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Conserved domains on  [gi|20130037|ref|NP_611095|]
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clueless, isoform A [Drosophila melanogaster]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11700348)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 445-665 4.42e-114

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


:

Pssm-ID: 463814  Cd Length: 225  Bit Score: 357.63  E-value: 4.42e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    445 DWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDH 524
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    525 YKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQ----SVVYGSIDFGKTV 600
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20130037    601 LSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNF 665
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 870-1073 6.83e-70

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


:

Pssm-ID: 463717  Cd Length: 168  Bit Score: 231.69  E-value: 6.83e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    870 SSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFL 946
Cdd:pfam12807    1 SSFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPnkaRLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    947 NCLLTNGPvNPAVSSEEAHKKRGNGGKHNKhksskggkgqqqqqttgnqngsssgssnsssasDWTLMTPRSLWQQIRKE 1026
Cdd:pfam12807   81 NCLLGSSL-NPKPTAEIDELLKGLYKKKNR---------------------------------AWAKLTPESLWEEIEQE 126

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 20130037   1027 AKVYWDWELDCDSIETAVSKygilrISLMRAFCLKVGIQVLLREYNF 1073
Cdd:pfam12807  127 VKSRFRYELPEDWVDSGLQK-----ISLLREICLKTGIQLLAREYNF 168
CLU_N super family cl20917
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 163-232 3.65e-14

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


The actual alignment was detected with superfamily member pfam15044:

Pssm-ID: 464466  Cd Length: 79  Bit Score: 68.83  E-value: 3.65e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20130037    163 VQEIHQLLMDREETCHRTCFSLQLDNVT---LDNFAELKSI--NNLEQGSTIKVVEEPYTMREARIHVRHVRDLL 232
Cdd:pfam15044    5 VQDLRQVLSELPATKYLTNYHLEYQNGNgerLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
FxSxx_TPR super family cl48889
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1117-1309 9.40e-14

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


The actual alignment was detected with superfamily member NF040586:

Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 76.50  E-value: 9.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1117 GLFKEGYELISGALNLLNNVFGALHQENGSCLRMLArLSY-LLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSL 1195
Cdd:NF040586  492 GRFREALELDEETLERHRRVFGEDHPRTLRAANNLA-VSLrLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLAR 570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1196 YSFANGHVGMSLKLLYRA-RYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMH---VA 1271
Cdd:NF040586  571 DLRELGRYAEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDtlaAA 650

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 20130037  1272 LSYhlmARTQSCMGDFRSALNNEKETYSFYKSQLGENH 1309
Cdd:NF040586  651 LSL---ANDLRALGDADEARELAREVLDRYRRVLGEDH 685
GSKIP_dom super family cl05054
GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to ...
 324-387 3.72e-04

GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria.


The actual alignment was detected with superfamily member pfam05303:

Pssm-ID: 398795  Cd Length: 103  Bit Score: 41.41  E-value: 3.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20130037    324 DLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHISPSFRRAFQ 387
Cdd:pfam05303   30 GVAYINVTTLEGNRYCIELSAAGFRIVGYRYDCVDGESEDHTKYYETLYALLDYISPLYRESFG 93
 
Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 445-665 4.42e-114

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


Pssm-ID: 463814  Cd Length: 225  Bit Score: 357.63  E-value: 4.42e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    445 DWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDH 524
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    525 YKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQ----SVVYGSIDFGKTV 600
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20130037    601 LSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNF 665
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 870-1073 6.83e-70

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


Pssm-ID: 463717  Cd Length: 168  Bit Score: 231.69  E-value: 6.83e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    870 SSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFL 946
Cdd:pfam12807    1 SSFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPnkaRLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    947 NCLLTNGPvNPAVSSEEAHKKRGNGGKHNKhksskggkgqqqqqttgnqngsssgssnsssasDWTLMTPRSLWQQIRKE 1026
Cdd:pfam12807   81 NCLLGSSL-NPKPTAEIDELLKGLYKKKNR---------------------------------AWAKLTPESLWEEIEQE 126

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 20130037   1027 AKVYWDWELDCDSIETAVSKygilrISLMRAFCLKVGIQVLLREYNF 1073
Cdd:pfam12807  127 VKSRFRYELPEDWVDSGLQK-----ISLLREICLKTGIQLLAREYNF 168
CLU-central cd15466
An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the ...
 873-1073 1.10e-54

An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homolog (CluA), Caenorhabditis elegans clustered mitochondria protein homolog (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homolog), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homolog (CLUH). Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease). Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation.


Pssm-ID: 271318  Cd Length: 159  Bit Score: 187.56  E-value: 1.10e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  873 PIDGQSLTESLHSHGINVRYLGKVIKILSQMPRMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTN 952
Cdd:cd15466    1 PIDGASLTELLHRRGINMRYLGKVAELISKLPKLPHLKRLLLTEMVARAAKHILRAYLRSVPLAELSAAVAHFLNCLLGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  953 GPvNPAVSSEEAHKKRGNggkhnkhksskggkgqqqqqttgnqngsssgssnssSASDWTLMTPRSLWQQIRKEAKVYWD 1032
Cdd:cd15466   81 SS-NPAPSAEIDEELKPA------------------------------------ADTSWASLTPSFLWKEIKKEVKKRFR 123

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 20130037 1033 WELDCDSIETavskyGILRISLMRAFCLKVGIQVLLREYNF 1073
Cdd:cd15466  124 YDLPEESLDE-----GLRKLSLLRELCLKVGIQLLARDYDF 159
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 163-232 3.65e-14

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


Pssm-ID: 464466  Cd Length: 79  Bit Score: 68.83  E-value: 3.65e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20130037    163 VQEIHQLLMDREETCHRTCFSLQLDNVT---LDNFAELKSI--NNLEQGSTIKVVEEPYTMREARIHVRHVRDLL 232
Cdd:pfam15044    5 VQDLRQVLSELPATKYLTNYHLEYQNGNgerLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1117-1309 9.40e-14

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 76.50  E-value: 9.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1117 GLFKEGYELISGALNLLNNVFGALHQENGSCLRMLArLSY-LLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSL 1195
Cdd:NF040586  492 GRFREALELDEETLERHRRVFGEDHPRTLRAANNLA-VSLrLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLAR 570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1196 YSFANGHVGMSLKLLYRA-RYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMH---VA 1271
Cdd:NF040586  571 DLRELGRYAEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDtlaAA 650

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 20130037  1272 LSYhlmARTQSCMGDFRSALNNEKETYSFYKSQLGENH 1309
Cdd:NF040586  651 LSL---ANDLRALGDADEARELAREVLDRYRRVLGEDH 685
TPR_12 pfam13424
Tetratricopeptide repeat;
1227-1303 7.62e-11

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 7.62e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20130037   1227 EVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKS 1303
Cdd:pfam13424    1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1115-1337 5.97e-08

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 57.62  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1115 QQGLFKEGYELISGALNLL--NNVFGALHQEngsclRMLARLSY-----LLGDAQDALAIQQRAVIMSERVNGMDHPSTI 1187
Cdd:NF040586  446 SLGRYEEARELDEDTLERQrrVLGLGEDHPH-----TLMTAGGLgadlrALGRFREALELDEETLERHRRVFGEDHPRTL 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1188 LEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKD 1267
Cdd:NF040586  521 RAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVLGGPD 600

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1268 ----MHVALSYhlmARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTR----DSAECLRLL--TQQAVLLQRKMNDIY 1337
Cdd:NF040586  601 hpdtLRAAKSL---AVALRRAGRLEEALELAEDTYERYRRRFGPDHPDTLaaalSLANDLRALgdADEARELAREVLDRY 677
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1117-1321 1.68e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 56.08  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1117 GLFKEGYELISGALNLLNNVFGALHQEngsclRMLARLSY-----LLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYT 1191
Cdd:NF040586  619 GRLEEALELAEDTYERYRRRFGPDHPD-----TLAAALSLandlrALGDADEARELAREVLDRYRRVLGEDHPFTLACRN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1192 HLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRfiEHALKLNLKYFGDKDMHVA 1271
Cdd:NF040586  694 NLAVLLRALGDPEEARELAEAALEGLRERLGPDHPYTLAAAVNLANDLAALGDLDAALG--EEALERLRRLLGEDLRAGP 771

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 20130037  1272 LSYHLM------ARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRL 1321
Cdd:NF040586  772 DHPDTLacaanlALDLRATGRTEEAEELRADTLARLRRVLGPDHPDTVAAREGRRL 827
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1156-1322 6.68e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 50.69  E-value: 6.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1156 YLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLslysfANGH--VG-------MSLKLLYRARYLMVLicGEDHP 1226
Cdd:NF040586  403 YLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHL-----ANALrsLGryeeareLDEDTLERQRRVLGL--GEDHP 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1227 EVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKD------MH-VALSYHLMartqscmGDFRSALNNEKETYS 1299
Cdd:NF040586  476 HTLMTAGGLGADLRALGRFREALELDEETLERHRRVFGEDHprtlraANnLAVSLRLL-------GDYREALELDREVLR 548

                         170       180
                  ....*....|....*....|....*..
gi 20130037  1300 FYKSQLGENHEKTRDS----AECLRLL 1322
Cdd:NF040586  549 RRRRVLGPDHPRTLLSannlARDLREL 575
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1137-1331 3.67e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 48.38  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1137 FGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVN--GMDHPSTILeythlslysFANGHvGMSLKLL--Y- 1211
Cdd:NF040586  426 LGPDDRQTLRLRFHLANALRSLGRYEEARELDEDTLERQRRVLglGEDHPHTLM---------TAGGL-GADLRALgrFr 495

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1212 RARYL-------MVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCM 1284
Cdd:NF040586  496 EALELdeetlerHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLREL 575

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 20130037  1285 GDFRSALNNEKETYSFYKSQLGenhekTRDSAECLRLLTQQAVLLQR 1331
Cdd:NF040586  576 GRYAEALDLLEEALERYREVLG-----GPDHPDTLRAAKSLAVALRR 617
GSKIP_dom pfam05303
GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to ...
 324-387 3.72e-04

GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria.


Pssm-ID: 398795  Cd Length: 103  Bit Score: 41.41  E-value: 3.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20130037    324 DLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHISPSFRRAFQ 387
Cdd:pfam05303   30 GVAYINVTTLEGNRYCIELSAAGFRIVGYRYDCVDGESEDHTKYYETLYALLDYISPLYRESFG 93
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1096-1331 1.07e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037 1096 ISPRATDAYNFYttGQAKIQQGLFKEGYELISGALnllnnvfgALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMs 1175
Cdd:COG0457    3 LDPDDAEAYNNL--GLAYRRLGRYEEAIEDYEKAL--------ELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037 1176 ervngmdHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLmvlicgedHPEVALIDSNISLILHALGEYELSLRFIEHA 1255
Cdd:COG0457   72 -------DPDDAEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRYDEAIEAYERA 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20130037 1256 LKLNLKYfGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQR 1331
Cdd:COG0457  137 LELDPDD-ADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211
 
Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 445-665 4.42e-114

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


Pssm-ID: 463814  Cd Length: 225  Bit Score: 357.63  E-value: 4.42e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    445 DWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDH 524
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    525 YKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQ----SVVYGSIDFGKTV 600
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20130037    601 LSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNF 665
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 870-1073 6.83e-70

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


Pssm-ID: 463717  Cd Length: 168  Bit Score: 231.69  E-value: 6.83e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    870 SSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFL 946
Cdd:pfam12807    1 SSFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPnkaRLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037    947 NCLLTNGPvNPAVSSEEAHKKRGNGGKHNKhksskggkgqqqqqttgnqngsssgssnsssasDWTLMTPRSLWQQIRKE 1026
Cdd:pfam12807   81 NCLLGSSL-NPKPTAEIDELLKGLYKKKNR---------------------------------AWAKLTPESLWEEIEQE 126

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 20130037   1027 AKVYWDWELDCDSIETAVSKygilrISLMRAFCLKVGIQVLLREYNF 1073
Cdd:pfam12807  127 VKSRFRYELPEDWVDSGLQK-----ISLLREICLKTGIQLLAREYNF 168
CLU-central cd15466
An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the ...
 873-1073 1.10e-54

An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homolog (CluA), Caenorhabditis elegans clustered mitochondria protein homolog (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homolog), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homolog (CLUH). Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease). Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation.


Pssm-ID: 271318  Cd Length: 159  Bit Score: 187.56  E-value: 1.10e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  873 PIDGQSLTESLHSHGINVRYLGKVIKILSQMPRMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTN 952
Cdd:cd15466    1 PIDGASLTELLHRRGINMRYLGKVAELISKLPKLPHLKRLLLTEMVARAAKHILRAYLRSVPLAELSAAVAHFLNCLLGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  953 GPvNPAVSSEEAHKKRGNggkhnkhksskggkgqqqqqttgnqngsssgssnssSASDWTLMTPRSLWQQIRKEAKVYWD 1032
Cdd:cd15466   81 SS-NPAPSAEIDEELKPA------------------------------------ADTSWASLTPSFLWKEIKKEVKKRFR 123

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 20130037 1033 WELDCDSIETavskyGILRISLMRAFCLKVGIQVLLREYNF 1073
Cdd:cd15466  124 YDLPEESLDE-----GLRKLSLLRELCLKVGIQLLARDYDF 159
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 163-232 3.65e-14

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


Pssm-ID: 464466  Cd Length: 79  Bit Score: 68.83  E-value: 3.65e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20130037    163 VQEIHQLLMDREETCHRTCFSLQLDNVT---LDNFAELKSI--NNLEQGSTIKVVEEPYTMREARIHVRHVRDLL 232
Cdd:pfam15044    5 VQDLRQVLSELPATKYLTNYHLEYQNGNgerLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1117-1309 9.40e-14

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 76.50  E-value: 9.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1117 GLFKEGYELISGALNLLNNVFGALHQENGSCLRMLArLSY-LLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSL 1195
Cdd:NF040586  492 GRFREALELDEETLERHRRVFGEDHPRTLRAANNLA-VSLrLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLAR 570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1196 YSFANGHVGMSLKLLYRA-RYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMH---VA 1271
Cdd:NF040586  571 DLRELGRYAEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDtlaAA 650

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 20130037  1272 LSYhlmARTQSCMGDFRSALNNEKETYSFYKSQLGENH 1309
Cdd:NF040586  651 LSL---ANDLRALGDADEARELAREVLDRYRRVLGEDH 685
TPR_12 pfam13424
Tetratricopeptide repeat;
1227-1303 7.62e-11

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 7.62e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20130037   1227 EVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKS 1303
Cdd:pfam13424    1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1115-1337 5.97e-08

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 57.62  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1115 QQGLFKEGYELISGALNLL--NNVFGALHQEngsclRMLARLSY-----LLGDAQDALAIQQRAVIMSERVNGMDHPSTI 1187
Cdd:NF040586  446 SLGRYEEARELDEDTLERQrrVLGLGEDHPH-----TLMTAGGLgadlrALGRFREALELDEETLERHRRVFGEDHPRTL 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1188 LEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKD 1267
Cdd:NF040586  521 RAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVLGGPD 600

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1268 ----MHVALSYhlmARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTR----DSAECLRLL--TQQAVLLQRKMNDIY 1337
Cdd:NF040586  601 hpdtLRAAKSL---AVALRRAGRLEEALELAEDTYERYRRRFGPDHPDTLaaalSLANDLRALgdADEARELAREVLDRY 677
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1117-1321 1.68e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 56.08  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1117 GLFKEGYELISGALNLLNNVFGALHQEngsclRMLARLSY-----LLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYT 1191
Cdd:NF040586  619 GRLEEALELAEDTYERYRRRFGPDHPD-----TLAAALSLandlrALGDADEARELAREVLDRYRRVLGEDHPFTLACRN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1192 HLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRfiEHALKLNLKYFGDKDMHVA 1271
Cdd:NF040586  694 NLAVLLRALGDPEEARELAEAALEGLRERLGPDHPYTLAAAVNLANDLAALGDLDAALG--EEALERLRRLLGEDLRAGP 771

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 20130037  1272 LSYHLM------ARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRL 1321
Cdd:NF040586  772 DHPDTLacaanlALDLRATGRTEEAEELRADTLARLRRVLGPDHPDTVAAREGRRL 827
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1156-1322 6.68e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 50.69  E-value: 6.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1156 YLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLslysfANGH--VG-------MSLKLLYRARYLMVLicGEDHP 1226
Cdd:NF040586  403 YLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHL-----ANALrsLGryeeareLDEDTLERQRRVLGL--GEDHP 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1227 EVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKD------MH-VALSYHLMartqscmGDFRSALNNEKETYS 1299
Cdd:NF040586  476 HTLMTAGGLGADLRALGRFREALELDEETLERHRRVFGEDHprtlraANnLAVSLRLL-------GDYREALELDREVLR 548

                         170       180
                  ....*....|....*....|....*..
gi 20130037  1300 FYKSQLGENHEKTRDS----AECLRLL 1322
Cdd:NF040586  549 RRRRVLGPDHPRTLLSannlARDLREL 575
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1137-1331 3.67e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 48.38  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1137 FGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVN--GMDHPSTILeythlslysFANGHvGMSLKLL--Y- 1211
Cdd:NF040586  426 LGPDDRQTLRLRFHLANALRSLGRYEEARELDEDTLERQRRVLglGEDHPHTLM---------TAGGL-GADLRALgrFr 495

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037  1212 RARYL-------MVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCM 1284
Cdd:NF040586  496 EALELdeetlerHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLREL 575

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 20130037  1285 GDFRSALNNEKETYSFYKSQLGenhekTRDSAECLRLLTQQAVLLQR 1331
Cdd:NF040586  576 GRYAEALDLLEEALERYREVLG-----GPDHPDTLRAAKSLAVALRR 617
TPR_12 pfam13424
Tetratricopeptide repeat;
1110-1172 4.79e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.14  E-value: 4.79e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20130037   1110 GQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAV 1172
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERAL 72
TPR_10 pfam13374
Tetratricopeptide repeat;
1146-1184 1.43e-04

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 40.56  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20130037   1146 SCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHP 1184
Cdd:pfam13374    3 SSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHP 41
GSKIP_dom pfam05303
GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to ...
 324-387 3.72e-04

GSKIP domain; This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria.


Pssm-ID: 398795  Cd Length: 103  Bit Score: 41.41  E-value: 3.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20130037    324 DLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHISPSFRRAFQ 387
Cdd:pfam05303   30 GVAYINVTTLEGNRYCIELSAAGFRIVGYRYDCVDGESEDHTKYYETLYALLDYISPLYRESFG 93
TPR_12 pfam13424
Tetratricopeptide repeat;
1206-1261 7.91e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 7.91e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 20130037   1206 SLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLK 1261
Cdd:pfam13424   22 ALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1096-1331 1.07e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037 1096 ISPRATDAYNFYttGQAKIQQGLFKEGYELISGALnllnnvfgALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMs 1175
Cdd:COG0457    3 LDPDDAEAYNNL--GLAYRRLGRYEEAIEDYEKAL--------ELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037 1176 ervngmdHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLmvlicgedHPEVALIDSNISLILHALGEYELSLRFIEHA 1255
Cdd:COG0457   72 -------DPDDAEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRYDEAIEAYERA 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20130037 1256 LKLNLKYfGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQR 1331
Cdd:COG0457  137 LELDPDD-ADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1139-1291 4.18e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130037 1139 ALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMservngmdHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLmv 1218
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL-- 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20130037 1219 licgedHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYfgdkdmhvALSYHLMARTQSCMGDFRSAL 1291
Cdd:COG0457   72 ------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDD--------AEALYNLGLALLELGRYDEAI 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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