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Conserved domains on  [gi|24653992|ref|NP_611073|]
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transmembrane protein 131, isoform A [Drosophila melanogaster]

Protein Classification

TMEM131_like_N and TMEM131_like domain-containing protein( domain architecture ID 10574799)

TMEM131_like_N and TMEM131_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM131_like_N pfam12371
Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and ...
 54-137 2.68e-32

Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and other metazoa transmembrane proteins. Many of the members are multi-pass transmembrane proteins. This domain represents the N-terminal region which contains a conserved homology domain (CHD1).


:

Pssm-ID: 463553  Cd Length: 84  Bit Score: 120.84  E-value: 2.68e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992     54 LRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFLPRQLGAIAADL 133
Cdd:pfam12371    1 VSISPPVLDFGQQSLCVPASRVVTVVNMHQRETLFLLSVTTDSPDFYSSFFESVVLPPGGNTSFKVVFLPRELGASSASL 80


                   ....
gi 24653992    134 LIHT 137
Cdd:pfam12371   81 HLHT 84
TMEM131_like super family cl44944
Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a ...
 880-1064 4.20e-21

Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localization. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. This family is related to pfam12371.


The actual alignment was detected with superfamily member pfam19532:

Pssm-ID: 437364  Cd Length: 1429  Bit Score: 100.99  E-value: 4.20e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    880 KYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGC--QS-GNEAVV-VTRSFTARNSGVIP 955
Cdd:pfam19532  520 KVTSLILIRNNLTVLDMVTVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCrrQLkDSKQILsITKNFKVENIGPLP 599

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    956 IRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCA 1035
Cdd:pfam19532  600 ITVSSMKINGYNCQGYGFEVLDCHSFSLDPNSSREISIVFTPDFTSSWVIRELTLVTAAGLEFRFTLNVTLPHHLLPLCA 679

                          170       180
                   ....*....|....*....|....*....
gi 24653992   1036 SLLVRPGWESSLknAALVVLLASFGLVLV 1064
Cdd:pfam19532  680 DVVPGPSWEESF--WRLTVLFVSLSLLGV 706
 
Name Accession Description Interval E-value
TMEM131_like_N pfam12371
Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and ...
 54-137 2.68e-32

Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and other metazoa transmembrane proteins. Many of the members are multi-pass transmembrane proteins. This domain represents the N-terminal region which contains a conserved homology domain (CHD1).


Pssm-ID: 463553  Cd Length: 84  Bit Score: 120.84  E-value: 2.68e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992     54 LRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFLPRQLGAIAADL 133
Cdd:pfam12371    1 VSISPPVLDFGQQSLCVPASRVVTVVNMHQRETLFLLSVTTDSPDFYSSFFESVVLPPGGNTSFKVVFLPRELGASSASL 80


                   ....
gi 24653992    134 LIHT 137
Cdd:pfam12371   81 HLHT 84
TMEM131_like pfam19532
Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a ...
 880-1064 4.20e-21

Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localization. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. This family is related to pfam12371.


Pssm-ID: 437364  Cd Length: 1429  Bit Score: 100.99  E-value: 4.20e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    880 KYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGC--QS-GNEAVV-VTRSFTARNSGVIP 955
Cdd:pfam19532  520 KVTSLILIRNNLTVLDMVTVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCrrQLkDSKQILsITKNFKVENIGPLP 599

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    956 IRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCA 1035
Cdd:pfam19532  600 ITVSSMKINGYNCQGYGFEVLDCHSFSLDPNSSREISIVFTPDFTSSWVIRELTLVTAAGLEFRFTLNVTLPHHLLPLCA 679

                          170       180
                   ....*....|....*....|....*....
gi 24653992   1036 SLLVRPGWESSLknAALVVLLASFGLVLV 1064
Cdd:pfam19532  680 DVVPGPSWEESF--WRLTVLFVSLSLLGV 706
choice_anch_D NF012200
choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long ...
 52-135 3.14e-04

choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, such as type IX secrection (T9SS) or PEP-CTERM.


Pssm-ID: 467954 [Multi-domain]  Cd Length: 107  Bit Score: 41.84  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    52 GDLRLVPSRLDFGTWSVGQARSQTVTLFNQhSNRTLQLNAVA--GPSPAFYS---SFLGTreVPPQGNTTFNVVFLPRQL 126
Cdd:NF012200   15 PSITPSPASIDFGNVRVGDTASQTVTITNT-GTAALTIEGLTisGTNAGDFTvsgNSPTT--LAAGGSCTLTVTFDPTAA 91


                  ....*....
gi 24653992   127 GAIAADLLI 135
Cdd:NF012200   92 GARSGTLTI 100
 
Name Accession Description Interval E-value
TMEM131_like_N pfam12371
Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and ...
 54-137 2.68e-32

Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and other metazoa transmembrane proteins. Many of the members are multi-pass transmembrane proteins. This domain represents the N-terminal region which contains a conserved homology domain (CHD1).


Pssm-ID: 463553  Cd Length: 84  Bit Score: 120.84  E-value: 2.68e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992     54 LRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFLPRQLGAIAADL 133
Cdd:pfam12371    1 VSISPPVLDFGQQSLCVPASRVVTVVNMHQRETLFLLSVTTDSPDFYSSFFESVVLPPGGNTSFKVVFLPRELGASSASL 80


                   ....
gi 24653992    134 LIHT 137
Cdd:pfam12371   81 HLHT 84
TMEM131_like pfam19532
Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a ...
 880-1064 4.20e-21

Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localization. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. This family is related to pfam12371.


Pssm-ID: 437364  Cd Length: 1429  Bit Score: 100.99  E-value: 4.20e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    880 KYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGC--QS-GNEAVV-VTRSFTARNSGVIP 955
Cdd:pfam19532  520 KVTSLILIRNNLTVLDMVTVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCrrQLkDSKQILsITKNFKVENIGPLP 599

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    956 IRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCA 1035
Cdd:pfam19532  600 ITVSSMKINGYNCQGYGFEVLDCHSFSLDPNSSREISIVFTPDFTSSWVIRELTLVTAAGLEFRFTLNVTLPHHLLPLCA 679

                          170       180
                   ....*....|....*....|....*....
gi 24653992   1036 SLLVRPGWESSLknAALVVLLASFGLVLV 1064
Cdd:pfam19532  680 DVVPGPSWEESF--WRLTVLFVSLSLLGV 706
choice_anch_D NF012200
choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long ...
 52-135 3.14e-04

choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, such as type IX secrection (T9SS) or PEP-CTERM.


Pssm-ID: 467954 [Multi-domain]  Cd Length: 107  Bit Score: 41.84  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653992    52 GDLRLVPSRLDFGTWSVGQARSQTVTLFNQhSNRTLQLNAVA--GPSPAFYS---SFLGTreVPPQGNTTFNVVFLPRQL 126
Cdd:NF012200   15 PSITPSPASIDFGNVRVGDTASQTVTITNT-GTAALTIEGLTisGTNAGDFTvsgNSPTT--LAAGGSCTLTVTFDPTAA 91


                  ....*....
gi 24653992   127 GAIAADLLI 135
Cdd:NF012200   92 GARSGTLTI 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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