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Conserved domains on  [gi|19922002|ref|NP_610629|]
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NADH dehydrogenase (ubiquinone) B14 subunit, isoform A [Drosophila melanogaster]

Protein Classification

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6( domain architecture ID 14448821)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which is believed to be not involved in catalysis

Gene Ontology:  GO:0005747|GO:0032981|GO:0006120|GO:0008137|GO:0042776

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_NDUFA6_LYRM6 cd20266
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha ...
 22-96 2.07e-36

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins; NDUFA6, also called LYR motif-containing protein 6 (LYRM6), or Complex I-B14 (CI-B14), or NADH-ubiquinone oxidoreductase B14 subunit, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFA6 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380761  Cd Length: 75  Bit Score: 118.82  E-value: 2.07e-36
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19922002  22 REEARKRALNLYKAWYRQIPYIVMDYDIPMTVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKESVEIWKQ 96
Cdd:cd20266   1 LEEARRRVLQLYRAWYRSIPTIVEIYNLDITVSQLRSKIREEFRKNAHVTDPRVIDMLVIKGQMELQETLNAWKQ 75
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFA6_LYRM6 cd20266
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha ...
 22-96 2.07e-36

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins; NDUFA6, also called LYR motif-containing protein 6 (LYRM6), or Complex I-B14 (CI-B14), or NADH-ubiquinone oxidoreductase B14 subunit, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFA6 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380761  Cd Length: 75  Bit Score: 118.82  E-value: 2.07e-36
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19922002  22 REEARKRALNLYKAWYRQIPYIVMDYDIPMTVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKESVEIWKQ 96
Cdd:cd20266   1 LEEARRRVLQLYRAWYRSIPTIVEIYNLDITVSQLRSKIREEFRKNAHVTDPRVIDMLVIKGQMELQETLNAWKQ 75
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 27-89 3.49e-07

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 44.11  E-value: 3.49e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19922002    27 KRALNLYKAWYRQIpyivMDYDIPMTVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKE 89
Cdd:pfam05347   1 RQVLSLYRALLRAA----RKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFA6_LYRM6 cd20266
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha ...
 22-96 2.07e-36

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins; NDUFA6, also called LYR motif-containing protein 6 (LYRM6), or Complex I-B14 (CI-B14), or NADH-ubiquinone oxidoreductase B14 subunit, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFA6 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380761  Cd Length: 75  Bit Score: 118.82  E-value: 2.07e-36
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19922002  22 REEARKRALNLYKAWYRQIPYIVMDYDIPMTVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKESVEIWKQ 96
Cdd:cd20266   1 LEEARRRVLQLYRAWYRSIPTIVEIYNLDITVSQLRSKIREEFRKNAHVTDPRVIDMLVIKGQMELQETLNAWKQ 75
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 27-89 3.49e-07

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 44.11  E-value: 3.49e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19922002    27 KRALNLYKAWYRQIpyivMDYDIPMTVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKE 89
Cdd:pfam05347   1 RQVLSLYRALLRAA----RKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 29-89 1.32e-06

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 42.53  E-value: 1.32e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19922002  29 ALNLYKAWYRQIPYIVMDYdipmTVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKE 89
Cdd:cd20251   1 VLKLYRDLLRLARKGLPSR----KRDALRQRIREEFRKNKNETDPEKIEELLAEARRGLKN 57
Complex1_LYR_LYRM2 cd20262
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ...
 26-89 9.78e-06

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380757  Cd Length: 63  Bit Score: 40.21  E-value: 9.78e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19922002  26 RKRALNLYKAWYRQIpyivmdYDIPMTVEQ--CRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKE 89
Cdd:cd20262   3 RAQVLSLYRDILRAI------RKIPDPSTRreLRDWVREEFERNRNETDEDAIKYLLSQGKRQLKE 62
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 26-89 1.70e-04

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 37.54  E-value: 1.70e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19922002  26 RKRALNLYKAWYRQIPYIVMDYDIpmtVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQMELKE 89
Cdd:cd20263   2 KQRVLRLYRRALKTLLSWCVDRDI---FRYEAVLLRARFDANKDVKDPRKAEKLLEEGEAELWE 62
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 48-91 4.03e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 33.69  E-value: 4.03e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 19922002  48 DIPMtVEQCRDKLREEFVKHRNVTDIRVIDMLVIKGQ---MELKESV 91
Cdd:cd20267  19 DTPA-LKAARQKIREEFEKNRNETDPEKIAELLKEAReaaEFLRKNV 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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