NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19922624|ref|NP_611459|]
View 

EF-hand domain containing 1.2 [Drosophila melanogaster]

Protein Classification

DM10 domain-containing protein( domain architecture ID 12218360)

DM10 domain-containing protein contains multiple DUF1126 domains that may has a PH-like fold; similar to EF-hand domain-containing family member C1/C2 (EFHC1/EFHC2)

PubMed:  16572395

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 84-191 1.44e-44

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


:

Pssm-ID: 128921  Cd Length: 104  Bit Score: 155.16  E-value: 1.44e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624     84 DKQVLCFNAYFKENLTEIYhapyQVRKVKIFFYLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNV 163
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFY----LIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDDPEYYHASDLNV 76

                           90       100
                   ....*....|....*....|....*...
gi 19922624    164 DTDVQIFDRVYHISGCDVFTRQFLNRAG 191
Cdd:smart00676  77 GTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 440-547 3.56e-40

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


:

Pssm-ID: 128921  Cd Length: 104  Bit Score: 142.84  E-value: 3.56e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    440 DGCILRFGAKLISAIRDNGE-RDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDmysssRPEYYRANDFY 518
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFYLiRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPD-----DPEYYHASDLN 75

                           90       100
                   ....*....|....*....|....*....
gi 19922624    519 IGRTMTLKDHIFHIVSADEFTLMYMEQHP 547
Cdd:smart00676  76 VGTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 231-368 3.38e-34

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


:

Pssm-ID: 461948  Cd Length: 104  Bit Score: 126.04  E-value: 3.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   231 FAQFLEFDRRVLKFQGYWNDRSE--FGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPtTFLKRGKLPKEFSGLPlpgqq 308
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDPTEspEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGG-KFLKRQRIPKPGTGGP----- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   309 tamtllnvlgnsmrdvryvadplntgqkevQHYTDQDLQIGAVLNVFGRSVVLTSCDQFT 368
Cdd:pfam06565  75 ------------------------------EYYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
 
Name Accession Description Interval E-value
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 84-191 1.44e-44

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 155.16  E-value: 1.44e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624     84 DKQVLCFNAYFKENLTEIYhapyQVRKVKIFFYLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNV 163
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFY----LIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDDPEYYHASDLNV 76

                           90       100
                   ....*....|....*....|....*...
gi 19922624    164 DTDVQIFDRVYHISGCDVFTRQFLNRAG 191
Cdd:smart00676  77 GTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 440-547 3.56e-40

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 142.84  E-value: 3.56e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    440 DGCILRFGAKLISAIRDNGE-RDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDmysssRPEYYRANDFY 518
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFYLiRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPD-----DPEYYHASDLN 75

                           90       100
                   ....*....|....*....|....*....
gi 19922624    519 IGRTMTLKDHIFHIVSADEFTLMYMEQHP 547
Cdd:smart00676  76 VGTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 77-183 8.91e-37

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 133.36  E-value: 8.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    77 LPPWLAYDKQVLCFNAYFKENlTEIYHAPYqvRKVKIFFYLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFI 156
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDP-TESPEDEY--RKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPGTGGPEYY 77

                          90       100
                  ....*....|....*....|....*..
gi 19922624   157 SIFDLNVDTDVQIFDRVYHISGCDVFT 183
Cdd:pfam06565  78 TPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 433-539 1.17e-36

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 132.98  E-value: 1.17e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   433 FKKLFKYDGCILRFGAKLISA--IRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGqdmysSSRPE 510
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDPteSPEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPG-----TGGPE 75

                          90       100
                  ....*....|....*....|....*....
gi 19922624   511 YYRANDFYIGRTMTLKDHIFHIVSADEFT 539
Cdd:pfam06565  76 YYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 231-368 3.38e-34

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 126.04  E-value: 3.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   231 FAQFLEFDRRVLKFQGYWNDRSE--FGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPtTFLKRGKLPKEFSGLPlpgqq 308
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDPTEspEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGG-KFLKRQRIPKPGTGGP----- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   309 tamtllnvlgnsmrdvryvadplntgqkevQHYTDQDLQIGAVLNVFGRSVVLTSCDQFT 368
Cdd:pfam06565  75 ------------------------------EYYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 238-376 8.64e-31

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 116.26  E-value: 8.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    238 DRRVLKFQGYWNDR-SEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPtTFLKRGKLPKEfsglplpgqqtamtllnv 316
Cdd:smart00676   1 DKKVLRFDAYWEDPvAMFYLIRRFKIYYYLEDDTIEVFEPDVRNSGILQG-TFLRRQRVPKP------------------ 61

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    317 lgnsmrdvryvadplntGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKY 376
Cdd:smart00676  62 -----------------PPDDPEYYHASDLNVGTTINVFGRQFRIYDCDEFTRNYLESKG 104
 
Name Accession Description Interval E-value
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 84-191 1.44e-44

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 155.16  E-value: 1.44e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624     84 DKQVLCFNAYFKENLTEIYhapyQVRKVKIFFYLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNV 163
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFY----LIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDDPEYYHASDLNV 76

                           90       100
                   ....*....|....*....|....*...
gi 19922624    164 DTDVQIFDRVYHISGCDVFTRQFLNRAG 191
Cdd:smart00676  77 GTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 440-547 3.56e-40

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 142.84  E-value: 3.56e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    440 DGCILRFGAKLISAIRDNGE-RDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDmysssRPEYYRANDFY 518
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFYLiRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPD-----DPEYYHASDLN 75

                           90       100
                   ....*....|....*....|....*....
gi 19922624    519 IGRTMTLKDHIFHIVSADEFTLMYMEQHP 547
Cdd:smart00676  76 VGTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 77-183 8.91e-37

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 133.36  E-value: 8.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    77 LPPWLAYDKQVLCFNAYFKENlTEIYHAPYqvRKVKIFFYLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFI 156
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDP-TESPEDEY--RKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPGTGGPEYY 77

                          90       100
                  ....*....|....*....|....*..
gi 19922624   157 SIFDLNVDTDVQIFDRVYHISGCDVFT 183
Cdd:pfam06565  78 TPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 433-539 1.17e-36

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 132.98  E-value: 1.17e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   433 FKKLFKYDGCILRFGAKLISA--IRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGqdmysSSRPE 510
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDPteSPEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPG-----TGGPE 75

                          90       100
                  ....*....|....*....|....*....
gi 19922624   511 YYRANDFYIGRTMTLKDHIFHIVSADEFT 539
Cdd:pfam06565  76 YYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 231-368 3.38e-34

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 126.04  E-value: 3.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   231 FAQFLEFDRRVLKFQGYWNDRSE--FGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPtTFLKRGKLPKEFSGLPlpgqq 308
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDPTEspEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGG-KFLKRQRIPKPGTGGP----- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624   309 tamtllnvlgnsmrdvryvadplntgqkevQHYTDQDLQIGAVLNVFGRSVVLTSCDQFT 368
Cdd:pfam06565  75 ------------------------------EYYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 238-376 8.64e-31

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 116.26  E-value: 8.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    238 DRRVLKFQGYWNDR-SEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPtTFLKRGKLPKEfsglplpgqqtamtllnv 316
Cdd:smart00676   1 DKKVLRFDAYWEDPvAMFYLIRRFKIYYYLEDDTIEVFEPDVRNSGILQG-TFLRRQRVPKP------------------ 61

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922624    317 lgnsmrdvryvadplntGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKY 376
Cdd:smart00676  62 -----------------PPDDPEYYHASDLNVGTTINVFGRQFRIYDCDEFTRNYLESKG 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH