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Conserved domains on  [gi|24653442|ref|NP_610890|]
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uncharacterized protein Dmel_CG6191, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 596-713 5.93e-64

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410259  Cd Length: 119  Bit Score: 208.19  E-value: 5.93e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442 596 LTLSKLRSIKREMRRINKLDSRIDLVTISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMND-VKGDALKSLIEKTE 674
Cdd:cd20556   1 LTLSKLRSLKREMLKIALKLCGLDVSTVALAYVYFEKLVLKGLVNKSNRKLIAGACLLLAAKFNDdVKKEDLKSLLEEIE 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24653442 675 SVFRLNRKELISSEFAVLVALEFSLHVNRHEVLPHYQRL 713
Cdd:cd20556  81 DVFRLTRKELIAFEFPVLVALEFSLHVPDEEILPHLQRL 119
 
Name Accession Description Interval E-value
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 596-713 5.93e-64

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410259  Cd Length: 119  Bit Score: 208.19  E-value: 5.93e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442 596 LTLSKLRSIKREMRRINKLDSRIDLVTISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMND-VKGDALKSLIEKTE 674
Cdd:cd20556   1 LTLSKLRSLKREMLKIALKLCGLDVSTVALAYVYFEKLVLKGLVNKSNRKLIAGACLLLAAKFNDdVKKEDLKSLLEEIE 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24653442 675 SVFRLNRKELISSEFAVLVALEFSLHVNRHEVLPHYQRL 713
Cdd:cd20556  81 DVFRLTRKELIAFEFPVLVALEFSLHVPDEEILPHLQRL 119
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 598-699 5.55e-05

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 43.27  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442   598 LSKLRSIKREMRRI-----NKLDSRIDLV--TISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMNDVKGDALKSLI 670
Cdd:pfam00134  20 MDQQPDINPKMRAIlidwlVEVHEKFKLLpeTLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTVEDLV 99

                          90       100
                  ....*....|....*....|....*....
gi 24653442   671 EKTESVFRlnRKELISSEFAVLVALEFSL 699
Cdd:pfam00134 100 YITDNAYT--REEILRMERLILETLNFDL 126
 
Name Accession Description Interval E-value
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 596-713 5.93e-64

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410259  Cd Length: 119  Bit Score: 208.19  E-value: 5.93e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442 596 LTLSKLRSIKREMRRINKLDSRIDLVTISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMND-VKGDALKSLIEKTE 674
Cdd:cd20556   1 LTLSKLRSLKREMLKIALKLCGLDVSTVALAYVYFEKLVLKGLVNKSNRKLIAGACLLLAAKFNDdVKKEDLKSLLEEIE 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24653442 675 SVFRLNRKELISSEFAVLVALEFSLHVNRHEVLPHYQRL 713
Cdd:cd20556  81 DVFRLTRKELIAFEFPVLVALEFSLHVPDEEILPHLQRL 119
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 587-717 7.18e-49

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410305  Cd Length: 132  Bit Score: 167.91  E-value: 7.18e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442 587 FREKFPTIQLTLSKLRSIKREMRRINKLDSRIDLVTISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKM-NDVKGDA 665
Cdd:cd20602   1 FKEKFPHIKLTLSKIRSLKREMRKLAQEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIgSDLKKHE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 24653442 666 LKSLIEKTESVFRLNRKELISSEFAVLVALEFSLHVNRHEVLPHYQRLLYES 717
Cdd:cd20602  81 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQNS 132
CYCLIN_CABLES2 cd20603
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ...
 596-714 8.48e-42

cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410306  Cd Length: 121  Bit Score: 148.11  E-value: 8.48e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442 596 LTLSKLRSIKREMRRINKlDSRIDLVTISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMN-DVKGDALKSLIEKTE 674
Cdd:cd20603   1 LTLSKIRSLKREMRNVAE-ECNLEPVTVAMAYVYFEKLVLQGKLNKQNRKLCAGACVLLAAKISsDLKKHEVKHLIDKLE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 24653442 675 SVFRLNRKELISSEFAVLVALEFSLHVNRHEVLPHYQRLL 714
Cdd:cd20603  80 ERFRLNRRELISFEFTVLVALELALYLPENQVLPHYRRLT 119
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 598-699 5.55e-05

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 43.27  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442   598 LSKLRSIKREMRRI-----NKLDSRIDLV--TISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMNDVKGDALKSLI 670
Cdd:pfam00134  20 MDQQPDINPKMRAIlidwlVEVHEKFKLLpeTLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTVEDLV 99

                          90       100
                  ....*....|....*....|....*....
gi 24653442   671 EKTESVFRlnRKELISSEFAVLVALEFSL 699
Cdd:pfam00134 100 YITDNAYT--REEILRMERLILETLNFDL 126
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 603-688 3.58e-04

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 39.70  E-value: 3.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653442 603 SIKREMRRI-NKLDsrIDLVTISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMNDVKGDaLKSLIEktesVFRLNR 681
Cdd:cd00043   1 KAVDFIRRLcSKLG--LPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRT-LKEIAK----VSGVSE 73


                ....*..
gi 24653442 682 KELISSE 688
Cdd:cd00043  74 KELRKAE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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