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Conserved domains on  [gi|24654584|ref|NP_611261|]
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uncharacterized protein Dmel_CG10931 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
47-340 9.47e-85

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 261.77  E-value: 9.47e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  47 AIKHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWD 125
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 126 ARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLV 205
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 206 RLWDSSTGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIV 285
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24654584 286 SGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT--VRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
47-340 9.47e-85

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 261.77  E-value: 9.47e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  47 AIKHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWD 125
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 126 ARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLV 205
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 206 RLWDSSTGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIV 285
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24654584 286 SGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT--VRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-341 6.00e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 243.01  E-value: 6.00e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  49 KHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWDAR 127
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGtYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 128 SKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRL 207
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 208 WDSSTGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIVSG 287
Cdd:cd00200 162 WDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS--VAFSPDGY-LLASG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 24654584 288 SEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIWK 341
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 52-181 1.65e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 64.91  E-value: 1.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584   52 LLGHSGCVTGLKFSS-NGENLVSSSGDRLLKLWDLSATRCIQS-------LAGHGDGVNDVAW--SAAGLIASCSDDMTV 121
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFhpSAMNVLASAGADMVV 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  122 RLWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQ 181
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 170-209 4.28e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 4.28e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24654584    170 TGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWD 209
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
171-209 4.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 4.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24654584   171 GKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWD 209
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
47-340 9.47e-85

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 261.77  E-value: 9.47e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  47 AIKHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWD 125
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 126 ARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLV 205
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 206 RLWDSSTGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIV 285
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24654584 286 SGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT--VRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-341 6.00e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 243.01  E-value: 6.00e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  49 KHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWDAR 127
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGtYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 128 SKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRL 207
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 208 WDSSTGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIVSG 287
Cdd:cd00200 162 WDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS--VAFSPDGY-LLASG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 24654584 288 SEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIWK 341
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
50-300 4.35e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 244.82  E-value: 4.35e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  50 HSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWDARS 128
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLAT 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 129 KLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLW 208
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 209 DSSTGHVLKTLVDvDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIVSGS 288
Cdd:COG2319 316 DLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS--VAFSPDGR-TLASGS 391

                       250
                ....*....|..
gi 24654584 289 EDNTLCIWNLQT 300
Cdd:COG2319 392 ADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
47-340 4.40e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 242.12  E-value: 4.40e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  47 AIKHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWD 125
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 126 ARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLV 205
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 206 RLWDSSTGHVLKTLvDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIV 285
Cdd:COG2319 229 RLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS--VAFSPDGK-LLA 304

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24654584 286 SGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT--VRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
50-340 4.06e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.02  E-value: 4.06e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  50 HSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWDARS 128
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGrLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 129 KLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLW 208
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 209 DSSTGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIVSGS 288
Cdd:COG2319 190 DLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS--VAFSPDGR-LLASGS 265

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 24654584 289 EDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT--VRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
64-340 9.51e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 184.34  E-value: 9.51e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  64 FSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWDARSKLCVKVLEGHSRYS 142
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 143 FSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWDSSTGHVLKTLVDV 222
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 223 DNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCsnSNFSTTGGiWIVSGSEDNTLCIWNLQTRE 302
Cdd:COG2319 162 SG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGK-LLASGSADGTVRLWDLATGK 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 24654584 303 LVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGT--VRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-340 1.10e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.70  E-value: 1.10e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 131 CVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWDS 210
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 211 STGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNefYCSNSNFSTTGGIwIVSGSED 290
Cdd:cd00200  81 ETGECVRTLTGHTS-YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD--WVNSVAFSPDGTF-VASSSQD 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 24654584 291 NTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT--IKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
104-340 7.32e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.32e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 104 VAWSAAGLIASCSDDMTVRLWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDP 183
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 184 ITSVDFHRDGNIFVTSSYDGLVRLWDSSTGHVLKTLVDVDNiPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYR 263
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654584 264 GHLNEFYCsnSNFSTTGGiWIVSGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSyaIKIW 340
Cdd:COG2319 160 GHSGAVTS--VAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT--VRLW 231
PTZ00421 PTZ00421
coronin; Provisional
 52-181 1.65e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 64.91  E-value: 1.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584   52 LLGHSGCVTGLKFSS-NGENLVSSSGDRLLKLWDLSATRCIQS-------LAGHGDGVNDVAW--SAAGLIASCSDDMTV 121
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFhpSAMNVLASAGADMVV 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  122 RLWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQ 181
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-298 1.01e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  135 LEGHSRYSfSCCFNPQ-ANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHR-DGNIFVTSSYDGLVRLWDSST 212
Cdd:PLN00181 529 LASRSKLS-GICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQ 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  213 GHVLKTLVDVDNIPVgyVKF-SPNGRYILSSTLNNTLRLWNYKKPKC-MRTYRGHLNEF-YCSNSNFSTtggiwIVSGSE 289
Cdd:PLN00181 608 GVSIGTIKTKANICC--VQFpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVsYVRFVDSST-----LVSSST 680


                 ....*....
gi 24654584  290 DNTLCIWNL 298
Cdd:PLN00181 681 DNTLKLWDL 689
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 71-315 1.86e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584   71 LVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAG--LIASCSDDMTVRLWDARSKLCVKVLEGHSRYsfsCCF- 147
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADptLLASGSDDGSVKLWSINQGVSIGTIKTKANI---CCVq 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  148 --NPQANLLASTSFDETVRLWDVRTGKT-LKIVHAHQDPITSVDFhRDGNIFVTSSYDGLVRLWD---SSTG------HV 215
Cdd:PLN00181 625 fpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDlsmSISGinetplHS 703

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  216 LKTLVDVDNipvgYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRghlnefycsNSNFSTTGGIWIVSGSEDNTLCI 295
Cdd:PLN00181 704 FMGHTNVKN----FVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYK---------FKTIDPVSGLEVDDASQFISSVC 770

                        250       260
                 ....*....|....*....|
gi 24654584  296 WNLQTRELVQKISTEGDQIL 315
Cdd:PLN00181 771 WRGQSSTLVAANSTGNIKIL 790
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 170-209 4.28e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 4.28e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24654584    170 TGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWD 209
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
153-248 1.08e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 153 LLASTSFDETVRLWDVRTGKTLKIVHAHQDPiTSVDFHRDGN-IFVTSSYDGLVRLWDSSTGHVLKTlVDVDNIPVGyVK 231
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVAT-IPVGAGPHG-IA 158

                        90
                ....*....|....*...
gi 24654584 232 FSPNGRYIL-SSTLNNTL 248
Cdd:COG3391 159 VDPDGKRLYvANSGSNTV 176
WD40 pfam00400
WD domain, G-beta repeat;
171-209 4.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 4.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24654584   171 GKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWD 209
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 89-125 1.73e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24654584     89 RCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWD 125
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
89-125 4.78e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.78e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24654584    89 RCIQSLAGHGDGVNDVAWSAAG-LIASCSDDMTVRLWD 125
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 131-167 1.70e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.70e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24654584    131 CVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWD 167
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 94-172 4.44e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584   94 LAGHGDGVNDVAWSA--AGLIASCSDDMTVRLWDARSK----------LCvkVLEGHSRYSFSCCFNPQAN-LLASTSFD 160
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNdesvkeikdpQC--ILKGHKKKISIIDWNPMNYyIMCSSGFD 147

                         90
                 ....*....|..
gi 24654584  161 ETVRLWDVRTGK 172
Cdd:PTZ00420 148 SFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
50-84 4.94e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 4.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 24654584    50 HSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWD 84
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-84 7.49e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.49e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 24654584     50 HSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWD 84
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
131-167 2.45e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 24654584   131 CVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWD 167
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
197-304 1.02e-04

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 44.10  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 197 VTSSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNtLRLWNYK-KPKCMRTYrghLNEFYcsNSN 275
Cdd:COG5354   5 FPLDYSAVISVFWNSQSEVIHTRFESENWPVAYVSESPLGTYLFSEHAAG-VECWGGPsKAKLVRFR---HPDVK--YLD 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24654584 276 FSTTGGI---W-----------IVSGSEDNTLCIWNLQTRELV 304
Cdd:COG5354  79 FSPNEKYlvtWsrepiiepeieISPFTSKNNVFVWDIASGMIV 121
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 51-117 1.19e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 1.19e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654584   51 SLLGHSGCVTGLKFSsNGENLVSSSGDRLLKLWDLSATRC------IQSLAGHGDGVNDVAWSAA-GLIASCSD 117
Cdd:PLN00181 656 TMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSdGYIATGSE 728
PTZ00420 PTZ00420
coronin; Provisional
 104-209 2.88e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  104 VAWS--AAGLIAScsddmtVRLWDARSKLCVKVLEGHSRYSFSCCFNP-QANLLASTSFDETVRLWDVR----TGKTLK- 175
Cdd:PTZ00420  43 VPWEveGGGLIGA------IRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPhndeSVKEIKd 116

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 24654584  176 ---IVHAHQDPITSVDFH-RDGNIFVTSSYDGLVRLWD 209
Cdd:PTZ00420 117 pqcILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
74-276 1.07e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 40.78  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  74 SSGDRLLKLWDLSATRCiqSLAGHGDGVNDVAWSAAGLIASCSDDMTVRLWDARSKLCVK----VLEGHSRYSFSCCFNP 149
Cdd:COG5170 105 STNDKTIKLWKIYEKNL--KVVAENNLSDSFHSPMGGPLTSTKELLLPRLSEHDEIIAAKpcrvYANAHPYHINSISFNS 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 150 QANLLASTSfDETVRLWDV-RTGKTLKIV----HAHQD---PITSVDFHR-DGNIFVTSSYDGLVRLWD---SSTGHVLK 217
Cdd:COG5170 183 DKETLLSAD-DLRINLWNLeIIDGSFNIVdikpHNMEElteVITSAEFHPeMCNVFMYSSSKGEIKLNDlrqSALCDNSK 261

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654584 218 TL-------VDVDNI-----PVGYVKFSPNGRYILSSTLnNTLRLWNYKKPK-CMRTYRGH------LNEFYCSNSNF 276
Cdd:COG5170 262 KLfeltidgVDVDFFeeivsSISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHcdlmdeLNDVYENDAIF 338
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 146-243 1.15e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.26  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 146 CFNPQANLLASTSFDETVRLWDVRTGKTlKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRlWDSSTGHVlKTLVDVDNI 225
Cdd:COG3386  14 VWDPDGRLYWVDIPGGRIHRYDPDGGAV-EVFAEPSGRPNGLAFDPDGRLLVADHGRGLVR-FDPADGEV-TVLADEYGK 90

                        90       100
                ....*....|....*....|.
gi 24654584 226 PVGY---VKFSPNGRYILSST 243
Cdd:COG3386  91 PLNRpndGVVDPDGRLYFTDM 111
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 95-238 3.38e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.72  E-value: 3.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  95 AGHGDGVndvAWSAAG-LIASCSDDMTVRLWDARSKLcVKVLEGHSRYSFSCCFNPQANLLAsTSFDETVRLWDVRTGKT 173
Cdd:COG3386   7 FRLGEGP---VWDPDGrLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLV-ADHGRGLVRFDPADGEV 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654584 174 LKIVHAHQDPITS---VDFHRDGNIFVTSSYD-----GLVRLwdsSTGHVLKTLVDVDNIPVGyVKFSPNGRY 238
Cdd:COG3386  82 TVLADEYGKPLNRpndGVVDPDGRLYFTDMGEylptgALYRV---DPDGSLRVLADGLTFPNG-IAFSPDGRT 150
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
151-311 3.81e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 39.20  E-value: 3.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 151 ANLLASTsFDETVRLWDVRTGKTLKIVHA--HQDPITSVDFHRDGNIFVTSSYDGLVRlWDSSTGHV--LKTLVDVDNIP 226
Cdd:COG3292 282 IRLWIGT-YGGGLFRLDPKTGKFKRYNPNglPSNSVYSILEDSDGNLWIGTSGGGLYR-YDPKTGKFtkFSEDNGLSNNF 359

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584 227 VGYVKFSPNGRYILSStlNNTLRLWNYKKPKcMRTYRGHLNEFYCSNSN-----FSTTGGIWIvsGSEDNTLCIWNLQTR 301
Cdd:COG3292 360 IRSILEDSDGNLWVGT--NGGLYRLDPKTGK-FTNFTHDPDKNGLSSNYinsifEDSDGRLWI--GTDGGGLYRYDPKTG 434

                       170
                ....*....|
gi 24654584 302 ELVQKISTEG 311
Cdd:COG3292 435 KFKHFTTKDG 444
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 160-243 4.78e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.87  E-value: 4.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654584  160 DETVRLW--DVRTGKTLKIVHA-HQDPITSVDFHRDGNIFVTSSYDGL----VRLWDSSTGhvlkTLVDV------DNIP 226
Cdd:COG4946  407 DNRGRLWvvDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVETG----KTVQLtdgrydDGSP 482

                         90
                 ....*....|....*....
gi 24654584  227 VgyvkFSPNGRYI--LSST 243
Cdd:COG4946  483 A----FSPDGKYLyfLSSR 497
WD40 pfam00400
WD domain, G-beta repeat;
257-297 9.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24654584   257 KCMRTYRGHLNEFYCSNSNFSttgGIWIVSGSEDNTLCIWN 297
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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