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Conserved domains on  [gi|22026942|ref|NP_611816|]
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sulfotransferase 3, isoform A [Drosophila melanogaster]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-301 3.64e-78

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 239.17  E-value: 3.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942    45 DDDVWIVTLPKCGTTWMQELLWLLLNNCDFEG---ALAKDQELRTPFLEF-GYSVFHDPNRSFGPIEDLKSPRLIKSHLS 120
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseePHLFNNHNRSPFLEWyPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   121 LALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLH-QYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPfEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   200 TSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELaqvqhenagKEMHPFVRRGDVNGYKD 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---------KEVSPFFRKGLVGDWKN 231

                         250       260
                  ....*....|....*....|..
gi 22026942   280 ELKPEQIEKANVRIQEVLAKNG 301
Cdd:pfam00685 232 YFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-301 3.64e-78

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 239.17  E-value: 3.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942    45 DDDVWIVTLPKCGTTWMQELLWLLLNNCDFEG---ALAKDQELRTPFLEF-GYSVFHDPNRSFGPIEDLKSPRLIKSHLS 120
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseePHLFNNHNRSPFLEWyPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   121 LALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLH-QYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPfEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   200 TSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELaqvqhenagKEMHPFVRRGDVNGYKD 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---------KEVSPFFRKGLVGDWKN 231

                         250       260
                  ....*....|....*....|..
gi 22026942   280 ELKPEQIEKANVRIQEVLAKNG 301
Cdd:pfam00685 232 YFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 42-302 3.06e-08

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 54.54  E-value: 3.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   42 KLRDDDVWIVTLPKCGTTWMQELLWLLLNNCDFEGA----LAKDQELRTPFLEFGYSVFhdpnRSFGPIEDLKSPrLIKS 117
Cdd:PLN02164  76 QARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnplLKRNPHEFVPYIEIDFPFF----PSVDVLKDKGNT-LFST 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942  118 HLSLALLPSKLWEGKNKVIYVSRNPLDSYVS--RYYHGVSFGFNYGKSLHQYFDEVLASDDFPTEFIEHAHEFYQL--RN 193
Cdd:PLN02164 151 HIPYGLLPDSVVKSGCKMVYIWRDPKDTFISmwTFLHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKAyqEN 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942  194 EPWVFYTSFEMMKKDLRGVINDVSRFLNKPINDQQ-----MEKLLKHLSFAEMKK---NPTTNHLWELAQVQHENAgkem 265
Cdd:PLN02164 231 PDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNleaNKGEKDREDRPAVYANSA---- 306

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 22026942  266 hpFVRRGDVNGYKDELKPEQIEKANVRIQEVLAKNGV 302
Cdd:PLN02164 307 --YFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-301 3.64e-78

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 239.17  E-value: 3.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942    45 DDDVWIVTLPKCGTTWMQELLWLLLNNCDFEG---ALAKDQELRTPFLEF-GYSVFHDPNRSFGPIEDLKSPRLIKSHLS 120
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseePHLFNNHNRSPFLEWyPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   121 LALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLH-QYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPfEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   200 TSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELaqvqhenagKEMHPFVRRGDVNGYKD 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---------KEVSPFFRKGLVGDWKN 231

                         250       260
                  ....*....|....*....|..
gi 22026942   280 ELKPEQIEKANVRIQEVLAKNG 301
Cdd:pfam00685 232 YFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 42-302 3.06e-08

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 54.54  E-value: 3.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942   42 KLRDDDVWIVTLPKCGTTWMQELLWLLLNNCDFEGA----LAKDQELRTPFLEFGYSVFhdpnRSFGPIEDLKSPrLIKS 117
Cdd:PLN02164  76 QARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnplLKRNPHEFVPYIEIDFPFF----PSVDVLKDKGNT-LFST 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942  118 HLSLALLPSKLWEGKNKVIYVSRNPLDSYVS--RYYHGVSFGFNYGKSLHQYFDEVLASDDFPTEFIEHAHEFYQL--RN 193
Cdd:PLN02164 151 HIPYGLLPDSVVKSGCKMVYIWRDPKDTFISmwTFLHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKAyqEN 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026942  194 EPWVFYTSFEMMKKDLRGVINDVSRFLNKPINDQQ-----MEKLLKHLSFAEMKK---NPTTNHLWELAQVQHENAgkem 265
Cdd:PLN02164 231 PDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNleaNKGEKDREDRPAVYANSA---- 306

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 22026942  266 hpFVRRGDVNGYKDELKPEQIEKANVRIQEVLAKNGV 302
Cdd:PLN02164 307 --YFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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