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Conserved domains on  [gi|45550492|ref|NP_611675|]
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uncharacterized protein Dmel_CG4752 [Drosophila melanogaster]

Protein Classification

hydantoinase/oxoprolinase family protein( domain architecture ID 1004610)

hydantoinase/oxoprolinase family protein is involved in the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds; such as 5-oxoprolinase that catalyzes the hydrolysis of 5-oxoproline (5-OP) to L-glutamate

EC:  3.5.2.-
Gene Ontology:  GO:0005524|GO:0016812

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02666 super family cl33539
5-oxoprolinase
5-1262 0e+00

5-oxoprolinase


The actual alignment was detected with superfamily member PLN02666:

Pssm-ID: 215358 [Multi-domain]  Cd Length: 1275  Bit Score: 1856.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492     5 KYCFAIDRGGTFTDVLCICPNGK-VRTMKLLSEDPERYSDAPREGIRRILKEETGEDLAASGLVDTSKIGWVRMGTTVAT 83
Cdd:PLN02666    9 KFRFCIDRGGTFTDVYAEVPGGSdFRVLKLLSVDPANYDDAPREGIRRILEEVTGKKIPRSAKIPTERIEWIRMGTTVAT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    84 NALLERKGDPVVLVVNSGFRDLLYIGNQARPKIFDLNIRKPANLYKSVVEVDCRIVPKQADRcELNHSWKELEGVAGTKY 163
Cdd:PLN02666   89 NALLERKGERIALCVTKGFKDLLQIGNQARPNIFDLTVSKPSNLYEEVVEVDERVVLALEED-GDDAGGSVVKGVTGELV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   164 LEVRPVDEVAVRQALSDARDQGVSSVSVVLAHSYACPEHELRVGAIARELGFSHVTLSHQAMPMCRVVARGYTACAEAYL 243
Cdd:PLN02666  168 EVVKPLDEEALRPLLQGLLDKGIRSLAVVLMHSYTYPAHERAVGKLARSMGFKQVSLSSALVPMVRAVPRGHTASVDAYL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   244 TPHVDRYLASFKSGFDKQLEGVDVLFMQSDGGLTNMENFRGARAILSGPAGGVVGYALTGAR-ETELPLIGFDMGGTSTD 322
Cdd:PLN02666  248 TPVIKEYLSGFLSGFDDGLGDVNVLFMQSDGGLTPESRFSGHKAILSGPAGGVVGYAQTTFGlETEKPVIGFDMGGTSTD 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   323 VSRYAGTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFFRSGIFVVGPESAGSHPGPACYKKGGPLTVTDANLILGRI 402
Cdd:PLN02666  328 VSRYDGSYEQVLETQTAGVIIQAPQLDINTVAAGGGSKLKFQFGAFRVGPESVGAHPGPVCYRKGGELAVTDANLVLGRV 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   403 LPQYFPKIFGPQENEPLDHEIARSKFVELQAEINNYLKSSGDNRV-LSVEDVALGFIRVANETMCRPIRALTQSRGLDTA 481
Cdd:PLN02666  408 IPDYFPSIFGPNEDEPLDLEATRAAFEALAAQINSYRKSQDPSAKdMSVEEVALGFVRVANEAMCRPIRQLTEMKGYETA 487
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   482 NHVLSCFGGAGGQHACSIARNLGIAKVVVHKYAGILSAYGMALADVVQEFQEPNGLEFSDANAQQLKERLDALSKQCQDK 561
Cdd:PLN02666  488 NHALACFGGAGPQHACAIARALGMSEVFVHRYCGILSAYGMGLADVVAEAQEPYAAVYGPESLAEASRREDALAEKVRQK 567
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   562 LSEQGFKR--IELEPFLHLRYEGTDGALMVAPSTGKQSSDsnpllaayGDFHATFLERYRTEFGFVLQNRRIIVDDIRIR 639
Cdd:PLN02666  568 LQEQGFREdnITTETYLNLRYEGTDTAIMVAEPENGDGSD--------GDYAAAFVKLFRREYGFKLQNRDILIDDVRVR 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   640 GLGKNETPPESKVQAAAEAKPPAEANTRLYFDQGAFDSPIYLTKNLLAGHRITGPAVLIDQLSTIVVEPECGIQVTQFGD 719
Cdd:PLN02666  640 GIGVTNILKPLPLDAASGGLPEPERTTKVYFENGWHDTPVYKLENLGPGHEIPGPAIIMNGNSTVVVEPGCKAIVTKYGN 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   720 LIMDVKTGGKHGINAD-------LDPVHLSIFSHRFMSIAEQMGRVLQRTSISTNIKERLDFSCALFGPDGGLVSNAPHI 792
Cdd:PLN02666  720 IKIEVENSAEQSAEETvkaaekkADVVQLSIFNHRFMGIAEQMGRTLQRTSISTNIKERLDFSCALFGPDGGLVANAPHV 799
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   793 PVHLGAMQETVQYQLRVRGETLKNGDVILANHPSAGGSHLPDLTVITPVFYEThpRPVFFVASRGHHADIGGITPGSMPP 872
Cdd:PLN02666  800 PVHLGAMSSTVRWQLEYWGENLNEGDVLVTNHPQAGGSHLPDITVITPVFRDG--KIVFFVASRGHHADIGGITPGSMPP 877
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   873 HSTSLAQEGAAFKSFLIVENGLFQEQQIIEQLTTPTAAKGAV---GTRNLSDNLSDLKAQIAANHKGIQLVAELIGSYGL 949
Cdd:PLN02666  878 FSKTIWEEGAAIKAFKLVEGGVFQEEGITKLLQAPGSDETAPkipGTRRLQDNLSDLRAQVAANQRGISLIKELIDEYGL 957
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   950 DVVQAYMSHIQKNAELAVRDMLRQIG------RDTLERTGSTVLEAKEFMDDGSPIALKVTIDAEQGSALCDFTGSGVEV 1023
Cdd:PLN02666  958 GTVQAYMGHVQANAELAVREMLKSVAarvsseSPTFGDGSSVTLEAEDYMDDGSPIHLTLTIDRRKGSAVFDFEGTSPEV 1037
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  1024 WGNCNAPRAITLSALIYCLRCMVGHDVPLNQGCLAPIQVIIPKNSILDPSEGAAVVGGNVQTSQRIVDTVLKAFGVCAAS 1103
Cdd:PLN02666 1038 YGNWNAPPAVTAAAVIYCLRCLVDVDIPLNQGCLAPVTIRIPPGSFLSPSDKAAVVGGNVLTSQRVTDVVLTAFQACACS 1117
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  1104 QGCMNNITIGDESWGYYETVAGGAGAGPGWHGAGGVHTHMTNTRITDPEILELRYPMILKRFCLRtDGSGGRGQFHGGEG 1183
Cdd:PLN02666 1118 QGCMNNLTFGDDTFGYYETIAGGAGAGPTWDGTSGVQCHMTNTRITDPEILERRYPVLLHRFGLR-EGSGGDGLHRGGDG 1196
                        1210      1220      1230      1240      1250      1260      1270
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550492  1184 VERDLLFRKPVTLSVLTERRTLQPYGLAGGESGKSGRNLVVKRDGRVIALAGKTCIDVEAGDTFAMKTPGGGGYGPIED 1262
Cdd:PLN02666 1197 VVREIEFRRPVTVSILSERRVHAPRGLAGGGDGARGANLLIRKDGRRVNLGGKNTVHVEAGERLRILTPGGGGYGSKPS 1275
 
Name Accession Description Interval E-value
PLN02666 PLN02666
5-oxoprolinase
5-1262 0e+00

5-oxoprolinase


Pssm-ID: 215358 [Multi-domain]  Cd Length: 1275  Bit Score: 1856.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492     5 KYCFAIDRGGTFTDVLCICPNGK-VRTMKLLSEDPERYSDAPREGIRRILKEETGEDLAASGLVDTSKIGWVRMGTTVAT 83
Cdd:PLN02666    9 KFRFCIDRGGTFTDVYAEVPGGSdFRVLKLLSVDPANYDDAPREGIRRILEEVTGKKIPRSAKIPTERIEWIRMGTTVAT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    84 NALLERKGDPVVLVVNSGFRDLLYIGNQARPKIFDLNIRKPANLYKSVVEVDCRIVPKQADRcELNHSWKELEGVAGTKY 163
Cdd:PLN02666   89 NALLERKGERIALCVTKGFKDLLQIGNQARPNIFDLTVSKPSNLYEEVVEVDERVVLALEED-GDDAGGSVVKGVTGELV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   164 LEVRPVDEVAVRQALSDARDQGVSSVSVVLAHSYACPEHELRVGAIARELGFSHVTLSHQAMPMCRVVARGYTACAEAYL 243
Cdd:PLN02666  168 EVVKPLDEEALRPLLQGLLDKGIRSLAVVLMHSYTYPAHERAVGKLARSMGFKQVSLSSALVPMVRAVPRGHTASVDAYL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   244 TPHVDRYLASFKSGFDKQLEGVDVLFMQSDGGLTNMENFRGARAILSGPAGGVVGYALTGAR-ETELPLIGFDMGGTSTD 322
Cdd:PLN02666  248 TPVIKEYLSGFLSGFDDGLGDVNVLFMQSDGGLTPESRFSGHKAILSGPAGGVVGYAQTTFGlETEKPVIGFDMGGTSTD 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   323 VSRYAGTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFFRSGIFVVGPESAGSHPGPACYKKGGPLTVTDANLILGRI 402
Cdd:PLN02666  328 VSRYDGSYEQVLETQTAGVIIQAPQLDINTVAAGGGSKLKFQFGAFRVGPESVGAHPGPVCYRKGGELAVTDANLVLGRV 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   403 LPQYFPKIFGPQENEPLDHEIARSKFVELQAEINNYLKSSGDNRV-LSVEDVALGFIRVANETMCRPIRALTQSRGLDTA 481
Cdd:PLN02666  408 IPDYFPSIFGPNEDEPLDLEATRAAFEALAAQINSYRKSQDPSAKdMSVEEVALGFVRVANEAMCRPIRQLTEMKGYETA 487
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   482 NHVLSCFGGAGGQHACSIARNLGIAKVVVHKYAGILSAYGMALADVVQEFQEPNGLEFSDANAQQLKERLDALSKQCQDK 561
Cdd:PLN02666  488 NHALACFGGAGPQHACAIARALGMSEVFVHRYCGILSAYGMGLADVVAEAQEPYAAVYGPESLAEASRREDALAEKVRQK 567
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   562 LSEQGFKR--IELEPFLHLRYEGTDGALMVAPSTGKQSSDsnpllaayGDFHATFLERYRTEFGFVLQNRRIIVDDIRIR 639
Cdd:PLN02666  568 LQEQGFREdnITTETYLNLRYEGTDTAIMVAEPENGDGSD--------GDYAAAFVKLFRREYGFKLQNRDILIDDVRVR 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   640 GLGKNETPPESKVQAAAEAKPPAEANTRLYFDQGAFDSPIYLTKNLLAGHRITGPAVLIDQLSTIVVEPECGIQVTQFGD 719
Cdd:PLN02666  640 GIGVTNILKPLPLDAASGGLPEPERTTKVYFENGWHDTPVYKLENLGPGHEIPGPAIIMNGNSTVVVEPGCKAIVTKYGN 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   720 LIMDVKTGGKHGINAD-------LDPVHLSIFSHRFMSIAEQMGRVLQRTSISTNIKERLDFSCALFGPDGGLVSNAPHI 792
Cdd:PLN02666  720 IKIEVENSAEQSAEETvkaaekkADVVQLSIFNHRFMGIAEQMGRTLQRTSISTNIKERLDFSCALFGPDGGLVANAPHV 799
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   793 PVHLGAMQETVQYQLRVRGETLKNGDVILANHPSAGGSHLPDLTVITPVFYEThpRPVFFVASRGHHADIGGITPGSMPP 872
Cdd:PLN02666  800 PVHLGAMSSTVRWQLEYWGENLNEGDVLVTNHPQAGGSHLPDITVITPVFRDG--KIVFFVASRGHHADIGGITPGSMPP 877
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   873 HSTSLAQEGAAFKSFLIVENGLFQEQQIIEQLTTPTAAKGAV---GTRNLSDNLSDLKAQIAANHKGIQLVAELIGSYGL 949
Cdd:PLN02666  878 FSKTIWEEGAAIKAFKLVEGGVFQEEGITKLLQAPGSDETAPkipGTRRLQDNLSDLRAQVAANQRGISLIKELIDEYGL 957
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   950 DVVQAYMSHIQKNAELAVRDMLRQIG------RDTLERTGSTVLEAKEFMDDGSPIALKVTIDAEQGSALCDFTGSGVEV 1023
Cdd:PLN02666  958 GTVQAYMGHVQANAELAVREMLKSVAarvsseSPTFGDGSSVTLEAEDYMDDGSPIHLTLTIDRRKGSAVFDFEGTSPEV 1037
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  1024 WGNCNAPRAITLSALIYCLRCMVGHDVPLNQGCLAPIQVIIPKNSILDPSEGAAVVGGNVQTSQRIVDTVLKAFGVCAAS 1103
Cdd:PLN02666 1038 YGNWNAPPAVTAAAVIYCLRCLVDVDIPLNQGCLAPVTIRIPPGSFLSPSDKAAVVGGNVLTSQRVTDVVLTAFQACACS 1117
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  1104 QGCMNNITIGDESWGYYETVAGGAGAGPGWHGAGGVHTHMTNTRITDPEILELRYPMILKRFCLRtDGSGGRGQFHGGEG 1183
Cdd:PLN02666 1118 QGCMNNLTFGDDTFGYYETIAGGAGAGPTWDGTSGVQCHMTNTRITDPEILERRYPVLLHRFGLR-EGSGGDGLHRGGDG 1196
                        1210      1220      1230      1240      1250      1260      1270
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550492  1184 VERDLLFRKPVTLSVLTERRTLQPYGLAGGESGKSGRNLVVKRDGRVIALAGKTCIDVEAGDTFAMKTPGGGGYGPIED 1262
Cdd:PLN02666 1197 VVREIEFRRPVTVSILSERRVHAPRGLAGGGDGARGANLLIRKDGRRVNLGGKNTVHVEAGERLRILTPGGGGYGSKPS 1275
Hydantoinase_B pfam02538
Hydantoinase B/oxoprolinase; This family includes N-methylhydaintoinase B which converts ...
738-1259 0e+00

Hydantoinase B/oxoprolinase; This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyzes the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to pfam01968.


Pssm-ID: 460583  Cd Length: 507  Bit Score: 696.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    738 PVHLSIFSHRFMSIAEQMGRVLQRTSISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQYQLRVRGEtLKNG 817
Cdd:pfam02538    1 PITLEVFRNRLMSIAEEMGRTLQRTAFSPNIKERLDFSCAIFDADGRLVAQAPHIPVHLGSMSFAVKAVIEYGGD-LRPG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    818 DVILANHPSAGGSHLPDLTVITPVFYEthPRPVFFVASRGHHADIGGITPGSMPPHSTSLAQEGAAFKSFLIVENGLFQE 897
Cdd:pfam02538   80 DVFITNDPYAGGTHLPDITVITPVFHD--GELVFFVASRGHHADIGGIVPGSMPPDATEIYQEGLRIPPVKLVRRGVLNE 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    898 --QQIIEQlttptaakgavGTRNLSDNLSDLKAQIAANHKGIQLVAELIGSYGLDVVQAYMSHIQKNAELAVRDMLRQIG 975
Cdd:pfam02538  158 dvLRLLLA-----------NSRTPEDNLGDLKAQIAANRVGERRLLELIDEYGLDTVLAAMDEIQDYAERAVRAAIAALP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    976 RDTLErtgstvleAKEFMDDGSPIALKVTIDAEQGSALCDFTGSGVEVWGNCNAPRAITLSALIYCLRCMVGHDVPLNQG 1055
Cdd:pfam02538  227 DGTYE--------AEDYLDDGVPIPIRVTVTIDGDEATVDFTGTSPQVPGNINAPLAVTHSAVIYALRCLVDPDIPLNAG 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   1056 CLAPIQVIIPKNSILDPSEGAAVVGGNVQTSQRIVDTVLKAFG------VCAASQGCMNNITIG-------DESWGYYET 1122
Cdd:pfam02538  299 CLRPIEVIAPEGSLLNPSPPAAVVGGNVETSQRIVDVVLGALAqalperVPAASQGTMNNLTFGgvdprggGRFFGYYET 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   1123 VAGGAGAGPGWHGAGGVHTHMTNTRITDPEILELRYPMILKRFCLRTDgSGGRGQFHGGEGVERDLLFRKP-VTLSVLTE 1201
Cdd:pfam02538  379 IGGGSGARPGGDGLDGVHVHMTNTRNTPVEVLERRYPVLVERYELRPD-SGGAGRYRGGDGVVREIEFLAPdATVSILSE 457
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 45550492   1202 RRTLQPYGLAGGESGKSgrnlvvkrdGRVIALAGKTCIDVEAGDTFAMKTPGGGGYGP 1259
Cdd:pfam02538  458 RRVFPPWGLAGGEPGAP---------GRVNLGGKATDVELKPGDRLRIETPGGGGYGD 506
HyuA COG0145
N-methylhydantoinase A/oxoprolinase/acetone carboxylase, beta subunit [Amino acid transport ...
8-727 0e+00

N-methylhydantoinase A/oxoprolinase/acetone carboxylase, beta subunit [Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439915 [Multi-domain]  Cd Length: 678  Bit Score: 691.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    8 FAIDRGGTFTDVLCICPNGKVRTMKLLSeDPERYSDAPREGIRRILkEETGEDLAAsglvdtskIGWVRMGTTVATNALL 87
Cdd:COG0145    1 VGVDVGGTFTDVVAVDEDGRLRTHKVLS-TPEDPSDGVLEGIRELL-EDAGIPLAE--------IDLVVHGTTVATNALL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   88 ERKGDPVVLVVNSGFRDLLYIGNQARPKIFDLNIRKPANLYKS--VVEVDCRIvpkqadrcelnhswkeleGVAGTkylE 165
Cdd:COG0145   71 ERKGARTGLITTRGFRDVLEIGRQNRPDLYDLFIEKPEPLVPRrlRFEVRERI------------------DADGE---V 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  166 VRPVDEVAVRQALSDARDQGVSSVSVVLAHSYACPEHELRVGAIARE-LGFSHVTLSHQAMPMCRVVARGYTACAEAYLT 244
Cdd:COG0145  130 LTPLDEAEVRAAARELRAAGVEAVAVCFLHSYRNPAHERRAAEILREeLPDVPVSLSSEVSPEIREYERTSTTVVNAYLS 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  245 PHVDRYLASFKSGFDKQLEGVDVLFMQSDGGLTNMENF--RGARAILSGPAGGVVGYALTGARETELPLIGFDMGGTSTD 322
Cdd:COG0145  210 PILRRYLDRLEARLRERGFGGPLLIMQSNGGLASAEAAarRPVRTILSGPAGGVVGAAALARAAGFDNVITFDMGGTSTD 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  323 VSRYA-GTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFF-RSGIFVVGPESAGSHPGPACYKKGGP-LTVTDANLIL 399
Cdd:COG0145  290 VSLIEdGEPERTTETEVAGYPVRVPMVDIHTVGAGGGSIAWVdAGGRLRVGPESAGADPGPACYGRGGTePTVTDANLVL 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  400 GRILPQYFpkIFGpqeNEPLDHEIARSKFVELQAEINnylkssgdnrvLSVEDVALGFIRVANETMCRPIRALTQSRGLD 479
Cdd:COG0145  370 GRLDPDNF--LGG---RMPLDVEAARAAIEKLADPLG-----------LSVEEAAEGILRIANENMANAIRKVSVERGYD 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  480 TANHVLSCFGGAGGQHACSIARNLGIAKVVVHKYAGILSAYGMALADVVQEFQEPNGLEFSDANAQQLKERLDALSKQCQ 559
Cdd:COG0145  434 PRDFTLVAFGGAGPLHACALAEELGIPRVIVPPAAGVLSALGMLLADIRHDYVRSVEAPLDDADLAELNAAFAELEAEAR 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  560 DKLSEQGFK--RIELEPFLHLRYEGTDGALMVAPSTGKQSSDSnpLLAAYGDFHAtfleRYRTEFGFVLQNRRIIVDDIR 637
Cdd:COG0145  514 AELAAEGVAaeDIRVERSADMRYAGQGHELTVPLPAGRLDAAD--LAALRAAFHA----AHERRYGFALPDAPVEIVNLR 587
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  638 IRGLGKNETPPESKVQAAAEAKPPAEANTRLYFDQGAFDSPIYLTKNLLAGHRITGPAVLIDQLSTIVVEPECGIQVTQF 717
Cdd:COG0145  588 VEAIGPVPKPELPRLPPGGDAAPAPKGTRPVYFDGGWVDTPVYDREALPPGDRIAGPAIIEEPDTTTVVPPGWRATVDAY 667
                        730
                 ....*....|
gi 45550492  718 GDLIMDVKTG 727
Cdd:COG0145  668 GNLILTRAAA 677
 
Name Accession Description Interval E-value
PLN02666 PLN02666
5-oxoprolinase
5-1262 0e+00

5-oxoprolinase


Pssm-ID: 215358 [Multi-domain]  Cd Length: 1275  Bit Score: 1856.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492     5 KYCFAIDRGGTFTDVLCICPNGK-VRTMKLLSEDPERYSDAPREGIRRILKEETGEDLAASGLVDTSKIGWVRMGTTVAT 83
Cdd:PLN02666    9 KFRFCIDRGGTFTDVYAEVPGGSdFRVLKLLSVDPANYDDAPREGIRRILEEVTGKKIPRSAKIPTERIEWIRMGTTVAT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    84 NALLERKGDPVVLVVNSGFRDLLYIGNQARPKIFDLNIRKPANLYKSVVEVDCRIVPKQADRcELNHSWKELEGVAGTKY 163
Cdd:PLN02666   89 NALLERKGERIALCVTKGFKDLLQIGNQARPNIFDLTVSKPSNLYEEVVEVDERVVLALEED-GDDAGGSVVKGVTGELV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   164 LEVRPVDEVAVRQALSDARDQGVSSVSVVLAHSYACPEHELRVGAIARELGFSHVTLSHQAMPMCRVVARGYTACAEAYL 243
Cdd:PLN02666  168 EVVKPLDEEALRPLLQGLLDKGIRSLAVVLMHSYTYPAHERAVGKLARSMGFKQVSLSSALVPMVRAVPRGHTASVDAYL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   244 TPHVDRYLASFKSGFDKQLEGVDVLFMQSDGGLTNMENFRGARAILSGPAGGVVGYALTGAR-ETELPLIGFDMGGTSTD 322
Cdd:PLN02666  248 TPVIKEYLSGFLSGFDDGLGDVNVLFMQSDGGLTPESRFSGHKAILSGPAGGVVGYAQTTFGlETEKPVIGFDMGGTSTD 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   323 VSRYAGTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFFRSGIFVVGPESAGSHPGPACYKKGGPLTVTDANLILGRI 402
Cdd:PLN02666  328 VSRYDGSYEQVLETQTAGVIIQAPQLDINTVAAGGGSKLKFQFGAFRVGPESVGAHPGPVCYRKGGELAVTDANLVLGRV 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   403 LPQYFPKIFGPQENEPLDHEIARSKFVELQAEINNYLKSSGDNRV-LSVEDVALGFIRVANETMCRPIRALTQSRGLDTA 481
Cdd:PLN02666  408 IPDYFPSIFGPNEDEPLDLEATRAAFEALAAQINSYRKSQDPSAKdMSVEEVALGFVRVANEAMCRPIRQLTEMKGYETA 487
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   482 NHVLSCFGGAGGQHACSIARNLGIAKVVVHKYAGILSAYGMALADVVQEFQEPNGLEFSDANAQQLKERLDALSKQCQDK 561
Cdd:PLN02666  488 NHALACFGGAGPQHACAIARALGMSEVFVHRYCGILSAYGMGLADVVAEAQEPYAAVYGPESLAEASRREDALAEKVRQK 567
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   562 LSEQGFKR--IELEPFLHLRYEGTDGALMVAPSTGKQSSDsnpllaayGDFHATFLERYRTEFGFVLQNRRIIVDDIRIR 639
Cdd:PLN02666  568 LQEQGFREdnITTETYLNLRYEGTDTAIMVAEPENGDGSD--------GDYAAAFVKLFRREYGFKLQNRDILIDDVRVR 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   640 GLGKNETPPESKVQAAAEAKPPAEANTRLYFDQGAFDSPIYLTKNLLAGHRITGPAVLIDQLSTIVVEPECGIQVTQFGD 719
Cdd:PLN02666  640 GIGVTNILKPLPLDAASGGLPEPERTTKVYFENGWHDTPVYKLENLGPGHEIPGPAIIMNGNSTVVVEPGCKAIVTKYGN 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   720 LIMDVKTGGKHGINAD-------LDPVHLSIFSHRFMSIAEQMGRVLQRTSISTNIKERLDFSCALFGPDGGLVSNAPHI 792
Cdd:PLN02666  720 IKIEVENSAEQSAEETvkaaekkADVVQLSIFNHRFMGIAEQMGRTLQRTSISTNIKERLDFSCALFGPDGGLVANAPHV 799
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   793 PVHLGAMQETVQYQLRVRGETLKNGDVILANHPSAGGSHLPDLTVITPVFYEThpRPVFFVASRGHHADIGGITPGSMPP 872
Cdd:PLN02666  800 PVHLGAMSSTVRWQLEYWGENLNEGDVLVTNHPQAGGSHLPDITVITPVFRDG--KIVFFVASRGHHADIGGITPGSMPP 877
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   873 HSTSLAQEGAAFKSFLIVENGLFQEQQIIEQLTTPTAAKGAV---GTRNLSDNLSDLKAQIAANHKGIQLVAELIGSYGL 949
Cdd:PLN02666  878 FSKTIWEEGAAIKAFKLVEGGVFQEEGITKLLQAPGSDETAPkipGTRRLQDNLSDLRAQVAANQRGISLIKELIDEYGL 957
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   950 DVVQAYMSHIQKNAELAVRDMLRQIG------RDTLERTGSTVLEAKEFMDDGSPIALKVTIDAEQGSALCDFTGSGVEV 1023
Cdd:PLN02666  958 GTVQAYMGHVQANAELAVREMLKSVAarvsseSPTFGDGSSVTLEAEDYMDDGSPIHLTLTIDRRKGSAVFDFEGTSPEV 1037
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  1024 WGNCNAPRAITLSALIYCLRCMVGHDVPLNQGCLAPIQVIIPKNSILDPSEGAAVVGGNVQTSQRIVDTVLKAFGVCAAS 1103
Cdd:PLN02666 1038 YGNWNAPPAVTAAAVIYCLRCLVDVDIPLNQGCLAPVTIRIPPGSFLSPSDKAAVVGGNVLTSQRVTDVVLTAFQACACS 1117
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  1104 QGCMNNITIGDESWGYYETVAGGAGAGPGWHGAGGVHTHMTNTRITDPEILELRYPMILKRFCLRtDGSGGRGQFHGGEG 1183
Cdd:PLN02666 1118 QGCMNNLTFGDDTFGYYETIAGGAGAGPTWDGTSGVQCHMTNTRITDPEILERRYPVLLHRFGLR-EGSGGDGLHRGGDG 1196
                        1210      1220      1230      1240      1250      1260      1270
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550492  1184 VERDLLFRKPVTLSVLTERRTLQPYGLAGGESGKSGRNLVVKRDGRVIALAGKTCIDVEAGDTFAMKTPGGGGYGPIED 1262
Cdd:PLN02666 1197 VVREIEFRRPVTVSILSERRVHAPRGLAGGGDGARGANLLIRKDGRRVNLGGKNTVHVEAGERLRILTPGGGGYGSKPS 1275
Hydantoinase_B pfam02538
Hydantoinase B/oxoprolinase; This family includes N-methylhydaintoinase B which converts ...
738-1259 0e+00

Hydantoinase B/oxoprolinase; This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyzes the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to pfam01968.


Pssm-ID: 460583  Cd Length: 507  Bit Score: 696.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    738 PVHLSIFSHRFMSIAEQMGRVLQRTSISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQYQLRVRGEtLKNG 817
Cdd:pfam02538    1 PITLEVFRNRLMSIAEEMGRTLQRTAFSPNIKERLDFSCAIFDADGRLVAQAPHIPVHLGSMSFAVKAVIEYGGD-LRPG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    818 DVILANHPSAGGSHLPDLTVITPVFYEthPRPVFFVASRGHHADIGGITPGSMPPHSTSLAQEGAAFKSFLIVENGLFQE 897
Cdd:pfam02538   80 DVFITNDPYAGGTHLPDITVITPVFHD--GELVFFVASRGHHADIGGIVPGSMPPDATEIYQEGLRIPPVKLVRRGVLNE 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    898 --QQIIEQlttptaakgavGTRNLSDNLSDLKAQIAANHKGIQLVAELIGSYGLDVVQAYMSHIQKNAELAVRDMLRQIG 975
Cdd:pfam02538  158 dvLRLLLA-----------NSRTPEDNLGDLKAQIAANRVGERRLLELIDEYGLDTVLAAMDEIQDYAERAVRAAIAALP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    976 RDTLErtgstvleAKEFMDDGSPIALKVTIDAEQGSALCDFTGSGVEVWGNCNAPRAITLSALIYCLRCMVGHDVPLNQG 1055
Cdd:pfam02538  227 DGTYE--------AEDYLDDGVPIPIRVTVTIDGDEATVDFTGTSPQVPGNINAPLAVTHSAVIYALRCLVDPDIPLNAG 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   1056 CLAPIQVIIPKNSILDPSEGAAVVGGNVQTSQRIVDTVLKAFG------VCAASQGCMNNITIG-------DESWGYYET 1122
Cdd:pfam02538  299 CLRPIEVIAPEGSLLNPSPPAAVVGGNVETSQRIVDVVLGALAqalperVPAASQGTMNNLTFGgvdprggGRFFGYYET 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   1123 VAGGAGAGPGWHGAGGVHTHMTNTRITDPEILELRYPMILKRFCLRTDgSGGRGQFHGGEGVERDLLFRKP-VTLSVLTE 1201
Cdd:pfam02538  379 IGGGSGARPGGDGLDGVHVHMTNTRNTPVEVLERRYPVLVERYELRPD-SGGAGRYRGGDGVVREIEFLAPdATVSILSE 457
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 45550492   1202 RRTLQPYGLAGGESGKSgrnlvvkrdGRVIALAGKTCIDVEAGDTFAMKTPGGGGYGP 1259
Cdd:pfam02538  458 RRVFPPWGLAGGEPGAP---------GRVNLGGKATDVELKPGDRLRIETPGGGGYGD 506
HyuA COG0145
N-methylhydantoinase A/oxoprolinase/acetone carboxylase, beta subunit [Amino acid transport ...
8-727 0e+00

N-methylhydantoinase A/oxoprolinase/acetone carboxylase, beta subunit [Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439915 [Multi-domain]  Cd Length: 678  Bit Score: 691.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    8 FAIDRGGTFTDVLCICPNGKVRTMKLLSeDPERYSDAPREGIRRILkEETGEDLAAsglvdtskIGWVRMGTTVATNALL 87
Cdd:COG0145    1 VGVDVGGTFTDVVAVDEDGRLRTHKVLS-TPEDPSDGVLEGIRELL-EDAGIPLAE--------IDLVVHGTTVATNALL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492   88 ERKGDPVVLVVNSGFRDLLYIGNQARPKIFDLNIRKPANLYKS--VVEVDCRIvpkqadrcelnhswkeleGVAGTkylE 165
Cdd:COG0145   71 ERKGARTGLITTRGFRDVLEIGRQNRPDLYDLFIEKPEPLVPRrlRFEVRERI------------------DADGE---V 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  166 VRPVDEVAVRQALSDARDQGVSSVSVVLAHSYACPEHELRVGAIARE-LGFSHVTLSHQAMPMCRVVARGYTACAEAYLT 244
Cdd:COG0145  130 LTPLDEAEVRAAARELRAAGVEAVAVCFLHSYRNPAHERRAAEILREeLPDVPVSLSSEVSPEIREYERTSTTVVNAYLS 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  245 PHVDRYLASFKSGFDKQLEGVDVLFMQSDGGLTNMENF--RGARAILSGPAGGVVGYALTGARETELPLIGFDMGGTSTD 322
Cdd:COG0145  210 PILRRYLDRLEARLRERGFGGPLLIMQSNGGLASAEAAarRPVRTILSGPAGGVVGAAALARAAGFDNVITFDMGGTSTD 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  323 VSRYA-GTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFF-RSGIFVVGPESAGSHPGPACYKKGGP-LTVTDANLIL 399
Cdd:COG0145  290 VSLIEdGEPERTTETEVAGYPVRVPMVDIHTVGAGGGSIAWVdAGGRLRVGPESAGADPGPACYGRGGTePTVTDANLVL 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  400 GRILPQYFpkIFGpqeNEPLDHEIARSKFVELQAEINnylkssgdnrvLSVEDVALGFIRVANETMCRPIRALTQSRGLD 479
Cdd:COG0145  370 GRLDPDNF--LGG---RMPLDVEAARAAIEKLADPLG-----------LSVEEAAEGILRIANENMANAIRKVSVERGYD 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  480 TANHVLSCFGGAGGQHACSIARNLGIAKVVVHKYAGILSAYGMALADVVQEFQEPNGLEFSDANAQQLKERLDALSKQCQ 559
Cdd:COG0145  434 PRDFTLVAFGGAGPLHACALAEELGIPRVIVPPAAGVLSALGMLLADIRHDYVRSVEAPLDDADLAELNAAFAELEAEAR 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  560 DKLSEQGFK--RIELEPFLHLRYEGTDGALMVAPSTGKQSSDSnpLLAAYGDFHAtfleRYRTEFGFVLQNRRIIVDDIR 637
Cdd:COG0145  514 AELAAEGVAaeDIRVERSADMRYAGQGHELTVPLPAGRLDAAD--LAALRAAFHA----AHERRYGFALPDAPVEIVNLR 587
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  638 IRGLGKNETPPESKVQAAAEAKPPAEANTRLYFDQGAFDSPIYLTKNLLAGHRITGPAVLIDQLSTIVVEPECGIQVTQF 717
Cdd:COG0145  588 VEAIGPVPKPELPRLPPGGDAAPAPKGTRPVYFDGGWVDTPVYDREALPPGDRIAGPAIIEEPDTTTVVPPGWRATVDAY 667
                        730
                 ....*....|
gi 45550492  718 GDLIMDVKTG 727
Cdd:COG0145  668 GNLILTRAAA 677
HyuB COG0146
N-methylhydantoinase B/oxoprolinase/acetone carboxylase, alpha subunit [Amino acid transport ...
732-1259 0e+00

N-methylhydantoinase B/oxoprolinase/acetone carboxylase, alpha subunit [Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439916  Cd Length: 563  Bit Score: 612.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  732 INADLDPVHLSIFSHRFMSIAEQMGRVLQRTSISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQYQLRVRG 811
Cdd:COG0146    1 LGTTVDPVTLEVIRNRLIAIAEEMGETLQRTAFSPNIKERLDFSCALFDADGRLVAQAPGIPVHLGSMPEAVKAVIERFG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  812 -ETLKNGDVILANHPSAGGSHLPDLTVITPVFYEThpRPVFFVASRGHHADIGGITPGSMPPHSTSLAQEGAAFKSFLIV 890
Cdd:COG0146   81 nDGIRPGDVFITNDPYLGGTHLPDITVVTPVFHDG--ELVGFVASRAHHADIGGIVPGSMPPDATEIFQEGLRIPPVKLV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  891 ENGLFQEQqIIEQLTTptaakgavGTRNLSDNLSDLKAQIAANHKGIQLVAELIGSYGLDVVQAYMSHIQKNAELAVRDM 970
Cdd:COG0146  159 EAGELNED-VLRLILA--------NVRTPDQNLGDLRAQIAANRVGERRLLELVERYGLDTVEAAMDELLDYAERAVRAA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492  971 LRQI--GrdtlertgstVLEAKEFMDDGS----PIALKVTIDAEQGSALCDFTGSGVEVWGNCNAPRAITLSALIYCLRC 1044
Cdd:COG0146  230 IAALpdG----------TYRAEDFLDDDGvgdePIKIKVTVTVKGDRITVDFTGTSPQVPGNINAPLAVTRAAVLYALRC 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492 1045 MVGHDVPLNQGCLAPIQVIIPKNSILDPSEGAAVVGGNVQTSQRIVDTVLKAFG------VCAASQGCMNNITIG----- 1113
Cdd:COG0146  300 LLDPDIPLNAGCLRPIEVIAPEGSILNPRYPAAVVAGNVETSQRVVDAVFGALAqalperVPAASQGTMNNLTFGgvdpr 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492 1114 DESWGYYETVAGGAGAGPGWHGAGGVHTHMTNTRITDPEILELRYPMILKRFCLRTDgSGGRGQFHGGEGVERDLLFRKP 1193
Cdd:COG0146  380 GEPFVYYETIGGGSGARPGGDGLDAVHTHMTNTRNTPVEVLEARYPVLVERYELRPD-SGGAGKYRGGLGVVREIRFLEP 458
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45550492 1194 -VTLSVLTERRTLQPYGLAGGESGKSGRNLVVKRDGRVIALAGKTCIDVEAGDTFAMKTPGGGGYGP 1259
Cdd:COG0146  459 eMTVSLLGDRRRFPPWGLAGGGPGAPGRNVLVRGDGDEEELGGKATVPLQPGDVVVIETPGGGGYGD 525
Hydantoinase_A pfam01968
Hydantoinase/oxoprolinase; This family includes the enzymes hydantoinase and oxoprolinase EC:3. ...
233-530 6.63e-125

Hydantoinase/oxoprolinase; This family includes the enzymes hydantoinase and oxoprolinase EC:3.5.2.9. Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds.


Pssm-ID: 396517 [Multi-domain]  Cd Length: 288  Bit Score: 387.41  E-value: 6.63e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    233 RGYTACAEAYLTPHVDRYLASFKSGFDKQLEGVDVLFMQSDGGLTNMENFRG--ARAILSGPAGGVVGYALTGARETELP 310
Cdd:pfam01968    1 RTVTAVVNAYLAPIMREYLEGVEDSLEKVGSKAPVYVMQSDGGLVSIDEARKrpVETILSGPAAGVVGAAYTGKLLGNKN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    311 LIGFDMGGTSTDVSRYA-GTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRL-FFRSGIFVVGPESAGSHPGPACYKKGG 388
Cdd:pfam01968   81 LIGFDMGGTSTDISPIIdGEPEITTETEVAGYPTRLPRLDINTVGAGGGSILvSFLGGKVRVGPESAGADPGPACYRKGG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492    389 -PLTVTDANLILGRILPQYFPKIfgpqeNEPLDHEIARSKFVELQAEINnylkssgdnrvLSVEDVALGFIRVANETMCR 467
Cdd:pfam01968  161 tFPTVTDANLVLGRLNPEDFLGG-----DGKLDVEAARRAFEKLADPLN-----------LGVEEVAEGIIRIANETMAR 224
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45550492    468 PIRALTQSRGLDTANHVLSCFGGAGGQHACSIARNLGIAKVVVHKYAGILSAYGMALADVVQE 530
Cdd:pfam01968  225 AVRLVTVERGYDPSEFVLVVFGGAGPQHAPALAEELGIKKVIVPPYPGVLSAYGMALADLRAE 287
Hydant_A_N pfam05378
Hydantoinase/oxoprolinase N-terminal region; This family is found at the N-terminus of the ...
8-214 2.72e-67

Hydantoinase/oxoprolinase N-terminal region; This family is found at the N-terminus of the pfam01968 family.


Pssm-ID: 398834 [Multi-domain]  Cd Length: 176  Bit Score: 224.09  E-value: 2.72e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492      8 FAIDRGGTFTDVLCICPNGK-VRTMKLLSEDperysDAPREGIRRILKEETGEDLaasglVDTSKIGWVRMGTTVATNAL 86
Cdd:pfam05378    2 IGIDVGGTFTDAVALDEGDGeVAVIKVLTTP-----DDPVEGIREALEELLGELG-----PRTGKVDTVRHGTTVATNAL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550492     87 LERKGDPVVLVVNSGFRDLLYIGNQARPKIFDlnIRKPANLYKSVVEVDCRIVPkqadrcelnhswkelegvagtKYLEV 166
Cdd:pfam05378   72 LERKGARVGLITTKGFRDLLEIGRQNRPDLFD--LYKPLVLYELVVEVDERVDA---------------------DGEVL 128
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 45550492    167 RPVDEVAVRQALSDARDQGVSSVSVVLAHSYACPEHELRVGAIARELG 214
Cdd:pfam05378  129 KPLDEEEVREALKALKDAGVEAIAVVLLHSYLNPEHELRVAEIAREEG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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