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Conserved domains on  [gi|161077094|ref|NP_611025|]
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integrin alphaPS4 subunit [Drosophila melanogaster]

Protein Classification

VCBS and Int_alpha domain-containing protein( domain architecture ID 12146452)

protein containing domains VCBS, Int_alpha, and Integrin_alpha2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 super family cl26747
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 486-808 4.18e-28

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


The actual alignment was detected with superfamily member pfam08441:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 118.96  E-value: 4.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   486 PVVKIHAIIKPKLQNVNPEEER----------VNITVCYRLSSKSDSKAKAlmeqELVIRIDIDT---KSKIKLAVF--D 550
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRACFSYTGKPIPNPSL----VLNYELELDRqkkKGLPPRVLFldS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   551 EEHGSQMSFKAKAFHEEICSEFQIEM--DKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPKFVTEYITFNTGC 628
Cdd:pfam08441   78 QQPSLTGTLVLLSQGRKVCRTTKAYLrdEFRDKLSPIVISLNYSLRVDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDC 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   629 ATD-VCVADLKIS----CINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQV-------PGNCKVNEA 696
Cdd:pfam08441  158 GEDnVCVPDLQLSakfdSRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrregsekQLSCTAKKE 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   697 ----VMVCDLnhGQRMAKGDTDSLTISFDVRQLR--GRSLEIQAEVLSARDEsNPENNKLTNVLSLREKADIYVSGVQTN 770
Cdd:pfam08441  238 nstrQVVCDL--GNPMKRGTQVTFGLRFSVSGLElsTEELSFDLQIRSTNEQ-NSNSNPVSLKVPVVAEAQLSLSGVSKP 314

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 161077094   771 DHVVL-------KESPYTAE----VVNY-YEIKSHGPSTLENLTVSLYIP 808
Cdd:pfam08441  315 DQVVGgsvkgesAMKPRSEEdigpLVEHtYEVINNGPSTVSGASLEISWP 364
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 384-434 2.24e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 62.78  E-value: 2.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 161077094    384 SGGRFGTTLSRIGDINKDGYNDVAVGAPFAGN----GSVFIYLGSENGLRDPPSQ 434
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQ 55
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 335-408 1.65e-09

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 54.54  E-value: 1.65e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161077094   335 DLNGDGKTDVIISaplyalrnsyDDGAIYVFINKGSFTFEERIIRSPAGSGGRFGTTlsrIGDINKDGYNDVAV 408
Cdd:pfam13517    1 DLDGDGKLDLVVA----------NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVA---VGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-492 6.55e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.37  E-value: 6.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 161077094    447 GSYmFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHA 492
Cdd:smart00191    2 GSY-FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 486-808 4.18e-28

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 118.96  E-value: 4.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   486 PVVKIHAIIKPKLQNVNPEEER----------VNITVCYRLSSKSDSKAKAlmeqELVIRIDIDT---KSKIKLAVF--D 550
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRACFSYTGKPIPNPSL----VLNYELELDRqkkKGLPPRVLFldS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   551 EEHGSQMSFKAKAFHEEICSEFQIEM--DKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPKFVTEYITFNTGC 628
Cdd:pfam08441   78 QQPSLTGTLVLLSQGRKVCRTTKAYLrdEFRDKLSPIVISLNYSLRVDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDC 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   629 ATD-VCVADLKIS----CINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQV-------PGNCKVNEA 696
Cdd:pfam08441  158 GEDnVCVPDLQLSakfdSRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrregsekQLSCTAKKE 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   697 ----VMVCDLnhGQRMAKGDTDSLTISFDVRQLR--GRSLEIQAEVLSARDEsNPENNKLTNVLSLREKADIYVSGVQTN 770
Cdd:pfam08441  238 nstrQVVCDL--GNPMKRGTQVTFGLRFSVSGLElsTEELSFDLQIRSTNEQ-NSNSNPVSLKVPVVAEAQLSLSGVSKP 314

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 161077094   771 DHVVL-------KESPYTAE----VVNY-YEIKSHGPSTLENLTVSLYIP 808
Cdd:pfam08441  315 DQVVGgsvkgesAMKPRSEEdigpLVEHtYEVINNGPSTVSGASLEISWP 364
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 384-434 2.24e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 62.78  E-value: 2.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 161077094    384 SGGRFGTTLSRIGDINKDGYNDVAVGAPFAGN----GSVFIYLGSENGLRDPPSQ 434
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQ 55
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 335-408 1.65e-09

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 54.54  E-value: 1.65e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161077094   335 DLNGDGKTDVIISaplyalrnsyDDGAIYVFINKGSFTFEERIIRSPAGSGGRFGTTlsrIGDINKDGYNDVAV 408
Cdd:pfam13517    1 DLDGDGKLDLVVA----------NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVA---VGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 323-367 4.60e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.45  E-value: 4.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 161077094    323 FGEYFGYSV-LAEDLNGDGKTDVIISAPLYAlrNSYDDGAIYVFIN 367
Cdd:smart00191    1 PGSYFGYSVaGVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-492 6.55e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.37  E-value: 6.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 161077094    447 GSYmFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHA 492
Cdd:smart00191    2 GSY-FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSS 46
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 388-421 1.24e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.96  E-value: 1.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 161077094   388 FGTTLSrIGDINKDGYNDVAVGAPFA---GNGSVFIY 421
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
COG1572 COG1572
Serine protease, subtilase family [Posttranslational modification, protein turnover, ...
 636-807 3.79e-04

Serine protease, subtilase family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441180 [Multi-domain]  Cd Length: 459  Bit Score: 44.19  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094  636 DLKISCINASSTLVLGTTAvlRLTYNITNNGefayhpkfsVTNSAGLSL-----AQVPGNCKVNEAVMVCDLNHgqrmak 710
Cdd:COG1572   133 DLVVTSVTAPSTLTPGTTI--TVSVTVNNQG---------SAPANGSSVdfdasDTLLGSFTVASLTLAAGASY------ 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094  711 gdTDSLTISFDVRQLRGRSLEIQAEVLSARDESNPENNKLT----NVLSLreKADIYVSGVQTNDHVVLkESPYTAEvvn 786
Cdd:COG1572   196 --TFNPTLTLPVTASGNYYLLVVADPDNYVLETNETNNTTAaaeiTVSGT--PPDLTVTSVTAPSTVVE-GDTITVS--- 267

                         170       180
                  ....*....|....*....|.
gi 161077094  787 yYEIKSHGPSTLENLTVSLYI 807
Cdd:COG1572   268 -ATVKNQGTAAAGATTVAFYL 287
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 451-482 5.14e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.56  E-value: 5.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 161077094   451 FGHGLSRGsDIDGNGFNDFAIGAP-----NAEAVYLY 482
Cdd:pfam01839    1 FGYSVAVG-DLNGDGYADLAVGAPgeggaGAGAVYVL 36
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 486-808 4.18e-28

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 118.96  E-value: 4.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   486 PVVKIHAIIKPKLQNVNPEEER----------VNITVCYRLSSKSDSKAKAlmeqELVIRIDIDT---KSKIKLAVF--D 550
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRACFSYTGKPIPNPSL----VLNYELELDRqkkKGLPPRVLFldS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   551 EEHGSQMSFKAKAFHEEICSEFQIEM--DKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPKFVTEYITFNTGC 628
Cdd:pfam08441   78 QQPSLTGTLVLLSQGRKVCRTTKAYLrdEFRDKLSPIVISLNYSLRVDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDC 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   629 ATD-VCVADLKIS----CINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQV-------PGNCKVNEA 696
Cdd:pfam08441  158 GEDnVCVPDLQLSakfdSRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrregsekQLSCTAKKE 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094   697 ----VMVCDLnhGQRMAKGDTDSLTISFDVRQLR--GRSLEIQAEVLSARDEsNPENNKLTNVLSLREKADIYVSGVQTN 770
Cdd:pfam08441  238 nstrQVVCDL--GNPMKRGTQVTFGLRFSVSGLElsTEELSFDLQIRSTNEQ-NSNSNPVSLKVPVVAEAQLSLSGVSKP 314

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 161077094   771 DHVVL-------KESPYTAE----VVNY-YEIKSHGPSTLENLTVSLYIP 808
Cdd:pfam08441  315 DQVVGgsvkgesAMKPRSEEdigpLVEHtYEVINNGPSTVSGASLEISWP 364
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 384-434 2.24e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 62.78  E-value: 2.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 161077094    384 SGGRFGTTLSRIGDINKDGYNDVAVGAPFAGN----GSVFIYLGSENGLRDPPSQ 434
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQ 55
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 335-408 1.65e-09

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 54.54  E-value: 1.65e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161077094   335 DLNGDGKTDVIISaplyalrnsyDDGAIYVFINKGSFTFEERIIRSPAGSGGRFGTTlsrIGDINKDGYNDVAV 408
Cdd:pfam13517    1 DLDGDGKLDLVVA----------NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVA---VGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 327-365 3.06e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 53.28  E-value: 3.06e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 161077094   327 FGYSVLAEDLNGDGKTDVIISAPLYalrNSYDDGAIYVF 365
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE---GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 323-367 4.60e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.45  E-value: 4.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 161077094    323 FGEYFGYSV-LAEDLNGDGKTDVIISAPLYAlrNSYDDGAIYVFIN 367
Cdd:smart00191    1 PGSYFGYSVaGVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-492 6.55e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.37  E-value: 6.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 161077094    447 GSYmFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHA 492
Cdd:smart00191    2 GSY-FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSS 46
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 388-421 1.24e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.96  E-value: 1.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 161077094   388 FGTTLSrIGDINKDGYNDVAVGAPFA---GNGSVFIY 421
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
COG1572 COG1572
Serine protease, subtilase family [Posttranslational modification, protein turnover, ...
 636-807 3.79e-04

Serine protease, subtilase family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441180 [Multi-domain]  Cd Length: 459  Bit Score: 44.19  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094  636 DLKISCINASSTLVLGTTAvlRLTYNITNNGefayhpkfsVTNSAGLSL-----AQVPGNCKVNEAVMVCDLNHgqrmak 710
Cdd:COG1572   133 DLVVTSVTAPSTLTPGTTI--TVSVTVNNQG---------SAPANGSSVdfdasDTLLGSFTVASLTLAAGASY------ 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094  711 gdTDSLTISFDVRQLRGRSLEIQAEVLSARDESNPENNKLT----NVLSLreKADIYVSGVQTNDHVVLkESPYTAEvvn 786
Cdd:COG1572   196 --TFNPTLTLPVTASGNYYLLVVADPDNYVLETNETNNTTAaaeiTVSGT--PPDLTVTSVTAPSTVVE-GDTITVS--- 267

                         170       180
                  ....*....|....*....|.
gi 161077094  787 yYEIKSHGPSTLENLTVSLYI 807
Cdd:COG1572   268 -ATVKNQGTAAAGATTVAFYL 287
MJ0795 COG1361
S-layer protein MJ0795, predicted component of type IV pili-like system [General function ...
 635-817 4.49e-03

S-layer protein MJ0795, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 440972 [Multi-domain]  Cd Length: 409  Bit Score: 40.83  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094  635 ADLKISCINASSTLVLGTTAVLRLTynITNNG-EFAYHPKFSVTNSAGLSLAQVPGNCKVNEAVMVCD-----LNHGQ-- 706
Cdd:COG1361   136 PRFEVVSVTSPDSLTPGDTGTLTLT--IKNTGtGTAKNVTVTLTSPSGDLTDLEPGPRPATNVVVVLSspvspVGSNSva 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077094  707 --RMAKGDTDSLTISFDV-RQLRGRSLEIQAEVlSARDESNpennkltNVLSLREKADIYVSGVQTNDHVVLKESPYTAE 783
Cdd:COG1361   214 lgTLEPGESATFTFKVDVsEDAEPGPYPLPLTV-TYRDEDG-------DTYSDTVTIGVYVAPKADFEVENVESTITAGE 285

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 161077094  784 VVNYY-EIKSHGPSTLENLTVSLYIPVAYKTPDST 817
Cdd:COG1361   286 TVTITiTVTNTGNETAKNVVARLSADDPLSSLDDE 320
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 451-482 5.14e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.56  E-value: 5.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 161077094   451 FGHGLSRGsDIDGNGFNDFAIGAP-----NAEAVYLY 482
Cdd:pfam01839    1 FGYSVAVG-DLNGDGYADLAVGAPgeggaGAGAVYVL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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