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Conserved domains on  [gi|442622687|ref|NP_610267|]
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pawn, isoform B [Drosophila melanogaster]

Protein Classification

EGF_CA and EGF_2 domain-containing protein( domain architecture ID 11256704)

EGF_CA and EGF_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1026-1075 9.55e-09

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 9.55e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 442622687   1026 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLRDpwadqparsGRECQ 1075
Cdd:smart00179    1 DIDECASG--NPCQNGGTCVNTVGSYRCECPPGYTD---------GRNCE 39
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1081-1109 8.68e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 8.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 442622687  1081 VCNNHGTCSYAEDGaqlCTCDSSHYGAQC 1109
Cdd:pfam07974    1 ICSGRGTCVNQCGK---CVCDSGYQGATC 26
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 273-413 2.20e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622687  273 RPSASRINNRGPPRISEAQNLPIDYEAQKPGTSMRPPPYPfdRPERPFITGVPIPEQIVP---VRPGF-VSNRPPW---- 344
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA--QPTAPPPPPGPPPPSLPLggsVAPGGdVRRRPPSrspa 2872

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442622687  345 ----------YRNKPRPPIATSVGGNRRPLPQYKPLPAPPVQAPLQPQDPLdrknEQEKEQNHQEQPQPTDDVVLPTDT 413
Cdd:PHA03247 2873 akpaaparppVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP----PPPPQPQPPPPPPPRPQPPLAPTT 2947
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1026-1075 9.55e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 9.55e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 442622687   1026 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLRDpwadqparsGRECQ 1075
Cdd:smart00179    1 DIDECASG--NPCQNGGTCVNTVGSYRCECPPGYTD---------GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1026-1058 1.51e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.51e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442622687  1026 DLDECQSPElNDCHSGASCSNTWGSFRCACEAG 1058
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1075 1.52e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 1.52e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 442622687 1026 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLrdpwadqparSGRECQ 1075
Cdd:cd00054     1 DIDECASG--NPCQNGGTCVNTVGSYRCSCPPGY----------TGRNCE 38
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1081-1109 8.68e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 8.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 442622687  1081 VCNNHGTCSYAEDGaqlCTCDSSHYGAQC 1109
Cdd:pfam07974    1 ICSGRGTCVNQCGK---CVCDSGYQGATC 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 273-413 2.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622687  273 RPSASRINNRGPPRISEAQNLPIDYEAQKPGTSMRPPPYPfdRPERPFITGVPIPEQIVP---VRPGF-VSNRPPW---- 344
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA--QPTAPPPPPGPPPPSLPLggsVAPGGdVRRRPPSrspa 2872

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442622687  345 ----------YRNKPRPPIATSVGGNRRPLPQYKPLPAPPVQAPLQPQDPLdrknEQEKEQNHQEQPQPTDDVVLPTDT 413
Cdd:PHA03247 2873 akpaaparppVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP----PPPPQPQPPPPPPPRPQPPLAPTT 2947
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1026-1075 9.55e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 9.55e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 442622687   1026 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLRDpwadqparsGRECQ 1075
Cdd:smart00179    1 DIDECASG--NPCQNGGTCVNTVGSYRCECPPGYTD---------GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1026-1058 1.51e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.51e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442622687  1026 DLDECQSPElNDCHSGASCSNTWGSFRCACEAG 1058
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1075 1.52e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 1.52e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 442622687 1026 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLrdpwadqparSGRECQ 1075
Cdd:cd00054     1 DIDECASG--NPCQNGGTCVNTVGSYRCSCPPGY----------TGRNCE 38
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1081-1109 8.68e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 8.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 442622687  1081 VCNNHGTCSYAEDGaqlCTCDSSHYGAQC 1109
Cdd:pfam07974    1 ICSGRGTCVNQCGK---CVCDSGYQGATC 26
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1036-1058 3.12e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.50  E-value: 3.12e-04
                           10        20
                   ....*....|....*....|...
gi 442622687  1036 NDCHSGASCSNTWGSFRCACEAG 1058
Cdd:pfam12947    6 GGCHPNATCTNTGGSFTCTCNDG 28
PHA03247 PHA03247
large tegument protein UL36; Provisional
 273-413 2.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622687  273 RPSASRINNRGPPRISEAQNLPIDYEAQKPGTSMRPPPYPfdRPERPFITGVPIPEQIVP---VRPGF-VSNRPPW---- 344
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA--QPTAPPPPPGPPPPSLPLggsVAPGGdVRRRPPSrspa 2872

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442622687  345 ----------YRNKPRPPIATSVGGNRRPLPQYKPLPAPPVQAPLQPQDPLdrknEQEKEQNHQEQPQPTDDVVLPTDT 413
Cdd:PHA03247 2873 akpaaparppVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP----PPPPQPQPPPPPPPRPQPPLAPTT 2947
PHA03247 PHA03247
large tegument protein UL36; Provisional
 212-405 2.50e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622687  212 SGSPIRPSPSNTATSATAASATQAPH-SPRQNGNPDIQDIITGIVKLLN-----GNVNVHANTQGIRRPSASRINNRGP- 284
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSpSPAANEPDPHPPPTVPPPERPRddpapGRVSRPRRARRLGRAAQASSPPQRPr 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622687  285 PRISEAQNLPIDYEAQKPGtsmrPPPYPFDRPeRPFITGVPIPeqIVPVRPGFVSNRPPWYRNKPRPPIATSVGGN---- 360
Cdd:PHA03247 2685 RRAARPTVGSLTSLADPPP----PPPTPEPAP-HALVSATPLP--PGPAAARQASPALPAAPAPPAVPAGPATPGGparp 2757

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 442622687  361 -RRPLPQYKPLPAPPVQAPLQPQDPLDRKNEQEKEQNHQEQPQPTD 405
Cdd:PHA03247 2758 aRPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803
EGF smart00181
Epidermal growth factor-like domain;
1029-1058 5.89e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.96  E-value: 5.89e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 442622687   1029 ECQSPelNDCHSGaSCSNTWGSFRCACEAG 1058
Cdd:smart00181    1 ECASG--GPCSNG-TCINTPGSYTCSCPPG 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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