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Conserved domains on  [gi|24762694|ref|NP_611950|]
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uncharacterized protein Dmel_CG3640 [Drosophila melanogaster]

Protein Classification

CAP domain-containing protein( domain architecture ID 10143468)

CAP (CSP/antigen 5/PR1) domain-containing protein similar to Venom allergen 5, CRISP/Allergen/PR-1 and scoloptoxins

CATH:  3.40.33.10
PubMed:  18824526
SCOP:  4001882

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 65-213 2.01e-29

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


:

Pssm-ID: 349399  Cd Length: 144  Bit Score: 109.08  E-value: 2.01e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694  65 QAFIVHQVNFYRNQVASGGLSAFGPARRMASVRWDPELAQLAELAAKRCSLSGDGCRNTrrfKHVGQLTGHVifSAGKHS 144
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNT---GGVGQNLASV--SSSGKD 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694 145 DLELLRHKISNWFGQYMRAS-KDLQAADPSSNISSFRQLIQESSTHMGCGVLRQRSHmLWHQQFIVCNFA 213
Cdd:cd05380  76 LKELIEDAVNAWFDELKDYGfGSNPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKG-GGNKTYVVCNYS 144
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 65-213 2.01e-29

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 109.08  E-value: 2.01e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694  65 QAFIVHQVNFYRNQVASGGLSAFGPARRMASVRWDPELAQLAELAAKRCSLSGDGCRNTrrfKHVGQLTGHVifSAGKHS 144
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNT---GGVGQNLASV--SSSGKD 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694 145 DLELLRHKISNWFGQYMRAS-KDLQAADPSSNISSFRQLIQESSTHMGCGVLRQRSHmLWHQQFIVCNFA 213
Cdd:cd05380  76 LKELIEDAVNAWFDELKDYGfGSNPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKG-GGNKTYVVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 62-212 4.28e-10

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 57.01  E-value: 4.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694     62 NQLQAFIVHQvNFYRNQVASGGLSAfGPARRMASVRWDPELAQLAELAAKRCSLSGDGCRNTrrfkhVGQltGHVIFSAG 141
Cdd:smart00198   1 AQQQEILDAH-NKLRSQVAGGFLAA-PAASNMLKLTWDCELASSAQNWANQCPFGHSTPRPG-----YGE--NLAWWSSS 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24762694    142 KHSDLELLRHKISNW---FGQYMRASKDLqaADPSSNISSFRQLIQESSTHMGCGVLRQRShMLWHQQFIVCNF 212
Cdd:smart00198  72 TALPDTYASAAVQLWydeFQDYGYSSNTC--KDTNGKIGHYTQVVWAKTYKVGCGVANCPD-GTKKKTVVVCNY 142
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 86-212 5.04e-09

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 53.36  E-value: 5.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694    86 AFGPARRMASVRWDPELAQLAELAAKRCSLSgdGCRNTRrfkhvgQLTGHVIFSAGKHSDLELLRhkISNWFGQymRASK 165
Cdd:pfam00188   6 EYRAAAGLPPLSWDNELAAAAQDHAKYCADN--GSHNHR------SPYGGNIYARVVAAGYALGD--AGPDSAE--DAVD 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 24762694   166 DLQAADPSSNISSFRQLIQESSTHMGCGVLRQRSHMLWhqqFIVCNF 212
Cdd:pfam00188  74 GWYDSPGTYNCGHRTNLLWPKSTKVGCAVAKCGDGGTY---YFVCNY 117
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 65-213 2.01e-29

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 109.08  E-value: 2.01e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694  65 QAFIVHQVNFYRNQVASGGLSAFGPARRMASVRWDPELAQLAELAAKRCSLSGDGCRNTrrfKHVGQLTGHVifSAGKHS 144
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNT---GGVGQNLASV--SSSGKD 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694 145 DLELLRHKISNWFGQYMRAS-KDLQAADPSSNISSFRQLIQESSTHMGCGVLRQRSHmLWHQQFIVCNFA 213
Cdd:cd05380  76 LKELIEDAVNAWFDELKDYGfGSNPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKG-GGNKTYVVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 62-212 4.28e-10

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 57.01  E-value: 4.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694     62 NQLQAFIVHQvNFYRNQVASGGLSAfGPARRMASVRWDPELAQLAELAAKRCSLSGDGCRNTrrfkhVGQltGHVIFSAG 141
Cdd:smart00198   1 AQQQEILDAH-NKLRSQVAGGFLAA-PAASNMLKLTWDCELASSAQNWANQCPFGHSTPRPG-----YGE--NLAWWSSS 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24762694    142 KHSDLELLRHKISNW---FGQYMRASKDLqaADPSSNISSFRQLIQESSTHMGCGVLRQRShMLWHQQFIVCNF 212
Cdd:smart00198  72 TALPDTYASAAVQLWydeFQDYGYSSNTC--KDTNGKIGHYTQVVWAKTYKVGCGVANCPD-GTKKKTVVVCNY 142
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 68-212 8.72e-10

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 55.70  E-value: 8.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694  68 IVHQVNFYRNQVASgglsafgPARRMASVRWDPELAQLAELAAKRCSLSGDGCRNtrrfkhvGQLTGHVIFSAGKHSDLE 147
Cdd:cd00168   4 ILDLHNSYRSSVSP-------PASNMPLMAWDQELADVAIGYAKDCIFSHSSPTS-------RQLAGENIAASSYDMDGV 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24762694 148 LLRHkisNWFGQYMRASKDLQAADPSSNISSFRQLIQESSTHMGCGVLRQRSHMlwhqQFIVCNF 212
Cdd:cd00168  70 AALQ---AWHNEIKNYNFGTAQPGFNSGTGHYTQMVWEKTTKLGCGVADCSDNS----KFVVCNY 127
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 86-212 5.04e-09

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 53.36  E-value: 5.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694    86 AFGPARRMASVRWDPELAQLAELAAKRCSLSgdGCRNTRrfkhvgQLTGHVIFSAGKHSDLELLRhkISNWFGQymRASK 165
Cdd:pfam00188   6 EYRAAAGLPPLSWDNELAAAAQDHAKYCADN--GSHNHR------SPYGGNIYARVVAAGYALGD--AGPDSAE--DAVD 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 24762694   166 DLQAADPSSNISSFRQLIQESSTHMGCGVLRQRSHMLWhqqFIVCNF 212
Cdd:pfam00188  74 GWYDSPGTYNCGHRTNLLWPKSTKVGCAVAKCGDGGTY---YFVCNY 117
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 68-214 1.56e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 40.80  E-value: 1.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694  68 IVHQVNFYRNQVASgglsafgPARRMASVRWDPELAQLAELAAKRCSLSgDGCRNTRRFKhvGQLTGHVIFSAgkhSDLE 147
Cdd:cd05383   6 IVDLHNALRRSVNP-------PASNMLKMSWNPEAAENAQRWANRCNFT-HSPPNGRTIP--GIRCGENIFMS---SYPA 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24762694 148 LLRHKISNWFGQYMRASKDLQAADPSSNISSFRQLIQESSTHMGCGVLRQRSHMLWHqQFIVCNFAR 214
Cdd:cd05383  73 SWSEVIQAWYDEYKDFKYGVGAKPPGSVTGHYTQVVWYSSYLVGCAVAYCPSQGSLK-YFYVCQYCP 138
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 68-194 1.70e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 40.86  E-value: 1.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694  68 IVHQVNFYRNQVASgglsafgPARRMASVRWDPELAQLAELAAKRCSLSgdgcRNTRRfkhvgQLTGHVIF-SAGKHSDL 146
Cdd:cd05559   4 LVDLHNQYRSQVSP-------SAANMLKMTWDTELEALAKAYARKCIWE----HNPDR-----GRVGENLFaSTGKPLDV 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24762694 147 EllrHKISNWFGQymRASKDLQAAD--PSSNISSFRQLIQESSTHMGCGV 194
Cdd:cd05559  68 E---LAVEDWHNE--KEYYNFETKTcaPGKMCGHYTQVVWANTEKIGCGS 112
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 66-194 4.01e-03

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 37.00  E-value: 4.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762694  66 AFI-----VHqvNFYRNQVASgglsafgPARRMASVRWDPELAQLAELAAKRCSLSGDGCRNTR-----RFKHVGQ---L 132
Cdd:cd05385   1 AFIdecvrIH--NELRSKVSP-------PAANMRYMSWDKALAKTARAWARKCKFSHNICLKEPgkchpNFTTLGEniwL 71

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24762694 133 TGHVIFSAgkhsdlellRHKISNWfgqymraSKDLQAADPSSNISS-----FRQLIQESSTHMGCGV 194
Cdd:cd05385  72 GSIFSFSV---------ESAITSW-------YNEVKDYNFKTNSCSrvcghYTQVVWADSYKVGCAV 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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