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Conserved domains on  [gi|24656989|ref|NP_611582|]
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uncharacterized protein Dmel_CG17974 [Drosophila melanogaster]

Protein Classification

CAP domain-containing protein( domain architecture ID 10143468)

CAP (CSP/antigen 5/PR1) domain-containing protein similar to Venom allergen 5, CRISP/Allergen/PR-1 and scoloptoxins

CATH:  3.40.33.10
PubMed:  18824526
SCOP:  4001882

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 63-218 2.33e-36

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


:

Pssm-ID: 349399  Cd Length: 144  Bit Score: 126.03  E-value: 2.33e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  63 KADFLHAHNKRRNFLALGKVPGYYPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHNTYRYansGQNLCAVWrprSPHV 142
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGV---GQNLASVS---SSGK 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24656989 143 NVTSLVEECLGLWFNEFDLIDSSFIDSfkvTPIFEDYGHFAELSVDKNFAVGCSIMRFTRPDYPSVYiynFICNYA 218
Cdd:cd05380  75 DLKELIEDAVNAWFDELKDYGFGSNPN---NNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGGNKTY---VVCNYS 144
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 63-218 2.33e-36

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 126.03  E-value: 2.33e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  63 KADFLHAHNKRRNFLALGKVPGYYPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHNTYRYansGQNLCAVWrprSPHV 142
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGV---GQNLASVS---SSGK 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24656989 143 NVTSLVEECLGLWFNEFDLIDSSFIDSfkvTPIFEDYGHFAELSVDKNFAVGCSIMRFTRPDYPSVYiynFICNYA 218
Cdd:cd05380  75 DLKELIEDAVNAWFDELKDYGFGSNPN---NNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGGNKTY---VVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 65-217 1.34e-13

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 66.26  E-value: 1.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989     65 DFLHAHNKRRNFLALGKVPGYyPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHNTYryansGQNLCAVWrprSPHVNV 144
Cdd:smart00198   5 EILDAHNKLRSQVAGGFLAAP-AASNMLKLTWDCELASSAQNWANQCPFGHSTPRPGY-----GENLAWWS---SSTALP 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24656989    145 TSLVEECLGLWFNEFdlIDSSFiDSFKVTPIFEDYGHFAELSVDKNFAVGCSIMRFTRPDYPSVYIynfICNY 217
Cdd:smart00198  76 DTYASAAVQLWYDEF--QDYGY-SSNTCKDTNGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTVV---VCNY 142
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 67-217 6.33e-06

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 44.12  E-value: 6.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989    67 LHAHNKRRnflalgkvpgyyPAARMATMVWDDELQYLSMLNTRTCKLDHddcHNTYRYANSGQNLCAVWRPRSPHVNV-T 145
Cdd:pfam00188   1 LDLHNEYR------------AAAGLPPLSWDNELAAAAQDHAKYCADNG---SHNHRSPYGGNIYARVVAAGYALGDAgP 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24656989   146 SLVEECLGLWFNEfdlidssfidsfkvtPIFEDYGHFAELSVDKNFAVGCSIMRftrpdYPSVYIYNFICNY 217
Cdd:pfam00188  66 DSAEDAVDGWYDS---------------PGTYNCGHRTNLLWPKSTKVGCAVAK-----CGDGGTYYFVCNY 117
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 63-218 2.33e-36

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 126.03  E-value: 2.33e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  63 KADFLHAHNKRRNFLALGKVPGYYPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHNTYRYansGQNLCAVWrprSPHV 142
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGV---GQNLASVS---SSGK 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24656989 143 NVTSLVEECLGLWFNEFDLIDSSFIDSfkvTPIFEDYGHFAELSVDKNFAVGCSIMRFTRPDYPSVYiynFICNYA 218
Cdd:cd05380  75 DLKELIEDAVNAWFDELKDYGFGSNPN---NNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGGNKTY---VVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 65-217 1.34e-13

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 66.26  E-value: 1.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989     65 DFLHAHNKRRNFLALGKVPGYyPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHNTYryansGQNLCAVWrprSPHVNV 144
Cdd:smart00198   5 EILDAHNKLRSQVAGGFLAAP-AASNMLKLTWDCELASSAQNWANQCPFGHSTPRPGY-----GENLAWWS---SSTALP 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24656989    145 TSLVEECLGLWFNEFdlIDSSFiDSFKVTPIFEDYGHFAELSVDKNFAVGCSIMRFTRPDYPSVYIynfICNY 217
Cdd:smart00198  76 DTYASAAVQLWYDEF--QDYGY-SSNTCKDTNGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTVV---VCNY 142
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 65-218 2.92e-07

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 48.56  E-value: 2.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  65 DFLHAHNKRRnflalGKV-PgyyPAARMATMVWDDELQYLSMLNTRTCKLDHDD-------CHNTYRYAnsGQNLcavWR 136
Cdd:cd05385   5 ECVRIHNELR-----SKVsP---PAANMRYMSWDKALAKTARAWARKCKFSHNIclkepgkCHPNFTTL--GENI---WL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989 137 PRSPHVNVTSLVEEclglWFNEFDLIDssfidsFKVTPIFEDYGHFAELSVDKNFAVGCSIMRFTRPDYPSVYIYN--FI 214
Cdd:cd05385  72 GSIFSFSVESAITS----WYNEVKDYN------FKTNSCSRVCGHYTQVVWADSYKVGCAVHVCPNGGGFFSGSSSaiFV 141


                ....
gi 24656989 215 CNYA 218
Cdd:cd05385 142 CNYG 145
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 67-217 6.33e-06

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 44.12  E-value: 6.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989    67 LHAHNKRRnflalgkvpgyyPAARMATMVWDDELQYLSMLNTRTCKLDHddcHNTYRYANSGQNLCAVWRPRSPHVNV-T 145
Cdd:pfam00188   1 LDLHNEYR------------AAAGLPPLSWDNELAAAAQDHAKYCADNG---SHNHRSPYGGNIYARVVAAGYALGDAgP 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24656989   146 SLVEECLGLWFNEfdlidssfidsfkvtPIFEDYGHFAELSVDKNFAVGCSIMRftrpdYPSVYIYNFICNY 217
Cdd:pfam00188  66 DSAEDAVDGWYDS---------------PGTYNCGHRTNLLWPKSTKVGCAVAK-----CGDGGTYYFVCNY 117
CAP_CRISPLD2 cd18816
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 63-150 1.53e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349410  Cd Length: 146  Bit Score: 40.74  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  63 KADFLHAHNKRRnflalGKVpgYYPAARMATMVWDDELQYLSMLNTRTCKLDHDDchnTYRYANSGQNLCAVW-RPRSPH 141
Cdd:cd18816   1 KEEILQLHNKLR-----GQV--YPSASNMEYMTWDDELERSAEAWAQQCIWEHGP---TSLLPSIGQNLAVHWgRYRSPA 70


                ....*....
gi 24656989 142 VNVTSLVEE 150
Cdd:cd18816  71 FHVQSWYDE 79
CAP_CRISPLD1 cd18813
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 67-150 3.90e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349407  Cd Length: 146  Bit Score: 39.60  E-value: 3.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  67 LHAHNKRRnflalGKVpgYYPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHntyRYANSGQNLCAVW-RPRSPHVNVT 145
Cdd:cd18813   5 LDLHNKLR-----GQV--YPPASNMEYMTWDVELERSAEAWAETCLWEHGPAH---LLPSIGQNLGAHWgRYRPPTFHVQ 74


                ....*
gi 24656989 146 SLVEE 150
Cdd:cd18813  75 AWYDE 79
CAP_PI15-like cd18812
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 67-150 4.02e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349406  Cd Length: 146  Bit Score: 39.89  E-value: 4.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  67 LHAHNKRRnflalGKVpgYYPAARMATMVWDDELQYLSMLNTRTCKLDHDDchnTYRYANSGQNLCAVW-RPRSPHVNVT 145
Cdd:cd18812   5 LDYHNKLR-----GQV--YPPAANMEYMVWDKELARSAEAWATQCIWEHGP---SSLLRSIGQNLSAHWgRYRSPVFLVK 74


                ....*
gi 24656989 146 SLVEE 150
Cdd:cd18812  75 SWYDE 79
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 66-217 6.53e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 38.75  E-value: 6.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656989  66 FLHAHNKRRNFLALgkvpgyyPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHNTYRyanSGQNLCAVWRPRSphvnvt 145
Cdd:cd00168   4 ILDLHNSYRSSVSP-------PASNMPLMAWDQELADVAIGYAKDCIFSHSSPTSRQL---AGENIAASSYDMD------ 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24656989 146 slVEECLGLWFNEFdlidSSFIDSFKVTPIFEDYGHFAELSVDKNFAVGCSImrftrpDYPSVYIYNFICNY 217
Cdd:cd00168  68 --GVAALQAWHNEI----KNYNFGTAQPGFNSGTGHYTQMVWEKTTKLGCGV------ADCSDNSKFVVCNY 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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