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Conserved domains on  [gi|20178574|ref|NP_619995|]
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CPXV215 Protein [Cowpox virus]

Protein Classification

kelch repeat and BTB domain-containing protein( domain architecture ID 11476070)

kelch repeat and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Cowpox virus Kelch repeat and BTB domain-containing protein 2 (KBTB2), probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02713 PHA02713
hypothetical protein; Provisional
 1-557 0e+00

hypothetical protein; Provisional


:

Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 1013.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574    1 MDIENDIRNRRIIRNISNLLDDDILCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVK 80
Cdd:PHA02713   1 MDIDDIKHNRRVVSNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMFDKDAVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574   81 NIVQYLYNRHISSMNVIDVLKCADYLLIDDLVADCESYIKDYTNHDTCICMYHKLYEMIHIPIVKYIKRMLMSNIPTLIT 160
Cdd:PHA02713  81 NIVQYLYNRHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLIT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  161 TDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKWLEHNYITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYPSC 240
Cdd:PHA02713 161 TDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKWLEYNYITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYPSC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  241 IQFLIDNKQNRNIIPRQLCLVCHDTKYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLN 320
Cdd:PHA02713 241 IQFLLDNKQNRNIIPRQLCLVCHDTKYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  321 KVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSYGMCVLDQY 400
Cdd:PHA02713 321 KVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQY 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  401 IYIIGGSTLYIDYTSVHAVNSIDMEEDTDTSNKVIRYDTVNNIWETLPNFWTGTIKPGVVSHEDDIYVVCDIKDEKNVKT 480
Cdd:PHA02713 401 IYIIGGRTEHIDYTSVHHMNSIDMEEDTHSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVVCDIKDEKNVKT 480

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20178574  481 CIFRYNTNTYNGWELVTTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVYTREWNHTCHQHSNSYIMHNILPIY 557
Cdd:PHA02713 481 CIFRYNTNTYNGWELITTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVYTYEWNHICHQHSNSYIMHNILPIY 557
 
Name Accession Description Interval E-value
PHA02713 PHA02713
hypothetical protein; Provisional
 1-557 0e+00

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 1013.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574    1 MDIENDIRNRRIIRNISNLLDDDILCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVK 80
Cdd:PHA02713   1 MDIDDIKHNRRVVSNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMFDKDAVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574   81 NIVQYLYNRHISSMNVIDVLKCADYLLIDDLVADCESYIKDYTNHDTCICMYHKLYEMIHIPIVKYIKRMLMSNIPTLIT 160
Cdd:PHA02713  81 NIVQYLYNRHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLIT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  161 TDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKWLEHNYITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYPSC 240
Cdd:PHA02713 161 TDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKWLEYNYITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYPSC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  241 IQFLIDNKQNRNIIPRQLCLVCHDTKYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLN 320
Cdd:PHA02713 241 IQFLLDNKQNRNIIPRQLCLVCHDTKYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  321 KVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSYGMCVLDQY 400
Cdd:PHA02713 321 KVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQY 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  401 IYIIGGSTLYIDYTSVHAVNSIDMEEDTDTSNKVIRYDTVNNIWETLPNFWTGTIKPGVVSHEDDIYVVCDIKDEKNVKT 480
Cdd:PHA02713 401 IYIIGGRTEHIDYTSVHHMNSIDMEEDTHSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVVCDIKDEKNVKT 480

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20178574  481 CIFRYNTNTYNGWELVTTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVYTREWNHTCHQHSNSYIMHNILPIY 557
Cdd:PHA02713 481 CIFRYNTNTYNGWELITTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVYTYEWNHICHQHSNSYIMHNILPIY 557
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
276-469 7.99e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 95.61  E-value: 7.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 276 VYNINTMEYSVISTIPNHIINY-ASAIVDNEIIIAGGYNFNNPS---LNKVYKINIENKIHVELPPMIKNRCRFSLAVID 351
Cdd:COG3055  42 VYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLD 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 352 DTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSY-GMCVLDQYIYIIGGSTLYIDYTSV------------HA 418
Cdd:COG3055 122 GKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSNTWttlaplptaragHA 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20178574 419 VNSIDMEE-----DTDTSNKVIRYDTVNNIWETLPNFWTGTIKPGVVSHEDDIYVV 469
Cdd:COG3055 202 AAVLGGKIlvfggESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVI 257
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 19-121 6.62e-20

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 85.00  E-value: 6.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574    19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLY-NRHISSMNVI 97
Cdd:pfam00651   4 LREQGELCDVTLVV-GDKEFRAHKAVLAACSPYFKALFSGQESESS-VSEITLDDVSPEDFEALLEFMYtGKLISEENVD 81

                          90       100
                  ....*....|....*....|....
gi 20178574    98 DVLKCADYLLIDDLVADCESYIKD 121
Cdd:pfam00651  82 DLLAAADKLQIPSLVDKCEEFLIK 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-106 8.10e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 83.76  E-value: 8.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKC 102
Cdd:cd18186   1 LCDVTLVV-GGREFPAHRAVLAARSPYFRAMFSSGMKESS-SSEIELDDVSPEAFEALLDYIYTGEleLSEENVEELLAA 78


                ....
gi 20178574 103 ADYL 106
Cdd:cd18186  79 ADKL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 27-123 2.42e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 2.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574     27 DVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIaRDLVTRVNLQMFDKDAVKNIVQYLYNRHISSM--NVIDVLKCAD 104
Cdd:smart00225   1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFK-ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPeeNVEELLELAD 78

                           90
                   ....*....|....*....
gi 20178574    105 YLLIDDLVADCESYIKDYT 123
Cdd:smart00225  79 YLQIPGLVELCEEFLLKLL 97
 
Name Accession Description Interval E-value
PHA02713 PHA02713
hypothetical protein; Provisional
 1-557 0e+00

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 1013.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574    1 MDIENDIRNRRIIRNISNLLDDDILCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVK 80
Cdd:PHA02713   1 MDIDDIKHNRRVVSNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMFDKDAVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574   81 NIVQYLYNRHISSMNVIDVLKCADYLLIDDLVADCESYIKDYTNHDTCICMYHKLYEMIHIPIVKYIKRMLMSNIPTLIT 160
Cdd:PHA02713  81 NIVQYLYNRHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLIT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  161 TDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKWLEHNYITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYPSC 240
Cdd:PHA02713 161 TDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKWLEYNYITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYPSC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  241 IQFLIDNKQNRNIIPRQLCLVCHDTKYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLN 320
Cdd:PHA02713 241 IQFLLDNKQNRNIIPRQLCLVCHDTKYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  321 KVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSYGMCVLDQY 400
Cdd:PHA02713 321 KVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQY 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  401 IYIIGGSTLYIDYTSVHAVNSIDMEEDTDTSNKVIRYDTVNNIWETLPNFWTGTIKPGVVSHEDDIYVVCDIKDEKNVKT 480
Cdd:PHA02713 401 IYIIGGRTEHIDYTSVHHMNSIDMEEDTHSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVVCDIKDEKNVKT 480

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20178574  481 CIFRYNTNTYNGWELVTTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVYTREWNHTCHQHSNSYIMHNILPIY 557
Cdd:PHA02713 481 CIFRYNTNTYNGWELITTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVYTYEWNHICHQHSNSYIMHNILPIY 557
PHA03098 PHA03098
kelch-like protein; Provisional
 26-541 4.82e-34

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 135.67  E-value: 4.82e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574   26 CDVIITIR-DGEEIKAHKTILAAGSTYFKTMFTTPMIARDlvtrVNLQmFDKDAVKNIVQYLYNRHIS--SMNVIDVLKC 102
Cdd:PHA03098  10 CDESIIIVnGGGIIKVHKIILSSSSEYFKKMFKNNFKENE----INLN-IDYDSFNEVIKYIYTGKINitSNNVKDILSI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  103 ADYLLIDDLVADCESYIKDYTNHDTCICMY-----HKLYEmIHIPIVKYIKRmlmsNIPTLITTDAFKKTVFEILFDIIS 177
Cdd:PHA03098  85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYrfsffYGCKK-LYSAAYNYIRN----NIELIYNDPDFIYLSKNELIKILS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  178 tNDNVYLYREGYKVTILLKWLEHNYITEEQLLC-ILSCIDIQNLDKKSR------LLLYSNKTINMYPSCIQFLIDNKQN 250
Cdd:PHA03098 160 -DDKLNVSSEDVVLEIIIKWLTSKKNNKYKDIClILKVLRITFLSEEGIkklkrwKLRIKKKKIVFNKRCIKIIYSKKYN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  251 RN-IIPRQLClvcHDTKYNVCNPCILVYNINTMEYSVISTIPN-----HIINYASAIVDNEIIIAGGYNFNNPSLNKVYK 324
Cdd:PHA03098 239 LNkILPRSST---FGSIIYIHITMSIFTYNYITNYSPLSEINTiidihYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  325 INIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSYGMCVLDQYIYII 404
Cdd:PHA03098 316 YDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVI 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  405 GGstlyidytsvhavnsidMEEDTDTSNKVIRYDTVNNIWETLPNFWTGTIKPGVVSHEDDIYVVCDIKDEKNVK--TCI 482
Cdd:PHA03098 396 GG-----------------ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKvyNIV 458

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20178574  483 FRYNTNTYNGWELVTTTESRLSALHTILhDNTIMML--HCYESYMLQ-DTFNVYTREWNHTC 541
Cdd:PHA03098 459 ESYNPVTNKWTELSSLNFPRINASLCIF-NNKIYVVggDKYEYYINEiEVYDDKTNTWTLFC 519
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
276-469 7.99e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 95.61  E-value: 7.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 276 VYNINTMEYSVISTIPNHIINY-ASAIVDNEIIIAGGYNFNNPS---LNKVYKINIENKIHVELPPMIKNRCRFSLAVID 351
Cdd:COG3055  42 VYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLD 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 352 DTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSY-GMCVLDQYIYIIGGSTLYIDYTSV------------HA 418
Cdd:COG3055 122 GKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSNTWttlaplptaragHA 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20178574 419 VNSIDMEE-----DTDTSNKVIRYDTVNNIWETLPNFWTGTIKPGVVSHEDDIYVV 469
Cdd:COG3055 202 AAVLGGKIlvfggESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVI 257
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
335-515 4.61e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.22  E-value: 4.61e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 335 LPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSYGMCVL-DQYIYIIGGSTLYIDY 413
Cdd:COG3055   6 LPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTGANPS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 414 TSVhavnsidmeedtdtSNKVIRYDTVNNIWETLPNFWTGTIKPGVVSHEDDIYVVCDIKDEKNVKTcIFRYNTNTyNGW 493
Cdd:COG3055  86 STP--------------LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAW-VEVYDPAT-GTW 149

                       170       180
                ....*....|....*....|....*
gi 20178574 494 ELVT---TTESRLSAlhTILHDNTI 515
Cdd:COG3055 150 TQLAplpTPRDHLAA--AVLPDGKI 172
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 19-121 6.62e-20

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 85.00  E-value: 6.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574    19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLY-NRHISSMNVI 97
Cdd:pfam00651   4 LREQGELCDVTLVV-GDKEFRAHKAVLAACSPYFKALFSGQESESS-VSEITLDDVSPEDFEALLEFMYtGKLISEENVD 81

                          90       100
                  ....*....|....*....|....
gi 20178574    98 DVLKCADYLLIDDLVADCESYIKD 121
Cdd:pfam00651  82 DLLAAADKLQIPSLVDKCEEFLIK 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-106 8.10e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 83.76  E-value: 8.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKC 102
Cdd:cd18186   1 LCDVTLVV-GGREFPAHRAVLAARSPYFRAMFSSGMKESS-SSEIELDDVSPEAFEALLDYIYTGEleLSEENVEELLAA 78


                ....
gi 20178574 103 ADYL 106
Cdd:cd18186  79 ADKL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 27-123 2.42e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 2.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574     27 DVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIaRDLVTRVNLQMFDKDAVKNIVQYLYNRHISSM--NVIDVLKCAD 104
Cdd:smart00225   1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFK-ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPeeNVEELLELAD 78

                           90
                   ....*....|....*....
gi 20178574    105 YLLIDDLVADCESYIKDYT 123
Cdd:smart00225  79 YLQIPGLVELCEEFLLKLL 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
296-469 4.53e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 4.53e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 296 NYASAIVDNEIIIAGGYNFNNPSlNKVYKINIENKIHVELPPM-IKNRCRFSLAVIDDTIYAIGGQNGTNVERTI----E 370
Cdd:COG3055  15 EAAAALLDGKVYVAGGLSGGSAS-NSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPlndvY 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 371 CYTMGDDKWKLLPDMPIALSSYGMCVLDQYIYIIGGstlyidYTSVHAVNSIDmeedtdtsnkviRYDTVNNIWETLPNF 450
Cdd:COG3055  94 VYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG------WDDGGNVAWVE------------VYDPATGTWTQLAPL 155

                       170       180
                ....*....|....*....|
gi 20178574 451 WTGTIKP-GVVSHEDDIYVV 469
Cdd:COG3055 156 PTPRDHLaAAVLPDGKILVI 175
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-120 3.14e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 72.40  E-value: 3.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLK 101
Cdd:cd18230  20 ILCDVCIIV-EGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHlaLTSKNVIEVMS 98

                        90
                ....*....|....*....
gi 20178574 102 CADYLLIDDLVADCESYIK 120
Cdd:cd18230  99 AASYLQMTDIVQACHNFIK 117
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-120 3.80e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 71.60  E-value: 3.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  21 DDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFT-TPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVI 97
Cdd:cd18245  10 EEPHLCDATLVV-GGEEIPVQKNVLAAASPYFRAKLNyNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIklSEDNIQ 88

                        90       100
                ....*....|....*....|...
gi 20178574  98 DVLKCADYLLIDDLVADCESYIK 120
Cdd:cd18245  89 DIVQAADLLLMTDLKDLCCEFLE 111
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
274-408 4.58e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.58  E-value: 4.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 274 ILVYNINTMEYSVISTIPNHIINYASAIV-DNEIIIAGGYNFNNPSLNKVykinienkihvELPPMIKNRCRFSLAVIDD 352
Cdd:COG3055 139 VEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNGSGFSNTWT-----------TLAPLPTARAGHAAAVLGG 207

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20178574 353 TIYAIGGQNGTNveRTIECYTMGDDKWKLLPDMPIALSSYGMCVLDQYIYIIGGST 408
Cdd:COG3055 208 KILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGET 261
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-119 6.16e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 71.12  E-value: 6.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITI-RDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHISSMN-- 95
Cdd:cd18294   8 LINNPEFSDVKFLVgPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNht 87

                        90       100
                ....*....|....*....|....
gi 20178574  96 VIDVLKCADYLLIDDLVADCESYI 119
Cdd:cd18294  88 VIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 2.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 69.63  E-value: 2.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKC 102
Cdd:cd18238  15 LCDVTLKV-GEKSIHCHRLVLACVSPYFRAMFTSEM-AESKQDSITIKDIDEEAVELLVDFAYTGKltLTVDNVQSLLYA 92

                        90       100
                ....*....|....*....|....*..
gi 20178574 103 ADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18238  93 ASLLQVEEVAKACCEFMKDHLHPSNCL 119
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-124 3.33e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 69.21  E-value: 3.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFT-TPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVIDVL 100
Cdd:cd18201  20 ILCDVNIVV-SGKVFRAHKNILVAGSRFFKTLYCfTNKESCDQTTVTHLDVVAVQGFSVILDFMYSGNLvlTSQNAIEVM 98

                        90       100
                ....*....|....*....|....
gi 20178574 101 KCADYLLIDDLVADCESYIKDYTN 124
Cdd:cd18201  99 SVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-128 3.45e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 66.20  E-value: 3.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTrVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDVLKC 102
Cdd:cd18240  17 LCDVVIRV-NGVEFPAHRNILCACSPYFRALFTNGWNETEKKV-YKIPGVSPEMMELIIEYAYTRtvPITAENVEELLPA 94

                        90       100
                ....*....|....*....|....*.
gi 20178574 103 ADYLLIDDLVADCESYIKDYTNHDTC 128
Cdd:cd18240  95 ADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 3.95e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 66.36  E-value: 3.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNV 96
Cdd:cd18237  15 MRKQKTLCDVIL-IVEGREIKAHRVVLAAASHFFHLMFTSNMTESK-SSEVELKDAEPDIIELLVEFAYTARISvnSNNV 92

                        90       100       110
                ....*....|....*....|....*....|...
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18237  93 QSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-128 4.51e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 65.88  E-value: 4.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLvTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNV 96
Cdd:cd18255  12 LRAKGQLLDVTLIA-DGQRFQAHKVVLASCSDYFRAMFTGGMRESSQ-DEIELKGVSAKGLKHILDFAYTSEltLDLDCI 89

                        90       100       110
                ....*....|....*....|....*....|..
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTC 128
Cdd:cd18255  90 QDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-120 2.66e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 63.71  E-value: 2.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDVLKC 102
Cdd:cd18257  18 LCDVVLRV-GDVKIHAHKVVLASCSPYFKAMFTGNLSEKE-NSEVEFQCIDETALQAIVEYAYTGtvFISQATVESLLPA 95

                        90
                ....*....|....*...
gi 20178574 103 ADYLLIDDLVADCESYIK 120
Cdd:cd18257  96 ANLLQIKLVLKECCDFLE 113
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
379-537 4.20e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 66.72  E-value: 4.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 379 WKLLPDMPIALSSYGMCVLDQYIYIIGGSTlyidytsvhavnsidmeeDTDTSNKVIRYDTVNNIWETLPNF-WTGTIKP 457
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLS------------------GGSASNSFEVYDPATNTWSELAPLpGPPRHHA 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574 458 GVVSHEDDIYVV----CDIKDEKNVKTcIFRYNTNTyNGWELVTTTESRLSALHTILHDNTIMMLHCYESYMLQDTFNVY 533
Cdd:COG3055  65 AAVAQDGKLYVFggftGANPSSTPLND-VYVYDPAT-NTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVY 142


                ....*..
gi 20178574 534 ---TREW 537
Cdd:COG3055 143 dpaTGTW 149
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-131 5.58e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 63.27  E-value: 5.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARdLVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNV 96
Cdd:cd18268  17 LRQERILTDVILCT-GDKEIPCHRNVLASSSPYFRAMFCNNFRES-SQAKVDLKGIDSDVLDQIVDYVYTGeiLITRDNV 94

                        90       100       110
                ....*....|....*....|....*....|....*
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTCICM 131
Cdd:cd18268  95 LPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
Kelch smart00612
Kelch domain;
354-398 1.41e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 1.41e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 20178574    354 IYAIGGQNGTNVERTIECYTMGDDKWKLLPDMPIALSSYGMCVLD 398
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-115 1.49e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 61.67  E-value: 1.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVIDVLK 101
Cdd:cd18235  20 LLCDVIL-VADGVEIPAHRVVLASCSPYFHAMFTGDL-SESRANRVTLQDVDGKALLLLIDYVYTAEIqvTEENVQVLLP 97

                        90
                ....*....|....
gi 20178574 102 CADYLLIDDLVADC 115
Cdd:cd18235  98 AANLLQLTDVRDAC 111
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-121 2.09e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 61.14  E-value: 2.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIaRDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKC 102
Cdd:cd18247  19 LCDVTLKVGD-QKFSAHRIVLAATIPYFHAMFTHDMV-ESKQDEITMQGIEPSALEALINFAYSGRiaIDTSNVQSLLVG 96

                        90
                ....*....|....*....
gi 20178574 103 ADYLLIDDLVADCESYIKD 121
Cdd:cd18247  97 ASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-128 1.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 59.05  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  22 DDILCDVIITIRDGEEI-KAHKTILAAGSTYFKTMFTTPMIARDLVTrVNLQMFDKDAVKNIVQYLYNRHIS-SM-NVID 98
Cdd:cd18239  20 EGLLCDVTLVPGDGDETfPVHRAMMASASDYFKAMFTGGMKEQELMC-IKLHGVSKIGLKNIIDFIYTAKLSlNMdNLQD 98

                        90       100       110
                ....*....|....*....|....*....|
gi 20178574  99 VLKCADYLLIDDLVADCESYIKDYTNHDTC 128
Cdd:cd18239  99 TLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 3.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 57.66  E-value: 3.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFtTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDVLKC 102
Cdd:cd18306  18 FCDVILQV-GGHEIPAHRAVLACASPYLFELF-SSDSDGESILTVKLDGLDPDAVEVLVNYAYTSrlEVPADLVKSVYSA 95

                        90       100
                ....*....|....*....|....*..
gi 20178574 103 ADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18306  96 AKKLKMDRVKKACGDFLLEKLTPQNCI 122
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-119 4.72e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 57.14  E-value: 4.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPmiARDLV--TRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVID 98
Cdd:cd18329  19 ELFCDCSILV-EGQVFKAHRNVLFASSGYFKMLLSQN--AKETGqpTVATFDVFSPDTFTIILDFVYSGKLSltSQNVIE 95

                        90       100
                ....*....|....*....|.
gi 20178574  99 VLKCADYLLIDDLVADCESYI 119
Cdd:cd18329  96 VMSAASYLQMTDVISVCKTFI 116
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 342-386 5.03e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.93  E-value: 5.03e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 20178574   342 RCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKLLPDMP 386
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-120 7.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 56.79  E-value: 7.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTR------VNLQMFDKDAVKNIVQYLYNR--H 90
Cdd:cd18228  13 LRNEGHFCDVTIRVQD-KIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSpagkcvLDLHHVTVTGFAPLLEYAYTStlS 91

                        90       100       110
                ....*....|....*....|....*....|
gi 20178574  91 ISSMNVIDVLKCADYLLIDDLVADCESYIK 120
Cdd:cd18228  92 INTENIIDVLAAASYMQMFNVANTCSEFMK 121
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-119 8.68e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 56.62  E-value: 8.68e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNV 96
Cdd:cd18338  15 LRSQNLLCDVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEM-SESRAKRVRIKEVDGWTLKMLIDYVYTAEIqvTEENV 92

                        90       100
                ....*....|....*....|...
gi 20178574  97 IDVLKCADYLLIDDLVADCESYI 119
Cdd:cd18338  93 QVLLPAAGLLQLQDVKKTCCEFL 115
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-119 1.87e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 55.32  E-value: 1.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTtpmiarDLVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVLK 101
Cdd:cd18206  21 LLCDCTFVV-DGVDFKAHKAVLAACSEYFRMLFV------DQKDVVHLDISNAAGLGQVLEFMYTAKLSlsPENVDDVLA 93

                        90
                ....*....|....*...
gi 20178574 102 CADYLLIDDLVADCESYI 119
Cdd:cd18206  94 VATFLQMQDIVTACHALK 111
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-119 2.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 55.12  E-value: 2.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVL 100
Cdd:cd18199  16 DFFCDCSI-IVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYSGKLSltSQNVIEVM 94

                        90
                ....*....|....*....
gi 20178574 101 KCADYLLIDDLVADCESYI 119
Cdd:cd18199  95 SAASYLQMTDVINVCKTFI 113
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-115 3.93e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 54.56  E-value: 3.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVtRVNLQMFDKDAVKNIVQYLYNRH--ISSMNV 96
Cdd:cd18295  13 LLEQGSYSDVTFNVH-GESFPAHRCILSARSPYFAEMFETKWKDKREI-NLKHPLVNPDAFRALLQYLYTGRleIHVDDV 90

                        90       100
                ....*....|....*....|...
gi 20178574  97 IDVL----KCADYLLIDDLVADC 115
Cdd:cd18295  91 EDCKrlakQCRLEELIEELEAKC 113
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-129 3.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 54.78  E-value: 3.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTrVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLK 101
Cdd:cd18265  22 TFTDVVLLV-DGKDFPCHRATLSANSAYFRAMFGGHLKESRQAV-VEIQKVSAAAMEVLLDYMYGGGlrIQEDNVESVLE 99

                        90       100
                ....*....|....*....|....*...
gi 20178574 102 CADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18265 100 ASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-119 5.84e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 53.78  E-value: 5.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRHISSM---N 95
Cdd:cd18300   3 FLNKGLFSDVTFIV-EDGTIPAHKALLVARCDVMAAMFGGNFRESS-AKEVELPGVSKETFLALLEYLYTDQAPILedgD 80

                        90       100
                ....*....|....*....|....
gi 20178574  96 VIDVLKCADYLLIDDLVADCESYI 119
Cdd:cd18300  81 CVGLIVLANRLCLPRLVALCEQYI 104
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 6.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 53.52  E-value: 6.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMiaRDLV-TRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVLK 101
Cdd:cd18234   1 LCDVIL-IAGDRRIPAHRLVLSAVSDYFAAMFTNDV--REATeEEIKLKDVDPDALWTLVQYCYTGRLElkEDNVESLLA 77

                        90       100
                ....*....|....*....|....*...
gi 20178574 102 CADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18234  78 TACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-129 6.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 54.45  E-value: 6.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  22 DDILCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDV 99
Cdd:cd18252  18 DGLFTDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKS-NNVIKLSGIDHDILEALVNYVYTSQicITERNVQSL 96

                        90       100       110
                ....*....|....*....|....*....|
gi 20178574 100 LKCADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18252  97 LEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-120 8.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 53.75  E-value: 8.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEeIKAHKTILAAGSTYFKTmfttpMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHI------SSMNVID 98
Cdd:cd18333  21 LCDVIIVVQNAL-FRAHKNILAASSVYLKS-----LVVHDNLINLDHEMVSPGIFRLILDYIYTGRLsegdpgSEQNLGA 94

                        90       100
                ....*....|....*....|..
gi 20178574  99 VLKCADYLLIDDLVADCESYIK 120
Cdd:cd18333  95 VLAAASYLQIPDLVALCKKKLK 116
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-119 1.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 53.39  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVL 100
Cdd:cd18330  16 DFFCDCSI-IVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLDlcSENVIEVM 94

                        90
                ....*....|....*....
gi 20178574 101 KCADYLLIDDLVADCESYI 119
Cdd:cd18330  95 SAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-116 1.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 53.22  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIITIRDGEeIKAHKTILAAGSTYFKTMFTTpmiARDLVTRVNLQMFDKDAVKNIVQYLY--NRHISSMNVIDVL 100
Cdd:cd18217  16 GFLCDCTIVIGQFQ-FKAHRNVLAAFSEYFGAQYKD---TEDNIVFLDQSQVSADGFQKLLEFIYtgNLNLDSWNVAEIH 91

                        90
                ....*....|....*.
gi 20178574 101 KCADYLLIDDLVADCE 116
Cdd:cd18217  92 QAASYLGMEEVVAKCK 107
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-119 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 53.50  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVIDVLK 101
Cdd:cd18246  38 LLCDIVLHV-GTKEIKAHKVVLASCSPYFHAMFTNEM-SESRQTHVTLHDIDPQALEQLVQYAYTAEIvvGEGNVQTLLP 115

                        90
                ....*....|....*...
gi 20178574 102 CADYLLIDDLVADCESYI 119
Cdd:cd18246 116 AASLLQLNGVRDACCKFL 133
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 1.82e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 53.26  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTpMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHIS-SMNVI-DVLKC 102
Cdd:cd18264  28 LCDVVL-EAEGNEFPAHRSLLACSSDYFRALFKD-YTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSlSLDTLeDTLEA 105

                        90       100
                ....*....|....*....|....*..
gi 20178574 103 ADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18264 106 ASYLQVTEAIGLCSQYLINNLAPENCC 132
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-129 2.01e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 52.79  E-value: 2.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLK 101
Cdd:cd18256  19 EFCDVQLQV-GMELFSVHRLVLAASSPYFAALFAGGM-SESSKDVVQIHGVEPDIFHILLDFIYTGVveVTVSNVQELLV 96

                        90       100
                ....*....|....*....|....*...
gi 20178574 102 CADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18256  97 AADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 25-121 2.28e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 52.37  E-value: 2.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTPMIarDLVTRVNLQM-FDKDAVKNIVQYLYNRHIS----SMNV--- 96
Cdd:cd18302   5 LYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWI--EASSCSALTMpIPSDILEIILDYLYTDEASavkeSQNVefl 82

                        90       100
                ....*....|....*....|....*
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKD 121
Cdd:cd18302  83 CNVLVIADQLLITRLKEICEVALVE 107
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-120 2.86e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 52.42  E-value: 2.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVIDVLK 101
Cdd:cd18339  20 LLCDVTIVAED-VEIEAHRVVLAACSPYFCAMFTGDM-SESKAKKIEIKDVDGQTLSKLIDYIYTAEIevTEENVQVLLP 97

                        90
                ....*....|....*....
gi 20178574 102 CADYLLIDDLVADCESYIK 120
Cdd:cd18339  98 AASLLQLMDVRQNCCDFLQ 116
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 25-109 2.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 51.01  E-value: 2.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTpmIARDLVTRVNLQMFDKDAVKNIVQYLY--NRHISSMNVIDVLKC 102
Cdd:cd18315   1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALLKE--TPPDEHPVIILPDVPYSELKALLDFIYtgEVNVSQEQLESLLKL 77


                ....*..
gi 20178574 103 ADYLLID 109
Cdd:cd18315  78 AELLQIK 84
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-115 2.94e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 52.38  E-value: 2.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDG---EEIKAHKTILAAGSTYFKTMFTTPMIARDLvTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDV 99
Cdd:cd18248  21 LCDVTLKVKYQdpkEEFMAHKVVLASSSPYFKAMFTSGLRECGM-EVVPIEGVHPCVMSRLIEFAYTAsiSVGEKCVLHV 99

                        90
                ....*....|....*.
gi 20178574 100 LKCADYLLIDDLVADC 115
Cdd:cd18248 100 LPGAVMYQMDSVVKAC 115
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-128 3.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 52.55  E-value: 3.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITI--RDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMF------DKDAVKNIVQYLYNRHI--SS 93
Cdd:cd18241  22 LFCDITLAFggAGGREFRAHRSVLAAATEYFTPLLSGQF-SESRSGRVEMRKWssepgpDPDTVEAVIQYMYTGRIrvST 100

                        90       100       110
                ....*....|....*....|....*....|....*
gi 20178574  94 MNVIDVLKCADYLLIDDLVADCESYIKDYTNHDTC 128
Cdd:cd18241 101 GNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-123 4.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 51.38  E-value: 4.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEeIKAHKTILAAGSTYFKtmfttPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHISS-----MNVIDV 99
Cdd:cd18216  20 LCDVIIVVENSL-FRAHKNVLAASSGYFK-----SLVLHDNLIHLDQDMVSPTVFQQILDFIYTGKLLDslfeePNLSEV 93

                        90       100
                ....*....|....*....|....
gi 20178574 100 LKCADYLLIDDLVADCESYIKDYT 123
Cdd:cd18216  94 LAAANYLQLPDLAALCRSKLKRGG 117
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-115 4.72e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 51.81  E-value: 4.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  22 DDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIArDLVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDV 99
Cdd:cd18328  22 DGLLCDVVLIVQD-QEYRTHRSVLAACSKYFKKLFTAGTLA-DQPYVYEIDFVTPEALSAILEFAYTStlTITTSNVKHI 99

                        90
                ....*....|....*.
gi 20178574 100 LKCADYLLIDDLVADC 115
Cdd:cd18328 100 LNAAQMLEIQCIINVC 115
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-128 5.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 51.88  E-value: 5.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIARDLvTRVNLQMFDKDAVKNIVQYLY--NRHISSMNV 96
Cdd:cd18244  24 LYEEGLLLDVTLVIED-HQFQAHKALLATQSDYFRIMFTADMRERDQ-DKIHLKGLTATGFSHVLQFMYygTIELSMLTV 101

                        90       100       110
                ....*....|....*....|....*....|..
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTC 128
Cdd:cd18244 102 HEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-131 5.66e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 51.93  E-value: 5.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  21 DDDILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLY--NRHISSMNVID 98
Cdd:cd18270  22 EQQLLTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGL-SESKQTHVHLRNVDAATLQIIITYAYtgNLAINDSTVEQ 99

                        90       100       110
                ....*....|....*....|....*....|...
gi 20178574  99 VLKCADYLLIDDLVADCESYIKDYTNHDTCICM 131
Cdd:cd18270 100 LYETACFLQVEDVLQRCREYLIKKINAENCVRL 132
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-120 6.94e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 51.12  E-value: 6.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEeIKAHKTILAAGSTYFKTmfttpMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHI------SSMNVID 98
Cdd:cd18334  21 LCDVIIVVENAL-FRAHKNILAASSMYFKS-----LVLHDNLINLDTDMVNPTVFRQILDFIYTGKLltsdqpGEQNFNA 94

                        90       100
                ....*....|....*....|..
gi 20178574  99 VLKCADYLLIDDLVADCESYIK 120
Cdd:cd18334  95 LLTAASYLQLHDLAALCRKKLK 116
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-115 7.45e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 51.09  E-value: 7.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIArDLVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDVLK 101
Cdd:cd18326  24 LLCDVVILV-EGREFPTHRSVLAACSQYFKKLFTSGAVV-DQQNVYEIDFVSAEALTALLDFAYTAtlTVSTSNVGDILS 101

                        90
                ....*....|....
gi 20178574 102 CADYLLIDDLVADC 115
Cdd:cd18326 102 AARLLEIPAVSHVC 115
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-119 8.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 50.83  E-value: 8.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  20 LDD----DILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVT---RVNLQMFDKdavknIVQYLYNRH-- 90
Cdd:cd18277  18 LNDqrkkDVLCDVTILV-EGQRFRAHRSVLAACSSYFHSRIVGQADAELNITlpeEVTVKGFEP-----LIQFAYTAKli 91

                        90       100
                ....*....|....*....|....*....
gi 20178574  91 ISSMNVIDVLKCADYLLIDDLVADCESYI 119
Cdd:cd18277  92 LSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-121 8.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 51.19  E-value: 8.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEeIKAHKTILAAGSTYFKTMFTTPMIARDLVtRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVIDVLKC 102
Cdd:cd18325  23 LCDCTVLVGEAQ-FRAHRAVLASCSMYFHLFYRDQLDKRDIV-HLNSDIVTAPAFSLLLEFMYEGKLefSSLPVEDVLAA 100

                        90
                ....*....|....*....
gi 20178574 103 ADYLLIDDLVADCESYIKD 121
Cdd:cd18325 101 ASYLHMYDIVKVCKGKLKD 119
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-119 1.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 51.12  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  21 DDDILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVID 98
Cdd:cd18261  24 NDGILCDITL-VAEEQKFHAHKAVLAACSDYFRAMFSLCMVESE-ADEVNLHGVTSLGLKQALDFAYTGQIllEPGVIQD 101

                        90       100
                ....*....|....*....|.
gi 20178574  99 VLKCADYLLIDDLVADCESYI 119
Cdd:cd18261 102 VLAAGSHLQLLELLSLCSHYL 122
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 27-115 1.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 50.04  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  27 DVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIARDLvTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVIDVLKCAD 104
Cdd:cd18314   8 DVVLCVGD-RKFFAHRIVLCARSPVFRSMLTGSMIESNL-KEVTLEDVEPEIFETVLKYMYTGQVtlSEENVLDLLMLAS 85

                        90
                ....*....|.
gi 20178574 105 YLLIDDLVADC 115
Cdd:cd18314  86 KYQVPDLEKLC 96
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-119 1.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 50.31  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDV-IITIRDGEEIKAHKTILAAGSTYFKTMFTTpmiaRDLVTRVNLQM--FDKDAVKNIVQYLYNRH--ISSMNVIDV 99
Cdd:cd18231  14 LCDVdIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQ----NKQLQRVELSLeaLTSQGLQQILNFIYTSKllVNSCNVQDV 89

                        90       100
                ....*....|....*....|
gi 20178574 100 LKCADYLLIDDLVADCESYI 119
Cdd:cd18231  90 LNAAAVLQMNDIAASCQELI 109
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-132 1.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 50.98  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDGEEIKA-------HKTILAAGSTYFKTMFTTPMIARDLVTrVNLQMFDKDAVKNIVQYLY--NR 89
Cdd:cd18273  20 FYDARLLTDVTIEVNGPGSGPGsgrlfpcNRNVLAAASPYFKSMFTGGLYESKQET-VTIHDVDSESMALIIDYCYtgRV 98

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 20178574  90 HISSMNVIDVLKCADYLLIDDLVADCESYIKDYTNHDTCICMY 132
Cdd:cd18273  99 TLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 1.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 50.14  E-value: 1.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVLKC 102
Cdd:cd18249  23 LCDVVLVV-GAKKIYAHRVILSACSPYFRAMFTGEL-AESRQTEVTIRDIDERAMELLIDFAYTSQITveEGNVQTLLPA 100

                        90       100
                ....*....|....*....|....*..
gi 20178574 103 ADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18249 101 ACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-121 1.93e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 49.84  E-value: 1.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYN---RHISSMn 95
Cdd:cd18279  12 LWENSRFTDCCLCVG-GQEFQAHKAILAARSPVFSAMFEHEM-EESKKNRVEINDVDPEVFKEMMRFIYTgkaPNLDKM- 88

                        90       100
                ....*....|....*....|....*.
gi 20178574  96 VIDVLKCADYLLIDDLVADCESYIKD 121
Cdd:cd18279  89 ADDLLAAADKYALERLKVMCEDALCS 114
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-129 2.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 49.80  E-value: 2.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  21 DDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIArdlVTRVNLQMFDKDA--VKNIVQYLYNR--HISSMNV 96
Cdd:cd18276  17 ELAELTDVVLVA-EGEKFPCHRLVLAAFSPYFKAMFTCGLME---CSQREVVLHDITAesVSIILNYMYSSdlHLTNSNV 92

                        90       100       110
                ....*....|....*....|....*....|...
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18276  93 QGVATAAFFLQMEDIFSVCQKYMMDHMDASNCL 125
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-116 2.51e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 49.46  E-value: 2.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLvTRVNLQMFDKDAVKNIVQYLYNRHISSMNVI- 97
Cdd:cd18345  12 LFERSAFSDVTLCV-GGREFQAHKAILAARSPVFNAMFEHEMEERKQ-NRVEITDVDHEVMREMLRFIYTGKAPNLDKMa 89

                        90       100
                ....*....|....*....|
gi 20178574  98 -DVLKCADYLLIDDLVADCE 116
Cdd:cd18345  90 dDLLAAADKYALERLKVMCE 109
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-91 3.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 49.10  E-value: 3.28e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20178574  25 LCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPmiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI 91
Cdd:cd18209  18 LCDVLLIVGD-QKFRAHKNVLAASSEYFQSLFTEK--ENESQSVFQLDFCEPDAFENVLNYIYSSSL 81
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-129 3.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 49.46  E-value: 3.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  22 DDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDV 99
Cdd:cd18236  21 ENSLTDVILCV-DSQEFSCHRVVLAAASNYFRAMFCNDLKEKY-EEKIIIKGVDAETMQILLDYTYTSKvlITKQNVQRV 98

                        90       100       110
                ....*....|....*....|....*....|
gi 20178574 100 LKCADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18236  99 LEAASLFQFLRMVDACASFLTEALHPENCV 128
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-116 4.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 49.18  E-value: 4.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  35 GEEIKAHKTILAAGSTYFKTMFTTPMIARdLVTRVNLQMFDKDAVKNIVQYLY-----NRHISSMnVIDVLKCADYLLID 109
Cdd:cd18344  32 GHEFRAHKAILAARSPVFRAMFEHEMEER-LKNPIEIHDLDPQVFKEMMGFIYtgkapHLHSHSM-ACDVLAAADKYGLE 109


                ....*..
gi 20178574 110 DLVADCE 116
Cdd:cd18344 110 GLKVLCE 116
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-117 5.24e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 48.69  E-value: 5.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  26 CDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVLKCA 103
Cdd:cd18202  20 CDVTLLI-EGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYTSELTfdFCSMAEVAMLA 98

                        90
                ....*....|....
gi 20178574 104 DYLLIDDLVADCES 117
Cdd:cd18202  99 RHLFMNEVLEICES 112
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-103 5.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 48.59  E-value: 5.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDVLKC 102
Cdd:cd18242  21 LCDVTLRV-EGKEFPAHRIVLAACSDYFCAMFTSEMSEKG-KSEVELQGLTASTMEILLDFVYTEtvHVTVENVQELLPA 98


                .
gi 20178574 103 A 103
Cdd:cd18242  99 A 99
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-132 6.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 48.68  E-value: 6.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNV 96
Cdd:cd18340  21 LLDHNKFVDCVLKIKE-KEFPCHRLVLAACSPYFRAMFLSDL-EESKKREIVLEDVDPDVMGKILHYIYTSEIeiTEQNV 98

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTCICMY 132
Cdd:cd18340  99 QDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-115 6.97e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 48.32  E-value: 6.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  22 DDILCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPMIArDLVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDV 99
Cdd:cd18198  22 QGLLCDVVILVQ-GREYRTHRSVLAACSQYFKKLFTSGAVV-DQQNVYEIDFVSPEALTALLEFAYTAtlTVSTANVGDI 99

                        90
                ....*....|....*.
gi 20178574 100 LKCADYLLIDDLVADC 115
Cdd:cd18198 100 LSAARLLEIPCVSHVC 115
Kelch smart00612
Kelch domain;
306-352 1.01e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 1.01e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 20178574    306 IIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDD 352
Cdd:smart00612   2 IYVVGGFDGGQ-RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-123 1.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 48.12  E-value: 1.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIARDL-VTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDVLK 101
Cdd:cd18196  21 LCDCVIVVGN-RHFKAHRSVLAACSTHFRALFTVAEGDQTMnMIQLDSEVVTAEAFAALIDMMYTStlMLGESNVMDVLL 99

                        90       100
                ....*....|....*....|..
gi 20178574 102 CADYLLIDDLVADCESYIKDYT 123
Cdd:cd18196 100 AASHLHLNSVVKACKHYLTTRT 121
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-121 1.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 48.11  E-value: 1.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEeIKAHKTILAAGSTYFKTMFTTPMIARDLVtRVNLQMFDKDAVKNIVQYLYN--RHISSMNVIDVLKC 102
Cdd:cd18324  23 LCDCTVLVGDAQ-FRAHRAVLASCSMYFHLFYKDQLDKRDIV-HLNSDIVTAPAFALLLEFMYEgkLQFKDLPIEDVLAA 100

                        90
                ....*....|....*....
gi 20178574 103 ADYLLIDDLVADCESYIKD 121
Cdd:cd18324 101 ASYLHMYDIVKVCKKKLKE 119
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-115 1.37e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 47.48  E-value: 1.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  22 DDILCDVIITiRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDV 99
Cdd:cd18293  12 SGVFCDVLLQ-AEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQGLKAHTLLKLVDFLYTSelEVSSEEAQDV 90

                        90
                ....*....|....*.
gi 20178574 100 LKCADYLLIDDLVADC 115
Cdd:cd18293  91 LAAARRLQISELESLC 106
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-60 1.72e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 47.11  E-value: 1.72e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPM 60
Cdd:cd18263   7 LWEKGVGCDVQLEA-DGSIFRVHRVILAAGSDYFRAMFTSGM 47
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 2.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 46.75  E-value: 2.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMI-ARDLVTRVNlQMFdKDAVKNIVQYLYNRH--ISSMN 95
Cdd:cd18253  12 FRDSRLFTDVIICV-EGREFPCHRAILSACSSYFRAMFCNDHReSREMLVEIN-GIL-AEAMDCFLQYVYTGKvkITTEN 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 20178574  96 VIDVLKCADYLLIDDLVADCESYIKDYTnhDTCIC 130
Cdd:cd18253  89 VQYLFETSSLFQISPLRDACAKFLEEQL--DPCNC 121
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-115 3.09e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 46.76  E-value: 3.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTR------VNLQMFDKDAVKNIVQYLYNR--HISSMN 95
Cdd:cd18327  24 LLCDLTIKTR-GLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvCELDFVGPEALGALLEFAYTAtlTISSSN 102

                        90       100
                ....*....|....*....|
gi 20178574  96 VIDVLKCADYLLIDDLVADC 115
Cdd:cd18327 103 MREVLRAARLLEIPCVADAC 122
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-118 3.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 46.55  E-value: 3.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRHISSMNVID 98
Cdd:cd18280   8 LLESEEGADVTFNV-DGEKFRAHKLVLAARSPVFRSMLFGPMREEN-EGEIVIEDVEPPVFKALLHFIYKDELPDDVEPA 85

                        90       100
                ....*....|....*....|..
gi 20178574  99 VLKC--ADYLLIDDLVADCESY 118
Cdd:cd18280  86 GSDSssLDTTMAQHLLAAADRY 107
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-93 3.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 46.32  E-value: 3.32e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20178574  24 ILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIArdLVTRV-NLQMFDKDAVKNIVQYLYNRHISS 93
Cdd:cd18223  17 ILCDVTIVVED-TKFKAHKNVLAASSLYFKNAFSSQEIW--ISSHVlELPDLKAEVFAEILNFIYSSKVVV 84
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-119 3.90e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 46.09  E-value: 3.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTpMIARDLVTRVNLQMFDKdAVKNIVQYLYNRH--ISSMNVIDVL 100
Cdd:cd18278  29 DILCDVTL-IVEGKEFRAHRAVLAACSEYFLQALVG-QTENDLVVSLPEEVTAR-GFGPLLQFAYTAKllLSRENIQEVI 105

                        90
                ....*....|....*....
gi 20178574 101 KCADYLLIDDLVADCESYI 119
Cdd:cd18278 106 RCAEFLRMHNLEDSCFRFL 124
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 26-117 4.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 45.65  E-value: 4.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  26 CDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNlqMFDKDAVKNIVQYLY--NRHISSMNVIDVLKCA 103
Cdd:cd18311  15 CDLTLQFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMPN--ELQADAVVPVINFMYtgQLEFEEKSYGKLLRTA 92

                        90
                ....*....|....
gi 20178574 104 DYLLIDDLVADCES 117
Cdd:cd18311  93 KELNMTVLLKLLEA 106
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-121 5.14e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 45.97  E-value: 5.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEeIKAHKTILAAGSTYFKTMFTTPMIARDLVtRVNLQMFDKDAVKNIVQYLYNRHI--SSMNVIDVLKC 102
Cdd:cd18194  23 LCDCTVLVGSAQ-FPAHRAVLASCSMYFHLFYRDRLDKRDLV-RLNSDIVTAPAFGLLLDFMYEGRLalRDLPVEDVLAA 100

                        90
                ....*....|....*....
gi 20178574 103 ADYLLIDDLVADCESYIKD 121
Cdd:cd18194 101 ASYLHMYDIVKVCKGRLQE 119
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-116 6.37e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.77  E-value: 6.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  35 GEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHISSMNVI--DVLKCADYLLIDDLV 112
Cdd:cd18343  30 GQEFKAHKSILAARSPVFNAMFEHEM-EESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMadNLLAAADKYALERLK 108


                ....
gi 20178574 113 ADCE 116
Cdd:cd18343 109 VMCE 112
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 9.73e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 45.36  E-value: 9.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNV 96
Cdd:cd18274  16 MYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGL-TESTQKEVRIVGVEAESMHLVLDYAYTSRVtlTEANV 94

                        90       100       110
                ....*....|....*....|....*....|...
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18274  95 QALFTAASIFQIPSLQDQCAQFMISRLDPQNSI 127
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-119 1.84e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 44.08  E-value: 1.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMfDKDAVKNIVQYLYNRH--ISSMNVIDVL 100
Cdd:cd18331  22 DILTDVVIVV-SREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEI-NPEGFNILLDFMYTSRlnLREGNIMAVM 99

                        90
                ....*....|....*....
gi 20178574 101 KCADYLLIDDLVADCESYI 119
Cdd:cd18331 100 ATAMYLQMEHVVDTCRKFI 118
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-112 1.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 44.26  E-value: 1.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPM-IARDLVTRVNLQMFdkdavKNIVQYLYNRHIsSMNVID---V 99
Cdd:cd18290  26 LYCDVSVVVK-GHAFKAHRAVLAASSSYFRDLFNSSRsAVVELPAAVQPQSF-----QQILSFCYTGRL-SMNVGDqflL 98

                        90
                ....*....|...
gi 20178574 100 LKCADYLLIDDLV 112
Cdd:cd18290  99 MYTAGFLQIQEIM 111
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-120 1.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 44.32  E-value: 1.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNV 96
Cdd:cd18269  21 LLDENKFVDCVLKIGD-KEFPCHRLVLAACSPYFRAMFLSDL-EESKKKEVVLEDVDPDVMGMILKYLYTSEIdlNDQNV 98

                        90       100
                ....*....|....*....|....
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIK 120
Cdd:cd18269  99 QDIFALASRFQIPSIFTVCVSYLQ 122
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-121 2.54e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 44.03  E-value: 2.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDGEeIKAHKTILAAGSTYFKTMF-TTPMIARDLVtRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVLK 101
Cdd:cd18956  23 LCDCTVLVGDAR-FPAHRAVLAACSVYFHLFYrDRPAGGRDTV-RLNGDIVTAPAFGRLLDFMYEGRLDlrSLPVEDVLA 100

                        90       100
                ....*....|....*....|
gi 20178574 102 CADYLLIDDLVADCESYIKD 121
Cdd:cd18956 101 AASYLHMYDIVKVCKGRLRE 120
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-126 2.83e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 44.11  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVLK 101
Cdd:cd18266  24 LFCDVVL-VADEQRVPAHRNLLAVCSDYFNSMFTIGM-REAHQKEVELVGASYIGLKAVIDFLYSSELPldGGNIDYVLE 101

                        90       100
                ....*....|....*....|....*
gi 20178574 102 CADYLLIDDLVADCESYIKDYTNHD 126
Cdd:cd18266 102 TAHLLQIWKVVDFCCEYLENEVSEE 126
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-119 3.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 42.84  E-value: 3.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMiARDLVtrVNLQmfDKDAVKN---IVQYLYNRHI--SSMNVIDV 99
Cdd:cd18955   1 LCDVTIVVED-QRFRAHRAVLAACSDYFLSRVVGQT-DGDLV--ITLP--EEVTVKGfepLLQFAYTAKLllSKENVLEV 74

                        90       100
                ....*....|....*....|
gi 20178574 100 LKCADYLLIDDLVADCESYI 119
Cdd:cd18955  75 CRCAEFLGVHNIEKACFDFL 94
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-117 3.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 43.42  E-value: 3.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  35 GEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRHISSMNV-----IDVLKCADYLLID 109
Cdd:cd18297  21 GRPFYAHKIVLVTASDRFKSMLSSGSTEAQ-TPVIEIPDIRYDIFQLMMQYLYTGGVESLDVaqddaLELLRAASFFQLD 99


                ....*...
gi 20178574 110 DLVADCES 117
Cdd:cd18297 100 GLKRHCEI 107
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-125 3.67e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 43.40  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  20 LDDDILC--------DVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYN--- 88
Cdd:cd18286   4 LGKDLLQlflngedsDITIKV-DGKTFKAHRCILCARSSYFAAMLSGSW-AESNSSEITLTGVSHAAVSFVLLFIYGgvl 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 20178574  89 RHISSMNVIDVLKCADYLLIDDLVADCESYIKDYTNH 125
Cdd:cd18286  82 DLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCH 118
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-120 3.94e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 42.96  E-value: 3.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  24 ILCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQmfDKDAVKNIVQYLYNRH--ISSMNVIDVLK 101
Cdd:cd18233  17 LLCDCMLVVK-GVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIK--NVGGIGQILDFMYTSHldLNQDNVQVMLD 93

                        90
                ....*....|....*....
gi 20178574 102 CADYLLIDDLVADCESYIK 120
Cdd:cd18233  94 IAQCLQVQNVLNMCYTFLK 112
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-128 4.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 43.22  E-value: 4.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  27 DVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKCAD 104
Cdd:cd18250  23 DVTLCA-GGREFPCHRTVLAAASSYFRAMFAGEL-RESRADRVVLHGVSAEILGLLLDFSYTGRvtVTQDNVEALLRAAD 100

                        90       100
                ....*....|....*....|....
gi 20178574 105 YLLIDDLVADCESYIKDYTNHDTC 128
Cdd:cd18250 101 LFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-118 5.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 42.66  E-value: 5.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDK--DAVKNIVQYLYNRHIS--SMNVIDVL 100
Cdd:cd18292  17 LSDIVLRVG-GKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPEcaAVFEKFLRYLYTGQISvnLETALPLL 95

                        90
                ....*....|....*...
gi 20178574 101 KCADYLLIDDLVADCESY 118
Cdd:cd18292  96 MLADKYNVTDLKQLCVDF 113
Kelch_6 pfam13964
Kelch motif;
297-342 6.04e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 6.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 20178574   297 YASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNR 342
Cdd:pfam13964   5 HSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_6 pfam13964
Kelch motif;
342-388 6.28e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 6.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 20178574   342 RCRFSLAVIDDTIYAIGGQ-NGTNVERTIECYTMGDDKWKLLPDMPIA 388
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTP 49
PHA02790 PHA02790
Kelch-like protein; Provisional
 35-415 6.70e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 45.42  E-value: 6.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574   35 GEEIKAHKTILAAGSTYFKTMFTTPMIA-RDLVTRVNLQMfDKDAVKNIVQYLYNR--HISSMNVIDVLKCADYLLIDDL 111
Cdd:PHA02790  30 GGNIIVNSTILKKLSPYFRTHLRQKYTKnKDPVTRVCLDL-DIHSLTSIVIYSYTGkvYIDSHNVVNLLRASILTSVEFI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  112 VADCESYIKDYTNHDTCICMYHKLYEMIHIPIVKYIKRMLMSNIPTLitTDAFKKTVFEILFDIISTNDNVYLYREGYKV 191
Cdd:PHA02790 109 IYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL--EDDIIDNFDYLSMKLILESDELNVPDEDYVV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  192 TILLKW------------------LEHNYITEE---QLLCILSCIDIQNLDKKSR---------LLLYSNKTINMYPSC- 240
Cdd:PHA02790 187 DFVIKWymkrrnrlgnlllliknvIRSNYLSPRginNVKWILDCTKIFHCDKQPRksykypfieYPMNMDQIIDIFHMCt 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  241 ------IQFLIDNKQNRNIIPRQLCLVChdtkynVCNPCILVYNINTMEYsvistipnhiinYASAI-VDNEIIIAGGYn 313
Cdd:PHA02790 267 sthvgeVVYLIGGWMNNEIHNNAIAVNY------ISNNWIPIPPMNSPRL------------YASGVpANNKLYVVGGL- 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  314 fnnPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVerTIECYTMGDDKWKLLPDMPIALSSYG 393
Cdd:PHA02790 328 ---PNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDT--TTEYLLPNHDQWQFGPSTYYPHYKSC 402

                        410       420
                 ....*....|....*....|...
gi 20178574  394 MCVLDQYIYIIG-GSTLYIDYTS 415
Cdd:PHA02790 403 ALVFGRRLFLVGrNAEFYCESSN 425
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 26-87 7.15e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 42.76  E-value: 7.15e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20178574  26 CDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMF-DKDAVKNIVQYLY 87
Cdd:cd18309  21 CDITLLL-DGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVpSRQAFDSLLRYIY 82
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-87 8.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 42.34  E-value: 8.57e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20178574  25 LCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPmIARDLVTRVNLQMFDKDAVKNIVQYLY 87
Cdd:cd18336  19 LCDVLL-IAGNLKIPAHRLVLSAVSDYFAAMFTND-VREAKQEEIKMEGVDPDALKALVHYAY 79
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-116 1.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 41.63  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  35 GEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHISSMNVI--DVLKCADYLLIDDLV 112
Cdd:cd18342  31 GQEFQAHKAILAARSPVFSAMFEHEM-EESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMadDLLAAADKYALERLK 109


                ....
gi 20178574 113 ADCE 116
Cdd:cd18342 110 VMCE 113
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-116 1.60e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 41.76  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIR---DGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNR--HISSMNVIDV 99
Cdd:cd18211  25 LCDVTVQVEhqgSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTADFASFLEFVYTAkvEVEEDRVQRM 104

                        90
                ....*....|....*..
gi 20178574 100 LKCADYLLIDDLVADCE 116
Cdd:cd18211 105 LEIAEKLKCLDLSETCF 121
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-118 1.77e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 41.53  E-value: 1.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  27 DVIITIRDGEeIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRHISSMNVIDVLK---CA 103
Cdd:cd18359  22 DVTFMLDDGT-ISAHKPLLISSCDWMAAMFGGPFVESS-TTEVVFPYTSRSSMRAVLEYLYTGQFSSSPDLDDMKliiLA 99

                        90
                ....*....|....*
gi 20178574 104 DYLLIDDLVADCESY 118
Cdd:cd18359 100 NRLCLPHLVALTEQY 114
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-111 2.38e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 41.13  E-value: 2.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  27 DVIITIrDGEEIKAHKTILAAGSTYFKTMFTTP----MIARDLVTRVNLQMFDKDAVKNIVQYLY--NRHISSMNVIDVL 100
Cdd:cd18296  19 DVCFQV-EGHRFPCHKAFFCGRSDYFKALLRDHfaesEENNGSIPVVTLHDVSPEVFAIVLYYIYtdDTDLPPENAYDVL 97

                        90
                ....*....|.
gi 20178574 101 KCADYLLIDDL 111
Cdd:cd18296  98 YVADMYLLPGL 108
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-120 3.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 40.97  E-value: 3.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrdGE-EIKAHKTILAAGSTYFKTMFTTPMIARDLVTrVNLQMFDKDAVKNIVQYLYNRHISSMN--VIDVLK 101
Cdd:cd18323  23 LCDCTVLV--GStQFLAHRAVLASCSPFFHMFYKEQLDKRDLVC-INNEIVTAPAFSLLLEFMYEGRLSFNDtpVEDVLA 99

                        90
                ....*....|....*....
gi 20178574 102 CADYLLIDDLVADCESYIK 120
Cdd:cd18323 100 AASYLHMNDIVKVCKKRLQ 118
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-119 3.34e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 40.24  E-value: 3.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPmiARDLVTRVNLQMF-DKDAVKNIVQYLYNRHI--SSMNVIDV 99
Cdd:cd18215  17 DILTDVVLVV-GREQFRAHKTVLMACSGLFYSIFTDQ--LKNNVSVINLDPEiEPEGFRILLDFMYTSRLnlREGNIMAV 93

                        90       100
                ....*....|....*....|
gi 20178574 100 LKCADYLLIDDLVADCESYI 119
Cdd:cd18215  94 MATAMYLQMEHVVDTCRKFI 113
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 3.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 40.57  E-value: 3.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNV 96
Cdd:cd18251  17 LRDSGILFDVVLVV-EGKPIEAHRILLAASCDYFRGMFAGGLREMQ-QTEVLIHGVSYNAMCKILDFIYTSEleLSLDNV 94

                        90       100       110
                ....*....|....*....|....*....|
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHD 126
Cdd:cd18251  95 QETLTAACQLQIPEVIGFCCDFLMSWVDNE 124
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-118 4.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 39.79  E-value: 4.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  26 CDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMI--ARDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLK 101
Cdd:cd18307   2 CDVVISV-DNHSFAAHRNVLAAVSPFVKSLISSNDMkaTDELSITIDCDYLSPETVEQLLDYFYTGKivISEKNVEDLLK 80

                        90
                ....*....|....*..
gi 20178574 102 CADYLLIDDLVADCESY 118
Cdd:cd18307  81 GAKYFNIPRLKDHCVDF 97
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-129 4.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 40.20  E-value: 4.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  21 DDDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIARD--LVTRVNLQmfdKDAVKNIVQYLYN--RHISSMNV 96
Cdd:cd18271  20 EQNAFFDFNIIVKD-ETIPCHRCVLAACSDFFRAMFEVNMKERDdgSVTISNLS---PKAVKAFLDYAYTgkAEITDDNV 95

                        90       100       110
                ....*....|....*....|....*....|...
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18271  96 EMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-112 4.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 40.16  E-value: 4.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPM-IARDLVTrvnLQMFDKDAVKNIVQYLY--NRHISSMNVIDV 99
Cdd:cd18212  21 DFLCDITLIVEN-VQFRAHKALLAASSEYFSMMFADEGeVGQSIYM---LEGMVAETFGALLEFIYtgCLQVGEKSLEQI 96

                        90
                ....*....|...
gi 20178574 100 LKCADYLLIDDLV 112
Cdd:cd18212  97 LATAQFLKVNDLV 109
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-87 6.73e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 40.26  E-value: 6.73e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20178574  20 LDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMI-ARDLVtrVNLQMFDKDAVKNIVQYLY 87
Cdd:cd18272  27 LEDGLFADVTISV-EGKEFQLHRLVLSAQSCFFRSMFTSNLKeARNRV--IELKDVSESVFQLLVDYIY 92
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-120 6.98e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 39.67  E-value: 6.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDG---EEIKAHKTILAAGSTYFKTMFTTPMIARDlvTRVNLQMFDKDAVKNIVQYLYNR--HISS 93
Cdd:cd18347  16 LFNNEVLSDVHFLVGKGlgsQRIPAHRFVLAVGSAVFDAMFNGGMATTS--TEIELPDVEPAAFLALLKFLYSDevQIGP 93

                        90       100
                ....*....|....*....|....*..
gi 20178574  94 MNVIDVLKCADYLLIDDLVADCESYIK 120
Cdd:cd18347  94 ETVMTTLYTAKKYAVPALEAHCVEFLK 120
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-92 7.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 39.25  E-value: 7.64e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20178574  26 CDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPMIarDLVTRVNLQMFDKDAVKNIVQYLYNRHIS 92
Cdd:cd18204  19 CDIAIVVED-VKFRAHRCVLAACSTYFKKLFKKLEV--DSSSVIEIDFLRSDIFEEVLNYMYTAKIS 82
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 8.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 39.64  E-value: 8.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPmIARDLVTRVNLQMFDKDAVKNIVQYLYN--RHISSMNVIDVLKC 102
Cdd:cd18335  19 LCDVILIAGN-RKIPAHRLVLSAVSDYFAAMFTSD-VCEAKQEEIKMEGIDPNALWDLVQFAYTgcLELKEDTIENLLAA 96

                        90       100
                ....*....|....*....|....*..
gi 20178574 103 ADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18335  97 ACLLQLSQVVEVCCHFLMKLLHPSNCL 123
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 388-449 9.59e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 9.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20178574   388 ALSSYGMCVLDQYIYIIGGSTlyidytsvhavnsidmeeDTDTSNKVIRYDTVNNIWETLPN 449
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD------------------GNQSLNSVEVYDPETNTWSKLPS 44
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-103 9.76e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 39.14  E-value: 9.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIItIRDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRHIS-----S 93
Cdd:cd18287  16 LFLNEEYSDVTF-VVEEKRFPAHRVILAARSEYFRALLYGGM-RESQQSEIELKDTNAEAFKALLKYIYTGRLTltdlkE 93

                        90
                ....*....|
gi 20178574  94 MNVIDVLKCA 103
Cdd:cd18287  94 DVLLDVLGLA 103
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-106 1.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 38.03  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  28 VIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDlVTRVNLQMFDKDAVKNIVQYLYN--RHISSMNVIDVLKCADY 105
Cdd:cd01165   1 VVLVV-EGEKFHVNKELLAQSSEYFRALFRGGFRESG-QAEINLRDISPEDFRALLEFLYGgkRDLDASNLLELLEAANF 78


                .
gi 20178574 106 L 106
Cdd:cd01165  79 L 79
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-106 1.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 38.24  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  27 DVIITIrDGEEIKAHKTILAAGSTYFKTmfttpMIARDLvtrVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKCAD 104
Cdd:cd18275   6 DLVIEV-SGQRIRAHKSVLAAKSDYFRA-----RLSRDI---LKVKGLSYATLRLLVDYVYSGRmaVSKDNVVEVVAGAR 76


                ..
gi 20178574 105 YL 106
Cdd:cd18275  77 FL 78
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-57 1.63e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 38.86  E-value: 1.63e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 20178574  26 CDVIITIRdGEEIKAHKTILAAGSTYFKTMFT 57
Cdd:cd18289  30 CDVSIVVK-GQAFKAHRAVLAASSLYFRDLFS 60
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-120 1.98e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 38.41  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIItiRDGEE-IKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLYNRHIssmnVI------ 97
Cdd:cd18207  27 FCDVLL--RVGEEsFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDILDFAYTSRI----VVrlesfp 100

                        90       100
                ....*....|....*....|...
gi 20178574  98 DVLKCADYLLIDDLVADCESYIK 120
Cdd:cd18207 101 ELMTAAKFLLMRSVIDICQEVIK 123
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 2.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 38.67  E-value: 2.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDgEEIKAHKTILAAGSTYFKTMFTTPmIARDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SSMNV 96
Cdd:cd18341  21 LLDENKFVDCTLKAGD-KSLPCHRLILAACSPYFREYFLSE-ESEEKKKEVVLDNVDPNIMDMILKYLYSAEIdlNDGNV 98

                        90       100       110
                ....*....|....*....|....*....|...
gi 20178574  97 IDVLKCADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18341  99 QDIFALASRFQIPSVFTVCVTYLQKRLSPANCL 131
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 148-217 2.13e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 37.73  E-value: 2.13e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20178574 148 KRMLMSNIPTLITTDAFKKTVFEILFDIISTnDNVYLYREGYKVTILLKWLEHNYITEEQLL-CILSCIDI 217
Cdd:cd18479  26 KRMVEHKFTAVYHQEAFMQLSHDLLIDILSS-DNLNVEKEETVREAAMLWLEYNTESRSQYLsSVLSQIRI 95
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 2.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 38.07  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKtmfttpmiARDLVTRVNLQM--FDKDAVKNIVQYLYNRHIS-SMN 95
Cdd:cd18303  12 LFDKELYSDITIKL-ADKSIPAHKFVLAARSEKWS--------NENLASTNELDLsdISYEVVLALLRWLYTDELDlTLD 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 20178574  96 ---VIDVLKCADYLLIDDLVADCESYIKDYTNHDTCIC 130
Cdd:cd18303  83 defLLELMKAAKRFQLTDLVERCERALMSSVNVDNCIR 120
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 2.65e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 38.27  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMiARDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKC 102
Cdd:cd18259  32 LSDVTLLV-GGREFPCHRSVLALCSHYFNAMFTGDF-VESISARVEIKDVDPAVMESLIDFAYTGKltINQGNVEALIRT 109

                        90       100
                ....*....|....*....|....*..
gi 20178574 103 ADYLLIDDLVADCESYIKDYTNHDTCI 129
Cdd:cd18259 110 SNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-87 3.45e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 37.33  E-value: 3.45e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20178574  19 LLDDDILCDVIITIrDGEEIKAHKTILAAGSTYFKTMFTTPMIARDLVTRVNLQMFDKDAVKNIVQYLY 87
Cdd:cd18285   9 LLREELHTDVTFYV-GSTLFKAHKAILLARVPEFFSHIIGKLSSLEDQEPINIENLEASEFKTFLRQVY 76
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-106 3.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 37.29  E-value: 3.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  29 IITIRDGEEIKAHKTILAAGSTYFKTMFttpmiaRDLVTR--VNLQMFDKDAVKNIVQYLYNRHI---SSMNVIDVLKCA 103
Cdd:cd18221  21 ITLIVDGHQFKAHKAVLAACSQFFYKFF------QDFTQEplVEIEGVSNMAFRHLIEFTYTAKLmvqGEEEANDVWKAA 94


                ...
gi 20178574 104 DYL 106
Cdd:cd18221  95 EYL 97
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-120 4.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 37.42  E-value: 4.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDV--IITIRDGEE-IKAHKTILAAGSTYFKTMFTTPMiaRDLVTRVNLQMFDKDAVKNIVQYLYNR--HISS 93
Cdd:cd18281  16 LFNNETLSDVhfIVGKGDNEQrIPAHKFVLSIGSAVFDAMFNGGM--ATTSAEIELPDVEPAAFLALLRFLYSDevQIGP 93

                        90       100
                ....*....|....*....|....*..
gi 20178574  94 MNVIDVLKCADYLLIDDLVADCESYIK 120
Cdd:cd18281  94 ETVMTTLYTAKKYAVPALESACVEFLK 120
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-121 5.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 37.12  E-value: 5.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIITIrDGEEIKAHKTILAAGSTYFKTMF--TTPMIAR----DLVTRVNlqmFDKdavknIVQYLYNRHISS--M 94
Cdd:cd18224  24 ETMCDVTIVV-GNRSFAAHKAVLACAAGYFQKLFlsTELDVARtyvvDFITPAN---FEK-----VLSFIYTSELFTdlI 94

                        90       100
                ....*....|....*....|....*..
gi 20178574  95 NVIDVLKCADYLLIDDLVADCESYIKD 121
Cdd:cd18224  95 NVGVIYEVAEKLGMEDLLKACHSTFPD 121
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-120 6.93e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 36.42  E-value: 6.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  19 LLDDDILCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTpMIARDLVTRVNLQMFdkdavKNIVQYLYNRHISSMNVI- 97
Cdd:cd18299   6 LLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFADLFLM-MTVVTLDSDITPEAF-----RRVLEFLYTGVLDENEDDl 79

                        90       100
                ....*....|....*....|....
gi 20178574  98 -DVLKCADYLLIDDLVADCESYIK 120
Cdd:cd18299  80 kELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-120 7.78e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 36.37  E-value: 7.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  23 DILCDVIITIRdGEEIKAHKTILAAGSTYFKTMFTTPmiARDLVTRVNL-QMFDKDAVKNIVQYLYNRH--ISSMNVIDV 99
Cdd:cd18332  17 DILTDVTLLVG-GTPLRAHKAVLIACSGFFYSIFSGR--VGEGVSVLTLpSGLEARGFQLLLDFMYTSRlpLTPRTVPAV 93

                        90       100
                ....*....|....*....|.
gi 20178574 100 LKCADYLLIDDLVADCESYIK 120
Cdd:cd18332  94 LAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 19-87 8.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 36.90  E-value: 8.59e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20178574  19 LLD--DDILCDVIITIRDGEEIKAHKTILAAGSTYFKTMFTTpMIARDLVTRVNLQMFD--------KDAVKNIVQYLY 87
Cdd:cd18310  10 LLDspDLFYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFAS-AKAEGANTKPKLELRElipggivgYDAFMLVLSYLY 87
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-115 9.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 36.56  E-value: 9.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20178574  25 LCDVIITIRdGEEIKAHKTILAAGSTYFKT-MFTTPMIARDLVTRVNLQMFDKdavknIVQYLYNRHI--SSMNVIDVLK 101
Cdd:cd18222  25 LCDIVVNVQ-GQSFRAHKVVLAASSPYFRDhMSLNEMSTVSISVIKNPTVFEQ-----LLSFCYTGRIclQLADIISYLT 98

                        90
                ....*....|....
gi 20178574 102 CADYLLIDDLVADC 115
Cdd:cd18222  99 AASFLQMQHIIDKC 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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