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Conserved domains on  [gi|21358323|ref|NP_647679|]
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Microfibril-associated protein 1 [Drosophila melanogaster]

Protein Classification

microfibrillar-associated 1 family protein( domain architecture ID 12073021)

microfibrillar-associated 1 family protein similar to human microfibrillar-associated protein 1, also called spliceosome B complex protein MFAP1, which is involved in pre-mRNA splicing as a component of the spliceosome

Gene Ontology:  GO:0000398|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFAP1 pfam06991
Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with ...
 233-437 9.97e-89

Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesized that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.


:

Pssm-ID: 462060 [Multi-domain]  Cd Length: 215  Bit Score: 269.81  E-value: 9.97e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358323   233 PRLKPLFVRKRDRATIQEKEREAQKQKQLEAEAKRAAKERRRATLRMVEESVKKDLEKTKPETNEACIEDVC-TDDENDE 311
Cdd:pfam06991  10 PLLKPVFVPKSKRGTIAEREKLEAEEEEEEEEAKKEAEERKKEADKLVEEEIRREAAAKEAGDEDENEEDVDdTDGLDPE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358323   312 VEYEAWKLRELKRMKRDREERDNVEREKLDIDRMRNMTEEERRQELRQNPKVVTNKATKGKYKFLQKYYHRGAFYLDEEN 391
Cdd:pfam06991  90 AEYEAWKLRELKRIKRDREEREAREKEREEIERRRNMTEEERLAEDRENPKKQREKKPKGKMKFMQKYYHKGAFFQDEDE 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 21358323   392 DVLKRDFAQATLEDHFDKTILPKVMQVKNFGRCGRTKYTHLVDQDT 437
Cdd:pfam06991 170 DIYKRDFSAPTGEDKVDKSLLPKVMQVRDFGKKGRTKYTHLKDEDT 215
 
Name Accession Description Interval E-value
MFAP1 pfam06991
Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with ...
 233-437 9.97e-89

Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesized that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.


Pssm-ID: 462060 [Multi-domain]  Cd Length: 215  Bit Score: 269.81  E-value: 9.97e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358323   233 PRLKPLFVRKRDRATIQEKEREAQKQKQLEAEAKRAAKERRRATLRMVEESVKKDLEKTKPETNEACIEDVC-TDDENDE 311
Cdd:pfam06991  10 PLLKPVFVPKSKRGTIAEREKLEAEEEEEEEEAKKEAEERKKEADKLVEEEIRREAAAKEAGDEDENEEDVDdTDGLDPE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358323   312 VEYEAWKLRELKRMKRDREERDNVEREKLDIDRMRNMTEEERRQELRQNPKVVTNKATKGKYKFLQKYYHRGAFYLDEEN 391
Cdd:pfam06991  90 AEYEAWKLRELKRIKRDREEREAREKEREEIERRRNMTEEERLAEDRENPKKQREKKPKGKMKFMQKYYHKGAFFQDEDE 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 21358323   392 DVLKRDFAQATLEDHFDKTILPKVMQVKNFGRCGRTKYTHLVDQDT 437
Cdd:pfam06991 170 DIYKRDFSAPTGEDKVDKSLLPKVMQVRDFGKKGRTKYTHLKDEDT 215
 
Name Accession Description Interval E-value
MFAP1 pfam06991
Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with ...
 233-437 9.97e-89

Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesized that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.


Pssm-ID: 462060 [Multi-domain]  Cd Length: 215  Bit Score: 269.81  E-value: 9.97e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358323   233 PRLKPLFVRKRDRATIQEKEREAQKQKQLEAEAKRAAKERRRATLRMVEESVKKDLEKTKPETNEACIEDVC-TDDENDE 311
Cdd:pfam06991  10 PLLKPVFVPKSKRGTIAEREKLEAEEEEEEEEAKKEAEERKKEADKLVEEEIRREAAAKEAGDEDENEEDVDdTDGLDPE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358323   312 VEYEAWKLRELKRMKRDREERDNVEREKLDIDRMRNMTEEERRQELRQNPKVVTNKATKGKYKFLQKYYHRGAFYLDEEN 391
Cdd:pfam06991  90 AEYEAWKLRELKRIKRDREEREAREKEREEIERRRNMTEEERLAEDRENPKKQREKKPKGKMKFMQKYYHKGAFFQDEDE 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 21358323   392 DVLKRDFAQATLEDHFDKTILPKVMQVKNFGRCGRTKYTHLVDQDT 437
Cdd:pfam06991 170 DIYKRDFSAPTGEDKVDKSLLPKVMQVRDFGKKGRTKYTHLKDEDT 215
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 230-359 2.69e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.57  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358323   230 DNEPRLKPLFVRKRDRATIQEKEREAQKQKQLEAEAKRAAKERRRATLRMVEESVKKDLEKTKPEtneaciedvctdden 309
Cdd:pfam17380 304 EKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQE--------------- 368

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 21358323   310 dEVEYEAWKLRELKRMKRDREERDNVEREKLDIDRMRNMTEEERRQELRQ 359
Cdd:pfam17380 369 -EIAMEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQ 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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