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Conserved domains on  [gi|24655298|ref|NP_647620|]
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pinstripe, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN1_DENND5 cd17677
RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 839-1091 2.66e-101

RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the first RUN domain of DENND5.


:

Pssm-ID: 439039  Cd Length: 183  Bit Score: 320.88  E-value: 2.66e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  839 LIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLKG---DGIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHL 915
Cdd:cd17677    1 VIAQTNWKFVEGLLKECKMKTKRMLVEKMGQEAVELGHGEvniTGVEENTLIASLCDLLERIWSHGLQTKQGKSALWSHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  916 QAYLEMQEArgagdssgteqtppvssspggkmtiataspalawnamrkrmdylstfqtdfdsppspnrsrsrdrnkfvgl 995
Cdd:cd17677   81 LAYQENEER----------------------------------------------------------------------- 89

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  996 eqLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHL 1075
Cdd:cd17677   90 --LKPLPESLLFDMKNVQNMKEIKTDVGYARAWIRLALEKKLLSKHLKTLLSNQDLLRSLYKRYAFLRCEDEREQFLYHL 167

                        250
                 ....*....|....*.
gi 24655298 1076 LTLNTVDYFSFTNIYP 1091
Cdd:cd17677  168 LSLNAVDYFCFTNTFT 183
RUN2_DENND5 cd17678
RUN2 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 1243-1440 2.13e-81

RUN2 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the second RUN domain of DENND5.


:

Pssm-ID: 439040  Cd Length: 182  Bit Score: 264.84  E-value: 2.13e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1243 EIQHQLGNCVNVLVKWHYKPSRDRdvGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHNLQM 1322
Cdd:cd17678    1 EIQELLGDAVNNIVKYFYKPEKER--GSLTLLLCGESGLVSCLEQVFLYGFKSSRLFRRNLYIWDFIEKVKEYFESLLKQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1323 ELEDSSSSldssfsngsgsggnslQRREISSIWRLYVQLMDEINGTA--LGKDGKFQLLICLSLREHLLTRLIKPMALTK 1400
Cdd:cd17678   79 EESDKDYE----------------LSKEDRSAMRSFCRLVQKINNASssIGKDGKFQLFICLGLRDHLLHRWLPLLASSP 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 24655298 1401 VTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSIT 1440
Cdd:cd17678  143 VTLQMYEENSFLRDPDLLSFLVQLLESLNEFNITLENSLT 182
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1095-1203 4.52e-60

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238855  Cd Length: 114  Bit Score: 201.23  E-value: 4.52e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1095 LPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRN 1174
Cdd:cd01757    1 MPYHVVIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQNLGKLTTVQIGHDNSGLLAKWLVEYVMVRN 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 24655298 1175 EVTGHTYKFPCGRWLGRGVD-----DDSTERLLV 1203
Cdd:cd01757   81 EITGHTYKFPCGRWLGEGVDdgngeDGSLERVLV 114
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 243-435 7.14e-53

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 183.55  E-value: 7.14e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298     243 VAKSITLICQAPYAFAAQMFLKNLYRClpRQPGAGISLESYVYNILYEVmlPQPGKSIRVY-LPPTEPHlppialILQRP 321
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRL--LPSSSNLPLELLISLLLYPV--PPPGGSLVLVsLGPGDLI------ELQRP 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298     322 LlATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFL 401
Cdd:smart00799   71 L-DSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVL 149

                           170       180       190
                    ....*....|....*....|....*....|....
gi 24655298     402 DAPVPFVMGLHAECEAAHKIGSEATLCFVDIDKK 435
Cdd:smart00799  150 SAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 70-171 2.41e-26

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 103.95  E-value: 2.41e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298      70 SRFADYFVICGLDLDTGlepdrfagdnlhcsPLDRAYKSKPLAHYPENVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPR 149
Cdd:smart00800    2 SRLFDYFVVVGLDSDTG--------------PLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFVTQTSSKDPQ 67

                            90       100
                    ....*....|....*....|..
gi 24655298     150 FHSFATTREDGKRCYGFSLVFY 171
Cdd:smart00800   68 FFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 626-701 4.36e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 82.72  E-value: 4.36e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24655298     626 NNSVREIFLNRFVHMFHAYEYFVIYpnqardeWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNK 701
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRE-------LRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
RUN1_DENND5 cd17677
RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 839-1091 2.66e-101

RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the first RUN domain of DENND5.


Pssm-ID: 439039  Cd Length: 183  Bit Score: 320.88  E-value: 2.66e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  839 LIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLKG---DGIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHL 915
Cdd:cd17677    1 VIAQTNWKFVEGLLKECKMKTKRMLVEKMGQEAVELGHGEvniTGVEENTLIASLCDLLERIWSHGLQTKQGKSALWSHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  916 QAYLEMQEArgagdssgteqtppvssspggkmtiataspalawnamrkrmdylstfqtdfdsppspnrsrsrdrnkfvgl 995
Cdd:cd17677   81 LAYQENEER----------------------------------------------------------------------- 89

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  996 eqLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHL 1075
Cdd:cd17677   90 --LKPLPESLLFDMKNVQNMKEIKTDVGYARAWIRLALEKKLLSKHLKTLLSNQDLLRSLYKRYAFLRCEDEREQFLYHL 167

                        250
                 ....*....|....*.
gi 24655298 1076 LTLNTVDYFSFTNIYP 1091
Cdd:cd17677  168 LSLNAVDYFCFTNTFT 183
RUN2_DENND5 cd17678
RUN2 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 1243-1440 2.13e-81

RUN2 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the second RUN domain of DENND5.


Pssm-ID: 439040  Cd Length: 182  Bit Score: 264.84  E-value: 2.13e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1243 EIQHQLGNCVNVLVKWHYKPSRDRdvGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHNLQM 1322
Cdd:cd17678    1 EIQELLGDAVNNIVKYFYKPEKER--GSLTLLLCGESGLVSCLEQVFLYGFKSSRLFRRNLYIWDFIEKVKEYFESLLKQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1323 ELEDSSSSldssfsngsgsggnslQRREISSIWRLYVQLMDEINGTA--LGKDGKFQLLICLSLREHLLTRLIKPMALTK 1400
Cdd:cd17678   79 EESDKDYE----------------LSKEDRSAMRSFCRLVQKINNASssIGKDGKFQLFICLGLRDHLLHRWLPLLASSP 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 24655298 1401 VTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSIT 1440
Cdd:cd17678  143 VTLQMYEENSFLRDPDLLSFLVQLLESLNEFNITLENSLT 182
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1095-1203 4.52e-60

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 201.23  E-value: 4.52e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1095 LPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRN 1174
Cdd:cd01757    1 MPYHVVIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQNLGKLTTVQIGHDNSGLLAKWLVEYVMVRN 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 24655298 1175 EVTGHTYKFPCGRWLGRGVD-----DDSTERLLV 1203
Cdd:cd01757   81 EITGHTYKFPCGRWLGEGVDdgngeDGSLERVLV 114
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 243-435 7.14e-53

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 183.55  E-value: 7.14e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298     243 VAKSITLICQAPYAFAAQMFLKNLYRClpRQPGAGISLESYVYNILYEVmlPQPGKSIRVY-LPPTEPHlppialILQRP 321
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRL--LPSSSNLPLELLISLLLYPV--PPPGGSLVLVsLGPGDLI------ELQRP 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298     322 LlATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFL 401
Cdd:smart00799   71 L-DSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVL 149

                           170       180       190
                    ....*....|....*....|....*....|....
gi 24655298     402 DAPVPFVMGLHAECEAAHKIGSEATLCFVDIDKK 435
Cdd:smart00799  150 SAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 242-434 2.74e-46

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 164.67  E-value: 2.74e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298    242 YVAKSITLICQAPYAFAAQMFLKNLYR----CLPRQPgagisLESYVYNILYEVMLPQPGKSIRVYlpptePHLPPIALI 317
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRrrtiSPLPNP-----IERFIANLLYEVPFPPPGRTQKLK-----PLGGTEPIL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298    318 LQRPLlATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAAL 397
Cdd:pfam02141   71 LQRPE-DSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASL 149

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 24655298    398 HHFLDAPVPFVMGLHAECEAAHkIGSEATLCFVDIDK 434
Cdd:pfam02141  150 LDVLSAPTPFIIGVHSRYFDLL-EDPLDDVVLVDLDT 185
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 70-171 2.41e-26

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 103.95  E-value: 2.41e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298      70 SRFADYFVICGLDLDTGlepdrfagdnlhcsPLDRAYKSKPLAHYPENVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPR 149
Cdd:smart00800    2 SRLFDYFVVVGLDSDTG--------------PLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFVTQTSSKDPQ 67

                            90       100
                    ....*....|....*....|..
gi 24655298     150 FHSFATTREDGKRCYGFSLVFY 171
Cdd:smart00800   68 FFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 626-701 4.36e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 82.72  E-value: 4.36e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24655298     626 NNSVREIFLNRFVHMFHAYEYFVIYpnqardeWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNK 701
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRE-------LRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
RUN smart00593
domain involved in Ras-like GTPase signaling;
1026-1088 3.04e-18

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 79.97  E-value: 3.04e-18
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24655298    1026 RAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTN 1088
Cdd:smart00593    2 RAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFNLPVD 64
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 111-169 4.71e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 68.02  E-value: 4.71e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24655298    111 LAHYPENVPWNPFDAHGICMLSLPQGLRfrtQKHCIEPRFHSFATTREDGKRCYGFSLV 169
Cdd:pfam03456    4 LDRYPEDDWSDPPLPDGIPMFCFPEGLE---TLSSREPTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 668-720 3.67e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.91  E-value: 3.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24655298    668 FDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKilamwESQPDEQLQLFDQR 720
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEER-----LESSDPSIDLFDEE 48
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1097-1198 5.94e-12

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 63.99  E-value: 5.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298   1097 YRVVIFPSRKYGSYhTSSNVWIMVSGTMNETQRVPVPKGSLEF---------IFHYKNLGLLTTMRIGHDNSGPSHKWLV 1167
Cdd:pfam01477    1 YQVKVVTGDELGAG-TDADVYISLYGKVGESAQLEITLDNPDFergaedsfeIDTDWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 24655298   1168 EQV-VMRNEVTGHTYKFPCGRWLGRGVDDDST 1198
Cdd:pfam01477   80 KSItVEVPGETGGKYTFPCNSWVYGSKKYKET 111
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 995-1083 2.53e-11

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 62.68  E-value: 2.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298    995 LEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYH 1074
Cdd:pfam02759   40 VGKLVPPAEELLSSVQELEQIHTPYSPDGRGRAWIRLALNEKLLDQWLKLLLSNKELLSEYYEPWALLADPEFGEILLGL 119


                   ....*....
gi 24655298   1075 LLTLNTVDY 1083
Cdd:pfam02759  120 LVGLSALDF 128
RUN smart00593
domain involved in Ras-like GTPase signaling;
1376-1436 3.98e-10

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 56.85  E-value: 3.98e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24655298    1376 FQLLICLSLREHLLTRLIKPMALT-KVTHEMYEEESFLRRRNLLTFLIQILEPL--DDCHIVLE 1436
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDeELLSKYYEPWAFLRDPEEGEQLLGLLVGLsaLDFNLPVD 64
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 1285-1428 4.71e-06

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 47.65  E-value: 4.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298   1285 LEQVFLCGFRS-------ARFFGRNLYIWDYFTKIKELFEHnlqmeledssssldssfsngsgsggnslQRREISSiwrl 1357
Cdd:pfam02759    6 LEALLSHGLKRssllilrAAGLLPERSFWALLERVGKLVPP----------------------------AEELLSS---- 53

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24655298   1358 yVQLMDEINgTALGKDGKFQLLICLSLREHLLTRLIKPMAL-TKVTHEMYEEESFLRRRNLLTFLIQILEPL 1428
Cdd:pfam02759   54 -VQELEQIH-TPYSPDGRGRAWIRLALNEKLLDQWLKLLLSnKELLSEYYEPWALLADPEFGEILLGLLVGL 123
 
Name Accession Description Interval E-value
RUN1_DENND5 cd17677
RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 839-1091 2.66e-101

RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the first RUN domain of DENND5.


Pssm-ID: 439039  Cd Length: 183  Bit Score: 320.88  E-value: 2.66e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  839 LIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLKG---DGIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHL 915
Cdd:cd17677    1 VIAQTNWKFVEGLLKECKMKTKRMLVEKMGQEAVELGHGEvniTGVEENTLIASLCDLLERIWSHGLQTKQGKSALWSHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  916 QAYLEMQEArgagdssgteqtppvssspggkmtiataspalawnamrkrmdylstfqtdfdsppspnrsrsrdrnkfvgl 995
Cdd:cd17677   81 LAYQENEER----------------------------------------------------------------------- 89

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  996 eqLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHL 1075
Cdd:cd17677   90 --LKPLPESLLFDMKNVQNMKEIKTDVGYARAWIRLALEKKLLSKHLKTLLSNQDLLRSLYKRYAFLRCEDEREQFLYHL 167

                        250
                 ....*....|....*.
gi 24655298 1076 LTLNTVDYFSFTNIYP 1091
Cdd:cd17677  168 LSLNAVDYFCFTNTFT 183
RUN2_DENND5 cd17678
RUN2 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 1243-1440 2.13e-81

RUN2 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the second RUN domain of DENND5.


Pssm-ID: 439040  Cd Length: 182  Bit Score: 264.84  E-value: 2.13e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1243 EIQHQLGNCVNVLVKWHYKPSRDRdvGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHNLQM 1322
Cdd:cd17678    1 EIQELLGDAVNNIVKYFYKPEKER--GSLTLLLCGESGLVSCLEQVFLYGFKSSRLFRRNLYIWDFIEKVKEYFESLLKQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1323 ELEDSSSSldssfsngsgsggnslQRREISSIWRLYVQLMDEINGTA--LGKDGKFQLLICLSLREHLLTRLIKPMALTK 1400
Cdd:cd17678   79 EESDKDYE----------------LSKEDRSAMRSFCRLVQKINNASssIGKDGKFQLFICLGLRDHLLHRWLPLLASSP 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 24655298 1401 VTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSIT 1440
Cdd:cd17678  143 VTLQMYEENSFLRDPDLLSFLVQLLESLNEFNITLENSLT 182
RUN1_DENND5A cd17690
RUN1 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, ...
 839-1090 3.76e-75

RUN1 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, also called Rab6-interacting protein 1 (Rab6IP1), is present predominantly in developing neuronal tissue, and functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5A.


Pssm-ID: 439052 [Multi-domain]  Cd Length: 209  Bit Score: 248.39  E-value: 3.76e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  839 LIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALG---LKGDGIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHL 915
Cdd:cd17690    1 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGhgeVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  916 QAYlemQEARGAGDSSGteqtppvssspggkmtiATASPALAWNAMRKRMDYLSTfqtdfdsppspnrsrsrdrnkfvgl 995
Cdd:cd17690   81 LHY---QENRERKTTSS-----------------GLSTSGIILDSERRKSDASLA------------------------- 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  996 eqLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHL 1075
Cdd:cd17690  116 --MPPLKISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHL 193

                        250
                 ....*....|....*
gi 24655298 1076 LTLNTVDYFSFTNIY 1090
Cdd:cd17690  194 LSFNAVDYFCFTNVF 208
RUN1_DENND5B cd17691
RUN1 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, ...
 839-1090 4.16e-75

RUN1 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, also called Rab6-interacting protein 1 (Rab6IP1)-like protein, functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5B.


Pssm-ID: 439053 [Multi-domain]  Cd Length: 206  Bit Score: 248.05  E-value: 4.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  839 LIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGlKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAH 914
Cdd:cd17691    1 VIAQTNWKFVEGLLKECRMKTKRMLVEKMGHEAVELG-HGEanitGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  915 LQAYLEMQEARgagdssgtEQtppVSSSPGGKmtiataspalawnamrkrmdylstfqtdfdsppSPNRSRSRDRNKFVG 994
Cdd:cd17691   80 LLHFQEREEKQ--------EH---VAESPVAN---------------------------------GLERRKSETGVNLPT 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  995 LEQlcplpeSLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYH 1074
Cdd:cd17691  116 LRV------SLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQALTKKLYKRYAFLRCEEEKEQFLYH 189

                        250
                 ....*....|....*.
gi 24655298 1075 LLTLNTVDYFSFTNIY 1090
Cdd:cd17691  190 LLSLNAVDYFCFTSVF 205
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1095-1203 4.52e-60

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 201.23  E-value: 4.52e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1095 LPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRN 1174
Cdd:cd01757    1 MPYHVVIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQNLGKLTTVQIGHDNSGLLAKWLVEYVMVRN 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 24655298 1175 EVTGHTYKFPCGRWLGRGVD-----DDSTERLLV 1203
Cdd:cd01757   81 EITGHTYKFPCGRWLGEGVDdgngeDGSLERVLV 114
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 243-435 7.14e-53

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 183.55  E-value: 7.14e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298     243 VAKSITLICQAPYAFAAQMFLKNLYRClpRQPGAGISLESYVYNILYEVmlPQPGKSIRVY-LPPTEPHlppialILQRP 321
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRL--LPSSSNLPLELLISLLLYPV--PPPGGSLVLVsLGPGDLI------ELQRP 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298     322 LlATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFL 401
Cdd:smart00799   71 L-DSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVL 149

                           170       180       190
                    ....*....|....*....|....*....|....
gi 24655298     402 DAPVPFVMGLHAECEAAHKIGSEATLCFVDIDKK 435
Cdd:smart00799  150 SAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 242-434 2.74e-46

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 164.67  E-value: 2.74e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298    242 YVAKSITLICQAPYAFAAQMFLKNLYR----CLPRQPgagisLESYVYNILYEVMLPQPGKSIRVYlpptePHLPPIALI 317
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRrrtiSPLPNP-----IERFIANLLYEVPFPPPGRTQKLK-----PLGGTEPIL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298    318 LQRPLlATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAAL 397
Cdd:pfam02141   71 LQRPE-DSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASL 149

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 24655298    398 HHFLDAPVPFVMGLHAECEAAHkIGSEATLCFVDIDK 434
Cdd:pfam02141  150 LDVLSAPTPFIIGVHSRYFDLL-EDPLDDVVLVDLDT 185
RUN2_DENND5B cd17693
RUN2 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, ...
 1243-1440 1.22e-37

RUN2 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, also called Rab6-interacting protein 1 (Rab6IP1)-like protein, functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the second RUN domain of DENND5B.


Pssm-ID: 439055  Cd Length: 179  Bit Score: 139.59  E-value: 1.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1243 EIQHQLGNCVNVLVKWHYKPSRDRdvGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHNLQM 1322
Cdd:cd17693    1 QIQEGIGEAVNNIVKHFHKPEKER--GSLTVLLCGENGLVAALEQVFHHGFKSARIFQKNVFIWDFIEKAVAYFETTDQI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1323 ELEDSSSSLDssfsngsgsggnslqrreiSSIWRLYVQLMDEINGTA--LGKDGKFQLLICLSLREHLLTRLIKPMALTK 1400
Cdd:cd17693   79 GDLEEDLLIL-------------------KSSCKTFCHYVNAINTAPrnIGKDGKFQLLVCLGARDHLLPQWIPLLAECP 139

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 24655298 1401 VTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSIT 1440
Cdd:cd17693  140 VITRMYEENALLRDRMTVNSLIRVLQTLQDFNITLEGSLI 179
RUN2_DENND5A cd17692
RUN2 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, ...
 1243-1440 1.28e-33

RUN2 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, also called Rab6-interacting protein 1 (Rab6IP1), is present predominantly in developing neuronal tissue, and functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the second RUN domain of DENND5A.


Pssm-ID: 439054  Cd Length: 176  Bit Score: 128.12  E-value: 1.28e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1243 EIQHQLGNCVNVLVKWHYKPSRDRdvGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFgRNLYIWDYFTKIKELFEhnlqm 1322
Cdd:cd17692    1 QIQEAVGEAINGIVKHFHKPEKER--GSLTLLLCGENGLVSALEQVFQHGFKSPRLF-KNVFIWDFLEKAQAYYE----- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1323 eledssssldssfsngsgsggnSLQRREIS--SIW----RLYVQLMDEINGTA--LGKDGKFQLLICLSLREHLLTRLIK 1394
Cdd:cd17692   73 ----------------------SLEQNELVpeENWqtraRNFCRFVNAINSTPrnIGKDGKFQMLVCLGARDHLLHHWIA 130

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 24655298 1395 PMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSIT 1440
Cdd:cd17692  131 LLADCPITAQMYEDTALIKDHTLVNSLIRVLQTLQEFNITLEASLV 176
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 70-171 2.41e-26

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 103.95  E-value: 2.41e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298      70 SRFADYFVICGLDLDTGlepdrfagdnlhcsPLDRAYKSKPLAHYPENVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPR 149
Cdd:smart00800    2 SRLFDYFVVVGLDSDTG--------------PLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFVTQTSSKDPQ 67

                            90       100
                    ....*....|....*....|..
gi 24655298     150 FHSFATTREDGKRCYGFSLVFY 171
Cdd:smart00800   68 FFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 626-701 4.36e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 82.72  E-value: 4.36e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24655298     626 NNSVREIFLNRFVHMFHAYEYFVIYpnqardeWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNK 701
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRE-------LRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
RUN smart00593
domain involved in Ras-like GTPase signaling;
1026-1088 3.04e-18

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 79.97  E-value: 3.04e-18
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24655298    1026 RAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTN 1088
Cdd:smart00593    2 RAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFNLPVD 64
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1096-1203 4.74e-18

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 81.45  E-value: 4.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1096 PYRVVIFPSRKYGSyHTSSNVWIMV------SGTM---NETQRVPVPKGSL-EFIFHYKNLGLLTTMRIGHDNSGPSHKW 1165
Cdd:cd01756    2 TYEVTVKTGDVKGA-GTDANVFITLygengdTGKRklkKSNNKNKFERGQTdKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 24655298 1166 LVEQVVMRNEVTGHTYKFPCGRWLGRGVDDDSTERLLV 1203
Cdd:cd01756   81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELY 118
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 995-1086 1.57e-15

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 75.54  E-value: 1.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  995 LEQLCPLPESLEF--DVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFL 1072
Cdd:cd17671   62 LEALEKLLPAPSLkqAIRDINSLSNVKTDDGRGRAWIRLALNEKSLESYLAALLSDQSLLRKYYEPWALLRDPEEAELFL 141

                         90
                 ....*....|....
gi 24655298 1073 YHLLTLNTVDyFSF 1086
Cdd:cd17671  142 SLLVGLSSLD-FNL 154
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1097-1202 4.25e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 73.08  E-value: 4.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1097 YRVVIFPSRKYGSyHTSSNVWIMVSGTmNETQRVPVPKGSLEFIFHY-----------KNLGLLTTMRIGHDNSGPSHKW 1165
Cdd:cd01752    3 YLVTVFTGWRRGA-GTTAKVTITLYGA-EGESEPHHLRDPEKPIFERgsvdsfllttpFPLGELQSIRLWHDNSGLSPSW 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 24655298 1166 LVEQVVMRNEVTGHTYKFPCGRWLGRGVDDDSTERLL 1202
Cdd:cd01752   81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTF 117
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1096-1201 1.19e-14

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 71.60  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1096 PYRVVIFPSRKYGSYhTSSNVWIMVSGTMNETQRVPVPKGSLEF----IFHYK-----NLGLLTTMRIGHDNSGPSHKWL 1166
Cdd:cd00113    2 RYTVTIKTGDKKGAG-TDSNISLALYGENGNSSDIPILDGPGSFergsTDTFQidlklDIGDITKVYLRRDGSGLSDGWY 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 24655298 1167 VEQVVMRNEVTGHTYKFPCGRWLGRGVDDDSTERL 1201
Cdd:cd00113   81 CESITVQALGTKKVYTFPVNRWVLGGKWYTSVRSL 115
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 111-169 4.71e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 68.02  E-value: 4.71e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24655298    111 LAHYPENVPWNPFDAHGICMLSLPQGLRfrtQKHCIEPRFHSFATTREDGKRCYGFSLV 169
Cdd:pfam03456    4 LDRYPEDDWSDPPLPDGIPMFCFPEGLE---TLSSREPTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 668-720 3.67e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.91  E-value: 3.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24655298    668 FDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKilamwESQPDEQLQLFDQR 720
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEER-----LESSDPSIDLFDEE 48
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1097-1198 5.94e-12

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 63.99  E-value: 5.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298   1097 YRVVIFPSRKYGSYhTSSNVWIMVSGTMNETQRVPVPKGSLEF---------IFHYKNLGLLTTMRIGHDNSGPSHKWLV 1167
Cdd:pfam01477    1 YQVKVVTGDELGAG-TDADVYISLYGKVGESAQLEITLDNPDFergaedsfeIDTDWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 24655298   1168 EQV-VMRNEVTGHTYKFPCGRWLGRGVDDDST 1198
Cdd:pfam01477   80 KSItVEVPGETGGKYTFPCNSWVYGSKKYKET 111
RUN_RUFY1_like cd17681
RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar ...
 995-1083 2.06e-11

RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar proteins; This family includes RUN and FYVE domain-containing protein RUFY1, RUFY2, and RUFY3. RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. RUFY1, RUFY2, and RUFY3 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439043  Cd Length: 155  Bit Score: 63.36  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  995 LEQLCPL-PESLEFdVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLrCEEEKEQFLY 1073
Cdd:cd17681   66 LEHVEKLvPEANEI-TASVRDLPGIKTPLGRARAWLRLALMQKKLADYFRALIENKDLLSEFYEPGALM-MSEEAVVIAG 143

                         90
                 ....*....|
gi 24655298 1074 HLLTLNTVDY 1083
Cdd:cd17681  144 LLVGLNVIDC 153
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 995-1083 2.53e-11

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 62.68  E-value: 2.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298    995 LEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYH 1074
Cdd:pfam02759   40 VGKLVPPAEELLSSVQELEQIHTPYSPDGRGRAWIRLALNEKLLDQWLKLLLSNKELLSEYYEPWALLADPEFGEILLGL 119


                   ....*....
gi 24655298   1075 LLTLNTVDY 1083
Cdd:pfam02759  120 LVGLSALDF 128
RUN_PLEKHM1 cd17679
RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and ...
 1018-1086 1.11e-10

RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and similar proteins; PLEKHM1, also called PH domain-containing family M member 1, or 162 kDa adapter protein (AP162), may act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. This model represents the RUN domain of PLEKHM1.


Pssm-ID: 439041 [Multi-domain]  Cd Length: 171  Bit Score: 61.84  E-value: 1.11e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24655298 1018 IKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLntvDYFSF 1086
Cdd:cd17679   94 ITTDVGRCRAWIRLALNDGLLESYLEAILKDKSALKSYYNPSAFLRDPEQLDILKSLLQGL---ESFQF 159
RUN smart00593
domain involved in Ras-like GTPase signaling;
1376-1436 3.98e-10

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 56.85  E-value: 3.98e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24655298    1376 FQLLICLSLREHLLTRLIKPMALT-KVTHEMYEEESFLRRRNLLTFLIQILEPL--DDCHIVLE 1436
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDeELLSKYYEPWAFLRDPEEGEQLLGLLVGLsaLDFNLPVD 64
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 1281-1430 5.03e-10

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 59.36  E-value: 5.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298 1281 LVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHnlqmeledssssldssfsngsgsggnslqrreissiwRLYVQ 1360
Cdd:cd17671   34 LCAALEAILSHGLKPKRFGGGKVSFWDFLEALEKLLPA-------------------------------------PSLKQ 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24655298 1361 LMDEINGTALGK--DGKFQLLICLSLREHLLTRLIKP-MALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDD 1430
Cdd:cd17671   77 AIRDINSLSNVKtdDGRGRAWIRLALNEKSLESYLAAlLSDQSLLRKYYEPWALLRDPEEAELFLSLLVGLSS 149
RUN_SNX29 cd17689
RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN ...
 882-1066 4.26e-09

RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN domain-containing protein 2A (RUNDC2A), belongs to the sorting nexin family. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain, a phospholipid-binding motif, or through protein-protein interactions with membrane-associated protein complexes. Some sorting nexin family members have been shown to facilitate protein sorting. This model contains the RUN domain of SNX29.


Pssm-ID: 439051  Cd Length: 166  Bit Score: 57.24  E-value: 4.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  882 EENTLIASMCDLLEKIWSHGLQNKQGKSalwahlQAYLEMQEARGAGDSSGTEQTPPVssspggkmtiataspalAWNAM 961
Cdd:cd17689   22 ESDSRVSCLCAQLEAVLQHGLKTSRSPN------LVSSAVTQVSGLAGSLGSAETEPT-----------------FWPFV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  962 RkrmDYLStfqtdfdsppspnrsrSRDRNKFvgleqlcplpESLefdvKNvlamadIKTHIGYTRAWVRLSLEKKLLSRH 1041
Cdd:cd17689   79 K---EHLT----------------KHELERF----------ELL----KN------IWTDIGRGRAWLRSALNEHSLERY 119

                        170       180
                 ....*....|....*....|....*
gi 24655298 1042 FRTLLSDEALLRSLYKRSAFLRCEE 1066
Cdd:cd17689  120 LHILLSNENLLRQYYEDWAFLRDEE 144
RUN_RUFY2 cd17695
RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; ...
 995-1082 1.12e-07

RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. This model represents the RUN domain of RUFY2.


Pssm-ID: 439057  Cd Length: 156  Bit Score: 52.67  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  995 LEQLCPLPESLEFDVKNvlaMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLrCEEEKEQFLYH 1074
Cdd:cd17695   69 VEKLCPEAEEIAASVRD---LPGLKTPLGRARAWLRLALMQKKLADYLRCLIIRRDLLSEFYEYHALM-MEEEGAVIVGL 144


                 ....*...
gi 24655298 1075 LLTLNTVD 1082
Cdd:cd17695  145 LVGLNVID 152
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 995-1082 2.72e-07

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 51.46  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  995 LEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYH 1074
Cdd:cd17682   60 LKKLNKIPKSLSDAVKFVKSCKKVKTNQGRGRLFIRYALNKKCLHDPVQQLVKNPKLLSDYYSPDSILGNEILSEILLSL 139


                 ....*...
gi 24655298 1075 LLTLNTVD 1082
Cdd:cd17682  140 LYQLNEIN 147
RUN_RUBCN cd17686
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ...
 979-1066 1.28e-06

RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN.


Pssm-ID: 439048  Cd Length: 151  Bit Score: 49.57  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  979 PSPNRSRSRDRNKFV-GLEQLCPLPESLEFDVKNVLAMADIKTHIGytRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYK 1057
Cdd:cd17686   38 EFQGLNKEIDDWEFVqGLRWLQPTLAPSIEQQSRSSPSESEVSDKG--RLWLRQSLQQHCLSSQLQWLVSDKELLRKYYE 115


                 ....*....
gi 24655298 1058 RSAFLRCEE 1066
Cdd:cd17686  116 DEAFLRQEG 124
RUN_RUFY1 cd17694
RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; ...
 995-1082 1.57e-06

RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY1 contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439056  Cd Length: 156  Bit Score: 49.52  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  995 LEQLCPLPESLEFDVKNvlaMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAfLRCEEEKEQFLYH 1074
Cdd:cd17694   69 VEKLCPEASDIATSARN---LPELKTAVGRGRAWLHLALMQKKLADYLKVLIDRKDLLSEFYEPGA-LMMEEEGAVIVGL 144


                 ....*...
gi 24655298 1075 LLTLNTVD 1082
Cdd:cd17694  145 LVGLNVID 152
RUN_RUNDC3 cd17684
RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 ...
 1009-1086 2.38e-06

RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 contains two isoforms, RUNDC3A and RUNDC3B. RUNDC3A, also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. RUNDC3B, also called Rap2-binding protein 9, or Rap2-interacting protein 9 (RPIP-9), contains a RUN domain in its N-terminal region that mediates interaction with Rap2, an important component of the Mitogen-Activated Protein Kinase (MAPK) cascade, which regulates cellular proliferation and differentiation. It also contains characteristic binding sites for MAPK intermediates. Both RUNDC3A and RUNDC3B contain a RUN domain.


Pssm-ID: 439046  Cd Length: 150  Bit Score: 48.93  E-value: 2.38e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655298 1009 VKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKeQFLYHLLTLNTVDyFSF 1086
Cdd:cd17684   75 IASIEQMENIKSPKAKGRAWIRVALMEKRLSEYLSTALKQTRLTRNFYQDGAIMLSEDAT-VLCGMLIGLNAID-FSF 150
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 1285-1428 4.71e-06

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 47.65  E-value: 4.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298   1285 LEQVFLCGFRS-------ARFFGRNLYIWDYFTKIKELFEHnlqmeledssssldssfsngsgsggnslQRREISSiwrl 1357
Cdd:pfam02759    6 LEALLSHGLKRssllilrAAGLLPERSFWALLERVGKLVPP----------------------------AEELLSS---- 53

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24655298   1358 yVQLMDEINgTALGKDGKFQLLICLSLREHLLTRLIKPMAL-TKVTHEMYEEESFLRRRNLLTFLIQILEPL 1428
Cdd:pfam02759   54 -VQELEQIH-TPYSPDGRGRAWIRLALNEKLLDQWLKLLLSnKELLSEYYEPWALLADPEFGEILLGLLVGL 123
RUN_RUFY3 cd17696
RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; ...
 995-1082 5.45e-06

RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. This model represents the RUN domain of RUFY3.


Pssm-ID: 439058  Cd Length: 156  Bit Score: 48.07  E-value: 5.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655298  995 LEQLCPLPESLEFDVKNvlaMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAfLRCEEEKEQFLYH 1074
Cdd:cd17696   69 VEKLVPEAAEITASVKD---LPGLKTPVGRGRAWLRLALMQKKLSEYMKALINRKDLLSEFYEPNA-LMMEEEGAIIAGL 144


                 ....*...
gi 24655298 1075 LLTLNTVD 1082
Cdd:cd17696  145 LVGLNVID 152
RUN_PLEKHM2 cd17680
RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and ...
 1009-1063 1.12e-03

RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and similar proteins; PLEKHM2, also called PH domain-containing family M member 2, or Salmonella-induced filaments A (SifA) and Kinesin-Interacting Protein (SKIP), is the lysosome, melanosome and lytic granule cargo adaptor that controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. In addition to kinesin-1, it also interacts with several Rabs to affect endosomal trafficking. This model represents the RUN domain of PLEKHM2.


Pssm-ID: 439042  Cd Length: 145  Bit Score: 41.07  E-value: 1.12e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24655298 1009 VKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLR 1063
Cdd:cd17680   69 IKQIENLPNVTTDLGRGRAWLYLALNEGSLESYLRSFLENRKLVKKFYHKHALLR 123
RUN_RUNDC3A cd17699
RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN ...
 1009-1086 2.46e-03

RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN domain-containing protein 3A (RUNDC3A), also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. It contains a RUN domain.


Pssm-ID: 439061  Cd Length: 151  Bit Score: 40.01  E-value: 2.46e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655298 1009 VKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLrCEEEKEQFLYHLLTLNTVDyFSF 1086
Cdd:cd17699   75 ISSIENMENISTSRAKGRAWIRVALMEKRLSEYIATALRDTRTTRRFYDDGAIM-LREESTVLTGMLIGLSAID-FSF 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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