllstdyyealrrGNVELVTGgIERITEDGVVFA 301

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19921694 253 DGSTESFDHVMFCTGYKYTFPCLSTDvGVQVIDNFVQP-LWKHCININHPTMAFVGLPFNVIP---THIFDMQVRF 324
Cdd:COG2072 302 DGTEHEVDVIVWATGFRADLPWLAPL-DVRGRDGRSGPrAYLGVVVPGFPNLFFLGPNSPSGHsslTLGAERQARY 376
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
81-269 1.05e-11

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 65.32  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    81 PDYSYPDDITESFITSNQVLEFLRSYAEHFKLkaHIKLQHEVIRVRPRLDDWEVyvwdhSTDTcDPVYYDFVYVCNGHYT 160
Cdd:pfam13738  59 PGTSPAFTFNREHPSGNEYAEYLRRVADHFEL--PINLFEEVTSVKKEDDGFVV-----TTSK-GTYQARYVIIATGEFD 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   161 EPDLPEVEGLdlfegnKMHSHLYRKADKFKDARVLIIGAGPSGMDI-TNHVRLAAK-QVFLSHHLSTTPNTAFMGNVtqK 238
Cdd:pfam13738 131 FPNKLGVPEL------PKHYSYVKDFHPYAGQKVVVIGGYNSAVDAaLELVRKGARvTVLYRGSEWEDRDSDPSYSL--S 202

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 19921694   239 PD---------------------VKRFTKDGAV----FTDG-STESFDHVMFCTGYK 269
Cdd:pfam13738 203 PDtlnrleelvkngkikahfnaeVKEITEVDVSykvhTEDGrKVTSNDDPILATGYH 259
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 102-267 1.33e-08

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 55.97  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694 102 FLRSYAEHFKLKAHIKLQHEVIRVRPrlDDWEVYVWDHSTDTcdpvyYDFVYVCNGhyTEPDLPEVEGLDLfegNKMHS- 180
Cdd:COG0446  39 LVRTPESFERKGIDVRTGTEVTAIDP--EAKTVTLRDGETLS-----YDKLVLATG--ARPRPPPIPGLDL---PGVFTl 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694 181 -------HLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFL----SHHLSTTP---NTAFMGNVTQKP------- 239
Cdd:COG0446 107 rtlddadALREALKEFKGKRAVVIGGGPIGLELAEALRKRGLKVTLveraPRLLGVLDpemAALLEEELREHGvelrlge 186

                       170       180       190
                ....*....|....*....|....*....|.
gi 19921694 240 DVKRFTKDG---AVFTDGSTESFDHVMFCTG 267
Cdd:COG0446 187 TVVAIDGDDkvaVTLTDGEEIPADLVVVAPG 217
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
9-206 1.23e-06

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 50.34  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   9 RRVCVIGAGTAGLCALKN---SLEAGLDAVAYERGTEIG-GtwifseeMPkdeYDEVHSSMyeglRTNLPKEVMG-YPD- 82
Cdd:COG4529   6 KRIAIIGGGASGTALAIHllrRAPEPLRITLFEPRPELGrG-------VA---YSTDSPEH----LLNVPAGRMSaFPDd 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  83 ------------YSYPDDITESFITSNQVL-EFLRSYAEHF--KLKAHIKLQH---EVIRVRPRLDDWEVYvwdhsTDTC 144
Cdd:COG4529  72 pdhflrwlrengARAAPAIDPDAFVPRRLFgEYLRERLAEAlaRAPAGVRLRHiraEVVDLERDDGGYRVT-----LADG 146

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19921694 145 DPVYYDFVYVCNGHYTePDLPEVEGLDlfegnkmHSHLYR---KADKFK----DARVLIIGAGPSGMDI 206
Cdd:COG4529 147 ETLRADAVVLATGHPP-PAPPPGLAAG-------SPRYIAdpwPPGALArippDARVLIIGTGLTAIDV 207
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 10-269 4.02e-06

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 48.47  E-value: 4.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    10 RVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEiggtwifseeMPkdeydevhssmyeGLRTNLPKEVMGYPDysypddI 89
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGT----------CP-------------YGGCVLSKALLGAAE------A 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694    90 TESFITSNQVLEflrSYAEH-FKLKAHIK--LQHEVIRVRPrlDDWEVYVWDHSTDTCDPVYYDFVYVCNGhyTEPDLPE 166
Cdd:pfam07992  53 PEIASLWADLYK---RKEEVvKKLNNGIEvlLGTEVVSIDP--GAKKVVLEELVDGDGETITYDRLVIATG--ARPRLPP 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694   167 VEGLDL--FEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLSHHLST------TPNTAFMGNVTQK 238
Cdd:pfam07992 126 IPGVELnvGFLVRTLDSAEALRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDRllrafdEEISAALEKALEK 205

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 19921694   239 PD--------VKRFTKDG----AVFTDGSTESFDHVMFCTGYK 269
Cdd:pfam07992 206 NGvevrlgtsVKEIIGDGdgveVILKDGTEIDADLVVVAIGRR 248
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
11-221 4.51e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 45.11  E-value: 4.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  11 VCVIGAGTAGLCAlknSLEA---GLDAVAYERGtEIGG--TWifseempkdeYDEVHssmyeglrtNLPkevmGYPDysy 85
Cdd:COG0492   3 VVIIGAGPAGLTA---AIYAaraGLKTLVIEGG-EPGGqlAT----------TKEIE---------NYP----GFPE--- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921694  86 pdditesFITSNQVLEFLRSYAEHFKlkAHIKLQhEVIRVRPRLDDWEVyvwdhSTDTCDPVYYDFVYVCNGhyTEPDLP 165
Cdd:COG0492  53 -------GISGPELAERLREQAERFG--AEILLE-EVTSVDKDDGPFRV-----TTDDGTEYEAKAVIIATG--AGPRKL 115

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19921694 166 EVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLSH 221
Cdd:COG0492 116 GLPGEEEFEGRGVSYCATCDGFFFRGKDVVVVGGGDSALEEALYLTKFASKVTLIH 171
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 4-49 3.97e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 39.34  E-value: 3.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 19921694    4 TSVDKRrVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIF 49
Cdd:PRK12769 324 TKSDKR-VAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 9-45 8.81e-03

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 38.22  E-value: 8.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 19921694    9 RRVCVIGAGTAGL-CA--LknsLEAGLDAVAYERGTEIGG 45
Cdd:PRK12810 144 KKVAVVGSGPAGLaAAdqL---ARAGHKVTVFERADRIGG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH