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Conserved domains on  [gi|24586614|ref|NP_610391|]
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uncharacterized protein Dmel_CG42326, isoform D [Drosophila melanogaster]

Protein Classification

PAN/Apple domain-containing protein( domain architecture ID 10099731)

PAN/Apple domain-containing protein similar to Homo sapiens plasminogen-like proteins A and B, which may bind noncovalently to lysine binding sites present in the kringle structures of plasminogen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 44-136 1.26e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 66.72  E-value: 1.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614  44 KACFRRVLAGKRIAPHFVRRSISCERVEECMRECGRERRFMCEGFNYRldpsgHGQGDCELVEMPLAQMDlysSPDRRDA 123
Cdd:cd01099   1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYN-----YKSKECILSDEDRMSSG---VKLLYDS 72

                        90
                ....*....|...
gi 24586614 124 NllrhpdYDYYER 136
Cdd:cd01099  73 N------VDYYEN 79
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 560-646 4.60e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 65.18  E-value: 4.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614 560 QCFFRAIDATRFF-KSIVRDSLTVRSVGECEMECIRSTKFTCRAFAFRYGQQrhagvidNCQLSDWPVRDMDKERhlILD 638
Cdd:cd01099   1 LNDFKFVLVLNKIlVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSK-------ECILSDEDRMSSGVKL--LYD 71


                ....*...
gi 24586614 639 AAFDIFER 646
Cdd:cd01099  72 SNVDYYEN 79
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 446-529 1.02e-08

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 52.86  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614 446 ECSAKTSEGFRLHKTAVRHAYNVPTLTECERLCSDPRpSFVCHTFSYRYNqagRDNCMLCDRPINMLDyyVDIEPDRDYD 525
Cdd:cd01099   2 NDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEET-EFTCRSFNYNYK---SKECILSDEDRMSSG--VKLLYDSNVD 75


                ....
gi 24586614 526 IYSM 529
Cdd:cd01099  76 YYEN 79
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 44-136 1.26e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 66.72  E-value: 1.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614  44 KACFRRVLAGKRIAPHFVRRSISCERVEECMRECGRERRFMCEGFNYRldpsgHGQGDCELVEMPLAQMDlysSPDRRDA 123
Cdd:cd01099   1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYN-----YKSKECILSDEDRMSSG---VKLLYDS 72

                        90
                ....*....|...
gi 24586614 124 NllrhpdYDYYER 136
Cdd:cd01099  73 N------VDYYEN 79
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 560-646 4.60e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 65.18  E-value: 4.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614 560 QCFFRAIDATRFF-KSIVRDSLTVRSVGECEMECIRSTKFTCRAFAFRYGQQrhagvidNCQLSDWPVRDMDKERhlILD 638
Cdd:cd01099   1 LNDFKFVLVLNKIlVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSK-------ECILSDEDRMSSGVKL--LYD 71


                ....*...
gi 24586614 639 AAFDIFER 646
Cdd:cd01099  72 SNVDYYEN 79
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 446-529 1.02e-08

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 52.86  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614 446 ECSAKTSEGFRLHKTAVRHAYNVPTLTECERLCSDPRpSFVCHTFSYRYNqagRDNCMLCDRPINMLDyyVDIEPDRDYD 525
Cdd:cd01099   2 NDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEET-EFTCRSFNYNYK---SKECILSDEDRMSSG--VKLLYDSNVD 75


                ....
gi 24586614 526 IYSM 529
Cdd:cd01099  76 YYEN 79
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 44-136 1.26e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 66.72  E-value: 1.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614  44 KACFRRVLAGKRIAPHFVRRSISCERVEECMRECGRERRFMCEGFNYRldpsgHGQGDCELVEMPLAQMDlysSPDRRDA 123
Cdd:cd01099   1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYN-----YKSKECILSDEDRMSSG---VKLLYDS 72

                        90
                ....*....|...
gi 24586614 124 NllrhpdYDYYER 136
Cdd:cd01099  73 N------VDYYEN 79
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 560-646 4.60e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 65.18  E-value: 4.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614 560 QCFFRAIDATRFF-KSIVRDSLTVRSVGECEMECIRSTKFTCRAFAFRYGQQrhagvidNCQLSDWPVRDMDKERhlILD 638
Cdd:cd01099   1 LNDFKFVLVLNKIlVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSK-------ECILSDEDRMSSGVKL--LYD 71


                ....*...
gi 24586614 639 AAFDIFER 646
Cdd:cd01099  72 SNVDYYEN 79
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 446-529 1.02e-08

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 52.86  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586614 446 ECSAKTSEGFRLHKTAVRHAYNVPTLTECERLCSDPRpSFVCHTFSYRYNqagRDNCMLCDRPINMLDyyVDIEPDRDYD 525
Cdd:cd01099   2 NDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEET-EFTCRSFNYNYK---SKECILSDEDRMSSG--VKLLYDSNVD 75


                ....
gi 24586614 526 IYSM 529
Cdd:cd01099  76 YYEN 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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