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Conserved domains on  [gi|148747298|ref|NP_620815|]
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coronin-6 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-466 1.56e-106

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 325.31  E-value: 1.56e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SAFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTGPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  88 DWCPHNDNVIASASDDTTVMVWQIPDYTPVRNITEPVITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 164
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 165 EVLLSlddiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAErFAAHEGMRPMRAVFT-RLGHIFTTGFTRMSQ 243
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 244 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 323
Cdd:PTZ00421 237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 324 RGLDVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLK---EGYVPP 398
Cdd:PTZ00421 315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPE 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 399 KHREFRVTKRNILDVRPPASPRRSQSASEA----------------PLSQQHTLETLLEEMKALRERVQAQEERITALEN 462
Cdd:PTZ00421 395 LMGASALSPSGKPRHSGVSVPASTSAMTHSfddntskhadpcamgvKRMDEGILDERLGRLQALSEKLRTQHEEIKRCRE 474


                 ....
gi 148747298 463 MLCE 466
Cdd:PTZ00421 475 ALQK 478
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-466 1.56e-106

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 325.31  E-value: 1.56e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SAFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTGPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  88 DWCPHNDNVIASASDDTTVMVWQIPDYTPVRNITEPVITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 164
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 165 EVLLSlddiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAErFAAHEGMRPMRAVFT-RLGHIFTTGFTRMSQ 243
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 244 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 323
Cdd:PTZ00421 237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 324 RGLDVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLK---EGYVPP 398
Cdd:PTZ00421 315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPE 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 399 KHREFRVTKRNILDVRPPASPRRSQSASEA----------------PLSQQHTLETLLEEMKALRERVQAQEERITALEN 462
Cdd:PTZ00421 395 LMGASALSPSGKPRHSGVSVPASTSAMTHSfddntskhadpcamgvKRMDEGILDERLGRLQALSEKLRTQHEEIKRCRE 474


                 ....
gi 148747298 463 MLCE 466
Cdd:PTZ00421 475 ALQK 478
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.86e-34

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 123.38  E-value: 1.86e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148747298    4 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSAFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-296 1.40e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  78 TGHTGPVLDIDWCPHnDNVIASASDDTTVMVWQIPDytpvrniTEPVITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 158 IWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAeRFAAHEGmrPMRAV--FTRLGHIFT 235
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148747298 236 TGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 296
Cdd:cd00200  195 SS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 1.32e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.32e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  77 VTGHTGPVLDIDWCPhNDNVIASASDDTTVMVWQIPDytpvrniTEPVITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 157 IIWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAErFAAHEGmRPMRAVFTRLGHIFTT 236
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLAS 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148747298 237 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319  348 GS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 1.28e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.28e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 148747298    78 TGHTGPVLDIDWCPhNDNVIASASDDTTVMVW 109
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-466 1.56e-106

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 325.31  E-value: 1.56e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SAFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTGPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  88 DWCPHNDNVIASASDDTTVMVWQIPDYTPVRNITEPVITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 164
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 165 EVLLSlddiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAErFAAHEGMRPMRAVFT-RLGHIFTTGFTRMSQ 243
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 244 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 323
Cdd:PTZ00421 237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 324 RGLDVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLK---EGYVPP 398
Cdd:PTZ00421 315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPE 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 399 KHREFRVTKRNILDVRPPASPRRSQSASEA----------------PLSQQHTLETLLEEMKALRERVQAQEERITALEN 462
Cdd:PTZ00421 395 LMGASALSPSGKPRHSGVSVPASTSAMTHSfddntskhadpcamgvKRMDEGILDERLGRLQALSEKLRTQHEEIKRCRE 474


                 ....
gi 148747298 463 MLCE 466
Cdd:PTZ00421 475 ALQK 478
PTZ00420 PTZ00420
coronin; Provisional
 21-408 2.51e-69

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 230.99  E-value: 2.51e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  21 ADQAYEDIRVSKVTWDSAFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRvdkNYPLVT--GHTGPVLDIDWCPHNDNVIA 98
Cdd:PTZ00420  15 SNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSEILA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  99 SASDDTTVMVWQIP-DYTPVRNITEPVITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLddIHPDV 177
Cdd:PTZ00420  92 SGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI--NMPKK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 178 IHSVCWNSNGSLLATTCKDKTLRIIDPRKsQVVAERFAAHEGMRPMRAVFTR-LG----HIFTTGFTRMSQRELGLWDPN 252
Cdd:PTZ00420 170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIDgLGgddnYILSTGFSKNNMREMKLWDLK 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 253 NFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPpfVHYLNTFSSKEPQRGMGFMPKRGLDVSKCE 332
Cdd:PTZ00420 249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148747298 333 IARFYK-LHERKCEPIVMTVPRK-SDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLKEgyvpPKHREFRVTKR 408
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.86e-34

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 123.38  E-value: 1.86e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148747298    4 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSAFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-296 1.40e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  78 TGHTGPVLDIDWCPHnDNVIASASDDTTVMVWQIPDytpvrniTEPVITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 158 IWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAeRFAAHEGmrPMRAV--FTRLGHIFT 235
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148747298 236 TGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 296
Cdd:cd00200  195 SS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 1.32e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.32e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  77 VTGHTGPVLDIDWCPhNDNVIASASDDTTVMVWQIPDytpvrniTEPVITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 157 IIWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAErFAAHEGmRPMRAVFTRLGHIFTT 236
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLAS 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148747298 237 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319  348 GS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-295 6.77e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 6.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  35 WDSAFCAVNPKFLAiiveAGGGGAFIVLPLaKTGRVDKNYplvTGHTGPVLDIDWCPHNDnVIASASDDTTVMVWQIPDY 114
Cdd:cd00200   55 RDVAASADGTYLAS----GSSDKTIRLWDL-ETGECVRTL---TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 115 tpvrnitEPVITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTC 194
Cdd:cd00200  126 -------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 195 KDKTLRIIDPRKSQVVAErFAAHEGmRPMRAVFTRLGHIFTTGFtrmSQRELGLWDPNNFEEPVALQEmdTSNGVLLPFY 274
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGT-LRGHEN-GVNSVAFSPDGYLLASGS---EDGTIRVWDLRTGECVQTLSG--HTNSVTSLAW 269

                        250       260
                 ....*....|....*....|.
gi 148747298 275 DPDSSIVYLCGKgDSSIRYFE 295
Cdd:cd00200  270 SPDGKRLASGSA-DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
78-298 1.08e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 1.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  78 TGHTGPVLDIDWCPhNDNVIASASDDTTVMVWQIPDYTPVRnitepviTLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:COG2319  117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLR-------TLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 158 IWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAeRFAAHEGmRPMRAVFTRLGHIFTTG 237
Cdd:COG2319  188 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR-TLTGHSG-SVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148747298 238 ftrMSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 298
Cdd:COG2319  265 ---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
76-205 2.90e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 2.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  76 LVTGHTGPVLDIDWCPhNDNVIASASDDTTVMVWQIPDYTPVRnitepviTLEGHSKRVGILSWHPTARnVLLSAGGDNV 155
Cdd:COG2319  283 TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGK-TLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 148747298 156 IIIWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPR 205
Cdd:COG2319  354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 344-386 1.90e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 84.10  E-value: 1.90e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148747298  344 CEPIVMTVPRKS-DLFQDDLYPDTPGPEPALEADEWLSGQDAEP 386
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 1.91e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 1.91e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  77 VTGHTGPVLDIDWCPhNDNVIASASDDTTVMVWQIPDytpvrniTEPVITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319   74 LLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 157 IIWNVGTGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAeRFAAHEGmRPMRAVFTRLGHIFTT 236
Cdd:COG2319  145 RLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR-TLTGHTG-AVRSVAFSPDGKLLAS 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148747298 237 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319  222 GS---ADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASGS-ADGTVR 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-292 1.98e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 1.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 123 PVITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWNVGTGEVLLSLdDIHPDVIHSVCWNSNGSLLATTCKDKTLRII 202
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 203 DPRKSQVVAErFAAHEGmrPMRAV-FTRLGHIFTTGftrMSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIV 281
Cdd:cd00200   79 DLETGECVRT-LTGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFV 150

                        170
                 ....*....|.
gi 148747298 282 YlCGKGDSSIR 292
Cdd:cd00200  151 A-SSSQDGTIK 160
WD40 COG2319
WD40 repeat [General function prediction only];
78-163 1.32e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298  78 TGHTGPVLDIDWCPhNDNVIASASDDTTVMVWQIPDYTPVRnitepviTLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:COG2319  327 TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLR-------TLTGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                 ....*.
gi 148747298 158 IWNVGT 163
Cdd:COG2319  398 LWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 1.28e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.28e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 148747298    78 TGHTGPVLDIDWCPhNDNVIASASDDTTVMVW 109
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 163-203 3.80e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.80e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148747298   163 TGEVLLSLDDiHPDVIHSVCWNSNGSLLATTCKDKTLRIID 203
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 89-186 4.17e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.96  E-value: 4.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298   89 WCPHNDnVIASASDDTTV--------MVWQIPdytpvrnitepvitLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWN 160
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 148747298  161 VGTGEVLLSLdDIHPDVIHSVCWNSN 186
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-298 1.31e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747298 174 HPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAeRFAAHEGmrPMRAV----FTRLghIFTTGFTRMSQrelgLW 249
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaasaDGTY--LASGSSDKTIR----LW 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148747298 250 DPNNFEEPVALqEMDTSnGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 298
Cdd:cd00200   79 DLETGECVRTL-TGHTS-YVSSVAFSPDGRIL-SSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 122-160 1.33e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148747298   122 EPVITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 160
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
78-109 1.68e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.68e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148747298   78 TGHTGPVLDIDWCPhNDNVIASASDDTTVMVW 109
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
174-203 1.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.36e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 148747298  174 HPDVIHSVCWNSNGSLLATTCKDKTLRIID 203
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
122-160 1.43e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148747298  122 EPVITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 160
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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