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Conserved domains on  [gi|19923024|ref|NP_612062|]
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uncharacterized protein Dmel_CG13887, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bap31 pfam05529
Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic ...
 1-134 4.55e-46

Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This family also contains the Bap29 protein that forms a heterodimer with Bap 31.


:

Pssm-ID: 461673  Cd Length: 137  Bit Score: 149.56  E-value: 4.55e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923024     1 MSLVWTLIAGFLYAEIALVLLLVLPVLTPYRwNRFFKSKFLSMLGQQAHIYFLLIMGILVIFLLEAIREMRKYSGLQQS- 79
Cdd:pfam05529   1 MTLQWTLVFGFLYAEMAVFLLLVLPLPSPVR-QKIFKSRSESPLSAKFQIGFKITIIFLLILFLDAVRRVRKYSAELESa 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19923024    80 ---NEVHLNVEMQHSMKLFRAQRNFYISGFAIFLALVIRRLVNLICTQANLMAQSEAS 134
Cdd:pfam05529  80 kanAHQHPSARMEVQARKFYAQRNLYICGFTLFLSLVLRRTVTLISELATLEAKLEAL 137
Bap31_Bap29_C pfam18035
Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the ...
 174-228 7.58e-12

Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This entry represents the cytoplasmic domain which forms a heterodimeric coiled-coil with Bap29. This Bap29 and Bap31 are homologous to each other and this entry includes both proteins.


:

Pssm-ID: 465623 [Multi-domain]  Cd Length: 52  Bit Score: 58.44  E-value: 7.58e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19923024   174 ERVQELTSDLNREKKDKEAVKSQAESINREYDRLTEEYSKLQkkitIGGGGNKDD 228
Cdd:pfam18035   1 KEIEKLKKELKKKKSDIEALKKQAEGLQREYDRLSDEHAKLQ----LDEGEDKKD 51
 
Name Accession Description Interval E-value
Bap31 pfam05529
Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic ...
 1-134 4.55e-46

Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This family also contains the Bap29 protein that forms a heterodimer with Bap 31.


Pssm-ID: 461673  Cd Length: 137  Bit Score: 149.56  E-value: 4.55e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923024     1 MSLVWTLIAGFLYAEIALVLLLVLPVLTPYRwNRFFKSKFLSMLGQQAHIYFLLIMGILVIFLLEAIREMRKYSGLQQS- 79
Cdd:pfam05529   1 MTLQWTLVFGFLYAEMAVFLLLVLPLPSPVR-QKIFKSRSESPLSAKFQIGFKITIIFLLILFLDAVRRVRKYSAELESa 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19923024    80 ---NEVHLNVEMQHSMKLFRAQRNFYISGFAIFLALVIRRLVNLICTQANLMAQSEAS 134
Cdd:pfam05529  80 kanAHQHPSARMEVQARKFYAQRNLYICGFTLFLSLVLRRTVTLISELATLEAKLEAL 137
Bap31_Bap29_C pfam18035
Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the ...
 174-228 7.58e-12

Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This entry represents the cytoplasmic domain which forms a heterodimeric coiled-coil with Bap29. This Bap29 and Bap31 are homologous to each other and this entry includes both proteins.


Pssm-ID: 465623 [Multi-domain]  Cd Length: 52  Bit Score: 58.44  E-value: 7.58e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19923024   174 ERVQELTSDLNREKKDKEAVKSQAESINREYDRLTEEYSKLQkkitIGGGGNKDD 228
Cdd:pfam18035   1 KEIEKLKKELKKKKSDIEALKKQAEGLQREYDRLSDEHAKLQ----LDEGEDKKD 51
COG5374 COG5374
Uncharacterized conserved protein [Function unknown];
1-177 9.44e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227666 [Multi-domain]  Cd Length: 192  Bit Score: 39.02  E-value: 9.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923024   1 MSLVWTLIAGFLYAEIALVLLLVLPVLTPYR---WNRFFKSKFLsmlGQQAHIYFLLIMGILVIFLLEAIREMRKYSGLQ 77
Cdd:COG5374   1 MGIYYTLVFSLLVVEMVMFFILVLPLPKRLRrslMKLYSTSKVY---RGFKHILKITFIFILLLFIDSWKRVYRVSKEAN 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923024  78 QSNEVHLNVEMQHSMKLFR---AQRNFYISGFAIFLALVIRR----LVNLICTQANLMAQS---EASFKQAQSATAAARS 147
Cdd:COG5374  78 LYSASINNYAVTRIAVLASrfyAQRNMYLSGSALFLSIVVMRvmsiVEEMLEENAKKGGKIdkmEADSTDLKARLRKAQI 157

                       170       180       190
                ....*....|....*....|....*....|
gi 19923024 148 LLEnknTEKAKEAGEDTTLIELNKLRERVQ 177
Cdd:COG5374 158 LLE---GLQKNQEELFKLLDKYNELREQVQ 184
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 168-220 5.01e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 37.40  E-value: 5.01e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 19923024 168 ELNKLRERVQELTSDLNREKKDKEAVKSQAESINREYDRLTEEYSKLQKKITI 220
Cdd:COG4026 129 EYNELREELLELKEKIDEIAKEKEKLTKENEELESELEELREEYKKLREENSI 181
 
Name Accession Description Interval E-value
Bap31 pfam05529
Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic ...
 1-134 4.55e-46

Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This family also contains the Bap29 protein that forms a heterodimer with Bap 31.


Pssm-ID: 461673  Cd Length: 137  Bit Score: 149.56  E-value: 4.55e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923024     1 MSLVWTLIAGFLYAEIALVLLLVLPVLTPYRwNRFFKSKFLSMLGQQAHIYFLLIMGILVIFLLEAIREMRKYSGLQQS- 79
Cdd:pfam05529   1 MTLQWTLVFGFLYAEMAVFLLLVLPLPSPVR-QKIFKSRSESPLSAKFQIGFKITIIFLLILFLDAVRRVRKYSAELESa 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19923024    80 ---NEVHLNVEMQHSMKLFRAQRNFYISGFAIFLALVIRRLVNLICTQANLMAQSEAS 134
Cdd:pfam05529  80 kanAHQHPSARMEVQARKFYAQRNLYICGFTLFLSLVLRRTVTLISELATLEAKLEAL 137
Bap31_Bap29_C pfam18035
Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the ...
 174-228 7.58e-12

Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This entry represents the cytoplasmic domain which forms a heterodimeric coiled-coil with Bap29. This Bap29 and Bap31 are homologous to each other and this entry includes both proteins.


Pssm-ID: 465623 [Multi-domain]  Cd Length: 52  Bit Score: 58.44  E-value: 7.58e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19923024   174 ERVQELTSDLNREKKDKEAVKSQAESINREYDRLTEEYSKLQkkitIGGGGNKDD 228
Cdd:pfam18035   1 KEIEKLKKELKKKKSDIEALKKQAEGLQREYDRLSDEHAKLQ----LDEGEDKKD 51
COG5374 COG5374
Uncharacterized conserved protein [Function unknown];
1-177 9.44e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227666 [Multi-domain]  Cd Length: 192  Bit Score: 39.02  E-value: 9.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923024   1 MSLVWTLIAGFLYAEIALVLLLVLPVLTPYR---WNRFFKSKFLsmlGQQAHIYFLLIMGILVIFLLEAIREMRKYSGLQ 77
Cdd:COG5374   1 MGIYYTLVFSLLVVEMVMFFILVLPLPKRLRrslMKLYSTSKVY---RGFKHILKITFIFILLLFIDSWKRVYRVSKEAN 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923024  78 QSNEVHLNVEMQHSMKLFR---AQRNFYISGFAIFLALVIRR----LVNLICTQANLMAQS---EASFKQAQSATAAARS 147
Cdd:COG5374  78 LYSASINNYAVTRIAVLASrfyAQRNMYLSGSALFLSIVVMRvmsiVEEMLEENAKKGGKIdkmEADSTDLKARLRKAQI 157

                       170       180       190
                ....*....|....*....|....*....|
gi 19923024 148 LLEnknTEKAKEAGEDTTLIELNKLRERVQ 177
Cdd:COG5374 158 LLE---GLQKNQEELFKLLDKYNELREQVQ 184
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 168-220 5.01e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 37.40  E-value: 5.01e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 19923024 168 ELNKLRERVQELTSDLNREKKDKEAVKSQAESINREYDRLTEEYSKLQKKITI 220
Cdd:COG4026 129 EYNELREELLELKEKIDEIAKEKEKLTKENEELESELEELREEYKKLREENSI 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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