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Conserved domains on  [gi|20130139|ref|NP_611385|]
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juvenile hormone epoxide hydrolase 1 [Drosophila melanogaster]

Protein Classification

epoxide hydrolase family protein( domain architecture ID 12070441)

epoxide hydrolase family protein may catalyze the conversion of epoxides to trans-dihydrodiols, thus preventing or reducing their reaction with cellular macromolecules such as protein or DNA

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19469578|12369917|19508187|37582413|31545554
SCOP:  4000716

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EHN pfam06441
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ...
 64-173 3.54e-38

Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.


:

Pssm-ID: 461913  Cd Length: 106  Bit Score: 134.52  E-value: 3.54e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139    64 RLSYPDKTIADLKERLNRTlRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYlpRWREREVFLWQFNHFTTDIQGLRTHFL 143
Cdd:pfam06441   5 TIHVPDEELDDLRQRLALT-RWPDELEGDDWWYGVPLDYLRELVDYWRDGY--DWRAQEARLNSFPQFTTEIDGLDIHFV 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 20130139   144 HLmvyddnKVGKKH-YPVLLLHGWPGSVREF 173
Cdd:pfam06441  82 HV------RSNKPDaIPLLLLHGWPGSFLEF 106
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 129-260 2.87e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 80.43  E-value: 2.87e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139 129 NHFTTDIQGLRTHFLHlmvyddnkVGKKHYPVLLLHGWPGSVREFYDFIHLLHQTnldnnnkyiFNVVVPSLPGYGWSQG 208
Cdd:COG0596   3 TPRFVTVDGVRLHYRE--------AGPDGPPVVLLHGLPGSSYEWRPLIPALAAG---------YRVIAPDLRGHGRSDK 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 20130139 209 TSRkGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIATLYPENVLG 260
Cdd:COG0596  66 PAG-GYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAG 116
 
Name Accession Description Interval E-value
EHN pfam06441
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ...
 64-173 3.54e-38

Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.


Pssm-ID: 461913  Cd Length: 106  Bit Score: 134.52  E-value: 3.54e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139    64 RLSYPDKTIADLKERLNRTlRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYlpRWREREVFLWQFNHFTTDIQGLRTHFL 143
Cdd:pfam06441   5 TIHVPDEELDDLRQRLALT-RWPDELEGDDWWYGVPLDYLRELVDYWRDGY--DWRAQEARLNSFPQFTTEIDGLDIHFV 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 20130139   144 HLmvyddnKVGKKH-YPVLLLHGWPGSVREF 173
Cdd:pfam06441  82 HV------RSNKPDaIPLLLLHGWPGSFLEF 106
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 129-260 2.87e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 80.43  E-value: 2.87e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139 129 NHFTTDIQGLRTHFLHlmvyddnkVGKKHYPVLLLHGWPGSVREFYDFIHLLHQTnldnnnkyiFNVVVPSLPGYGWSQG 208
Cdd:COG0596   3 TPRFVTVDGVRLHYRE--------AGPDGPPVVLLHGLPGSSYEWRPLIPALAAG---------YRVIAPDLRGHGRSDK 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 20130139 209 TSRkGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIATLYPENVLG 260
Cdd:COG0596  66 PAG-GYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAG 116
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 158-346 1.93e-13

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 69.84  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139   158 YPVLLLHGWPGSVREFYDFIhllhqtnlDNNNKYIFNVVVPSLPGYGWSQGTSRKGLGP-AQVAVMMRNLMLRLGYNKFF 236
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLA--------PALARDGFRVIALDLRGFGKSSRPKAQDDYRtDDLAEDLEYILEALGLEKVN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139   237 IQGGDWGSIIGSNIATLYPENVLGYHSnMCNNLSPKSLakGLVAEFWPSLFvPSGFEDF---FFPKSNEM---RYLMEES 310
Cdd:pfam00561  73 LVGHSMGGLIALAYAAKYPDRVKALVL-LGALDPPHEL--DEADRFILALF-PGFFDGFvadFAPNPLGRlvaKLLALLL 148

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 20130139   311 GYFHIQATKPDTIGAALT---DNPVGLAAYILEKFSTWT 346
Cdd:pfam00561 149 LRLRLLKALPLLNKRFPSgdyALAKSLVTGALLFIETWS 187
 
Name Accession Description Interval E-value
EHN pfam06441
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ...
 64-173 3.54e-38

Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.


Pssm-ID: 461913  Cd Length: 106  Bit Score: 134.52  E-value: 3.54e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139    64 RLSYPDKTIADLKERLNRTlRLTPPLEGVAFEYGFNTNYLKEVVEYWRDDYlpRWREREVFLWQFNHFTTDIQGLRTHFL 143
Cdd:pfam06441   5 TIHVPDEELDDLRQRLALT-RWPDELEGDDWWYGVPLDYLRELVDYWRDGY--DWRAQEARLNSFPQFTTEIDGLDIHFV 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 20130139   144 HLmvyddnKVGKKH-YPVLLLHGWPGSVREF 173
Cdd:pfam06441  82 HV------RSNKPDaIPLLLLHGWPGSFLEF 106
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 129-260 2.87e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 80.43  E-value: 2.87e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139 129 NHFTTDIQGLRTHFLHlmvyddnkVGKKHYPVLLLHGWPGSVREFYDFIHLLHQTnldnnnkyiFNVVVPSLPGYGWSQG 208
Cdd:COG0596   3 TPRFVTVDGVRLHYRE--------AGPDGPPVVLLHGLPGSSYEWRPLIPALAAG---------YRVIAPDLRGHGRSDK 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 20130139 209 TSRkGLGPAQVAVMMRNLMLRLGYNKFFIQGGDWGSIIGSNIATLYPENVLG 260
Cdd:COG0596  66 PAG-GYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAG 116
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 158-346 1.93e-13

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 69.84  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139   158 YPVLLLHGWPGSVREFYDFIhllhqtnlDNNNKYIFNVVVPSLPGYGWSQGTSRKGLGP-AQVAVMMRNLMLRLGYNKFF 236
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLA--------PALARDGFRVIALDLRGFGKSSRPKAQDDYRtDDLAEDLEYILEALGLEKVN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139   237 IQGGDWGSIIGSNIATLYPENVLGYHSnMCNNLSPKSLakGLVAEFWPSLFvPSGFEDF---FFPKSNEM---RYLMEES 310
Cdd:pfam00561  73 LVGHSMGGLIALAYAAKYPDRVKALVL-LGALDPPHEL--DEADRFILALF-PGFFDGFvadFAPNPLGRlvaKLLALLL 148

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 20130139   311 GYFHIQATKPDTIGAALT---DNPVGLAAYILEKFSTWT 346
Cdd:pfam00561 149 LRLRLLKALPLLNKRFPSgdyALAKSLVTGALLFIETWS 187
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
154-258 4.60e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 38.46  E-value: 4.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130139 154 GKKHYP-VLLLHGWPGS-VREFYDFIHLLHQTNldnnnkyiFNVVVPSLPGYGWSQGTSRKGLGPAQVAVMmrNLMLRLG 231
Cdd:COG1506  19 DGKKYPvVVYVHGGPGSrDDSFLPLAQALASRG--------YAVLAPDYRGYGESAGDWGGDEVDDVLAAI--DYLAARP 88

                        90       100       110
                ....*....|....*....|....*....|
gi 20130139 232 Y---NKFFIQGGDWGSIIGSNIATLYPENV 258
Cdd:COG1506  89 YvdpDRIGIYGHSYGGYMALLAAARHPDRF 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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