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Conserved domains on  [gi|19921788|ref|NP_610346|]
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uncharacterized protein Dmel_CG14762, isoform A [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
131-410 9.26e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 9.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 131 LTQLDVSLNQMKTVPsQALQHLFHLLILNLNHNKITVIhNNAFEGLETLEILTLYENKITQIdPEAFRGLEdHIKRLNLG 210
Cdd:COG4886 115 LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLT-NLKELDLS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 211 GNDLTNIPqKALSILSTLKKLEIQENKIRTISEgDFEGLQSLDSLILAHNMITTVPAnvFSHLTLLNSLELEGNKISVID 290
Cdd:COG4886 191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 291 KDAFKgleENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFEN 370
Cdd:COG4886 267 PLANL---TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 19921788 371 LNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLN 410
Cdd:COG4886 344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
131-410 9.26e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 9.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 131 LTQLDVSLNQMKTVPsQALQHLFHLLILNLNHNKITVIhNNAFEGLETLEILTLYENKITQIdPEAFRGLEdHIKRLNLG 210
Cdd:COG4886 115 LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLT-NLKELDLS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 211 GNDLTNIPqKALSILSTLKKLEIQENKIRTISEgDFEGLQSLDSLILAHNMITTVPAnvFSHLTLLNSLELEGNKISVID 290
Cdd:COG4886 191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 291 KDAFKgleENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFEN 370
Cdd:COG4886 267 PLANL---TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 19921788 371 LNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLN 410
Cdd:COG4886 344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-315 6.39e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.88  E-value: 6.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   57 LDILCETTDLAHITKSMGTLKgkspiifylkLRHNNLPKLQGFvfLALDIRHLTIHNSSLAAIEEnalsSLGAGLTQLDV 136
Cdd:PRK15370 185 LKILGLTTIPACIPEQITTLI----------LDNNELKSLPEN--LQGNIKTLYANSNQLTSIPA----TLPDTIQEMEL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  137 SLNQMKTVPSQ---ALQHLfhllilNLNHNKITVIHNNAFEGLETLEIltlYENKITQIdPEAfrgLEDHIKRLNLGGND 213
Cdd:PRK15370 249 SINRITELPERlpsALQSL------DLFHNKISCLPENLPEELRYLSV---YDNSIRTL-PAH---LPSGITHLNVQSNS 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  214 LTNIPQkalSILSTLKKLEIQENKIRTISEGDFEGLQSLDsliLAHNMITTVPANVFSHLTLLNslelegnkisvIDKDA 293
Cdd:PRK15370 316 LTALPE---TLPPGLKTLEAGENALTSLPASLPPELQVLD---VSKNQITVLPETLPPTITTLD-----------VSRNA 378

                        250       260
                 ....*....|....*....|....*.
gi 19921788  294 FKGLEEN----LQYLRLGDNQIHTIP 315
Cdd:PRK15370 379 LTNLPENlpaaLQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 158-407 1.16e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 1.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 158 LNLNHNKITVIHNnaFEGLETLEILTLYENKITQIDpeafrGLE--DHIKRLNLGGNDLTNIPQkaLSILSTLKKLEIQE 235
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE-----NLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 236 NKIRTIsegdfEGLQSLDSLilahnmittvpanvfSHLTLLNSLELEGNKISvIDKDAFKGLEENLQYLRLGDNQIHTIp 315
Cdd:cd21340  78 NRISVV-----EGLENLTNL---------------EELHIENQRLPPGEKLT-FDPRSLAALSNSLRVLNISGNNIDSL- 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 316 sEALRPLHRLRHLDLRNNNInvlaedaftgfgdsltflnlqkNDIKVLpSLLFENLNSLETLNLQNNKLQRIPQdIMEPV 395
Cdd:cd21340 136 -EPLAPLRNLEQLDASNNQI----------------------SDLEEL-LDLLSSWPSLRELDLTGNPVCKKPK-YRDKI 190

                       250
                ....*....|....*...
gi 19921788 396 I---DTLRIID---ITDN 407
Cdd:cd21340 191 IlasKSLEVLDgkeITDT 208
LRR_8 pfam13855
Leucine rich repeat;
276-335 8.48e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 8.48e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   276 LNSLELEGNKISVIDKDAFKGLEeNLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNI 335
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
131-410 9.26e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 9.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 131 LTQLDVSLNQMKTVPsQALQHLFHLLILNLNHNKITVIhNNAFEGLETLEILTLYENKITQIdPEAFRGLEdHIKRLNLG 210
Cdd:COG4886 115 LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLT-NLKELDLS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 211 GNDLTNIPqKALSILSTLKKLEIQENKIRTISEgDFEGLQSLDSLILAHNMITTVPAnvFSHLTLLNSLELEGNKISVID 290
Cdd:COG4886 191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 291 KDAFKgleENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFEN 370
Cdd:COG4886 267 PLANL---TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 19921788 371 LNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLN 410
Cdd:COG4886 344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-409 8.27e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 8.27e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 109 LTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENK 188
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 189 ITQIDPEAFRGLEDHIKRLNLGGNDltnipqkALSILSTLKKLEIQENKIRTISEgDFEGLQSLDSLILAHNMITTVPAn 268
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 269 VFSHLTLLNSLELEGNKISVIDKdAFKGLEeNLQYLRLGDNQIHTIPsEALRPLHRLRHLDLRNNNINVLAEDaFTGFGd 348
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLT- 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19921788 349 SLTFLNLQKNDIKVLPSLlfENLNSLETLNLQNNKLQRIPQdimEPVIDTLRIIDITDNPL 409
Cdd:COG4886 229 NLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-385 6.46e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 6.46e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 105 DIRHLTIHNSSLAAIEEnALSSLgAGLTQLDVSLNQMKTVPSqALQHLFHLLILNLNHNKITVIhNNAFEGLETLEILTL 184
Cdd:COG4886 114 NLESLDLSGNQLTDLPE-ELANL-TNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 185 YENKITQIdPEAFRGLEdHIKRLNLGGNDLTNIPqKALSILSTLKKLEIQENKIRTISEgdFEGLQSLDSLILAHNMITT 264
Cdd:COG4886 190 SNNQITDL-PEPLGNLT-NLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 265 VPANvfSHLTLLNSLELEGNKISV--IDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDA 342
Cdd:COG4886 265 LPPL--ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19921788 343 FTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQ 385
Cdd:COG4886 343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-315 6.39e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.88  E-value: 6.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   57 LDILCETTDLAHITKSMGTLKgkspiifylkLRHNNLPKLQGFvfLALDIRHLTIHNSSLAAIEEnalsSLGAGLTQLDV 136
Cdd:PRK15370 185 LKILGLTTIPACIPEQITTLI----------LDNNELKSLPEN--LQGNIKTLYANSNQLTSIPA----TLPDTIQEMEL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  137 SLNQMKTVPSQ---ALQHLfhllilNLNHNKITVIHNNAFEGLETLEIltlYENKITQIdPEAfrgLEDHIKRLNLGGND 213
Cdd:PRK15370 249 SINRITELPERlpsALQSL------DLFHNKISCLPENLPEELRYLSV---YDNSIRTL-PAH---LPSGITHLNVQSNS 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  214 LTNIPQkalSILSTLKKLEIQENKIRTISEGDFEGLQSLDsliLAHNMITTVPANVFSHLTLLNslelegnkisvIDKDA 293
Cdd:PRK15370 316 LTALPE---TLPPGLKTLEAGENALTSLPASLPPELQVLD---VSKNQITVLPETLPPTITTLD-----------VSRNA 378

                        250       260
                 ....*....|....*....|....*.
gi 19921788  294 FKGLEEN----LQYLRLGDNQIHTIP 315
Cdd:PRK15370 379 LTNLPENlpaaLQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 158-407 1.16e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 1.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 158 LNLNHNKITVIHNnaFEGLETLEILTLYENKITQIDpeafrGLE--DHIKRLNLGGNDLTNIPQkaLSILSTLKKLEIQE 235
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE-----NLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 236 NKIRTIsegdfEGLQSLDSLilahnmittvpanvfSHLTLLNSLELEGNKISvIDKDAFKGLEENLQYLRLGDNQIHTIp 315
Cdd:cd21340  78 NRISVV-----EGLENLTNL---------------EELHIENQRLPPGEKLT-FDPRSLAALSNSLRVLNISGNNIDSL- 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 316 sEALRPLHRLRHLDLRNNNInvlaedaftgfgdsltflnlqkNDIKVLpSLLFENLNSLETLNLQNNKLQRIPQdIMEPV 395
Cdd:cd21340 136 -EPLAPLRNLEQLDASNNQI----------------------SDLEEL-LDLLSSWPSLRELDLTGNPVCKKPK-YRDKI 190

                       250
                ....*....|....*...
gi 19921788 396 I---DTLRIID---ITDN 407
Cdd:cd21340 191 IlasKSLEVLDgkeITDT 208
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
132-409 3.96e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.57  E-value: 3.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  132 TQLDVSLNQMKTVPSQALQHLFHLLilnLNHNKITVIHNNAFEGLETLEIltlYENKITQIdPEAfrgLEDHIKRLNLGG 211
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLI---LDNNELKSLPENLQGNIKTLYA---NSNQLTSI-PAT---LPDTIQEMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  212 NDLTNIPQKalsILSTLKKLEIQENKIRTISEGDFEGLQSLDsliLAHNMITTVPANVFSHLTLLNsleLEGNKISVIDK 291
Cdd:PRK15370 251 NRITELPER---LPSALQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTLPAHLPSGITHLN---VQSNSLTALPE 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  292 DafkgLEENLQYLRLGDNQIHTIPsEALRPlhrlrhldlrnnninvlaedaftgfgdSLTFLNLQKNDIKVLPSLLFEnl 371
Cdd:PRK15370 322 T----LPPGLKTLEAGENALTSLP-ASLPP---------------------------ELQVLDVSKNQITVLPETLPP-- 367

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 19921788  372 nSLETLNLQNNKLQRIPQDImePVidTLRIIDITDNPL 409
Cdd:PRK15370 368 -TITTLDVSRNALTNLPENL--PA--ALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 234-409 1.57e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 1.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 234 QENKIRTIseGDFEGLQSLDSLILAHNMITTVPAnvFSHLTLLNSLELEGNKISVIDkdafkGLE--ENLQYLRLGDNQI 311
Cdd:cd21340  10 NDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-----NLEnlVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 312 HTIpsEALRPLHRLRHLDLRNNNI---NVLAEDAFT--GFGDSLTFLNLQKNDIKVLPSLlfENLNSLETLNLQNNKLQR 386
Cdd:cd21340  81 SVV--EGLENLTNLEELHIENQRLppgEKLTFDPRSlaALSNSLRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISD 156

                       170       180
                ....*....|....*....|....*
gi 19921788 387 IpQDIMEPVID--TLRIIDITDNPL 409
Cdd:cd21340 157 L-EELLDLLSSwpSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
276-335 8.48e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 8.48e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   276 LNSLELEGNKISVIDKDAFKGLEeNLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNI 335
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
154-214 1.24e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 1.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19921788   154 HLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEdHIKRLNLGGNDL 214
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-291 9.32e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 9.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 131 LTQLDVSLNQMKTVPSqaLQHLFHLLILNLNHNKITVIhnnafEGLETLEILTlyenkitqidpeafrglEDHIKRLNLG 210
Cdd:cd21340  48 LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV-----EGLENLTNLE-----------------ELHIENQRLP 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 211 -GNDLTNIPQKALSILSTLKKLEIQENKIRTISegDFEGLQSLDSLILAHNMITTVP--ANVFSHLTLLNSLELEGNKIS 287
Cdd:cd21340 104 pGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVC 181


                ....
gi 19921788 288 VIDK 291
Cdd:cd21340 182 KKPK 185
LRR_8 pfam13855
Leucine rich repeat;
226-286 1.27e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.27e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19921788   226 STLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKI 286
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
203-262 5.98e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 5.98e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   203 HIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMI 262
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
300-360 1.05e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.05e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19921788   300 NLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFgDSLTFLNLQKNDI 360
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
250-311 2.52e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 2.52e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19921788   250 QSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLeENLQYLRLGDNQI 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-409 3.44e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 3.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   81 PIIFYLKLRHNNLP-KLQGFVF-LALDIRHLTIHNSSLA-AIEENALSslgaGLTQLDVSLNQMKTVPSQALQHLFHLLI 157
Cdd:PLN00113  93 PYIQTINLSNNQLSgPIPDDIFtTSSSLRYLNLSNNNFTgSIPRGSIP----NLETLDLSNNMLSGEIPNDIGSFSSLKV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  158 LNLNHNKITVIHNNAFEGLETLEILTLYENKIT-QIDPEAfrGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQEN 236
Cdd:PLN00113 169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPREL--GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  237 KIRTISEGDFEGLQSLDSLILAHNMIT-TVPANVFShLTLLNSLELEGNKISVIDKDAFKGLeENLQYLRLGDNQIH-TI 314
Cdd:PLN00113 247 NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQL-QNLEILHLFSNNFTgKI 324

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  315 PsEALRPLHRLRHLDLRNNNINVlAEDAFTGFGDSLTFLNLQKNDIK-VLPS-----------LLFEN------------ 370
Cdd:PLN00113 325 P-VALTSLPRLQVLQLWSNKFSG-EIPKNLGKHNNLTVLDLSTNNLTgEIPEglcssgnlfklILFSNslegeipkslga 402

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 19921788  371 LNSLETLNLQNNKLQ-RIPQDIME-PVIDTLriiDITDNPL 409
Cdd:PLN00113 403 CRSLRRVRLQDNSFSgELPSEFTKlPLVYFL---DISNNNL 440
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 163-277 8.07e-08

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 51.01  E-value: 8.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   163 NKITVIHNNAFEGLETLEILTLYENkITQIDPEAFRGLedHIKRLNLGGNdLTNIPQKALSILSTLKKLEIQENkIRTIS 242
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC--SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIG 94

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 19921788   243 EGDFEGLqSLDSLILaHNMITTVPANVFSHLTLLN 277
Cdd:pfam13306  95 SYAFSNC-SLKSITI-PSSVTTIGSYAFSNCSNLK 127
LRR_8 pfam13855
Leucine rich repeat;
130-189 1.16e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.16e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   130 GLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKI 189
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 97-344 2.99e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 2.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  97 QGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQ------LDVSLNQM--KTVPS--QALQHLFHLLILNLNHNKIT 166
Cdd:COG5238 170 AISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQnttvttLWLKRNPIgdEGAEIlaEALKGNKSLTTLDLSNNQIG 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 167 ----VIHNNAFEGLETLEILTLYENKITqidpeafrglEDHIKRLNlggndltnipqKALSILSTLKKLEIQENKI---- 238
Cdd:COG5238 250 degvIALAEALKNNTTVETLYLSGNQIG----------AEGAIALA-----------KALQGNTTLTSLDLSVNRIgdeg 308

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 239 -RTISEGdFEGLQSLDSLILAHNMITTVPAN-VFSHL---TLLNSLELEGNKISVIDKDAF-KGLEEN--LQYLRLGDNQ 310
Cdd:COG5238 309 aIALAEG-LQGNKTLHTLNLAYNGIGAQGAIaLAKALqenTTLHSLDLSDNQIGDEGAIALaKYLEGNttLRELNLGKNN 387

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 19921788 311 IHTIPSEALRPL---HRLRHLDLRNNNINVLAEDAFT 344
Cdd:COG5238 388 IGKQGAEALIDAlqtNRLHTLILDGNLIGAEAQQRLE 424
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-412 5.93e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  131 LTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFrGLEDHIKRLNLG 210
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNL-GKHNNLTVLDLS 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  211 GNDLT-NIPQ-----------------------KALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVP 266
Cdd:PLN00113 365 TNNLTgEIPEglcssgnlfklilfsnslegeipKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRI 444

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  267 ANVFSHLTLLNSLELEGNKISVIDKDAFKGleENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGF 346
Cdd:PLN00113 445 NSRKWDMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSC 522

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19921788  347 gDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQ-RIPQDIMEpvIDTLRIIDITDNPLNCS 412
Cdd:PLN00113 523 -KKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGN--VESLVQVNISHNHLHGS 586
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 158-316 2.48e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  158 LNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGleDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENK 237
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK 510

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  238 IRTISEGDFEGLQSLDSLILAHNMIT-TVPANvFSHLTLLNSLELEGNKISViDKDAFKGLEENLQYLRLGDNQIH-TIP 315
Cdd:PLN00113 511 LSGEIPDELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSG-EIPKNLGNVESLVQVNISHNHLHgSLP 588


                 .
gi 19921788  316 S 316
Cdd:PLN00113 589 S 589
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
49-305 6.93e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.54  E-value: 6.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   49 ICTVKKNGLDILCETTDlAHIT------KSMGTLKGKSPIIFYLKLRHNNL-------PKLQGFVFLALDIRHLTIHNSS 115
Cdd:PRK15387 205 VLNVGESGLTTLPDCLP-AHITtlvipdNNLTSLPALPPELRTLEVSGNQLtslpvlpPGLLELSIFSNPLTHLPALPSG 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  116 LAA--IEENALSSLGA---GLTQLDVSLNQMKTVPSQALQhlfhLLILNLNHNKIT------------VIHNNAFEGLET 178
Cdd:PRK15387 284 LCKlwIFGNQLTSLPVlppGLQELSVSDNQLASLPALPSE----LCKLWAYNNQLTslptlpsglqelSVSDNQLASLPT 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  179 L--EILTL--YENKITQIDpeafrGLEDHIKRLNLGGNDLTNIPqkalSILSTLKKLEIQENKIRTISEgdfegLQS-LD 253
Cdd:PRK15387 360 LpsELYKLwaYNNRLTSLP-----ALPSGLKELIVSGNRLTSLP----VLPSELKELMVSGNRLTSLPM-----LPSgLL 425

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 19921788  254 SLILAHNMITTVPANVFsHLTLLNSLELEGNKISvidkdafkglEENLQYLR 305
Cdd:PRK15387 426 SLSVYRNQLTRLPESLI-HLSSETTVNLEGNPLS----------ERTLQALR 466
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 166-318 1.49e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 41.38  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   166 TVIHNNAFEG--LETLEIltlyENKITQIDPEAFRGLedhikrlnlggndltnipqkalsilSTLKKLEIQENkIRTISE 243
Cdd:pfam13306   1 TSIGSYAFYNcsLTSITI----PSSLTSIGEYAFSNC-------------------------TSLKSITLPSS-LTSIGS 50

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19921788   244 GDFEGLqSLDSLILAHNmITTVPANVFSHLTLLNSLELEGNkISVIDKDAFKGLeeNLQYLRLGDNqIHTIPSEA 318
Cdd:pfam13306  51 YAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGSYAFSNC--SLKSITIPSS-VTTIGSYA 119
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 93-384 5.48e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 5.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788  93 LPKLQGFVflALDIRHLTIHNSSLAAIEENALSSlgAGLTQLDVSLNQMKTVPS------QALQHLFHLLILNLNHNKIT 166
Cdd:cd00116  19 LPKLLCLQ--VLRLEGNTLGEEAAKALASALRPQ--PSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 167 VIHNNAFEGL---ETLEILTLYENKItQIDPEAF--RGLEDH---IKRLNLGGNDLTNIP----QKALSILSTLKKLEIQ 234
Cdd:cd00116  95 PDGCGVLESLlrsSSLQELKLNNNGL-GDRGLRLlaKGLKDLppaLEKLVLGRNRLEGAScealAKALRANRDLKELNLA 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788 235 ENKIRTisegdfEGLQSLdslilahnmittvpANVFSHLTLLNSLELEGNKISvidkdafkgleenlqylRLGDNQIhti 314
Cdd:cd00116 174 NNGIGD------AGIRAL--------------AEGLKANCNLEVLDLNNNGLT-----------------DEGASAL--- 213

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19921788 315 pSEALRPLHRLRHLDLRNNNINV--LAE--DAFTGFGDSLTFLNLQKNDIKVLPSLLF----ENLNSLETLNLQNNKL 384
Cdd:cd00116 214 -AETLASLKSLEVLNLGDNNLTDagAAAlaSALLSPNISLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
349-409 6.25e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 6.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19921788   349 SLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPvIDTLRIIDITDNPL 409
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG-LPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 168-399 2.97e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   168 IHNNAFEGLETLEILTLYENKITQID------PEAFRGLEDHIKRLNLGGNDLTNIPQKALSilSTLKKLEIQENKIRTI 241
Cdd:PLN03210  549 IHENAFKGMRNLLFLKFYTKKWDQKKevrwhlPEGFDYLPPKLRLLRWDKYPLRCMPSNFRP--ENLVKLQMQGSKLEKL 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   242 SEG--DFEGLQSLD-----------SLILAHNMITTVPANVFS---------HLTLLNSLELEG-----------NKISV 288
Cdd:PLN03210  627 WDGvhSLTGLRNIDlrgsknlkeipDLSMATNLETLKLSDCSSlvelpssiqYLNKLEDLDMSRcenleilptgiNLKSL 706

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921788   289 IDKD--------AFKGLEENLQYLRLGDNQIHTIPSE-ALRPLHRLRHLDLRNNNINV---LAEDAFTGFGDSLTFLNLQ 356
Cdd:PLN03210  707 YRLNlsgcsrlkSFPDISTNISWLDLDETAIEEFPSNlRLENLDELILCEMKSEKLWErvqPLTPLMTMLSPSLTRLFLS 786

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 19921788   357 KNDIKV-LPSlLFENLNSLETLNLQNNK-LQRIPQDIMEPVIDTL 399
Cdd:PLN03210  787 DIPSLVeLPS-SIQNLHKLEHLEIENCInLETLPTGINLESLESL 830
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 300-334 7.35e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 7.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19921788   300 NLQYLRLGDNQIHTIPseALRPLHRLRHLDLRNNN 334
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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